Methods and approaches to disease mechanisms using systems kinomics
作者机构：Department of Medical MicrobiologyUniversity of ManitobaWinnipegR3E 0J9Canada JC Wilt Infectious Diseases Research CentrePublic Health Agency of CanadaWinnipegCanada Canadian Food Inspection AgencyWinnipegCanada
出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)
年 卷 期：2018年第3卷第1期
页 面：34-43页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：diseases homeostasis utilizing
摘 要：All cellular functions,ranging from regular cell maintenance and homeostasis,specialized functions specific to cellular types,or generating responses due to external stimulus,are mediated by proteins within the *** of these proteins allows the cell to alter its behavior under different circumstances.A major mechanism of protein regulation is utilizing protein kinases and phosphatases;enzymes that catalyze the transfer of phosphates between substrates[1].Proteins involved in phosphate signaling are well studied and include kinases and phosphatases that catalyze opposing reactions regulating both structure and function of the *** is the study of kinases,phosphatases and their targets,and has been used to study the functional changes in numerous diseases and infectious diseases with aims to delineate the cellular functions *** the phosphate signaling pathways changed by certain diseases or infections can lead to novel therapeutic ***,a daunting 518 putative protein kinase genes have been identified[2],indicating that this protein family is very large and *** which enzymes are specific to a particular disease can be a laborious *** this review,we will provide information on large-scale systems biology methodologies that allow global screening of the kinome to more efficiently identify which kinase pathways are pertinent for further study.
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