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Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy

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World Journal of Gastrointestinal Oncology 2019年第4期11卷 295-309页

作者： Chloé Serayssol Charlotte Maulat Florence Breibach Fatima-Zohra Mokrane Janick Selves Rosine Guimbaud Philippe Otal Bertrand Suc Emilie berard Fabrice Muscari Department of Digestive Surgery and Liver Transplantation Toulouse-Rangueil University Hospital Department of Pathology Toulouse University Hospital Department of Radiology Toulouse-Rangueil University Hospital Department of Oncology Toulouse-Rangueil University Hospital The Toulouse Research Methodology Support Unit Toulouse University Hospital

BACKGROUND Colorectal cancer is the third most common cancer in men and the second most common in women worldwide. Almost a third of the patients has or will develop liver metastases. Neoadjuvant chemotherapy(NAC) has recently become nearly systematic prior to surgery of colorectal livers metastases(CRLMs). The response to NAC is evaluated by radiological imaging according to morphological *** recently, the response to NAC has been evaluated based on histological criteria of the resected specimen. The most often used score is the tumor regression grade(TRG), which considers the necrosis, fibrosis, and number of viable tumor *** To analyze the predictive factors of the histological response, according to the TRG, on CRLM surgery performed after *** January 2006 to December 2013, 150 patients who had underwent surgery for CRLMs after NAC were included. The patients were separated into two groups based on their histological response, according to Rubbia-Brandt *** on their TRG, each patient was either assigned to the responder(R) group(TRG 1, 2, and 3) or to the non-responder(NR) group(TRG 4 and 5). All of the histology slides were re-evaluated in a blind manner by the same specialized pathologist. Univariate and multivariate analyses were *** Seventy-four patients were classified as responders and 76 as *** postoperative mortality rate was 0.7%, with a complication rate of 38%.Multivariate analysis identified five predictive factors of histological *** were predictive of non-response: More than seven NAC sessions, the absence of a radiological response after NAC, and a repeat hepatectomy(P <0.005). Two were predictive of a good response: A rectal origin of the primary tumor and a liver-first strategy(P < 0.005). The overall survival was 57% at 3 yr and 36% at 5 yr. The disease-free survival rates were 14% at 3 yr and 11% at 5 *** factors contributing to a poor prognosis for disease-free survi

关键词： Colorectal liver metastasis Tumor regression grade Neoadjuvant chemotherapy Liver surgery Histological response Hepatectomy

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富士彩色Reala CS胶片

感光材料 1990年第4期 52-56页

作者： berard Leblanc 杜立成

一、结构和技术1.结构Reala CS 胶片的剖面示意图(图1)表明,在片基上仍然是涂有15个涂层。总体是富士的常规结构。在高感层和低感层之间,感绿层和感红层之间设有一些控制影像的中间抑制层。感青层安排在感蓝层和黄滤色层下面,我们会看... 详细信息

一、结构和技术1.结构Reala CS 胶片的剖面示意图(图1)表明,在片基上仍然是涂有15个涂层。总体是富士的常规结构。在高感层和低感层之间,感绿层和感红层之间设有一些控制影像的中间抑制层。感青层安排在感蓝层和黄滤色层下面,我们会看到它的实际光谱作用和比色作用。

关键词：富士牌彩色感光胶片 Reala CS

EDF EPR PROJECT: OPERATING PRINCIPLES VALIDATION AND HUMAN FACTOR ENGINEERING PROGRAM

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EDF EPR PROJECT: OPERATING PRINCIPLES VALIDATION AND HUMAN F...

Thymic langerhans cell histiocytosis in children:A case report

第十三届国际核工程大会

作者： Bruno Lefebvre Eric berard Jean-Marc Arpino EDF Nuclear department EDF Nuclear department EDF Nuclear department

＜正＞ This article describes the specificities of the operating principles chosen by EDF for the EPR project as a result of an extensive Human Factor Engineering program successfully implemented in an industrial project context. The design process and its achievements benefit of the EDF experience feedback not only in term of NPP operation -including the fully computerized control room of the N4-serie - but also in term of NPP

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Open Journal of Pediatrics 2012年第4期2卷 303-305页

作者： Marie Poncelet Camille Chabert Jean Pierre Pracros Perrine Marec berard Pediatric Institute of Hematology and Oncology Institut d’Hématologie et d’Oncologie Pédiatrique(IHOP)LyonFrance Pediatric Unit of Radiology Hopital Femme Mere Enfant(HFME)LyonFrance

Langerhans cell histiocytosis has long been described as a rare systemic disorder involving the proliferation of Langerhans cells with formation of granuloma. The disease may be localised or diffuse. Typical forms of the disease involving the bone, the skin or the pituitary gland have been well described whereas others, such as thymic histiocytosis, are still poorly understood. Here, we report a case of isolated Langerhans cell histiocytosis of the thymus in an infant with non-specific symptoms. We provide a description of the disease and discuss patient management.

