Complement activation kindles the transition of acute post-traumatic brain injury to a chronic inflammatory disease

作     者：Andrew Erwood Ali M.Alawieh Andrew Erwood;Ali M.Alawieh

作者机构：Department of NeurosurgeryEmory University School of MedicineAtlantaGAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第10期

页      面：2228-2229页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：acute injuries injury 

摘      要：Traumatic brain injury(TBI)remains a major cause of disability among young adults in both civilian and military settings contributing to a high burden on healthcare systems(Badhiwala et al.,2019).Sequel of TBI,even mild injuries,include motor and sensory dysfunction,neurocognitive decline,neuropsychiatric complications,as well as increased risk of neurodegenerative and neurovascular events such as Alzheimer’s disease and stroke(Breunig et al.,2013;Burke et al.,2013;Li et al.,2017).Despite the acute nature of the insult in TBI,pathological changes in the traumatized brain are better recognized as a chronic rather than an acute neurological disease,a phenomenon that remains under-investigated.