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Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury

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Neural Regeneration Research 2014年第9期9卷 919-923页

作者： Fatemeh Anbari Mohammad ali Khalili Ahmad Reza Bahrami Arezoo Khoradmehr Fatemeh Sadeghian Farzaneh Fesahat ali nabi Research and Clinical Center for Infertility Shahid Sadoughi University of Medical Sciences Institute of Biotechnology Ferdowsi University of Mashhad

To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.

关键词： nerve regeneration bone marrow mesenchymal stem cells traumatic brain injury intravenous administration cell differentiation neurologic function,cerebral cortex rats neural regeneration

National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

Review of acute ischaemic stroke in Pakistan:progress in management and future perspectives

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Stroke & Vascular Neurology 2017年第1期2卷 30-39页

作者： ali Zohair Nomani Sumaira nabi Mazhar Badshah Shahzad Ahmed Department of Neurology Pakistan Institute of Medical SciencesIslamabadPakistan

Ischaemic stroke is a major cause of neurological morbidity and *** objective of this review article is to summarise facts pertaining to acute ischaemic stroke and its various aspects in a developing country like Pakistan,where resources are limited and the healthcare system is *** large-scale epidemiological studies are available to determine the true incidence of stroke in *** reviewed the available literature on stroke from Pakistan and through this article we primarily aim to present the current acute ischaemic stroke management in Pakistan in juxtaposition to that of the developed *** also intend to highlight areas for future development and improvement in *** routine practice in Pakistan is that of using stat dose of aspirin in emergency(ER)at large with only a handful of centres offering thrombolytic therapy with recombinant tissue plasminogen activator for acute ischaemic *** too is faced with the problem of long window periods before the patient reaches a proper stroke care *** facilities of interventional therapies like arterial thrombolysis and endovascular surgery are non-existent and rehabilitation facilities *** opportunities for training physicians in acute stroke are also *** in children is underdiagnosed and that in women not availing facilities at stroke care *** basic research has gained pace regarding local demographic data,advanced research and genetic studies are extremely *** field of stroke neurology needs to grow at a substantial pace in Pakistan to be at par with the developed world.

关键词： routine centre Pakistan

High HbA1c is associated with higher risk of ischaemic stroke in Pakistani population without diabetes

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Stroke & Vascular Neurology 2016年第3期1卷 133-139页

作者： ali Zohair Nomani Sumaira nabi Shahzad Ahmed Mansoor Iqbal Haris Majid Rajput Suhail Rao Department of Neurology Pakistan institute of Medical SciencesIslamabadPakistan

Context:The role of glycated haemoglobin(HbA1c)in the prediction of ischaemic stroke in individuals without diabetes is ***:We performed a study to analyse the role of HbA1c in the risk prediction of ischaemic stroke in Pakistani population without *** further studied the difference between HbA1c values of individuals with diabetes and without diabetes with *** and design:Single centre,case–*** and methods:In phase I,a total of 233 patients without diabetes with ischaemic stroke and 245 as controls were *** of HbA1c levels,lipid profiles and blood pressure recordings with ischaemic stroke was *** phase II,comparison was done between diabetics and nondiabetics with *** analysis:Comparison of the mean variables was performed with Student’s *** regression analysis with ischaemic stroke as the dependent variable was performed for phase ***:In phase I,the ischaemic stroke group had significantly higher HbA1c levels(5.9±2.9%vs 5.5±1.6%)compared with controls(p0.05).Conclusions:Higher HbA1c indicated a significantly increased risk for ischaemic *** HbA1c value above 5.6%(prediabetic range)predicted future risk of stroke and efforts to maintain glucose level within the normal range(≤5.6%)in individuals with high cardiovascular risk are important.

