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Neural Regeneration Research 2020年第12期15卷 2235-2236页

作者： alexandra m.Iavorovschi Aijun Wang Surgical Bioengineering Laboratory Department of SurgerySchool of MedicineUniversity of California-DavisInstitute for Pediatric Regenerative MedicineShriners Hospitals for Children-Northern CaliforniaSacramentoCAUSA Department of Biomedical Engineering University of CaliforniaDavis School of EngineeringDavisCAUSA

Treatment for central nervous system(CNS)disorders is known to be limited by the low regenerative potential of neurons,and thus neurodegenerative insults became known as nearly irreversible *** recovery for acquired CNS disorders,such as spinal cord injury(SCI),traumatic brain injury,ischemic stroke,Alzheimer’s disease,Parkinson’s disease,multiple sclerosis(mS),and for congenital CNS abnormalities,such as spina bifida,is not spontaneous and effective treatments are limited to *** in the past decades has proven the regenerative potential of stem cells,especially that of mesenchymal stromal/stem cells(mSCs)from various origins,such as bone marrow,placenta,and adipose tissue.

关键词： disorders treatment Alzheimer

Analysis of per-and polyfluoroalkyl substances in Houston Ship Channel and Galveston Bay following a large-scale industrial fire using ion-mobility-spectrometry-mass spectrometry

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Journal of Environmental Sciences 2022年第5期34卷 350-362页

作者： Alan Valdiviezo Noor AAly Yu-Syuan Luo alexandra Cordova Gaston Casillas maKayla Foster Erin SBaker Ivan Rusyn Interdisciplinary Faculty of Toxicology Texas A&M UniversityCollege StationTX 77843USA Department of Veterinary Integrative Biosciences Texas A&M UniversityCollege StationTX 77843USA Department of Environmental and Occupational Health Texas A&M UniversityCollege StationTX 77843USA Department of Chemistry North Carolina State UniversityRaleighNC 27695USA

Per-and polyfluoroalkyl substances(PFAS)are persistent organic pollutants of concern be-cause of their ubiquitous presence in surface and ground water;analytical methods that can be used for rapid comprehensive exposure assessment and fingerprinting of PFAS are *** the fires at the Intercontinental Terminals Company(ITC)in Deer Park,TX in 2019,large quantities of PFAS-containing firefighting foams were *** release of these substances into the Houston Ship Channel/Galveston Bay(HSC/GB)prompted con-cerns over the extent and level of PFAS contamination.A targeted liquid chromatography-tandem mass spectrometry(LC-mS/mS)-based study of temporal and spatial patterns of PFAS associated with this incident revealed presence of 7 species;their levels gradually de-creased over a 6-month *** the targeted LC-mS/mS analysis was focused on about 30 PFAS molecules,it may have missed other PFAS compounds present in firefighting ***,we utilized untargeted LC-ion mobility spectrometry-mass spectrome-try(LC-ImS-mS)-based analytical approach for a more comprehensive characterization of PFAS in these water *** analyzed 31 samples from 9 sites in the HSC/GB that were collected over 5 months after the *** data showed that additional 19 PFAS were detected in surface water of HSC/GB,most of them decreased gradually after the *** features detected by LC-mS/mS correlated well in abundance with LC-ImS-mS data;however,LC-ImS-mS identified a number of additional PFAS,many known to be compo-nents of firefighting *** findings therefore illustrate that untargeted LC-ImS-mS improved our understanding of PFAS presence in complex environmental samples.

关键词： Emergency Environmental disaster PFAS

Satellite mapping of air temperature under polar night conditions

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Geo-Spatial Information Science 2022年第2期25卷 325-336页

作者： Kritsuk Sergei Victor Gornyy Tatiana Davidan Iscander Latypov alexandra manvelova Pavel Konstantinov Andrei Tronin mikhail Varentsov mikhail Vasiliev Saint-Petersburg Scientific Research Center for Ecological Safety Russian Academy of SciencesSaint-PetersburgRussia Faculty of Geography/Research Computing Center Lomonosov Moscow State UniversityMoscowRussia

