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俄罗斯发动机制造商寻求新订单

国际航空 2000年第12期 59-60页

作者：亚历克斯艾·科马罗夫,alexey Komarov ,立生

前苏联解体后，俄罗斯航空发动机业一直处于低谷状况。普京上台后对国防工业支持力度加大，使这种状况正在逐步扭转。但由于存在的问题较多，国内外的发动机订单仍较少，所以制造商之间竞争激烈

关键词：发动机制造商乌克兰订单飞机俄罗斯设计局

Assembly of Oligoglycine Layers on Mica Surface

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Journal of Biomaterials and Nanobiotechnology 2011年第1期2卷 91-97页

作者： Svetlana V. Tsygankova Alexander A. Chinarev Alexander B. Tuzikov Ilya S. Zaitsev Nikolai Severin alexey A. Kalachev Jurgen P. Rabe Nicolai V. Bovin 不详

Assembly of [Gly7-NHCH2-]4C, [Gly7-NHCH2-]3C CH3 and [Gly4NH(CH2)5-]2 peptides on mica surface in aqueous so-lution was studied. The peptides are capable of forming atomically smooth (2.65-4.3 nm in height) layers assembled as polyglycine II. Monomers in the layers are situated normally to the surface. Formation of analogous flat 2D structures also takes place in solution but much more slowly than on mica surface, i.e. negatively charged surface plays an active role promoting the assembly.

关键词： Self-Assembling Oligoglycine Scanning Force Microscopy Monolayers

Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection

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World Journal of Gastroenterology 2018年第12期24卷 1361-1372页

作者： Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng Peking University People’s Hospital and Peking University Hepatology Institute Beijing 100044China Qingdao Municipal Hospital Qingdao 266011Shandong ProvinceChina Guangzhou No.8 People’s Hospital Guangzhou 510060Guangdong ProvinceChina Beijing Youan Hospital Capital Medical UniversityBeijing 100069China Shanghai Ruijin Hospital Jiaotong University School of MedicineShenyang 200025Liaoning ProvinceChina TheFirst Affiliated Hospital with Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina Hepatology Unit Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina West China Hospital Sichuan UniversityChengdu 610041Sichuan ProvinceChina China Medical University Shengjing HospitalShenyang 110004Liaoning ProvinceChina Bristol-Myers Squibb PrincetonNJ 08540United States Bristol-Myers Squibb WallingfordCT 06492United States 302 Military Hospital of China Beijing 100039China Bristol-Myers Squibb Shanghai 200040China the Sixth People’s Hospital of Shenyang Shenyang 110006Liaoning ProvinceChina Beijing Friendship Hospital Capital Medical UniversityBeijing 100050China Saint-Petersburg State Healthcare Institution'Clinical Infectious Hospital n.a.S.P.Botkin’ Saint-Petersburg 191167Russia Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China I.M.Sechenov First Moscow State Medical University Moscow 119991Russia The First Hospital of Jilin University Jilin 1300021Jilin ProvinceChina SMG-SNU Boramae Medical Center Seoul 07061South Korea

AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms *** In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent

关键词： Asunaprevir Daclatasvir Direct-acting antiviral Chronic hepatitis C Liver disease NS3 NS5A Genotype 1b

New Record Ocean Temperatures and Related Climate Indicators in 2023

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Advances in Atmospheric Sciences 2024年第6期41卷 1068-1082页

作者： Lijing CHENG John ABRAHAM Kevin E.TRENBERTH Tim BOYER Michael EMANN Jiang ZHU Fan WANG Fujiang YU Ricardo LOCARNINI John FASULLO Fei ZHENG Yuanlong LI Bin ZHANG Liying WAN Xingrong CHEN Dakui WANG Licheng FENG Xiangzhou SONG Yulong LIU Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN alexey MISHONOV Jim REAGAN Karina VON SCHUCKMANN Yuying PAN Zhetao TAN Yujing ZHU Wangxu WEI Guancheng LI Qiuping REN Lijuan CAO Yayang LU International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of St.Thomas School of EngineeringMinnesota 55105USA NSF National Center for Atmospheric Research BoulderColorado 80307USA University of Auckland Auckland 1010New Zealand National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA Department of Earth and Environmental Science University of PennsylvaniaPhiladelphiaPennsylvania 19104USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine Environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China Oceanographic Data Center Chinese Academy of SciencesQingdao 266071China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information Service Tianjin 300171China Italian National Agency for New Technologies Energy and Sustainable Economic DevelopmentS.Teresa Research CenterLerici 19032Italy Istituto Nazionale di Geofisica e Vulcanologia Sede di BolognaBologna 40128Italy South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China ESSIC/CISESS-MD University of MarylandCollege ParkMD20740USA Mercator Ocean International Toulouse 31400France Eco-Environmental Monitoring and Research Center Pearl River Valley and South China Sea Ecology and Environment AdministrationMinistry of Ecology and EnvironmentPRCGuangzhou 510611China National Meteorological Information Center China Meteorological AdministrationBeijing 100081China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China