关键词： diabetes cholesterol cardiovascular

Tailoring the optical and magnetic properties of La-BaM hexaferrites by Ni substitution

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Chinese Physics B 2022年第2期31卷 570-575页

作者： Hafiz T.ali MRamzan M Imran Arshad Nicola A.Morley M.Hassan Abbas Mohammad Yusuf Atta Ur Rehman Khalid Mahmood Adnan ali Nasir Amin MAjaz-un-nabi Department of Mechanical Engineering College of EngineeringTaif UniversityTaif 21944Saudi Arabia Department of Physics Government College UniversityFaisalabadPakistan Department of Materials Science and Engineering University of SheffieldSir Robert Hadfield BuildingMapping St.SheffieldS13JDUK Department of Clinical Pharmacy College of PharmacyTaif UniversityTaif 21944Saudi Arabia

We investigate the impact of Ni insertion on the structural,optical,and magnetic properties of Ba_(0.8)La_(0.2)Fe_(12-x)Ni_(x)O_(19)hexaferrites(Ni substituted La-BaM hexaferrites).Samples were prepared using the conventional co-precipitation method and sintered at 1000℃for 4 hours to assist the crystallization *** analysis of the structure of the samples was carried out using an x-ray diffraction(XRD)*** M-type hexagonal structure of all the samples was confirmed using XRD *** lattice parameters a and c were found to be in the ranges of 5.8925±0.001 nm–5.8952±0.001 nm and 23.2123±0.001 nm–23.2219±0.001 nm,*** M-type hexagonal nature of the prepared samples was also indicated by the presence of corresponding FT-IR bands and Raman modes in the FT-IR and Raman spectra,*** results confirmed the successful synthesis of the samples according to the required stoichiometric ratio.A UV-vis spectrometer was used to record the absorption spectra of the prepared samples in the wavelength range of 200 nm–1100 *** optical energy bandgap of the samples was found to be in the range of 1.21 eV–3.39 *** M–H loops of the samples were measured at room temperature at an applied magnetic field range of 0 kOe–60 kOe.A high saturation magnetization of 99.92 emu/g was recorded in the sample with x=0 at a microwave operating frequency of 22.2 *** high value of saturation magnetization is due to the substitution of La3+ions at the spin-up(12k,2a,and 2b)*** Ni substitution is proven to be a potential candidate for the tuning of the optical and magnetic parameters of M-type ***,we suggest that the prepared samples are suitable for use in magneto-optic applications.

关键词： M-type hexaferrite nanostructured materials magnetic properties optical properties

The electronic and magnetic properties of wurtzite Mn：CdS, Cr：CdS and Mn：Cr：CdS： first principles calculations

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Journal of Semiconductors 2017年第7期38卷 36-43页

作者： Azeem nabi Zarmeena Akhtar Tahir Iqbal Atif ali Muhammad Arshad Javid Department of Physics University of Gujrat Gujrat Pakistan Department of Basic Sciences (Physics) University of Engineering and Technology Taxila Pakistan

In this article, density functional theory（DFT） based on generalized gradient approximation（GGA）and GGACU, U is Hubbard term, is used to study the electronic properties of CdS doped with different dopants（Cr, Mn）. The calculations are carried out for Mn-doped CdS, Cr-doped CdS, and co-doping of Mn/Cr in CdS simultaneously. It is found that hopping of electrons is possible with Cr：CdS and Mn：Cr：CdS while Mn：CdS does not allow the hopping of electrons. Moreover, double exchange interactions are observed in Cr：CdS and d-d superexchange interactions are observed in Mn：CdS. Now the problem becomes interesting when one magnetic ion（Cr） supporting double exchange interactions and another ion（Mn） supporting d-d super-exchange interactions are doped simultaneously in the same system（CdS）. The co-doped CdS is more stable even at high Curie temperature due to p-d double exchange interactions and d-d super exchange interactions. Furthermore, the Cr-3d and Mn-3d states present in-between the band gap are responsible for inner shell transitions and hence for optical ***, the co-doped system is taken into account to enhance its applications in the field of spintronic and magneto-optical devices.

关键词： wurtzite first principles density functional theory

Bitter gourd extract improves glucose homeostasis and lipid profile via enhancing insulin signaling in the liver and skeletal muscles of diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2021年第8期11卷 344-352页

作者： Saber Mohamed Eweda Mennatallah Ahmed ali Hala Mohamed Abd El-Bary Nahed Hussein El-Sokkary Madiha Hassan Helmy Maher Abdel-nabi Kamel Department of Biochemistry Faculty of ScienceAlexandria UniversityAlexandriaEgypt Department of Pharmacology&Therapeutics Faculty of Pharmacy and Drug ManufacturingPharos University in AlexandriaAlexandriaEgypt Department of Biochemistry Medical Research InstituteAlexandria UniversityAlexandriaEgypt Department of Physiology Faculty of MedicineAlexandria UniversityAlexandriaEgypt Medical Laboratories Technology College of Applied Medical SciencesTaibah UniversityMadinahKSA

