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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba ali tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

An ab initio investigation of vibrational, thermodynamic, and optical properties of Sc_2AlC mAX compound

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Chinese Physics B 2016年第10期25卷 103-108页

作者： m A ali m t Nasir m R Khatun A K m A Islam S H Naqib Department of Physics Chittagong University of Engineering and Technology Department of Arts & Sciences Bangladesh Army University of Science and Technology Department of Physics University of Rajshahi International Islamic University Chittagong

the structural vibrational, thermodynamical, and optical properties of potentially technologically important, weakly coupled mAX compound, Sc2 Al C are calculated using density functional theory(DFt). the structural properties of ScAlC are compared with the results reported earlier. the vibrational, thermodynamical, and optical properties are theoretically estimated for the first time. the phonon dispersion curve is calculated and the dynamical stability of this compound is investigated. the optical and acoustic modes are observed clearly. We calculate the Helmholtz free energy(F), internal energy(E), entropy(S), and specific heat capacity(Cv) from the phonon density of states. Various optical parameters are also calculated. the reflectance spectrum shows that this compound has the potential to be used as an efficient solar reflector.

关键词： mAX compound phonon dispersion thermodynamical properties optical properties

Newtonian heating in stagnation point flow of Burgers fluid

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Applied mathematics and mechanics(English Edition) 2015年第1期36卷 61-68页

作者： t.HAYAt S.ali m.AWAIS m.S.ALHUtHali Department of mathematics Quaid-i-Azam University Nonlinear Analysis and Applied mathematics (NAAm) Research Group Faculty of Science King Abdulaziz University Faculty of Engineering Sciences Ghulam Ishaq Khan Institute of Engineering Sciences and Technology Department of mathematics COMSATS Institute of Information Technology

the Newtonian heating effects in the stagnation point flow of a Burgers fluid are addressed in this paper. the boundary layer flow problems are stated in the spatial domain from zero to infinity. the solution expressions for the velocity and the temperature are obtained and examined for the influential variables. the tabulated values show comparison with the previous results. It is observed that the obtained results are in good agreement with the existing results in limiting sense.

关键词： Burgers fluid Newtonian heating series solutions

New ordered mAX phase mo_2 tiAlC_2: Elastic and electronic properties from first-principles

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Chinese Physics B 2016年第10期25卷 323-329页

作者： m A Hadi m S ali Department of Physics University of Rajshahi Department of Physics Pabna University of Science and Technology

First-principles computation on the basis of density functional theory(DFt) is executed with the CAStEP code to explore the structural, elastic, and electronic properties along with Debye temperature and theoretical Vickers’ hardness of newly discovered ordered mAX phase carbide mo2tiAlC2. the computed structural parameters are very reasonable compared with the experimental results. the mechanical stability is verified by using the computed elastic constants. the brittleness of the compound is indicated by both the Poisson’s and Pugh’s ratios. the new mAX phase is capable of resisting the pressure and tension and also has the clear directional bonding between atoms. the compound shows significant elastic anisotropy. the Debye temperature estimated from elastic moduli(B, G) is found to be 413.6 K. the electronic structure indicates that the bonding nature of mo2tiAlC2is a mixture of covalent and metallic with few ionic characters. the electron charge density map shows a strong directional mo–C–mo covalent bonding associated with a relatively weak ti–C *** calculated Fermi surface is due to the low-dispersive mo 4d-like bands, which makes the compound a conductive *** hardness of the compound is also evaluated and a high value of 9.01 GPa is an indication of its strong covalent bonding.

