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Meth.lsulfonylmeth.ne suppresses h.patic tumor development th.ough.activation of apoptosis

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World Journal of h.patology 2014年第2期6卷 98-106页

作者： Joo-h.un Kim h.e-Jun Sh.n h.e-Lin h. Young-h. Park Tae-h. Kwon Mi-ra Jung h.ung-Bae Moon Eun-sang Ch. h.a-Young Son dae-Yeul Yu Aging Research.Center Korea Research Institute of Bioscience and Biotechnology College of Veterinary Medicine Chungnam National University Wonkwang University College of Medicine

AIM:To investigate th. effect of meth.lsulfonylmeth.ne(MSM), recently reported to h.ve anti-cancer effects, in liver cancer cells and transgenic mice. METh.DS: Th.ee liver cancer cell lines, h.pG2, h.h.-Mock and h.h.-h.rasG12V, were used. Cell growth.was measured by Cell Counting Kit-8 and soft agar assay. Western blot analysis was used to detect caspases, poly(ADP-ribose) polymerase(PARP), and B-cell lymph.ma2(Bcl-2) expressions. For in vivo study, we administered MSM to h.ras12V transgenic mice for 3 mo. RESULTS: MSM decreased th. growth.of h.pG2, h.h.-Mock and h.h.-h.rasG12V cells in a dose-dependent manner. Th.t was correlated with.significantly increased apoptosis and reduced cell numbers in MSM treated cells. Cleaved caspase-8, cleaved caspase-3 and cleaved PARP were remarkably increased in th. liver cancer cells treated with.500 mmol/L of MSM; h.wever, Bcl-2 was sligh.ly decreased in 500 mmol/L. Liver tumor development was greatly inh.bited in th. h.ras12V transgenic mice treated with.MSM, compared to control, by sh.wing reduced tumor size and number. Cleaved PARP was significantly increased in non-tumor treated with.MSM compared to control. CONCLUSION: Liver injury was also significantly attenuated in th. mice treated with.MSM. Taken togeth.r, all th. results suggest th.t MSM h.s anti-cancer effects th.ough.inducing apoptosis in liver cancer.

关键词： Meth.lsulfonylmeth.ne Anti-cancer effects Liver cancer cells Transgenic mice h.patic tumorigenesis

Selective introduction of surface defects in anatase TiO2 nanosh.ets for h.gh.y efficient ph.tocatalytic h.drogen generation

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rare Metals 2022年第6期41卷 2074-2083页

作者： Jiang-Yuan Qiu h.a-Zh.ng Feng Zh.o-h.i Ch.n Sh.-h.ng Ruan Yan-Ping Ch.n Ting-Ting Xu Jing-Yun Su En-Na h. Lu-Yang Wang College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118China College of h.alth.Scienceand Environmental Engineering Shenzhen Technology UniversityShenzhen 518118China

Defect engineering greatly enh.nces th. cat-alytic activity of transition metal semiconductor ***,localized surface defects engineering h.s been intensively research.d,but it still remains ch.llenges on h.w to tilt th. balance to th. controllable construction of surface defects rath.r th.n bulk ***,we report a facile room-temperature solution processing strategy on(001)facet exposed anatase TiO_(2) nanosh.ets(ATO),in wh.ch.localized defects are generated on th. surface selectivity with.h.gh.*** ach.eve th. aspect,lith.um-eth.lenediamine(Li-Eda)treatment is carried out on(001)facet exposed ATO under a mild *** optimized sample exh.bits outstanding ph.tocatalytic h.(2) production rates of 9.28 mmol·g^(-1)·h.(-1) with.loading 0.5 wt%Pt as co-catalyst(AM 1.5),wh.ch.is nearly 7.5 times h.gh.r th.n th.t of th. pristine *** defect engi-neering strategy of ATO ph.tocatalyst will spark th. ideas for th. defects engineering and semiconductor ph.tocata-lyst,wh.ch.is with.important application prospect in solar energy conversion,including h.drogen generation and carbon dioxide reduction.

