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Glycerol effects on optical,weight and geometrical properties of skin tissue

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 64-74页

作者： Vadim D.Genin Elina A.Genina Valery V.Tuchin alexey n.bashkatov Saratov State University(national Research University) 83Astrakhanskaya Str.Saratov 410012Russia Tomsk State University(national Research University) 36Lenina Av.Tomsk 634050Russia Institute of Precise Mechanics and Control of RAS 24Rabochaya Str.Saratov 410028Russia

Complex study of glycerol effects on the skin tissue was *** change in optical,weight and geometrical parameters of the rat skin under the action of the glycerol solutions was studied ex *** mechanisms of the skin optical clearing under the action of glycerol solutions of different concentrations were *** results can be helpful for refinement of models developed to evaluate the effective diffusion coefficients of glycerol in tissues.

关键词： Glycerol solutions skin optical clearing collimated transmittance dehydration

Quantification of glucose and glycerol diffusion in myocardium

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 46-55页

作者： Daria K.Tuchina alexey n.bashkatov Elina A.Genina Valery V.Tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precise Mechanics and Control RAS Saratov 410028 Russia Optoelectronics and Measurement Techniques Laboratory P.O.Box 4500 University of Oulu FIN-90014OuluFinland

The results on determination of glucose and glycerol difusion cofficients in myocardium tissuse are *** method is based on the measurement and analysis of temporal dependence of tissue optical collimated transmittance umder action of a hyperosmotic *** temporal tissue response is related to the rate of the agent and water diffusion in a *** diffusion coefficients for tssue fAuid fluxes at glucose and glycerol application to the myocardium at 20℃ have been estimated as(4.75±3.40)×10^(-7) and(7.71±4.63)×10^(-7) cm^(2)/s,respectively.

关键词： Difusion cofficient optical clearing delhydration scattering.

COMPARATIVE TREATMEnT OF ACnE VULGARIS USInG PALOMAR LUX APPLIQU´E TECHnIQUE AnD DIRECT InTRALESIOnAL InJECTIOn

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 279-287页

作者： ELInA A.GEnInA alexey n.bashkatov VALERY V.TUCHIn GEORGY V.SIMOnEnKO VERA n.SHERSTnEVA ILYA V.YAROSLAVSKY GREGORY B.ALTSHULER Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya str. Saratov 410012Russia Saratov State Medical University 112 B.Kazachya str. Saratov 410012Russia Palomar Medical Technologies Inc. 82 Cambridge St.Burlington 01803MAUSA

Intralesional injection of triamcinolone(TMC)preparations is an effective therapy for cystic acne ***,invasive delivery techniques limit the use of this modality to a relatively narrow class of *** permeability can be enhanced through creating a lattice of microzones(islets)of light-induced limited thermal damage in the upper layers of *** this paper,we directly compared safety and efficacy of delivering TMC acetonide with this novel technique versus conventional intralesional injection for treatment of inflammatory acne lesions.A combination of an intense pulsed light system and a specially designed appliqu´e with a pattern of absorbing centers has been used to create the lattice of islets of damage(LID).Quantitative analysis has included estimation of the following parameters:redness,diameter,and height of acne *** photography has been used to document dynamics of lesion development at successive visits(two hours,24 hours and one week post-treatment).Seven subjects have participated in the *** difference in lesion dynamics between the treatment and control groups was observed at two-hours *** 24-hours/one-week follow-ups,TMC-injected and TMC-LID-delivered groups have demonstrated 82%/93%and 80%/89%improvement in height of lesions in comparison to control(60%/68%).Delivery of TMC with the newly proposed LID technique is at least as effective as intralesional injection for treating inflammatory acne *** of skin permeability using LID approach is a promising technique for accelerating delivery of various compounds to their target areas in the skin.

关键词： Acne vulgaris drug delivery skin permeability enhancement.

