检索结果-南通市图书馆

Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats

引用

Cancer Biology & Medicine 2017年第1期14卷 100-107页

作者： viktoria v.Bekusova vasily M.Patsanovskii Alexander D.Nozdrachev alexandr P.Trashkov Margarita R.Artemenko vladimir N.Anisimov Department of Physiology St.Petersburg State UniversitySt.Petersburg 197183Russia I.P.Pavlov Institute of Physiology Russian Academy of Sciences St.Petersburg 199034Russia Deparment of Experimental Pharmacology I.M.Sechenov Institute of Evolutionary Physiology and BiochemistryThe Russian Academy of SciencesSt.Petersburg 194223Russia Department of Carcinogenesis and Oncogerontology N.N.Petrov Research Institute of OncologySt.Petersburg 197758 Russia

Effects of two doses of the anti-diabetic drug, metformin （MF）, on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine （DMH）-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulin- like growth factor-l, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized maiority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer.

关键词： Colon cancer prevention 1,2-dimethylhydrazine mefformin rat

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-equilibrium Gamma-emission Under Laser Exposure of Gold Nanoparticles in Aqueous Solutions of Uranium Salt

引用

材料科学与工程（中英文B版） 2011年第5期1卷 618-625页

作者： alexandr v. Simakin Georgy A. Shafeev Wave Research Center A.M. Prokhorov General Physics Institute Russian Academy of Seiences Moscow 119991 Russian Federation

Laser exposure of either Au or Ag nanoparticles in aqueous solutions of UO2Cl2 leads to accelerated decay of nuclides of 238U branching and is accompanied by non-equilibrium gamma-emission of the solution. The enhanced gamma-emission is observed in the range of 54-57 kev during laser exposure at laser intensity of order of 1011 W/cm2 and pulse duration of 10 ns. This gamma-emission is identified as the generation and decay of short-living isotopes 214Pb and 214Bi upon accelerated decay of nuclides of Uranium branching. Deviation from secular equilibrium in activity of nuclides of the 238U branching (234Th, 234mPa, 214Pb) is especially pronounced at laser peak power of 1012 W/cm2 at the wavelength of 355 nm and pulse duration of 150 ps.

关键词：金纳米粒子激光照射非平衡水溶液发射伽玛脉冲持续时间铀

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Circle of life:the common hamster(Cricetus cricetus)adaptations to the urban environment

引用

Integrative Zoology 2019年第4期14卷 383-395页

作者： Alexey v.SUROv Elena A.ZAYTSEvA alexandr v.KUPTSOv Elena A.KATZMAN Pavel L.BOGOMOLOv alexandra S.SAYAN Ekaterina v.POTASHNIKOvA Nikolay N.TOvPINETZ Ekaterina v.KUZNETSOvA Alexey Y.TSELLARIUS Natalia Y.FEOKTISTOvA Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscowRussia Centre of Hygiene and Epidemiology in Crimea and in the Municipal City Sevastopol SimferopolRussia

Traditionally,urbanization has been seen as a negative phenomenon for ***,changes in the environmental parameters induced by urbanization might be favorable for some *** the past half-century,the common hamster has actively populated cities,establishing populations in some European,Russian and Kazakhstan *** on integrative methods,we investigated free-range common hamsters inhabiting Simferopol from 2015 to 2018 to reveal possible adaptations to the urbanized environment across several parameters,including lifespan,hibernation period,reproductive activity and body *** show that in urban areas,the common hamster demonstrates an extremely short hibernation period compared to other localities,possibly due to enhanced food resources from urban forestry(walnuts,locus and hazelnut),allowing the species to start breeding very early(February)and finish as late as *** present the first evidence of polyandry for this species:mating of receptive females with several males and subsequent confirmation of multiple *** high reproductive potential,the lifespan of the common hamster in urban conditions is generally very short(less than 1 year).We speculate that in the process of synurbization,the common hamster’s innate plasticity across many life history traits permits it to successfully colonize throughout a wide range of habitats,with the ability to form novel adaptations to urban environments.

