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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary ali m.alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Complement activation kindles the transition of acute post-traumatic brain injury to a chronic inflammatory disease

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Neural Regeneration Research 2022年第10期17卷 2228-2229页

作者： Andrew Erwood ali m.alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA

Traumatic brain injury(TBI)remains a major cause of disability among young adults in both civilian and military settings contributing to a high burden on healthcare systems(Badhiwala et al.,2019).Sequel of TBI,even mild injuries,include motor and sensory dysfunction,neurocognitive decline,neuropsychiatric complications,as well as increased risk of neurodegenerative and neurovascular events such as Alzheimer’s disease and stroke(Breunig et al.,2013;Burke et al.,2013;Li et al.,2017).Despite the acute nature of the insult in TBI,pathological changes in the traumatized brain are better recognized as a chronic rather than an acute neurological disease,a phenomenon that remains under-investigated.

关键词： acute injuries injury

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Genuine entanglement under squeezed generalized amplitude damping channels with memory

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Chinese Physics B 2024年第2期33卷 158-163页

作者： mazhar ali Department of Electrical Engineering Faculty of EngineeringIslamic University MadinahMadinah 107Saudi Arabia

We study genuine entanglement among three qubits undergoing a noisy process that includes dissipation, squeezing,and decoherence. We obtain a general solution and analyze the asymptotic quantum states. We find that most of these asymptotic states can be genuinely entangled depending upon the parameters of the channel, memory parameter, and the parameters of the initial states. We study Greenberger–Horne–Zeilinger(GHZ) states and W states, mixed with white noise,and determine the conditions for them to be genuinely entangled at infinity. We find that for these mixtures, it is possible to start with a bi-separable state(with a specific mixture of white noise) and end with genuine entangled states. However, the memory parameter μ must be very high. We find that in contrast to the two-qubit case, none of the three-qubit asymptotic states for n → ∞ are genuinely entangled.

关键词： genuine entanglement squeezed thermal baths multipartite states

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metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： mohammad m Khan Zaw ali Khan mohsin ali Khan Laboratory of Translational Neurology and molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Using neural network modeling to improve the detection accuracy of land subsidence due to groundwater withdrawal

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Journal of mountain Science 2024年第7期21卷 2320-2333页

作者： ali m.RAJABI ali EDALAT Yasaman ABOLGHASEmI mahdi KHODAPARAST Department of Engineering Geology University of TehranTehran ***Iran Department of Civil Engineering University of QomQom ***Iran

Despite the high efficiency of remote sensing methods for rapid and large-scale detection of subsidence phenomena,this technique has limitations such as atmospheric impact and temporal and spatial decorrelation that affect the accuracy of the *** paper proposes a method based on an artificial neural network to improve the results of monitoring land subsidence due to groundwater overexploitation by radar interferometry in the aliabad plain(Central Iran).In this regard,vertical ground deformations were monitored over 18 months using the Sentinel-1A SAR *** model the land subsidence by a multilayer perceptron(mLP)artificial neural network,four parameters,including groundwater level,alluvial thickness,elastic modulus,and transmissivity have been *** model's generalizability was assessed using data derived for 144 *** to the results,the neural network estimates the land subsidence at each ground point with an accuracy of 6.8 mm.A comparison between the predicted and actual values indicated a significant *** mLP model can be used to improve the results of subsidence detection in the study area or other areas with similar characteristics.

关键词： DInSAR Land subsidence Groundwater withdrawal aliabad plain Artificial neural network

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Heat transfer analysis in particle-laden flows using the immersed boundary method

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Particuology 2024年第7期90卷 394-403页

作者： ali Abbas Zaidi Department of mechanical Engineering University of Manitoba75A Chancellors CircleWinnipegR3T 5V6Canada

This paper investigates an efficient immersed boundary method(IBm)for multiple-core CPU machines with local grid refinement for the calculation of heat transfer between fluids and finite-sized *** fluid momentum equations are solved by using the fractional step method,while the energy equation is solved by employing the second-order Adams-Bashforth *** efficient load balancing between the CPU cores,the coupling between particles and fluid is obtained by applying the body force in the fluid equations,which depends on the solid volume fraction of particles contained in each grid cell,and then by linearly interpolating the particle temperature and velocity on the fluid grid cell(in place of the delta function commonly used in literature).Several test cases from the literature are studied,and good agreement is observed between the simulation results and the ***,a scaling study on multiple core machines is performed,demonstrating the proposed IBm's capabilities for a significant reduction in processing time.

关键词： Heat transfer Immersed boundary method Particle resolved direct numerical simulations Fluid solid interactions

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Simulation of the deformable lateral boundaries in biaxial test using DEm

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Particuology 2024年第5期88卷 161-175页

作者： ali momeni Barry Clarke Yong Sheng ali Hassanpour WSP 3 Wellington PlaceLeedsLS1 4APUK Hull University HullHU6 7RXUK School of Civil Engineering University of LeedsLeedsLS2 9JTUK School of Computer Science University of HullHullHU6 7RXUK School of Chemical and Process Engineering University of LeedsLeedsLS2 9JTUK

Applying the discrete element method(DEm)in soil mechanics can provide abundant information at the particle-scale and facilitates illustration of the macro-mechanical behaviour of soils based on the inter-particle *** triaxial test is one of the most common laboratory methods to study the macro-mechanical behaviour of particulate materials such as ***,many problems in geotechnical design can be assumed and simplified as a plane strain *** a biaxial test can be conducted to reproduce the macro-mechanical behaviour of soil,where the sample is enclosed by two horizontal rigid platens and a vertical latex membrane,which is a deformable continuous element and allows the enclosed specimen to deform freely while maintaining confining stress during *** paper presents an algorithm to represent physical and mechanical characteristics of latex membrane in the 2D DEm simulation of biaxial test using the PFC^(2D) *** investigate the impact of the lateral boundary conditions on the micro-macro mechanical behaviours of soil samples,two sets of DEm biaxial tests are conducted,*** rigid and deformable lateral boundary *** DEm modeling results indicate that the lateral boundary conditions have a significant effect on the micro-scale fabric properties,thickness and inclination of the shear *** comparison between these two simulations also demonstrates that the lateral boundary conditions play a major role in the peak and post-peak stress-strain behaviours as well as the dilation and critical state behaviours of granular soils.