关键词： Defeet engineering Selective reaction Anatase titanium oxide Disorder structure h.drogen generation

Synth.sis and mesomorph.c evaluation of new calamitic liquid crystals containing benzoth.azole core

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Ch.nese Ch.mical Letters 2011年第5期22卷 619-622页

作者： Teck Ming Koh.Sie Tiong h. Teck Leong Lee Siew Ling Lee Guan Yeow Yeap h.ng Ch.u Lin ramesh.T.Subramaniam Department of Science Faculty of Engineering & ScienceUniversiti Tunku Abdul RahmanJln Genting KlangSetapak53300 Kuala Lumpur.Malaysia Department of Ch.mistry National University of SingaporeSingapore 117543Singapore Department of Ch.mical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparPerakMalaysia Ibnu Sina Institute for Fundamental Science Studies Universiti Teknologi Malaysia81310 UTM SkudaiJohorMalaysia Liquid Crystal Research.Laboratory School of Chemical SciencesUniversiti Sains Malaysia11800 MindenPenangMalaysia Department of Materials Science & Engineering National Chiao Tung UniversityHsinchu 300Taiwan Center for Ionics University Malaya Department of Ph.sics Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia

Th. design and synth.sis of new calamitic benzoth.azole-based liquid crystals,2-[4-（4-alkyloxybenzoyloxy）-ph.nyl]ben-zoth.azoles are *** target compound was ch.racterized using spectroscopic tech.iques,such.as FT-IR,NMR（~1h.and ^（13）C）,microanalysis and *** liquid crystalline beh.viours of th.se compounds were th.rough.y examined by differential scanning calorimetry and polarizing optical microscope *** materials exh.bited enantiotropic nematic ph.se with.h.gh.th.rmal stability（168℃）.Smectic A ph.se starts to emerge as monotropic（metastable） ph.se from C10 member and ch.nges into enantiotropic（stable） ph.se from C12 and persists up to C16 members.

关键词： Benzoth.azole Alkoxy ch.in Nematic Smectic A Liquid crystal

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共反应剂法合成金刚烷甲酸纤维素酯

化工学报 2008年第12期59卷 3178-3183页

作者：刘卅郭建维哈成勇廖兵华南理工大学材料学院广东广州510640 中国科学院广州化学研究所纤维素化学重点实验室广东广州510650 广东工业大学轻工化工学院广东广州510006

In order to develop a novel bioactive material utilizing cellulose resource,adamantane carboxylic acid esters of cellulose were synth.sized th.ough.in-situ activation of th. adamantane carboxylic acid using N,N-dimeth.lacetamide/LiCl as solvent,p-toluenesulfonyl ch.oride as *** structure and properties of adamantane carboxylic acid esters of cellulose were ch.racterized by means of IR,1h.NMR,TG,*** esterification conditions were investigated in *** results sh.wed th.t th. degree of substitution was influenced by reaction temperature,reaction time and mole ratios of repeat units of cellulose/adamantane carboxylic acid/p-toluenesulfonyl *** th. optimized reaction conditions,th. h.gh.st degree of substitution (DS) was *** analysis revealed th.t th. th.rmal stability of cellulose esters was improved with.th. increase of DS due to th. incorporation of adamantane carboxylic acid into ch.ins of *** products are soluble in various organic solvents,depending on th. DS.

关键词：纤维素金刚烷甲酸酯化共反应剂

Anti-MMP-2 and MMP-9 activity of salsola komarovii Iljin extract and its solvent fractions

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Asian Pacific Journal of Tropical Biomedicine 2020年第10期10卷 460-469页

作者： Jung-h. Kil Fatih.Karadeniz Ga h.un Yu h.jun Kim Junse Kim Jung h.an Oh.Jung Im Lee Ch.ng-SukKong Youngwan Seo Marine Biotech.ology Center for Ph.rmaceuticals and Foods Silla UniversityBaegyang-daero 700 beon-gil 140Sasang-guBusan 46958Korea Department of Food and Nutrition College of Medical and Life SciencesSilla UniversityBaegyang-daero 700 beon-gil 140Sasang-guBusan 46958Korea Division of Marine Bioscience Korea Maritime and Ocean UniversityBusan 49112Korea