The global physical and biogeochemical environment has been substantially altered in response to increased atmospheric greenhouse gases from human *** 2023,the sea surface temperature(SST)and upper 2000 m ocean heat content(OHC)reached record *** 0–2000 m OHC in 2023 exceeded that of 2022 by 15±10 ZJ(1 Zetta Joules=1021 Joules)(updated IAP/CAS data);9±5 ZJ(NCEI/NOAA data).The Tropical Atlantic Ocean,the Mediterranean Sea,and southern oceans recorded their highest OHC observed since the *** with the onset of a strong El Niño,the global SST reached its record high in 2023 with an annual mean of~0.23℃ higher than 2022 and an astounding>0.3℃ above 2022 values for the second half of *** density stratification and spatial temperature inhomogeneity indexes reached their highest values in 2023.

关键词： ocean heat content salinity stratification global warming climate

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Hierarchy of mesenchymal stem cells: Comparison of multipotentmesenchymal stromal cells with fibroblast colony forming units

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Journal of Biomedical Science and Engineering 2013年第8期6卷 66-73页

作者： Irina N. Shipounova Natalia A. Petinati alexey E. Bigildeev Natalia V. Sats Nina J. Drize Larisa A. Kuzmina Elena N. Parovichnikova Valery G. Savchenko Bone Marrow Transplantation Department FGBI National Hematological Scientific Center Moscow Russia Laboratory for Physiology of Hematopoiesis FGBI National Hematological Scientific Center Moscow Russia

The organization of the compartment of mesenchymal stem cells is still obscure. Two types of human stromal precursor cells are known. Both of them are analyzed in in vitro system: mesenchymal multipotent stromal cells (MMSC) and fibroblast colony forming units (CFU-F). The aim of this study was to compare the main characteristics of MMSC and CFU-F derived from the bone marrow of 24 healthy donors. Growth and differentiation parameters, as well as relative expression levels of different genes were analyzed in MMSC and CFU-F. MMSC were cultivated for 5 passages. CFU-F concentration was determined for each bone marrow sample. The data obtained demonstrated the heterogeneity and hierarchical organization of both studied populations of stromal precursor cells-MMSC and CFU-F. These two types of stromal precursor cells turned to be different in most parameters studied. Altogether MMSC seemed to be more immature cells than CFU-F and took up the higher position in hierarchical tree of mesenchymal stem cells. The rate of differentiation and proliferative potential decreased with the donor’s age in both populations MMSC and CFU-F.

关键词： Mesenchymal Multipotent Stromal Cells (MMSC) Fibroblast Colony Forming Units (CFU-F) Real-Time Polymerase Chain Reaction Gene Expression Level Aging

Polymorphisms in the SNCA Gene: Association with the Risk of Development of the Sporadic Form of Parkinson’s Disease and the Level of SNCA Gene Expression in Peripheral Blood of Patients from Russia

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Neuroscience & Medicine 2013年第4期4卷 208-214页

作者： Anelya Kh. Alieva Maria I. Shadrina Elena V. Filatova Vera V. Ustinova Ekaterina Yu Fedotova alexey V. Karabanov Sergey N. Illarioshkin Petr A. Slominsky Institute of Molecular Genetics Russian Academy of Sciences Moscow Russia Research Centre of Neurology Russian Academy of Medical Sciences Moscow Russi Research Centre of Neurology Russian Academy of Medical Sciences Moscow Russia

Parkinson’s disease (PD) is one of the most common human neurodegenerative disorders caused by the loss of dopaminergic neurons in the brain. The α-synuclein (SNCA) gene is one of the most studied genes involved in the pathogenesis of PD. In our study, we conducted a genetic analysis of promoter and intron single-nucleotide polymorphisms (SNPs) in the SNCA gene. We also analyzed the association of genotypes of these SNPs with expression levels of SNCA mRNA. One of four SNPs in the SNCA gene, and the rs2736990 polymorphism, associates with the risk of the sporadic form of PD in Russian population. The risk of PD was increased almost twofold in carriers of allele C (odds ratios = 1.9, 95% confidence interval: 1.2-2.91, p = 0.003). However, no association was found between any of the genotypes of SNPs tested (rs2583988, rs2619363, rs2619364 and rs2736990) and alterations in SNCA levels. Our findings support the hypothesis that the rs2736990 polymorphism is associated with PD. SNPs rs2583988, rs2619363 and rs2619364 in the promoter region of the SNCA gene themselves do not significantly influence the expression of SNCA. Most likely, SNCA gene expression is a very complex process that is affected by different genetic and epigenetic factors.

