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Multi-Material ALE with AMR for Modeling Hot Plasmas and Cold Fragmenting Materials

Plasma Science and Technology 2015年第2期17卷 117-128页

作者： alice koniges Nathan MASTERS Aaron FISHER David EDER Wangyi LIU Robert ANDERSON David BENSON Andrea BERTOZZI Lawrence Berkeley National Laboratory Lawrence Livermore National Laboratory Jacobs School of Engineering 9500 Gilman Dr.UCSDLa JollaCA 92093USA Department of Mathematics 520 Portola PlazaUCLALos AngelesCA 90095USA

We have developed a new 3D multi-physics multi-material code, ALE-AMR, which combines Arbitrary Lagrangian Eulerian （ALE） hydrodynamics with Adaptive Mesh Refinement （AMR） to connect the continuum to the microstructural regimes. The code is unique in its ability to model hot radiating plasmas and cold fragmenting solids. New numerical techniques were developed for many of the physics packages to work efficiently on a dynamically moving and adapting mesh. We use interface reconstruction based on volume fractions of the material components within mixed zones and reconstruct interfaces as needed. This interface reconstruction model is also used for void coalescence and fragmentation. A flexible strength/failure framework allows for pluggable material models, which may require material history arrays to determine the level of accumulated damage or the evolving yield stress in J2 plasticity models. For some applications laser rays are propagating through a virtual composite mesh consisting of the finest resolution representation of the modeled space. A new 2nd order accurate diffusion solver has been implemented for the thermal conduction and radiation transport packages. One application area is the modeling of laser/target effects including debris/shrapnel generation. Other application areas include warm dense matter, EUV lithography, and material wall interactions for fusion devices.

关键词： multi-physics simulations arbitrary lagrangian eulerian hydrodynamics,adaptive mesh refinement fragmentation laser ray tracing NIF

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Deciphering the epitranscriptome： A green perspective

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Journal of Integrative Plant Biology 2016年第10期58卷 822-835页

作者： alice Burgess School of Biological Sciences The University of Adelaide South Australia 5005 Australia School of Agriculture Food and Wine The WaiteResearch Institute The University of Adelaide South Australia 5005 Australia The University of Adelaide and Shanghai Jiao Tong University Joint International Centre for Agriculture and Health Joint International Research Laboratory of Metabolic & Developmental Sciences AdelaideAustralia

The advent of high-throughput sequencing technol- ogies coupled with new detection methods of RNA modifica- tions has enabled investigation of a new layer of gene regulation - the epitranscriptome. With over loo known RNA modifications, understanding the repertoire of RNA modifications is a huge undertaking. This review summarizes what is known about RNA modifications with an emphasis on discoveries in plants. RNA ribose modifications, base methyl- ations and pseudouridylation are required for normal develop- ment in Arabidopsis, as mutations in the enzymes modifying them have diverse effects on plant development and stress responses. These modifications can regulate RNA structure, turnover and translation. Transfer RNA and ribosomal RNA modifications have been mapped extensively and their functions investigated in many organisms, including plants. Recent work exploring the locations, functions and targeting of N6-methyladenosine （m^6A）, 5-methylcytosine （m^5C）, pseudour- idine （up）, and additional modifications in mRNAs and ncRNAs are highlighted, as well as those previously known on tRNAs and rRNAs. Many questions remain as to the exact mechanisms of targeting and functions of specific modified sites and whether these modifications have distinct functions in the different classes of RNAs.

关键词： RNA modifications epitranscriptome RNA 5-methylcytosine (m^5C) N^6-methyladenosine (m^6A) Pseudouridine (φ) Arabidopsis

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A perspective on age-related changes in cell environment and risk of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 719-720页

作者： alice Y.Liu Department of Cell Biology and Neuroscience Rutgers State University of New JerseyPiscatawayNJUSA

“Age-related neurodegenerative disease”underscores human age as the primary risk factor for disease development:Alzheimer’s,Parkinson’s,and Huntington’s disease(HD)as *** for the age-dependent delay in disease manifestation,in particular for autosomal dominant forms of the disease,and the underlying cause(s)of specific neuron dysfunction and death to manifest as memory loss,anxiety,depression,and agitation in disease subjects remain *** are interested in understanding age-related changes in cell environment that can modulate the structure,function,aggregation.