关键词： new ordered mAX phase density functional theory calculations Debye temperature Vickers hardness

Robust stability analysis of takagi-Sugeno uncertain stochastic fuzzy recurrent neural networks with mixed time-varying delays

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Chinese Physics B 2011年第8期20卷 1-15页

作者： m.Syed ali Department of mathematics Thiruvalluvar UniversityVellore-632 106TamilnaduIndia

In this paper, the global stability of takagi-Sugeno （tS） uncertain stochastic fuzzy recurrent neural networks with discrete and distributed time-varying delays （tSUSFRNNs） is considered. A novel LmI-based stability criterion is obtained by using Lyapunov functional theory to guarantee the asymptotic stability of tSUSFRNNs. the proposed stability conditions are demonstrated through numerical examples. Furthermore, the supplementary requirement that the time derivative of time-varying delays must be smaller than one is removed. Comparison results are demonstrated to show that the proposed method is more able to guarantee the widest stability region than the other methods available in the existing literature.

关键词： recurrent neural networks linear matrix inequality Lyapunov stability time-varyingdelays tS fuzzy model

Novel delay-dependent stability analysis of takagi-Sugeno fuzzy uncertain neural networks with time varying delays

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Chinese Physics B 2012年第7期21卷 49-60页

作者： m. Syed ali Department of mathematics Thiruvalluvar University

this paper presents the stability analysis for a class of neural networks with time varying delays that are represented by the takagi^ugeno It-S） model. the main results given here focus on the stability criteria using a new Lyapunov functional. New relaxed conditions and new linear matrix inequality-based designs are proposed that outperform the previous results found in the literature. Numerical examples are provided to show that the achieved conditions are less conservative than the existing ones in the literature.

关键词： neutral neural networks linear matrix inequality Lyapunov stability time varying delays

Stability analysis of markovian jumping stochastic Cohen Grossberg neural networks with discrete and distributed time varying delays

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Chinese Physics B 2014年第6期23卷 131-137页

作者： m.Syed ali Department of mathematics Thiruvalluvar University

In this paper, the global asymptotic stability problem of markovian jumping stochastic Cohen-Grossberg neural networks with discrete and distributed time-varying delays （mJSCGNNs） is considered. A novel LmI-based stability criterion is obtained by constructing a new Lyapunov functional to guarantee the asymptotic stability of mJSCGNNs. Our results can be easily verified and they are also less restrictive than previously known criteria and can be applied to Cohen-Grossberg neural networks, recurrent neural networks, and cellular neural networks. Finally, the proposed stability conditions are demonstrated with numerical examples.

关键词： Cohen-Grossberg neural networks global asymptotic stability linear matrix inequality Lyapunovfunctional time-varying delays

An Analysis of Peristaltic Flow of a micropolar Fluid in a Curved Channel

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Chinese Physics Letters 2011年第1期28卷 138-141页

作者： N. ali m. Sajid t. ,laved Z. Abbas Department of mathematics International Islamic University Islamabad Paksitan theoretical Plasma Physics Division PINSTECH P.O. Nilore Islamabad Pakistan

We analyze the two-dimensional peristaltic flow of a micropolar fluid in a curved channel. Long wavelength and low Reynolds number assumptions are used in deriving the governing equations. A shooting method with fourth-order Runge-Kutta algorithm is employed to solve the equations. the influence of dimensionless curvature radius on pumping and trapping phenomena is discussed with the help of graphical results. It is seen that the pressure rise per wavelength in the pumping region increases with an increase in the curvature of the channel. moreover the symmetry of the trapped bolus destroys in going from strmg＇ht to curved channel.

关键词： Fluid dynamics

Stretching a Curved Surface in a Viscous Fluid

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Chinese Physics Letters 2010年第2期27卷 149-152页

作者： m. Sajid N. ali t. Javed Z. Abbas theoretical Plasma Physics Division PINSTECH P.O. Nilore Islamabad 44000 Pakistan Faculty of Basic and Applied Sciences International Islamic University Islamabad 44000 Pakistan

this work is concerned with the viscous flow due to a curved stretching sheet. the similarity solution of the problem is obtained numerically by a shooting method using the Runge-Kutta algorithm. the physical quantities of interest like the fluid velocity and skin friction coefficient are obtained and discussed under the influence of dimensionless curvature. It is evident from the results that dimensionless curvature causes an increase in boundary layer thickness and a decrease in the skin friction coefficient.

关键词： Fluid dynamics mathematical physics