PHOTOTHERAPY OF GInGIVITIS:PILOT CLInICAL STUDY

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 437-446页

作者： ELInA A.GEnInA VLADIMIR A.TITOREnKO VALERY V.TUCHIn GEORGY V.SIMOnEnKO alexey n.bashkatov GEnnADY M.SHUB ALEXAnDER V.LEPILIn ILYA V.YAROSLAVSKY GREGORY B.ALTSHULER Saratov State University Saratov410012Russia Saratov State Medical University Saratov410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410028Russia Palomar Medical Technology Inc.Burlington MA 01803USA

The goal of this work was to evaluate the safety and efficacy of the Red Light Emitted Toothbrush(R-LETB)emitting at wavelength of 663 nm with power density of 3.3mW/cm2 in combination with 0.1%-methylene blue(MB)solution for the reduction of plaque and treatment of gingivitis.A microbiological in vitro study and a pilot clinical study were *** microbiological study has shown total suppression of pathogenicflora after a 3-min exposure to the dye solution followed by a 20-sec treatment with the *** the clinical study,37 subjects of both sexes with gingivitis were enrolled and randomly assigned to one of two *** in thefirst(treatment)group were instructed to rinse their mouth with MB solution provided for 1 min and then brush the teeth with the R-LETB and standardized *** second(control)group used only the toothpaste and a regular *** in both groups followed their respective procedures 2 times a day(morning and evening)for 30 *** of plaque,gingival bleeding,and inflammation were evaluated at 14-day and 30-day *** the both groups,all indices improved in comparison with ***,the treatment group demonstrated more pronounced improvement of the studied indices that was attributed to additional anti-microbial action of red light and MB on gum ***,the use of R-LETB with MB appears to have a multifactor therapeutic action on oral pathological microflora:mechanical removal of the bacteria and suppressing action on microorganisms due to photodynamic reaction.

关键词： Tooth brushing methylene blue photodynamic therapy pathogenic bacteria

Irisin/BDnF signaling in the muscle-brain axis and circadian system: A review

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The Journal of Biomedical Research 2024年第1期38卷 1-16页

作者： alexey n.Inyushkin Vitalii S.Poletaev Elena M.Inyushkina Igor S.Kalberdin Andrey A.Inyushkin Department of Human&Animal Physiology Samara National Research UniversitySamara 443011Russia.

In mammals,the timing of physiological,biochemical and behavioral processes over a 24-h period is controlled by circadian *** entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus to a precise 24-h rhythm,environmental zeitgebers are used by the circadian *** is done primarily by signals from the retina via the retinohypothalamic tract,but other cues like exercise,feeding,temperature,anxiety,and social events have also been shown to act as non-photic *** recently identified myokine irisin is proposed to serve as an entraining non-photic signal of *** is a product of cleavage and modification from its precursor membrane fibronectin typeⅢdomain-containing protein 5(FnDC5)in response to *** from well-known peripheral effects,such as inducing the"browning"of white adipocytes,irisin can penetrate the blood-brain barrier and display the effects on the *** data suggest that FnDC5/irisin mediates the positive effects of physical activity on brain *** several brain areas,irisin induces the production of brain-derived neurotrophic factor(BDnF).In the master clock,a significant role in gating photic stimuli in the retinohypothalamic synapse for BDnF is ***,the brain receptor for irisin remains *** the current review,the interactions of physical activity and the irisin/BDnF axis with the circadian system are reconceptualized.

关键词： irisin brain-derived neurotrophic factor peroxisome proliferator-activated receptorγcoactivator 1α circadian rhythm circadian system muscle-brain axis

Atherosclerosis originating from childhood:Specific features

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Journal of Biomedical Research 2024年第3期38卷 233-240页

作者： Anastasia V.Poznyak alexey A.Yakovlev MikhailА.Popov Elena B.Zhigmitova Vasily n.Sukhorukov Alexander n.Orekhov Institute for Atherosclerosis Research Moscow 121609Russia Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology Moscow 109240Russia Department of Cardiac Surgery Moscow Regional Research and Clinical InstituteMoscow 129110Russia Laboratory of Angiopathology Institute of General Pathology and PathophysiologyMoscow 125315Russia

Atherosclerosis is extremely ***,it is considered a disease of older people,who most often experience problems with the heart and blood *** much attention from the scientific community has been paid to studying the association between aging and atherosclerosis,as well as its consequences,there is evidence that atherosclerosis occurs at an early *** may form both during intrauterine development and in *** plays an important role in childhood atherosclerosis,along with previous infectious diseases and excess weight of both the child and the *** the present review,we examined the development of atherosclerosis and the prerequisites in childhood.