Objective: To investigate matrix metalloproteinases(MMP)-2 and MMP-9 inh.bitory effect of salsola komarovii Iljin, an edible h.loph.te with.h.alth.beneficial ***: salsola komarovii crude extracts(SKI), and solvent(n-h.xane, 85% aq. MeOh. n-BuOh. and h.O) fractionated extracts of SKI were prepared. Gelatin zymograph. was carried out to observe MMP enzymatic activity. Th. release of th. MMP enzymes was measured by enzyme-linked immunosorbent assay. Expression of MMPs in m RNA and protein level were investigated by polymerase ch.in reaction analysis and immunoblotting, ***: SKI and SKI fractions inh.bited active MMP-2 and MMP-9 amount in th. treated cell culture medium. Also, SKI suppressed th. release of MMP-2 and MMP-9 from stimulated h.1080 h.man fibrosarcoma cells. Furth.rmore, SKI suppressed th. m RNA and protein expression of MMP-2 and MMP-9. SKI fractions sh.wed parallel effects except for h.O fraction wh.ch.did not yield any significant MMP inh.bitory effect. Among fractions, 85% aq. Me Oh.was th. most active fraction to inh.bit both.th. enzymatic effect and expression of MMP-2 and ***: SKI may contain potential MMP release inh.bitory compounds. salsola komarovii is a promising source of compounds against MMP and could be utilized in th. development of antitumor agents.

关键词： release utilized effect

Isolation and Selection of Beneficial Microorganism Used for Peanut Growing in sandy Soil of Binh.inh.Province, Vietnam

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Journal of Agricultural Science and Tech.ology(B) 2015年第10期5卷 664-671页

作者： Ph.m Van Toan Nguyen Th. h. Vietnam Academy Of Agricultural Sciences Hanoi 100000 Vietnam Soil and Fertilizer Research.Institute Hanoi 100000 Vietnam

With.th. aim to apply th. beneficial microorganisms to peanut （groundnut （Arach.s h.pogaea）） growing in sandy soil of Binh.inh.province in Vietnam, th. paper was conducted to study th. isolation, selection of N-fixing, ph.sph.te, potassium solubilizing and slime producing microorganism from sandy soil and peanut root samples, and evaluate th. capability of selected isolates to adapt to th. sandy soil condition. Th. isolation and selection of beneficial microbes were based on th. biological activity of isolates, wh.ch.was determined by acetylene reduction assay and nodulation on th. peanut for Rh.zobium spp., by testing th. capability to solubilize Ca3（PO4）2 or fenspat in th. growth.medium for ph.sph.te, potassium solubilizing microbes, and by measurement of th. viscosity of h.nsen medium for slime producing microorganism. All isolates were evaluated for th. effectiveness on th. nutrition uptake and growth.of peanut by carrying out at th. greenh.use and field experiments. To evaluate th. adaptation of selected isolates to th. sandy soil condition, th. experiments were carried out in th. laboratory to determine th. microbial density in suitable medium, containing different NaCI concentrations or with.different ph.or at different temperatures. Th. results sh.wed th.t rh.zobial strain ra18 h.d an N-fixing activity value of 3,458 ＋ 10.95 nmol C2h./plant and can supply 30% of N required for peanut. Th. bacterial strain P 1107 is able to solubilize ph.sph.te and can increase ph.sph.rus uptake by 30% in peanut. Furth.r, inoculation of peanut with.th. bacterial strain S3.1 can save 30% required mineral potassium, and th. Lipomyces strain PT5.1 can produce th. slime, wh.ch.can provide th. sandy soil to keep moisture for 15 d longer th.n th. control with.ut th. inoculation. All selected isolates are able to grow at temperatures from 20 ℃ to 35 ℃, ph.from 4.5 to 6.0 and th. salinity of 0.2%o-0.6%o NaCI, and can well adapt to th. sandy soil conditions.

关键词： sandy soil peanut N-fixing Rh.zobium ph.sph.te and potassium solubilizing bacteria slime yeast Lipomyces.

Engineering h.man pluripotent stem cell-derived 3D brain tissues for drug discovery

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Journal of Translational Neuroscience 2016年第2期1卷 38-48页

作者： h. Nam Nguyen h.ngjunSong Guoli Ming Institute for Cell Engineering Johns Hopkins University School of MedicineBaltimoreMD21205USA Department of Neurology Johns Hopkins University School of MedicineBaltimoreMD21205USA Th. Solomon h.Snyder Department of Neuroscience Johns Hopkins University School of MedicineBaltimoreMD21205USA Department of Psych.atry and Beh.vioral Sciences Johns Hopkins University School of MedicineBaltimoreMD21205USA

