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Cancer Communications 2023年第8期43卷 943-946页

作者： François Bertucci alexandre De Nonneville Pascal Finetti Emilie Mamessier11Laboratory of Predictive Oncology Label Team“Ligue contre le cancer”Cancer Research Center of MarseillePaoli-Calmettes InstituteAix-Marseille UniversityInserm UMR1068CNRS UMR725MarseilleFrance Department of Medical Oncology Paoli-Calmettes InstituteMarseilleFrance

Dear Editor,Pembrolizumab,an immune checkpoint inhibitor(ICI),was recently approved for early-stage triple-negative breast cancer(eTNBC),and promising results have been reported in advanced hormone receptor-positive/human epidermal growth factor receptor 2-negative(HR+/HER2-)and HER2+BCs[1].Given the costs and potential toxicity,markers predictive of ICI benefits are ***,neither programmed death-ligand 1(PD-L1)expression nor other tested markers(i.e.,tumor mutational burden,microsatellite instability)effectively predict ICI benefit[2].Tertiary lymphoid structures(TLS)are secondary lymphoid organ-like aggregates that reside in the tumor microenvironment and are associated with clinical response to ICIs in metastatic melanoma,renal cell carcinoma.

关键词： lymphoid breast cancer

A Novel Approach to Measuring Spatiotemporal Changes in Social Vulnerability at the Local Level in Portugal

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International Journal of Disaster Risk Science 2022年第6期13卷 842-861页

作者： Pedro Pinto Santos JoséLuís Zêzere Susana Pereira Jorge Rocha alexandre Oliveira Tavares Centre for Geographical Studies Institute of Geography and Spatial PlanningTERRAUniversity of Lisbon(CEG-IGOT-ULisboa)1600-276 LisboaLAPortugal Centre for Social Studies Earth Science DepartmentScience and Technology FacultyUniversity of Coimbra(CES/DCT-FCT-UCoimbra)3000-995 CoimbraPortugal

Social vulnerability,as one of the risk components,partially explains the magnitude of the impacts observed after a *** this study,a spatiotemporally comparable assessment of social vulnerability and its drivers was conducted in Portugal,at the civil parish level,for three census *** first challenging step consisted of the selection of meaningful and consistent variables over *** were normalized using the Adjusted Mazziotta-Pareto Index(AMPI)to obtain comparable adimensional-normalized values.A joint principal component analysis(PCA)was applied,resulting in a robust set of variables,interpretable from the point of view of their self-grouping around vulnerability drivers.A separate PCA for each census was also conducted,which proved to be useful in analyzing changes in the composition and type of drivers,although only the joint PCA allows the monitoring of spatiotemporal changes in social vulnerability scores and drivers from 1991 to 2011.A general improvement in social vulnerability was observed for *** two main drivers are the economic condition(PC1),and aging and depopulation(PC2).The remaining drivers highlighted are uprooting and internal mobility,and daily *** data proved their value in the territorial,social,and demographic characterization of the country,to support medium-and long-term disaster risk reduction measures.

关键词： AMPI normalization Portugal Social vulnerability Spatiotemporal changes

Astrometric calibration and source characterisation of the latest generation neuromorphic event-based cameras for space imaging

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Astrodynamics 2023年第4期7卷 415-443页

作者： Nicholas Owen Ralph alexandre Marcireau Saeed Afshar Nicholas Tothill Andre van Schaik Gregory Cohen International Centre for Neuromorphic Systems MARCS Institute for BrainBehaviour and DevelopmentWestern Sydney UniversityKingswood 2747NSWAustralia

As an emerging approach to space situational awareness and space imaging,the practical use of an event-based camera(EBC)in space imaging for precise source analysis is still in its *** nature of event-based space imaging and data collection needs to be further explored to develop more effective event-based space imaging systems and advance the capabilities of event-based tracking systems with improved target measurement ***,for event measurements to be meaningful,a framework must be investigated for EBC calibration to project events from pixel array coordinates in the image plane to coordinates in a target resident space object’s reference *** this paper,the traditional techniques of conventional astronomy are reconsidered to properly utilise the EBC for space imaging and space situational *** paper presents the techniques and systems used for calibrating an EBC for reliable and accurate measurement *** techniques are vital in building event-based space imaging systems capable of real-world space situational awareness *** calibrating sources detected using the EBC,the spatiotemporal characteristics of detected sources or“event sources”can be related to the photometric characteristics of the underlying astrophysical ***,these characteristics are analysed to establish a foundation for principled processing and observing techniques which appropriately exploit the capabilities of the EBC.