关键词： Discrete element method Biaxial test Deformable boundaries Shear band Critical state Fabric anisotropy Geometrical stability index

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Sensing the heavy water concentration in an H_(2)O-D_(2)O mixture by solid-solid phononic crystals

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Chinese Physics B 2024年第4期33卷 493-498页

作者： mohammadreza Rahimi ali Bahrami Optoelectronic and Nanophotonics Research Laboratory(ONRL) Faculty of Electrical EngineeringSahand University of TechnologyTabrizIran

A new method based on phononic crystals is presented to detect the concentration of heavy water(D_(2)O)in an H_(2)O-D_(2)O *** have been obtained and analyzed in the concentration range of 0%-10%and 90%-100%D_(2)O.A proposed structure of tungsten scatterers in an aluminum host is *** order to detect the target material,a cavity region is considered as a sound wave resonator in which the target material with different concentrations of D_(2)O is *** changing the concentration of D_(2)O in the H_(2)O-D_(2)O mixture,the resonance frequency undergoes a frequency *** 1%change in D_(2)O concentration in the H_(2)O-D_(2)O mixture causes a frequency change of about 120 *** finite element method is used as the numerical method to calculate and analyze the natural frequencies and transmission spectra of the proposed *** performance evaluation index shows a high Q factor up to 1475758 and a high sensitivity up to 13075,which are acceptable values for sensing *** other figures of merit related to the detection performance also indicate high-quality performance of the designed sensor.

关键词： phononic crystals sensor H_(2)O-D_(2)O mixture cavity

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Experimental Study on Heat Storage Properties Comparison of Paraffin/metal Foams Phase Change material Composites

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Journal of Thermal Science 2024年第2期33卷 469-478页

作者： Waqar AHmED Abid HUSSAIN Hanzla SHAHID Imran ali Hafiz muhammad ali Department of mechanical Engineering University of Engineering and TechnologyTaxila47080Pakistan Department of mechanical Engineering Institute of Space TechnologyIslamabadPakistan Department of mechanical Mechatronics and Manufacturing EngineeringUniversity of Engineering and Technology LahoreFaisalabad CampusPunjabPakistan mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia

Heat storage properties of phase change materials(PCms) are essential characteristics that perform a key role in thermal heat energy storage *** thermal properties of PCms can be improved by developing metal foam/PCm *** addition of metal foam in PCms has a significant effect on the thermal characteristics of *** this paper,the heat storage properties of two different metal foam/PCm composites were experimentally *** behavior of paraffin in metal foam(copper and iron-nickel)/paraffin composites concerning pure paraffin at a constant heat flux of 1000 W/m^(2) in three directions simultaneously(x,y,and z) was *** was infiltrated into copper and iron-nickel foams to develop composite materials which resulted in enhancing the thermal conductivity of the paraffin.A comparative analysis is made on the heat storage properties of paraffin in copper and iron-nickel foams/paraffin *** temperature distribution during the phase transition process is experimentally *** comparison indicates that temperature uniformity in copper foam/paraffin composite is better than in iron-nickel foam/paraffin composite and pure paraffin at the same heat *** results show that at heat flux of 1000 W/m^(2),the heat storage time for copper foam/paraffin composite is 20.63% of that of iron-nickel foam/paraffin composite.

关键词： heat storage capacity paraffin/metal foam composite temperature uniformity heat storage rate phase transition process

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Emerging Trends in Damage Tolerance Assessment:A Review of Smart materials and Self-Repairable Structures

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Structural Durability & Health monitoring 2024年第1期18卷 1-18页

作者： ali Akbar Firoozi ali Asghar Firoozi Department of Civil Engineering Faculty of Engineering&TechnologyUniversity of BotswanaGaboroneUB0061Botswana Department of Civil Engineering University Kebangsaan Malaysia(UKM)Bangi43600Malaysia

The discipline of damage tolerance assessment has experienced significant advancements due to the emergence of smart materials and self-repairable *** review offers a comprehensive look into both traditional and innovative methodologies employed in damage tolerance *** a detailed exploration of damage tolerance concepts and their historical progression,the review juxtaposes the proven techniques of damage assessment with the cutting-edge innovations brought about by smart materials and self-repairable *** subsequent sections delve into the synergistic integration of smart materials with self-repairable structures,marking a pivotal stride in damage tolerance by establishing an autonomous system for immediate damage identification and *** holistic approach broadens the applicability of these technologies across diverse sectors yet brings forth unique challenges demanding further innovation and ***,the review examines future prospects that combine advanced manufacturing processes with data-centric methodologies,amplifying the capabilities of these‘intelligent’*** review culminates by highlighting the transformative potential of this union between smart materials and self-repairable structures,promoting a sustainable and efficient engineering paradigm.

关键词： Damage tolerance smart materials self-repairable structures structural health monitoring synergy autonomous system advanced manufacturing data-driven methodologies

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