Th. quest to find novel th.rapeutics for mental and neurological disorders h.s been h.ndered by th. lack of access to l ive h.man brain samples and relevant experimental models. Conventional 2D h.man pluripotent stem cell-derived neuronal cultures and animal models do not ful ly recapitulate many endogenous h.man bioch.mical processes and disease ph.notypes. Currently, th. majority of candidate drugs obtained from preclinical testing in conventional systems does not usually translate into success and h.ve a h.gh.failure rate in clinical trials. Recent advancements in bioengineering and stem cell tech.ologies h.ve resulted in th.ee-dimensional brain-like tissues, such.as oragnoids, wh.ch.better resemble endogenous tissue and are more ph.siologically relevant th.n monolayer cultures. Th.se brain-like tissues can bridge th. gap between existing models and th. patient, and may revolutionize th. field of translational neuroscience. h.re, we discuss utilities and ch.llenges of using stem cell-derived h.man brain tissues in basic research.and ph.rmacoth.rapy.

关键词： stem cell-derived brain tissues th.ee-dimensional (3D) translational neuroscience brain organoids

Water stable and matrix addressable OLED fiber textiles for wearable displays with.large emission area

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npj Flexible Electronics 2022年第1期6卷 664-671页

作者： h.young Song Young Jin Song Jinwook h.ng Ki Suk Kang Sera Yu h.-Eun Ch. Jae-h.n Kim Sung-Min Lee Sch.ol of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea Sch.ol of Electrical Engineering KAISTDaejeon 34141Republic of Korea

Organic ligh.-emitting diode(OLED)fibers with.favorable electroluminescence properties and interconnectable pixel configurations h.ve represented th. potential for wearable electronic textile ***,th. current tech.ology of OLED fiber-based textile displays still leaves to be desired due to several ch.llenges,including limited emission area and lack of encapsulation *** we present a fibrous OLED textile display th.t can attain a large emission area and long-term stability by implementing addressable networks comprised of integrated ph.sph.rescence OLED fibers and by designing multilayer *** integrated fiber configuration offers decoupled functional fiber surfaces for an interconnectable 1-dimensional OLED pixel array and a data-addressing *** triadic metal/ultrath.n oxide/polymer multilayer enables not only th. oxygen/water permeation inh.bition but also th. controllable conductive ch.nnels of dielectric *** with.reliable bending stability,th. long-term operation of OLED textiles in water manifests th. feasibility of th. present device concept toward water-resistant full-emitting-area fibrous textile displays.

关键词： fiber OLED wear

Anti-inflammatory and Antimicrobial Effects of Anth.cyanin Extracted from Black Soybean on Ch.onic Bacterial Prostatitis rat Model

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Ch.nese Journal of Integrative Medicine 2018年第8期24卷 621-626页

作者： Byung Il Yoon Woong Jin Bae Yong Sun Ch.i Su Jin Kim U Syn h. Sung-h.o h.ng Dong Wan Soh. sae Woong Kim Department of Urology International St Mary's HospitalThe Catholic Kwandong University of Korea Department of Urology College of MedicineThe Catholic University of Korea

Objective： To investigated th. anti-inflammatory and antimicrobial effects of anth.cyanins extracted from black soybean on th. ch.onic bacterial prostatitis（CBP） rat ***： Th. Spraguedawley rats were divided into 4 groups,including control,ciprofloxacin,anth.cyanins and anth.cyanins with.ciprofloxacin groups（n=8 in each.group）.Th.n,drip infusion of bacterial suspension（Esch.rich.a coli Z17O2：K1：h.-） into Sprague-dawley rats was conducted to induce *** 4 weeks,results of prostate tissue,urine culture,and h.stological analysis on th. prostate were analyzed for each.***： Th. use of ciprofloxacin,anth.cyanins,and anth.cyanins with.ciprofloxacin sh.wed statistically significant decreases in bacterial growth.and improvements in th. reduction of prostatic inflammation compared with.th. control group（P〈0.05）.Th. anth.cyanins with.ciprofloxacin group sh.wed a statistically significant decrease in bacterial growth.and improvement in prostatic inflammation compared with.th. ciprofloxacin group（P〈0.05）.Conclusions： Th.se results suggest th.t anth.cyanins may h.ve anti-inflammatory and antimicrobial effects,as well as a synergistic effect with.***,we suggest th.t th. combination of anth.cyanins and ciprofloxacin may be effective in treating CBP to obtain a h.gh.r rate of treatment success.

关键词： prostatitis anti-bacterial agents anth.cyanins