A novel satellite technique for air temperature mapping with a spatial resolution of~100 m was proposed for the town of Apatity,the Kola Peninsula(Russia),taken as a case *** main idea behind this novel technique is to find the statistical relationships between the land surface temperatures in each point of the study area,observed by multiple infrared thermal satellite imagery,and the time series of air temperatures recorded by World meteorological Organization(WmO)weather *** scenes of infrared thermal spectral band of the Landsat satellites for the period 2014–2019 were used,as well as the long-term time series of air temperature from the weather station and the results of air temperature observations carried out by the network of *** calm weather conditions,according to the ground truth,the error of air temperature mapping wasσ=1.5°C,and the precision was estimated asδ=1.0°*** analysis of the compiled air temperature map showed that,under polar night conditions,the air temperature on the hilltops was by 10–18°C higher than in the *** was concluded that,for economic reasons,as well as for the reasons of population health protection in the Arctic,it would be advisable to plan the placement of new cities on the *** of these new areas should be designed in a“semi-isolated”manner in order to minimize the time needed by the local people for crossing the lowlands between the nearby districts.A characteristic feature of modern megalopolises is their internal structure formed by the growing primary settlements that can be considered as nuclei interlinked by transportation ***,the new Arctic cities can be called“Arctic megalopolises”because of their internal structure that is specific to megalopolises.

关键词： Polar night town of Apatity air temperature satellite images time series regression mapping bioclimatic comfort

Cells and material-based strategies for regenerative endodontics

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Bioactive materials 2022年第8期7卷 234-249页

作者： Zain Siddiqui Amanda m.Acevedo-Jake alexandra Griffith Nurten Kadincesme Kinga Dabek Dana Hindi Ka Kyung Kim Yoshifumi Kobayashi Emi Shimizu Vivek Kumar Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Oral Biology Rutgers School of Dental MedicineNewarkNJ07103USA Department of Endodontics Rutgers School of Dental MedicineNewarkNJ07103USA Department of Chemicals and materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Biology New Jersey Institute of TechnologyNewarkNJ07102USA

The carious process leads to inflammation of pulp *** care options include root canal treatment or *** procedures,however,result in the loss of tooth vitality,sensitivity,and *** capping and dental pulp regeneration a... 详细信息

margin:0 cm;line-height:32px;font-size:12 pt;font-family:"Times New Roman",serif;color:rgb(0,0,0);">The carious process leads to inflammation of pulp *** care options include root canal treatment or *** procedures,however,result in the loss of tooth vitality,sensitivity,and *** capping and dental pulp regeneration are continually evolving techniques to regenerate pulp tissue,avoiding necrosis and loss of *** studies have successfully employed stem/progenitor cell populations,revascularization approaches,scaffolds or material-based strategies for pulp *** we outline advantages and disadvantages of different methods and techniques which are currently being used in the field of regenerative *** also summarize recent findings on efficacious peptide-based materials which target the dental niche..

关键词： Regenerative endodontics Pulp regeneration Tissue engineering Stem cells Scaffolds

Lower blood malondialdehyde is associated with past pesticide exposure:findings in Gulf War illness and healthy controls

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military medical Research 2022年第2期9卷 205-214页

作者： Beatrice alexandra Golomb Sridevi Devaraj Alexis K.messner Hayley Jean Koslik Jun Hee Han Barnabas Yik Department of medicine School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Department of Pathology and Immunology Baylor College of MedicineHoustonTX 77030USA Swedish medical Center SeattleWA 98109USA Henry m.Jackson Foundation for the Advancement of military medicine San DiegoCA 92134USA Santa Clara Valley medical Center San JoseCA 95128USA

Background: malondialdehyde(mDA) is a candidate general marker of oxidative stress(OS). We sought to assess the relation of mDA to Gulf War illness(GWI) and to a variety of ***: This is an observational study involving subjects from Southern California recruited from October 2011 to may 2014. mDA was assessed in 81 participants(41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. mDA case–control comparison was restricted to 40 matched pairs. The potential association between mDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific ***: Plasma mDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted mDA in the total sample, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate(OP) nerve gas was a strong predictor for lower mDA level in veterans with ***: Past pesticide exposures predicted lower mDA in both veterans with GWI and in healthy controls.