Objective:To investigate the modulatory effects of bitter gourd extract on the insulin signaling pathway in the liver and skeletal muscle tissues of diabetic ***:The ethanolic extract of bitter gourd was prepared and its contents of total polyphenols and flavonoids were assayed.A neonatal streptozotocin-induced diabetic rat model was established and the diabetic rats were assigned into different groups and were treated with different doses of bitter gourd extract(100,200,400,or 600 mg/kg)or with glibenclamide(0.1 mg/kg)for 30 *** blood glucose,insulin,and lipid profile were evaluated and the insulin signaling pathway in the liver and skeletal muscle of rats was *** correlations between homeostasis model assessment(HOMA)and the components of insulin signaling pathway were also ***:Different doses of bitter gourd extract significantly ameliorated fasting blood glucose level and HOMA index for insulin ***,bitter gourd extract increased serum insulin and improved disrupted serum lipid *** levels of insulin receptor substrate-1(IRS-1),p-insulin receptorβ(p-IR-β),protein kinase C(PKC),GLUT2,and GLUT4 were improved by treatment with bitter gourd *** best results were obtained with 400 mg/kg dose of the extract,the effect of which was equivalent to that of *** in the bitter gourd treated rats was negatively correlated with p-IR-β,IRS-1 and PKC in hepatic and skeletal *** was also negatively correlated with skeletal muscle ***:Bitter gourd extract improves glucose homeostasis and lipid profile in diabetic rats via enhancement of insulin secretion and ***,bitter gourd can be used as a potential pharmacological agent for the treatment of type 2 diabetes mellitus.

关键词： Neonatal Streptozotocin Diabetic Sulfonylurea Bitter gourd Phosphorylated insulin receptor Protein kinase C IRS-1 GLUT2/GLUT4 Insulin signaling

Enhancement of phosphors-solubility in ZnO by thermal annealing

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Journal of Semiconductors 2015年第12期36卷 30-33页

作者： K.Mahmood N.Amin A.ali M.Ajaz un nabi M.Imran Arshad M.Zafar M.Asghar Department of Physics GC University Faisalabad Department of Physics Islamia University of Bahawalpur

We have demonstrated the effect of annealing temperature on the diffusion density of phosphors in zinc oxide. The P-dopant P430 was sprayed on ZnO pellets and annealed at different temperatures from 500 to 1000 ℃ with a step of 100 ℃ for one hour using a programmable furnace. The concentration of P was controlled by varying the annealing temperature and the maximum solubility of P （3% At） was achieved at annealing 800 ℃ determined by energy dispersive X-ray diffraction （EDX） measurements. X-ray diffraction （XRD） confirmed the hexagonal structure of ZnO and showed that the growth direction was along the c-axis. We observed a maximum up shift in the （002） plane at an annealing temperature of 800 ℃, suggesting that P atoms replaced Zn atoms in the structure which results in the reduction of the lattice constant. Room temperature photoluminescence （PL） spectrum consists of a peak at 3.28 eV and related to band edge emission, but samples annealed at 800 and 900 ℃ have an additional donor acceptor pair peak at 3.2 eV. Hall effect measurements confirmed the p-type conductivity of the sample annealed at 800 ℃.

关键词： ZnO P-dopant EDX XRD PL

Simultaneous synthesis of bimetallic@3D graphene electrocatalyst for HER and OER

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Frontiers of Materials Science 2021年第2期15卷 305-315页

作者： nabi ULLAH Meng XIE Shahid HUSSAIN Waleed YASEEN Sayyar ali SHAH Bashir Adegbemiga YUSUF Chidinma Judith OLUICBO Haroon Ur RASHEED Yuanguo XU Jimin XIE School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China School of Pharmacy Jiangsu UniversityZhenjiang 212013China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Currently,the exploration of ultimate energy sources is a hot investigation area for researchers due to the swift diminution of fossil fuels and environmental pollution produced by the ignition of these fossil fuels[1-5].Hydrogen is an ideal alternative energy carrier and is considered to solve such problems due to its high energy density,sustainability,recyclability,and zero COx emission[6-9].

关键词： synthesis catalyst energy