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Macroalgal deep genomics illuminate multiple paths to aquatic,photosynthetic multicellularity

Molecular Plant 2024年第5期17卷 747-771页

作者： David R.Nelson alexandra Mystikou Ashish Jaiswal Cecilia Rad-Menendez Michael J.Preston Frederik De Boever Diana C.El Assal Sarah Daakour Michael W.Lomas Jean-Claude Twizere David H.Green William C.Ratcliff Kourosh Salehi-Ashtiani Division of Science and Math New York University Abu DhabiAbu DhabiUAE Center for Genomics and Systems Biology(CGSB) New York University Abu DhabiAbu DhabiUAE Biotechnology Research Center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE Culture Collection of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK National Center for Marine Algae and Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interactomes GIGA InstituteUniversity of LiegeLiegeBelgium School of Biological Sciences Georgia Institute of TechnologyAtlantaGAUSA

Macroalgae are multicellular,aquatic autotrophs that play vital roles in global climate maintenance and have diverse applications in biotechnology and eco-engineering,which are directly linked to their multicellularity ***,their genomic diversity and the evolutionary mechanisms underlying multicellularity in these organisms remain *** this study,we sequenced 110 macroalgal genomes from diverse climates and phyla,and identified key genomic features that distinguish them from their microalgal *** for cell adhesion,extracellular matrix formation,cell polarity,transport,and cell differentiation distinguish macroalgae from microalgae across all three major phyla,constituting conserved and unique gene sets supporting multicellular *** genes show phylum-and climate-specific expansions that may facilitate niche ***,our study reveals genetic determinants of convergent and divergent evolutionary trajectories that have shaped morphological diversity in macroalgae and provides genome-wide frameworks to understand photosynthetic multicellular evolution in aquatic environments.

关键词： macroalgae multicellularity comparative genomics evolution adhesome endogenous viral elements

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科技型中小企业专业培训对研发人员离职倾向的影响研究——以工作嵌入为中介变量

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西华大学学报（哲学社会科学版） 2024年第2期43卷 64-87页

作者：谷昊 alexandra Fernandes 丁奕文电子科技大学经济与管理学院四川成都611731 University Institute of Lisbon Lisbon 1649-026 成都信息工程大学管理学院四川成都610103

为寻求降低科技型中小企业研发人员离职倾向的路径,文章构建“专业培训—工作嵌入—离职倾向”的研究框架,并考虑员工性别、教育程度和职位层级的调节作用,采用大规模调查问卷的实证方法,通过数据分析发现:专业培训显著降低了研发人员... 详细信息

为寻求降低科技型中小企业研发人员离职倾向的路径,文章构建“专业培训—工作嵌入—离职倾向”的研究框架,并考虑员工性别、教育程度和职位层级的调节作用,采用大规模调查问卷的实证方法,通过数据分析发现:专业培训显著降低了研发人员离职倾向,工作嵌入发挥了中介作用,不同特征的员工接受专业培训的效果不同。文章的研究成果丰富了专业培训、工作嵌入等理论内涵并拓展其应用情境,系统地剖析了专业培训针对不同特征研发人员离职倾向的作用机制,具有深刻的理论与实践价值。

关键词：专业培训离职倾向工作嵌入员工特征科技型中小企业

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Genome-wide studies Reveal Genetic Risk Factors for Hepatic Fat Content

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den Berg Alexander Kurilshikov Dasha V.Zhernakova Ranko Gacesa Shixian Hu Esteban A.Lopera-Maya alexandra Zhernakova Lifelines Cohort study Vincent E.de Meijer Serena Sanna Robin P.F.Dullaart Hans Blokzijl Eleonora A.M.Festen Jingyuan Fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCM1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,TM6SF2,and *** of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).statistically significant genetic correlation(rg)between MRI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel MRI-PDFF genetic signals(CREB3L1 and GCM1)were replicated in the FLI *** identified two novel genes for MRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between MRI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAFLD Genome-wide association study Fatty liver index Magnetic resonance imaging proton density fat fraction

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霉菌毒素如何威胁家禽健康和生产性能

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国外畜牧学（猪与禽） 2024年第1期44卷 41-43页

作者： Kayla Price alexandra Weaver 蔡霞(译) 范美红(校) 李红(审) 不详

霉菌毒素是霉菌在受到应激或环境刺激时产生的代谢物。霉菌毒素一旦产生,就会非常稳定,在作物的整个收获、储存、加工和饲喂过程中都会残留在饲料中,对蛋鸡、种鸡和肉鸡都会造成危害。不同的霉菌会产生不同的霉菌毒素,这些霉菌毒素会影... 详细信息