关键词： malondialdehyde Oxidative stress Free radical Gulf War veterans Gulf War illness Pesticide

Network analyses:Inhibition of androgen receptor signaling reduces inflammation in the lung through AR-mAF-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert R.Wang Andrew m.Baschnagel Zijian Ni Sean R.Brennan Hypatia K.Newton Darya Buehler Christina Kendziorski Randall J.Kimple Gopal lyer Department of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin carbone Cancer Center MadisonWI 53705USA Department of Biostatistics and medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Department of Biology Tufts UniversityMedfordMA 02155USA Department of Pathology and Laboratory medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(AR)is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While AR regulation through paracrine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and RNA knockdown of AR identified a bZIP transcription factor mAF to be a common target of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

High entropy fluorides as conversion cathodes with tailorable electrochemical performance

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Journal of Energy Chemistry 2022年第9期31卷 342-351,I0010页

作者： Yanyan Cui Parvathy Anitha Sukkurji Kai Wang Raheleh Azmi alexandra mNunn Horst Hahn Ben Breitung Yin-Ying Ting Piotr mKowalski Payam Kaghazchi Qingsong Wang Simon Schweidler miriam Botros Institute of Nanotechnology Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Institute for Applied materials±Energy Storage Systems Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Faculty of Science University of WaterlooWaterlooON N2L 3G1Canada KIT-TUD-Joint Research Laboratory Nanomaterials Technical University DarmstadtDarmstadt 64287Germany Theory and Computation of Energy materials(IEK-13) Institute of Energy and Climate ResearchForschungszentrum Jülich GmbH52425 JülichGermany materials Synthesis and Processing(IEK-1) Institute of Energy and Climate ResearchForschungszentrum Jülich GmbH52425 JülichGermany

With the recent development of high entropy materials, an alternative approach to develop advanced functional materials with distinctive properties that show improved values compared to conventional materials has been provided. The high entropy concept was later successfully transferred to metal fluorides and high entropy fluorides(HEFs) were successfully synthesized. Owing to their high theoretical specific capacities in energy storage applications, HEFs were utilized as cathode materials for lithiumion batteries(LIBs) and their underlying storage mechanisms were investigated. Instead of a step-bystep reduction of each individual metal cation, the HEFs seem to exhibit a single-step reduction process,indicating a solid solution compound instead of merely a mixture of different metal fluorides. It was also observed that the electrochemical behavior of the HEFs depends on each individual incorporated element. Therefore, by altering the elemental composition, new materials that exhibit improved electrochemical properties can be designed. Remarkably, HEFs with seven incorporated metal elements exhibited a better cycling stability as well as a lower hysteresis compared to binary metal *** findings offer new guidelines for material design and tailoring towards high performance LIBs.

关键词： High entropy materials High entropy fluorides Conversion cathodes Tailored electrochemistry Li-ion batteries

New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis

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Bone Research 2023年第2期11卷 303-315页

作者： Emilie Hascoet Frédéric Blanchard Claudine Blin-Wakkach Jérôme Guicheux Philippe Lesclous alexandra Cloitre Nantes Université OnirisUniv AngersCHU NantesINSERMRegenerative Medicine and SkeletonRMeSUMR1229F-44000 NantesFrance UniversitéCote d'Azur CNRSLP2M NiceFrance

Rheumatoid arthritis(RA)and periodontitis are chronic inflammatory diseases leading to increased bone *** this inflammatory bone resorption is a major health *** diseases share immunopathogenic similarities and a common inflammatory *** autoimmune response or periodontal infection stimulates certain immune actors,leading in both cases to chronic inflammation that perpetuates bone ***,RA and periodontitis have a strong epidemiological association that could be explained by periodontal microbial *** dysbiosis is believed to be involved in the initiation of RA via three mechanisms.(i)The dissemination of periodontal pathogens triggers systemic inflammation.(ii)Periodontal pathogens can induce the generation of citrullinated neoepitopes,leading to the generation of anti-citrullinated peptide autoantibodies.(iii)Intracellular danger-associated molecular patterns accelerate local and systemic ***,periodontal dysbiosis could promote or sustain bone resorption in distant inflamed ***,in inflammatory conditions,the existence of osteoclasts distinct from“classical osteoclasts”has recently been *** have proinflammatory origins and *** populations of osteoclast precursors have been described in RA,such as classical monocytes,a dendritic cell subtype,and arthritis-associated osteoclastogenic *** aim of this review is to synthesize knowledge on osteoclasts and their precursors in inflammatory conditions,especially in RA and *** attention will be given to recent data related to RA that could be of potential value in periodontitis due to the immunopathogenic similarities between the two *** our understanding of these pathogenic mechanisms should lead to the identification of new therapeutic targets involved in the pathological inflammatory bone resorption associated with these diseases.