关键词： neuromorphic event-based camera(EBC) space imaging space situational awareness(SSA) astronomy

A combinatorial indexing strategy for low-cost epigenomic profiling of plant single cells

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Plant Communications 2022年第4期3卷 72-82页

作者： Xiaoyu Tu alexandre P.Marand Robert J.Schmitz Silin Zhong Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Collaborative Innovation Center of Agri-Seeds School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Department of Genetics University of GeorgiaAthensGA 30602USA State Key Laboratory of Agrobiotechnology School of Life SciencesThe Chinese University of Hong KongHong KongChina

Understanding how cis-regulatory elements facilitate gene expression is a key question in *** advances in single-cell genomics have led to the discovery of cell-specific chromatin landscapes that underlie transcription programs in animal ***,the high equipment and reagent costs of commercial systems limit their applications for many *** this study,we developed a combinatorial index and dual PCR barcode strategy to profile the Arabidopsis thaliana root single-cell epigenome without any specialized *** generated chromatin accessibility profiles for 13576 root nuclei with an average of 12784 unique Tn5 integrations per *** of the single-cell assay for transposaseaccessible chromatin sequencing and RNA sequencing data sets enabled the identification of 24 cell clusters with unique transcription,chromatin,and cis-regulatory *** with single-cell data generated using the commercial microfluidic platform from 10X Genomics revealed that this low-cost combinatorial index method is capable of unbiased identification of cell-type-specific chromatin *** anticipate that,by removing cost,instrumentation,and other technical obstacles,this method will be a valuable tool for routine investigation of single-cell epigenomes and provide new insights into plant growth and development and plant interactions with the environment.

关键词： combinatorial indexing single-cell ATAC-seq epigenome

Heat-resistant Al_(2)O_(3) nanowire-polyetherimide separator for safer and faster lithium-ion batteries

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Journal of Materials Science & Technology 2023年第11期142卷 112-120页

作者： Wenqiang Hu Wenbin Fu Samik Jhulki Liang Chen Aashray Narla Zhijian Sun Fujia Wang alexandre Magasinski Gleb Yushin School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Institute of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Sila Nanotechnologies Inc AlamedaCA 94501USA School of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyangHunan 414006China

Poor heat/flame-resistance of polyolefin(e.g.,polyethylene and polypropylene)separators and high flammability of organic electrolytes used in today’s lithium-ion batteries(LIBs)may trigger rare yet potentially catastrophic safety ***,we mitigate this challenge by developing a heat-resistant and flame-retardant porous composite membrane composed of polyetherimide(PEI)and Al_(2)O_(3) nanowires(NWs).The membranes are fabricated based on an industrially scalable non-solvent-induced phase separation process,which results in an intimately interconnected porous network of Al_(2)O_(3) NWs and *** produced composite membranes exhibit excellent flexibility,thermal stability,and ***,the composite membranes exhibit minimal thermal shrinkage and superior tensile strength(16 MPa)at temperatures as high as 200℃,significantly exceeding the performance of conventional polyolefin *** with commercial separators,their superior wettability and higher ionic conductivity(by up to 2.4 times)when filled with the same electrolyte,larger electrolyte uptake(-190 wt.%),as well as improved cycle and rate performance demonstrated in LiNiMnCoO_(2)(NCM)-based LIBs make them attractive choices for a variety of electrochemical energy storage devices.

关键词： Lithium-ion batteries Separators Al_(2)O_(3)NWs Polyetherimide Thermal resistance

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粒子云扩散完全解析和时间平均模拟的比较

Acta Mechanica Sinica 2022年第8期38卷 29-40页

作者： Akim Lavrinenko alexandre Fabregat Jordi Pallares Departament d’Enginyeria Mecánica Universitat Rovira i VirgiliSpainAv.Països CatalansTarragona 2643007Spain

本文将现有文献中轻度咳嗽的直接数值模拟(DNS)结果与k-ϵ模型的可压缩非定常雷诺平均N-S(URANS)方程得到的结果进行了比较.两种情况均采用单向耦合假设,将分散相模拟为球形拉格朗日粒子.URANS模型能够再现轻粒子(粒径小于64µm)的上升趋... 详细信息

本文将现有文献中轻度咳嗽的直接数值模拟(DNS)结果与k-ϵ模型的可压缩非定常雷诺平均N-S(URANS)方程得到的结果进行了比较.两种情况均采用单向耦合假设,将分散相模拟为球形拉格朗日粒子.URANS模型能够再现轻粒子(粒径小于64µm)的上升趋势,这归因于咳嗽所产生浮力的阻力作用.通过分析DNS和URANS的模拟结果发现,在重力作用下,大于64µm的粒子倾向于描述抛物线轨迹.网格独立性分析允许随着流动的发展,确定网格分辨率的增加对粒子云统计数据的影响.结果表明,k-ϵ模型过度预测了直径小于64µm颗粒的水平位移而对于大于64µm颗粒的预测则相反.