关键词： Parkinson’s Disease Expression Analysis SNCA SNP

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导言:金砖国家对治理模式的探索

复旦公共行政评论 2017年第2期 1-5页

作者： Christopher Tapscott Jose A.Puppim de Oliveira 敬乂嘉 alexey Barabashev Navdeep Mathur 肖丹南非西开普大学政府学院巴西FGV大学复旦大学国际关系与公共事务学院俄罗斯高等经济学院印度管理学院艾哈迈达巴德分校

金砖国家伙伴关系于2009年正式确立,它将巴西、俄罗斯、印度、中国和南非五个国家连接起来,这些国家约占世界人口总量的40%和经济总量的20%。尽管仍处于形成期,从宽泛的概念上讲,这种伙伴关系的建立有望发现和倡导在迄今为止由西方主导... 详细信息

金砖国家伙伴关系于2009年正式确立,它将巴西、俄罗斯、印度、中国和南非五个国家连接起来,这些国家约占世界人口总量的40%和经济总量的20%。尽管仍处于形成期,从宽泛的概念上讲,这种伙伴关系的建立有望发现和倡导在迄今为止由西方主导的国际体系中难以实现的全球合作新路径,并且创造一个能涵盖全球多数人口利益的世界新秩序。这个目标的实现程度取决于地缘政治和全球经济中多重因素的相互作用。考虑到五国在规模和体制上的差异。

关键词：公共部门改革伙伴关系地缘政治金砖国家治理模式

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下诺夫哥罗德仓库适应性改造项目

现代装饰 2022年第6期 82-87页

作者： Sergei Tchoban Igor Chlenov alexey Shubkin Dmity Chebanenko(摄影) Iya Ivanov(摄影) 范嘉苑(编译) 俄罗斯SPEECH建筑事务所不详

近期,位于下诺夫哥罗德(Nizhny Novgorod)的斯特列尔卡(Strelka)的一座展览中心的金属展亭经过改造,重新面向公众开放,该建筑曾是1882年和1896年的全俄罗斯展览的展馆。斯特列尔卡位于奥卡河和伏尔加河的交汇点,人们可以在此望见整座城... 详细信息

近期,位于下诺夫哥罗德(Nizhny Novgorod)的斯特列尔卡(Strelka)的一座展览中心的金属展亭经过改造,重新面向公众开放,该建筑曾是1882年和1896年的全俄罗斯展览的展馆。斯特列尔卡位于奥卡河和伏尔加河的交汇点,人们可以在此望见整座城市与河流全景,包括附近的Alexander Nevsky大教堂和下诺夫哥罗德体育馆。如今,建筑涵盖了一个音乐厅和画廊,新空间隐匿在历史结构之下。

关键词：适应性改造下诺夫哥罗德展览中心音乐厅体育馆奥卡河伏尔加河展馆

学习共同体对学习效果的影响——基于35项实验和准实验研究的元分析

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开放教育研究 2021年第5期27卷 81-90页

作者：余淑珍 [俄]安德罗索夫·阿列克谢张宝辉陕西师范大学教育学部陕西西安710062

本研究采用元分析方法,梳理分析近十年国内外学习共同体对学习效果影响的35项实验和准实验研究。结果表明:1)学习共同体对学习效果的整体平均效应值经调整后为0.352;2)学习共同体对认知及非认知学习效果均有中等程度的正向促进作用,其... 详细信息

本研究采用元分析方法,梳理分析近十年国内外学习共同体对学习效果影响的35项实验和准实验研究。结果表明:1)学习共同体对学习效果的整体平均效应值经调整后为0.352;2)学习共同体对认知及非认知学习效果均有中等程度的正向促进作用,其中对非认知层面的整体作用效果优于认知层面;3)学习共同体对学习效果的作用受调节变量的影响,学习模式、测量工具、测量方式对学习效果的调节作用组间差异显著;4)控制程度、共同体容量、教学周期、学段、课程类型、学习者类型对学习效果的调节作用组间差异不显著。最后,本研究结合元分析结果,为学习共同体的有效设计和实施提出建议。

关键词：学习共同体学习社区学习成效元分析

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