关键词： inflammatory osteoclast period

moving of a submarine under an ice cover in fluid of finite depth

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Journal of Hydrodynamics 2019年第3期31卷 562-569页

作者： alexandra V. Pogorelova Vitali L. Zemlyak Victor m. Kozin Sholom-A leichem Priamursky State University Birobidzhan Russia Institute of machining and metallurgy FEB RAS Komsomolsk-na-Amure Russia

The influence of a basin depth on ice cover deflections, when a submarine moves under it in fluid, is experimentally and theoretically analyzed. For a theoretical research the ice cover is modelled by an elastic floating plate, and the submarine is modelled by a source-sink system in a fluid flow. The problem is solved by means of asymptotic analysis and integral transformations. The experimental study is conducted with submarine models in the pool with the sizes L*B*H= 10m*3m*lm . The ice cover for experiments is modelled in two ways. The first way is the thin ice plate received by freezing of the surface layer of water at low temperatures. In the second case the rubber sheet floating on a reservoir surface is used. The special velocity (the velocity at which maximum values of the wave height are reached) is analyzed. It is obtained that the decrease of the basin depth leads to decrease of the special speed. For small speeds (less than the special speed) there is the fact that the basin depth decrease leads to the increase of the height of the flexural-gravity wave.

关键词： Ice cover submarine flexural gravity wave source-sink system

mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

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Cellular & molecular Immunology 2023年第8期20卷 955-968页

作者： manuel m.Vicente Inês Alves Ângela Fernandes Ana m.Dias Beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang alexandra Correia Anja münster-Kühnel Afonso R.m.Almeida Sarina Ravens Gabriel A.Rabinovich manuel Vilanova Ana E.Sousa SaloméS.Pinho i3S–Institute for Research and Innovation in Health University of PortoPortoPortugal Institute of Biomedical Sciences Abel Salazar(ICBAS) University of PortoPortoPortugal Graduate Program in Areas of Basic and Applied Biology(GABBA) ICBASUniversity of PortoPortoPortugal Faculty of medicine University of PortoPortoPortugal Nephrology Department Centro Hospitalar e Universitário do PortoPortoPortugal Institute of Immunology Hannover Medical SchoolHannoverGermany Institute of Clinical Biochemistry Hannover Medical SchoolHannoverGermany Instituto de medicina molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Laboratorio de Inmunopatología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Laboratorio de Inmuno-oncología Translacional Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Facultad de Ciencias Exactas y Naturales(FCEyN) Universidad de Buenos AiresCiudad de Buenos AiresArgentina

T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of *** is a major posttranslational modification present in virtually all cells,including T-lymphocytes,that regulates activity/*** these structures are known to be involved in TCR-selection in DP thymocytes,it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to ***,we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes,as well as dynamic *** restricting the N-glycosylation profile of thymocytes to high-mannose structures,using specific glycoengineered mice(Rag1Cremgat1fl/fl),we showed remarkable defects in key developmental checkpoints,includingß-selection,regulatory T-cell generation andγδT-cell development,associated with increased susceptibility to colon and kidney inflammation and *** further demonstrated that a single N-glycan antenna(modeled in Rag1Cremgat2fl/fl mice)is the sine-qua-non condition to ensure normal *** conclusion,we revealed that mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inflammation susceptibility.

关键词： N-glycosylation T-cell development Thymocytes Glycocalyx Inflammation