关键词：粒子云网格独立性统计数据单向耦合网格分辨率轻粒子抛物线

The Monarch Etrial:improving the clinical outcome in HR^(+)/HER2^(−)early breast cancer:recent results and next steps

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Cancer Communications 2023年第8期43卷 938-942页

作者： François Bertucci Pascal Finetti Emilie Mamessier alexandre De Nonneville Laboratory of Predictive Oncology Cancer Research Center of MarseillePaoli-Calmettes InstituteAix-Marseille UniversityINSERM UMR1068CNRS UMR725Team Labelled“Ligue contre le cancer”MarseilleFrance Department of Medical Oncology Paoli-Calmettes InstituteMarseilleFrance

Breast cancer(BC)is the most frequent cancer in women worldwide,and hormone receptor-positive/human epidermal growth factor receptor 2-negative(HR^(+)/HER2^(−))is the most frequent BC *** adjuvant systemic treatment of HR^(+)/HER2^(−)early-stage BC(eBC),based on prognostic factors[1],sometimes includes chemotherapy,and in most cases,it includes endocrine therapy(ET).In the past decade,advancements in ET,such as successive approvals of tamoxifen and aromatase inhibitors and the extension of ET duration to 10 years in high-risk patients.

关键词： HER2 cancer chemotherapy

Neural regeneration research model to be explored:SH-SY5Y human neuroblastoma cells

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Neural Regeneration Research 2023年第6期18卷 1265-1266页

作者： Lavynia Ferreira Hoffmann alexandre Martins Fernanda Majolo Verônica Contini Stefan Laufer Márcia Inês Goetiert Graduate Program in Biotechnology University of Vale do Taquari(Univates)LajeadoRio Grande do SulBrazil Graduate Program in Medical Sciences-PPGCM University of Vale do Taquari-UnivatesLajeado/RSBrazil Institute of Pharmacy Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery-TÜCADDEberhard Karls University TübingenTübingenGermany

In neuroscience research,neuronal models are crucial tools for elucidating the molecular and cellular processes involved in the disorders of the nervous *** easily and reproducibly executable studies,in vitro models,such as the SH-SY5Y cell line culture,help us explore the pathophysiological mechanisms of neurodegenerative diseases;they are also essential for the efficient screening of drugs for treating the diseases of the nervous system(Peng et al.,2021;Strother et al.,2021).

关键词： neuroblastoma diseases

Research and development of VUV optical coatings for micro mirror applications

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光学精密工程 2005年第4期13卷 465-470页

作者： alexandre Gatto Norbert Kaiser Fraunhofer IOF Albert-Einstein-Str. 7 D-07745 Jena GermanyFraunhofer IOF Albert-Einstein-Str. 7 D-07745 Jena Germany

This paper deals with vacuum UV optical coatings for micro mirror applications. High reflecting low-stress optical coatings have been developed for the next-generation of micro mechanical mirrors. The optimized metal systems are applicable in the VUV spectral region and can be integrated in the technology of MOEMS, such as spatial light modulators (SLM) and micro scanning mirrors.

关键词： VUV 光学涂覆技术微镜技术薄膜调节器

Root osmotic sensing from local perception to systemic responses

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Stress Biology 2022年第1期2卷 249-269页

作者： Lucille Gorgues Xuelian Li Christophe Maurel alexandre Martiniere Philippe Nacry IPSiM CNRSINRAEInstitut AgroUniv Montpellier34060 MontpellierFrance

Plants face a constantly changing environment,requiring fine tuning of their growth and *** have therefore developed numerous mechanisms to cope with environmental stress *** striking exam-ple is root response to water *** drought(which causes osmotic stress to cells),plants can among other responses alter locally their root system architecture(hydropatterning)or orientate their root growth to optimize water uptake(hydrotropism).They can also modify their hydraulic properties,metabolism and development coordi-nately at the whole root and plant *** of these developmental and physiological changes,plant roots must perceive and transduce signals for water ***,we review current knowledge on plant osmotic per-ception and discuss how long distance signaling can play a role in signal integration,leading to the great phenotypic plasticity of roots and plant development.

关键词： Drought Water deficit perception Local signaling Long distance signaling Local water deficit Adaptive development