关键词： Langerhans Cell Histiocytosis Children Thymus

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大气污染排放的测定

产业与环境 1992年第1期14卷 40-44页

作者：刘云清 berard Boeuf SERES公司市场及贸易负责人 B.P.87 13762 Les Milles Cedex France

法国对于重要工业装置的粉尘排放已经进行了长期测定。使用最广的一种测定方法,所依据的原理是光线在烟囱中存在的粒子上发生反射。当前更新的是气体连续测定。法国卡昌师范大学、光学研究所和埃尔夫·阿基坦公司研究中心开发了一种... 详细信息

法国对于重要工业装置的粉尘排放已经进行了长期测定。使用最广的一种测定方法,所依据的原理是光线在烟囱中存在的粒子上发生反射。当前更新的是气体连续测定。法国卡昌师范大学、光学研究所和埃尔夫·阿基坦公司研究中心开发了一种用来分析SO_2、NO和HCl的新方法。此方法使用干涉光谱仪技术,能检测许多种污染气体。利用的是被测气体吸收光谱的两个特征:吸收带的平均波长和该吸收带的精细结构。这样就保证了测定的专一性。烃类经常使用的是火焰离子化检定法。在法国已被批准使用的分析仪,其特征就是在负压下工作,这样就避免了在泵的阀门和隔膜上发生凝缩的危险。

关键词：大气污染测定排放

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旭苹果在贮藏中的β—半乳糖苷酶活性

国外农学(果树) 1983年第1期 22-23页

作者： berard L.S. 黄正琦

以前认为β一半乳糖苷酶参与苹果软化过程。而新近的研究表明,在苹果软化以前,β一半乳糖苷酶活性未必一定要增强,它可能不水解苹果胞壁物质。另一方面,有关用丁酰肼和减压贮藏(LPS)处理果实内酶活性的资料还很少,而这两种处理都可能推... 详细信息

以前认为β一半乳糖苷酶参与苹果软化过程。而新近的研究表明,在苹果软化以前,β一半乳糖苷酶活性未必一定要增强,它可能不水解苹果胞壁物质。另一方面,有关用丁酰肼和减压贮藏(LPS)处理果实内酶活性的资料还很少,而这两种处理都可能推迟软化。这方面的报导只有两篇:Babbitt等的报告表明,丁酰肼处理的西红柿纤维素酶活性较高,而Bangerth的报告则表明LPS处理的金冠苹果中苹果酸酶、酸性磷

关键词：旭苹果半乳糖酶活性己糖酶活力果肉果实形态气调贮藏 CA贮藏

口服糖皮质激素与心脑血管疾病风险的人群病例对照研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 18-19页

作者： Souverein P.C. berard A. Van Staa T.P. 张明娟 Dept. Pharm acoepidemiology P. Utrecht Inst. Pharmaceutical Sci. PO Box 80082 3508 TB Utr echt NetherlandsDr.

Objective: To assess whether use of oral glucocorticoids is associated with ca rdiovascular and cerebrovascular morbidity. Design and setting: Nested case-con trol study within a cohort of patients (≥50 years old) with at least one prescr iption for oral or non-systemic glucocorticoids. Data were from the general pra ctice research database. Patients: 50 656 patients were identified with a first record for ischaemic heart disease (International classification of diseases, ni nth revision (ICD-9) codes 410, 411, 413, and 414), ischaemic stroke or transie nt ischaemic attack (ICD-9 codes 430-436), or heart failure (ICD-9 code 428) between 1988 and 1998. One control was matched to each case by sex, age, general practice, underlying disease, and calendar time. Main outcome measure: Odds rat io (OR) of cardiovascular or cerebrovascular events in patients using oral gluco corticoids compared with non-users. Results: There was a significant associatio n between ever use of oral glucocorticoids and any cardiovascular or cerebrovasc ular outcome (adjusted OR 1.25, 95%confidence interval (CI) 1.21 to 1.29). The association was stronger for current use of oral glucocorticoids than for recent or past use. Among current users, the highest ORs were observed in the group wi th the highest average daily dose, although the dose-response relation was not continuous. Current use was associated with an increased risk of heart failure ( adjusted OR 2.66, 95%CI 2.46 to 2.87), which was consistent between patients wi th rheumatoid arthritis, patients with chronic obstructive pulmonary disease, an d patients without either of the two conditions. Also, current use was associate d with a smaller increased risk of ischaemic heart disease (OR 1.20, 95%CI 1.11 to 1.29). Conclusions: Oral glucocorticoid use was identified as a risk factor for heart failure. However, the evidence remains observational and only a random ised controlled trial of glucocorticoid treatment versus other disease modifyi

关键词：心脑血管疾病糖皮质激素病例对照研究一过性缺血发作缺血性脑卒中慢性阻塞性肺病心血管疾病缺血性心脏病国际疾病分类比值比

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多相流测量新技术

国外测井技术 2005年第6期20卷 51-62页

作者： Ian Atkinson Bertrand Theuveny Michel berard Gilbert Conort Trey Lowe Allan McDiarmid Parviz Mehdizadeh Bruno Pinguet Gerald Smith Kerry J．Willimnson 英国剑桥俄罗斯莫斯科美国得克萨斯州Rosharon 得克萨斯州休斯敦阿帕奇能源有限公司澳大利亚WestPerth 美国亚利桑那州Scottsdale 挪威卑尔根壳牌勘探与生产公司美国路易斯安那州新奥尔良

一种新的地面流量计从根本上改变了我们测量生产井复杂流动的方式。这种新技术引发的改变使我们能准确测量三相流体中的快速变化，包括以前很难定量测量的段塞流、泡状流和稳定乳状液流等。实时测量多相流提高了作业效率，节省了时间和... 详细信息

一种新的地面流量计从根本上改变了我们测量生产井复杂流动的方式。这种新技术引发的改变使我们能准确测量三相流体中的快速变化，包括以前很难定量测量的段塞流、泡状流和稳定乳状液流等。实时测量多相流提高了作业效率，节省了时间和费用。

关键词：多相流测量技术复杂流动快速变化三相流体准确测量定量测量实时测量生产井