关键词： Huntington Alzheimer death

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The neutron star zoo

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Frontiers of physics 2013年第6期8卷 679-692页

作者： alice K. Harding Astrophysics Science Division NASA Goddard Space Flight Center Greenbelt MD 20771 USA

Neutron stars are a very diverse population, both in their observational and their physical properties. They prefer to radiate most of their energy at X-ray and gamma-ray wavelengths. But whether their emission is powered by rotation, accretion, heat, magnetic fields or nuclear reactions, they are all different species of the same animal whose magnetic field evolution and interior composition remain a mystery. This article will broadly review the properties of inhabitants of the neutron star zoo, with emphasis on their high-energy emission.

关键词： stars neutron stars pulsars binary stars

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Biomarkers vs imaging in the early detection of hepatocellular carcinoma and prognosis

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World Journal of Clinical Cases 2019年第12期7卷 1367-1382页

作者： Lavinia alice Balaceanu Department of Internal Medicine Carol Davila University of Medicine and Pharmacy Sf. Ioan Clinical Emergency Hospital

Hepatocellular carcinoma (HCC) is the 5th most frequently diagnosed cancer in the world, according to the World Health Organization. The incidence of HCC is between 3/100000 and 78.1/100000, with a high incidence reported in areas with viral hepatitis B and hepatitis C, thus affecting Asia and Africa predominantly. Several international clinical guidelines address HCC diagnosis and are structured according to the geographical area involved. All of these clinical guidelines, however, share a foundation of diagnosis by ultrasound surveillance and contrast imaging techniques, particularly computed tomography, magnetic resonance imaging, and sometimes contrast-enhanced ultrasound. The primary objective of this review was to systematically summarize the recent published studies on the clinical utility of serum biomarkers in the early diagnosis of HCC and for the prognosis of this disease.

关键词： Hepatocellular carcinoma Biomarkers Imaging Ultrasonography Computed tomography Magnetic resonance imaging

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Energy tunnels:concept and design aspects

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Underground Space 2018年第4期3卷 268-276页

作者： Marco Barla alice Di Donna Department of Structural Building and Geotechnical EngineeringPolitecnico di TorinoCorso Duca degli Abruzzi 2410129 TorinoItaly

Geotechnical structures are increasingly employed as energy geostructures in Europe and *** being constructed for their primary structural role,they are equipped to exchange heat with the ground and supply thermal energy for heating and cooling of buildings and de-icing of *** technology can play a fundamental role in the current challenge of addressing the increasing need for clean and renewable sources of *** study investigates the possibility of thermal activation of tunnel ***,attention will be paid on a new energy segment,which can be used together with tunnel boring machine tunneling to create so-called energy *** and mechanical designs need to be developed by making effective use of computational methods to quantify the exploitable heat and assess the possible consequences on the surrounding ground and the structure *** on how to proceed in this direction will be provided in this study,showing how thermo-hydro and thermo-mechanical numerical analyses can be used to achieve a proper and effective design of energy *** examples of possible applications will also be presented.

关键词： Energy tunnel Geothermal energy Heating and cooling Geotechnical design

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National Carbon Capture Center:advancing fossil energy technology solutions

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Clean Energy 2020年第3期4卷 300-304页

作者： Jo alice Driggers Southern Company National Carbon Capture CenterWilsonvilleALUSA

Introduction The National Carbon Capture Center is the primary carbon-capture research facility for the US Department of Energy(DOE).Through its role as a neutral test site,the centre is advancing technologies to reduce greenhouse-gas(GHG)emis-sions from fossil-fueled power plants,while also supporting the development of technology solutions for carbon-dioxide(CO_(2))utilization and direct air capture(DAC).