霉菌毒素是霉菌在受到应激或环境刺激时产生的代谢物。霉菌毒素一旦产生,就会非常稳定,在作物的整个收获、储存、加工和饲喂过程中都会残留在饲料中,对蛋鸡、种鸡和肉鸡都会造成危害。不同的霉菌会产生不同的霉菌毒素,这些霉菌毒素会影响家禽的健康和生产性能。霉菌毒素污染是可控的,但必须采取从田间到农场的综合方法。

关键词：霉菌霉菌毒素家禽生产性能控制

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Pressure-induced structural changes cause large enhancement of photoluminescence in halide perovskites: a quantitative relationship

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National Science Review 2021年第9期8卷 13-14页

作者： alexandra Navrotsky Center for Materials of the Universe Arizona State University

Halide perovskites containing both organic and inorganic cations are receiving extensive attention for their promising optoelectronic properties, including photoluminescence (PL)[1,2]. Tuning these properties for specific applications and designing and synthesizing perovskites with optimized properties are major goals of materials science. These goals will be achieved faster and more economically by harnessing a fundamental understanding of structure–property relations, rather than by random searches for better materials. Chemical composition,temperature and pressure are the major‘knobs’ one can turn to adjust properties such as conductivity and bandgap[1,3]. Each of these variables has the potential to change interatomic distances,

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Efficiency of DNA barcodes for species delimitation:A case in Pterygiella Oliv.(Orobanchaceae)

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Journal of Systematics and Evolution 2011年第3期49卷 189-202页

作者： alexandra H.WORTLEY Royal Botanic Garden Edinburgh

DNA barcoding is becoming an increasingly popular means to identify *** obscure discrimination in the genus Pterygiella calls into question the re-assessment of the criterion for species *** collected 20 individuals,representing all five described species of this genus in its distributional *** aim was to use three proposed barcode DNA regions(rbcL,matK,and ITS) to diagnose Pterygiella species,and examine which barcode is more suitable for discerning the congeneric and related *** results showed that the core barcodes matK and rbcL were comparatively less ***,the ITS region,especially ITS-1 and ITS-2,successfully identified all species in the ***,the secondary structure of ITS-2 RNA,especially compensatory base changes,appears complementary to classical primary sequence analysis for DNA barcoding.

关键词： compensatory base changes(CBCs) DNA barcode ITS-2 non-monophyletic species Pterygiella Oliv. secondary structure.

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Investigation of electrophysical, photo- and gas-sensitive properties of ZnO–SnO_(2) sol–gel fflms

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Journal of Advanced Dielectrics 2024年第1期14卷 42-50页

作者： Irina A.Gulyaeva alexandra P.Ivanisheva Maria G.Volkova Victoria Yu.storozhenko Soslan A.Khubezhov Ekaterina M.Bayan Victor V.Petrov Research and Education Centre“Microsystem Technics and Multisensory Monitoring Systems”Southern Federal University Russia Department of Chemistry Southern Federal UniversityRussia Department of Physics North-Ossetian State University362025 VladikavkazRussia Department of Physics and Engineering ITMO University191002 PetersburgRussia

Thin nanocomposite fflms based on tin dioxide with a low content of zinc oxide(0.5–5 mol.%)were obtained by the sol–gel *** synthesized fflms are 300–600 nm thick and contains pore sizes of 19–29 *** resulting ZnO–SnO_(2) fflms were comprehensively studied by atomic force and Kelvin probe force microscopy,X-ray diffraction,scanning electron microscopy,and high-resolution X-ray photoelectron spectroscopy *** photoconductivity parameters on exposure to light with a wavelength of 470 nm were also *** study of the photosensitivity kinetics of ZnO–SnO_(2) fflms showed that the fflm with the Zn:Sn ratio equal to 0.5:99.5 has the minimum value of the charge carrier generation time *** of the activation energy of the conductivity,potential barrier,and surface potential of ZnO–SnO_(2) fflms showed that these parameters have maxima at ZnO concentrations of 0.5 mol.%and 1 mol.%.Films with 1 mol.%ZnO exhibit high response values when exposed to 5–50 ppm of nitrogen dioxide at operating temperatures of 200℃ and 250℃.