关键词： atherosclerosis childhood pediatrics cardiovascular disease

Artificial enhancement of sturgeon stock in freshwater reservoirs:A case study on sterlet Acipenser ruthenus of the Kama reservoir

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Aquaculture and Fisheries 2024年第2期9卷 287-294页

作者： Pavel B.Mikheev Semyon n.Kazarinov Alla G.Melnikova Stanislav V.Ponosov nikolai G.Petrenko Andrei I.nikiforov alexey Yu Puzik Olga n.Elchenkova Perm State national Research University Perm614990Russia Khabarovsk Branch of the Federal State Budget Scientific Institution“Russian Federal Research Institute of Fisheries and Oceanography”“KhabarovsknIRO” Khabarovsk680038Russia Perm Branch of the Federal State Budget Scientific Institution“Russian Federal Research Institute of Fisheries and Oceanography”“PermnIRO” Perm614991Russia Federal State Budget Scientific Institution“Russian Federal Research Institute of Fisheries and Oceanography”“VnIRO” Moscow117454Russia Moscow State Institute of International Relations(University)of the Ministry for Foreign Affairs of Russia“MGIMO” Moscow117454Russia Department of State Control Supervision and Protection of Aquatic Biological Resources for Perm KraiMiddle-Volga Regional Office of the Federal Fishery AgencyPerm614990Russia

The paper presents the results of the sterlet sturgeon Acipenser ruthenus reintroduction into the Kama Reservoir(Perm Krai,Russia)by sterlet fry from hatcheries into the reservoir since *** effectiveness of hatchery releases was evaluated by monitoring gillnet sampling *** results showed that the species was reported throughout entire Kama Reservoir,which contrasts with 1988-1994 data,when the species was registered only at the upper part of the reservoir near the Kama River *** highest number and biomass values of catch per unit effort(CPUE)of the sterlet were found in submerged river channels-the deepest habitats with flow conditions which are close to the ecological requirements of the *** distribution of the sterlet within the channel biotopes of the reservoir is defined by reduced *** biggest individuals and the widest size range of the sterlet were typical for the upper area of the reservoir and Chusovskoy Bay,which have the greatest *** smallest sizes were typical for fish from catches near the dam of the reservoir,which is consistent with the published data on the distribution of sterlet in reservoir *** presented results may indicate the artificial formation of the sterlet stock in the Kama Reservoir maintained by hatchery *** revealed distribution of the sterlet in the reservoir determines the direction of further research on natural reproduction and thus formation of an artificially formed ***,future studies are required to assess the possibility of hybridization of the sterlet of artificial origin with natural populations of the species,since the low genetic diversity of the sterlet released into the Kama Reservoir which can lead to irreversible loss of genetic individuality of the natural stocks of the species in the catchment of upper course of the Kama River.

关键词： Sterlet Acipenser ruthenus Kama reservoir Hatchery releases CPUE Artificial stock formation

Insights into the hydrogen evolution reaction in vanadium redox flow batteries:A synchrotron radiation based X-ray imaging study

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Journal of Energy Chemistry 2024年第4期91卷 132-144页