关键词： solutions dioxide neutral

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Mitochondrial bioenergetics and neurodegeneration:a paso doble

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Neural Regeneration Research 2021年第4期16卷 686-687页

作者： alice Rossi Paola Pizzo Department of Biomedical Sciences University of PaduaPaduaItaly Department of Neuroscience Max-Delbruck Centrum fur Molekulare MedizinBerlinGermany

Mitochondria and neuronal activity:The brain is one of the highest energy demanding organs,consuming~20%of the total ATP produced by the whole ***,neurons mainly rely on ATP synthesized by mitochondrial bioenergetics and neuronal activity is strictly dependent on specific mitochondrial localization at synapses,sites consuming a high amount of energy requested for both pre-and post-synaptic ***,mitochondria produce ATP and buffer Ca^2+rises,two essential processes for neurotransmission and generation of membrane potential along the axon(Magistretti and Allaman,2015).

关键词： organs consuming energetics

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An overarching framework to assess the life-time resilience of deteriorating transportation networks in seismic-prone regions

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Resilient Cities and Structures 2022年第2期1卷 87-96页

作者： alice Alipour Behrouz Shafei Department of Civil Constructionand Environmental EngineeringIowa State UniversityAmesIA 50011USA

This study develops a comprehensive framework to assess the resilience of transportation networks consisting of deteriorating bridges subjected to earthquake *** this purpose,the structural capacity of highway bridges is estimated during their service life using a set of detailed finite-element models that simulate the progress of *** developed models take into consideration the main environmental stressors and determine the extent of capacity loss as a function of *** on the degraded state of structural components,seismic fragility analyses are performed to obtain a probabilistic evaluation of the extent of damageability of the existing bridges under seismic *** each transportation link normally consists of a number of bridges,the state of damage in the individual bridges is mapped to the corresponding links and a scenario-based approach is employed to estimate the resilience of the entire transportation *** demonstrate how the consequences of structural degradation can be integrated into the developed framework,the large-scale transportation network of Los Angeles and Orange counties is investigated under a series of aging and earthquake *** outcome of this study indicates how the estimates associated with the functionality measures of a transportation network can be improved if the age factor is properly integrated into the framework used for resilience assessment.

关键词： Resilience assessment Transportation networks Aging bridges Deterioration Functionality measures

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Probability of failure estimation for highway bridges under combined effects of uncorrelated multiple hazards

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Resilient Cities and Structures 2022年第3期1卷 79-93页

作者： Ameh Fioklou alice Alipour Bridge Engineer Connecticut Department of TransportationPhD graduateDepartment of CivilConstructionand Environmental EngineeringIowa State UniversityAmesIowa 50011USA Associate Professor 358Town Engineering BuildingDepartment of CivilConstructionand Environmental EngineeringIowa State UniversityAmesIowa 50011USA

Majority of the highly populated regions of the United States are susceptible to multiple natural *** such regions,the design and construction of structures under multiple hazards are critical to achieve the appropriate structural performance and infrastructure ***-hazard reliability analysis of structural systems evaluates the system response under multiple random loads,some of which may occur simultaneously,or the effect of one may weaken the structural system before the occurrence of the next *** paper studies the combined effects of scouring and earthquakes,as two uncorrelated extreme events,on the performance of reinforced concrete highway *** a continuous effort to support future improvement in understanding the impact of multi-hazard loading scenario on bridges and to develop mitigation actions,this paper assesses the seismic vulnerability of a reinforced concrete highway bridge experiencing the effect of erosion due to the increase in frequency of flood *** analytical fragility approach uses a three-dimensional nonlinear finite element model of the bridge cases with various levels of *** a bridge is system of components,a component level fragility curve is used to track the response of the components for a given ground motion *** system fragility curves are developed to consider the vulnerability of critical components to assess the probability of bridge *** results indicate that under multi-hazard scenarios,the component governing the fragility of the bridge system varies depending on the level of scour sustained by the structure.

关键词： hazard flood bridges

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