关键词： Sol–gel method,ZnO–SnO_(2) films gas-sensitive properties surface potential potential barrier conduction activation energy

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Pandemic prevention and personality psychology: Gender differences in preventive health behaviors during COVID-19 and the roles of agreeableness and conscientiousness

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Journal of Safety Science and Resilience 2022年第1期3卷 87-91页

作者： Tobias Otterbring alexandra Festila Department of Management University of AgderKristiansandNorway Freelancer CopenhagenDenmark

One of the greatest public health crises in recent times,the COVID-19 pandemic,has come with a myriad of challenges in terms of health communication and public cooperation to prevent the spread of the ***-derstanding which are the key determinants that make certain individuals more cooperative is key in effectively tackling pandemics and similar future *** the present study(N=800),we investigated whether gen-der differences in compliance with preventive health behaviors(PHB)at the onset of the COVID-19 pandemic could be established,and,if so,whether the personality traits of agreeableness and conscientiousness could help explain this presumed *** with our theorizing,we found women to score higher than men on agreeableness and conscientiousness,and to be more willing to comply with a set of ***,both per-sonality traits were found to mediate the gender-compliance *** means that women’s greater compliance levels with PHB could,at least in part,be attributed to their higher agreeableness and conscientiousness scores.A greater understanding of the determinants of PHB in terms of gender and associated personality traits may help identify options for developing more effective communication campaigns,both in terms of communication channel selection and message content.

关键词： Covid-19 Pandemics Gender,personality Psychology Agreeableness Conscientiousness Preventive health behaviors

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Lineage plasticity-mediated therapy resistance in prostate cancer

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Asian Journal of Andrology 2019年第3期21卷 241-248页

作者： alexandra M Blee Haojie Huang Department of Biochemistry and Molecular Biology Mayo Clinic College of Medicine Rochester MN 55905 USA Biochemistry and Molecular Biology Graduate Program Mayo Clinic Graduate School of Biomedical Sciences Rochester MN 55905 USA Department of Urology Mayo Clinic College of Medicine Rochester MN 55905 USA Mayo Clinic Cancer Center Mayo Clinic College of Medicine Rochester MN 55905 USA

Therapy resistance is a significant challenge for prostate cancer treatment in clinic. Although targeted therapies such as androgen deprivation and androgen receptor (AR) inhibition are effective initially, tumor cells eventually evade these strategies through multiple mechanisms. Lineage reprogramming in response to hormone therapy represents a key mechanism that is increasingly observed. The studies in this area have revealed specific combinations of alterations present in adenocarcinomas that provide cells with the ability to transdifferentiate and perpetuate AR-independent tumor growth after androgen-based therapies. Interestingly, several master regulators have been identified that drive plasticity, some of which also play key roles during development and differentiation of the cell lineages in the normal prostate. Thus, further study of each AR-independent tumor type and understanding underlying mechanisms are warranted to develop combinational therapies that combat lineage plasticity in prostate cancer.

关键词： lineage plasticity neuroendocrine prostate cancer therapy resistance transdifferentiation

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Current progress in the treatment of chronic hepatitis C

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World Journal of Gastroenterology 2012年第42期18卷 6060-6069页

作者： alexandra Alexopoulou George V Papatheodoridis 2nd Department of Internal Medicine Athens University School of MedicineHippokration General Hospital of Athens115 27 AthensGreece

Over the last decade, the standard of care for the treat- ment of chronic hepatitis C has been the combination of pegylated-interferon-alfa （PEG-IFN） and ribavirin （RBV） which results in sustained virological response （SVR） rates of 75%-85% in patients with genotypes 2 or 3 but only of 40%-50% in patients with genotype 1. Cur- rently, there are rapid and continuous developments of numerous new agents against hepatitis C virus （HCV）, which are the focus of this review. Boceprevir and tela- previr, two first-generation NS3/4A HCV protease inhibi- tors, have been recently licensed in several countries around the world to be used in combination with PEG- IFN and RBV for the treatment of genotype 1 patients. Boceprevir or telaprevir based triple regimens, com- pared with the PEG-IFN/RBV combination, improve the SVR rates by 25%-31% in treatment-naTve genotype 1 patients, by 40%-64% in prior relapsers, by 33%-45% in prior partial responders and by 24%-28% in prior null responders. At the same time, the application of response-guided treatment algorithms according to the on-treatment virological response results in shortening of the total therapy duration to only 24 wk in 45%-55% of treatment-na＇ive patients. There are, however, several challenges with the use of the new triple combinations in genotype 1 patients, such as the need for immediate results of HCV RNA testing using sensitive quantitative assays, new and more frequent adverse events （anemia and dysgeusia for boceprevir; pruritus, rash and anemia for telaprevir）, new drug interactions and increasing dif- ficulties in compliance. Moreover, the SVR rates are still poor in very difficult to treat subgroups of genotype 1 patients, such as null responders with cirrhosis, while there is no benefit for patients who cannot tolerate PEG- IFN/RBV or who are infected with non-1 HCV genotype. Many newer anti-HCV agents of different classes and numerous combinations are currently under evaluation with encouraging results. Pre

关键词： Chronic hepatitis C Pegylated interferon Ribavirin Protease inhibitors, Nucleos(t)ide analogueinhibitors Non-nucleos(t)ide analogue inhibitors Hepa-titis C virus polymerase NS5A inhibitors Cyclophilininhibitors

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