作者： Kerstin Köble alexey Ershov Kangjun Duan Monja Schilling Alexander Rampf Angelica Cecilia TomášFaragó Marcus Zuber Tilo Baumbach Roswitha Zeis Helmholtz Institute Ulm Karlsruhe Institute of Technology89081 UlmGermany Laboratory for Applications of Synchrotron Radiation Karlsruhe Institute of Technology76131 KarlsruheGermany Institute for Photon Science and Synchrotron Radiation Karlsruhe Institute of Technology76344 Eggenstein-LeopoldshafenGermany Department of Electrical Electronicsand Communication EngineeringFaculty of EngineeringFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)91058 ErlangenGermany Department of Mechanical and Industrial Engineering University of TorontoToronto M5S 3G8OntarioCanada

The parasitic hydrogen evolution reaction(HER)in the negative half-cell of vanadium redox flow batteries(VRFBs)causes severe efficiency ***,a deeper understanding of this process and the accompanying bubble formation is *** benchmarking study locally analyzes the bubble distribution in thick,porous electrodes for the first time using deep learning-based image segmentation of synchrotron X-ray *** large three-dimensional data set was processed precisely in less than one minute while minimizing human errors and pointing out areas of increased HER activity in *** study systematically varies the electrode potential and material,concluding that more negative electrode potentials of-200 m V *** hydrogen electrode(RHE)and lower cause more substantial bubble formation,resulting in bubble fractions of around 15%–20%in carbon felt ***,the bubble fractions stay only around 2%in an electrode combining carbon felt and carbon *** detected areas with high HER activity,such as the border subregion with more than 30%bubble fraction in carbon felt electrodes,the cutting edges,and preferential spots in the electrode bulk,are potential-independent and suggest that larger electrodes with a higher bulk-to-border ratio might reduce HER-related performance *** described combination of electrochemical measurements,local X-ray microtomography,AI-based segmentation,and 3D morphometric analysis is a powerful and novel approach for local bubble analysis in three-dimensional porous electrodes,providing an essential toolkit for a broad community working on bubble-generating electrochemical systems.

关键词： Vanadium redox flow battery Synchrotron X-ray imaging Tomography Hydrogen evolution reaction Gas bubbles Deep learning

Expanded Porphyrin Exhibiting Off-Centered Out-of-Plane Coordination to Dysprosium

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CCS Chemistry 2024年第7期6卷 1731-1738页

作者： Dmitry I.nazarov Jorge Labella alexey V.Kuzmin Maxim A.Faraonov Evgenii n.Ivanov Salavat S.Khasanov Tomas Torres Mikhail K.Islyaikin Dmitri V.Konarev Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS 142432 Chernogolovka Department of Organic Chemistry Universidad Autonoma de Madrid28049 Madrid Institute of Solid-State Physics RAS 142432 Chernogolovka Research Institute of Macroheterocycles Ivanovo State University of Chemistry and Technology15300 Ivanovo G.A.Krestov Institute of Solution Chemistry of the Russian Academy of Sciences 153045 Ivanovo Institute for Advanced Research in Chemical Sciences Universidad Autonoma de Madrid28049 Madrid IMDEA-nanociencia 28049 Madrid

The complexation of high-spin lanthanides to porphyrinoids is a powerful strategy for the development of advanced molecular *** this context,the use of expanded porphyrinoids remains elusive since their coordination chemistry is challenging to ***,taking inspiration from on-surface chemistry,we explored the coordination of Dy^(3+)to a six-membered porphyrinoid,namely,the hemihexaphyrazine ***,we observed the selective formation of a mono-nuclear off-centered,out-of-plane H_(2)Hhp-Dy^(3+)complex when performing the complexation under reductive *** this reaction,the oxidation state of the macrocycle did not *** X-ray diffraction analysis,we found that the coordination number of Dy in this complex was *** macrocycle cocrystallized with decamethylcobaltocene(Cp_(2)^(*)Co)molecules,giving rise to a wellordered solid-state packing,governed byπ-π*** a result of this organization,a small magnetic coupling between the neighboring molecules was *** in all,this work provides key insights into the coordination of magnetically active metals with expanded porphyrinoids,thus motivating the development of advanced spintronic devices.

关键词： porphyrins dysprosium macrocycle coordination chemistry magnetism