关键词： body mass hibernation lifespan multiple paternity synurbization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

引用

Cancer Biology & Medicine 2021年第3期18卷 910-930页

作者： Evgeniya v.Dolgova Oleg M.Andrushkevich Polina E.Kisaretova Anastasia S.Proskurina Genrikh S.Ritter Tatyana D.Dubatolova Margarita v.Romanenko Oleg S.Taranov Yaroslav R.Efremov Evgeniy L.Zavyalov alexandr v.Romaschenko Sergey v.Mishinov Svetlana S.Kirikovich Evgeniy v.Levites Ekaterina A.Potter alexandr A.Ostanin Elena R.Chernykh Stanislav Yu.Roshchin Anatoliy v.Bervitskiy Galina I.Moysak Jamil A.Rzaev Sergey S.Bogachev Institute of Cytology and Genetics SB RAS Novosibirsk 630090Russia A.I.Evdokimov Moscow State University of Medicine and Dentistry Moscow 127473Russia Institute of Molecular and Cellular Biology Novosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia The State Research Center of virology and Biotechnology"vector" KoltsovoNovosibirsk 630559Russia First Department of Neurosurgery Ya.L.Tsivian Novosibirsk Research Institute of Traumatology and OrthopaedicsNovosibirsk 630091Russia Institute of Fundamental and Clinical immunology Novosibirsk 630099Russia Sklifosovsky Research Institute of Emergency Medicine Moscow 129010Russia Federal Center of Neurosurgery Novosibirsk 630048Russia

Objective:Glioma is a highly invasive tumor,frequently disposed in essential areas of the brain,which makes its surgical excision extremely difficult;meanwhile adjuvant therapy remains quite ***:In the current report,a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma *** approach,termed"Karanahan",is aimed at the eradication of cancer stem cells(CSCs),which were recently shown to be capable of internalizing fragments of extracellular double-stranded *** being internalized,these fragments interfere in the process of repairing interstrand cross-links caused by exposure to appropriate cytostatics,and such an interference results either in elimination of CSCs or in the loss of their tumorigenic *** of the approach requires a scheduled administration of cytostatic and complex composite double-stranded DNA ***:U87 cells treated in vitro in accordance with the Karanahan approach completely lost their tumorigenicity and produced no grafts upon intracerebral transplantation into immunodeficient *** SCID mice with developed subcutaneous grafts,the treatment resulted in reliable slowing down of tumor growth rate(Pveloped graft and subsequent therapeutic treatment,the Karanahan approach was shown to reliably slow down the tumor growth rate and increase the median survival of the mice twofold relative to the ***:The effectiveness of the Karanahan approach has been demonstrated both in vitro and in vivo in treating developed subcutaneous grafts as well as orthotopic grafts after surgical excision of the tumor.

关键词： Glioblastoma U87 cell line mytomycin C cancer stem cells TAMRA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Elucidation of the sodiation/desodiation mechanism in Ca_(0.5)Ti_(2)(PO_(4))_(3)/C as promising electrode for sodium batteries: New insights into the phase transitions

引用

Journal of Energy Chemistry 2022年第7期31卷 36-44,I0002页

作者： Abdelhaq Nassiri Noha Sabi Angelina Sarapulova Yingjin Wei Bouchaib Manoun Sylvio Indris alexandr Missyul Helmut Ehrenberg Ismael Saadoune IMED-Lab Faculty of Science and Technology-Cadi Ayyad University(UCA)Av.A.El KhattabiP.B.549MarrakeshMorocco Institute for Applied Materials(IAM) Karlsruhe Institute of Technology(KIT)P.O.Box 364076021 KarlsruheGermany Key Laboratory of Physics and Technology for Advanced Batteries(Ministry of Education) Jilin Engineering Laboratory of New Energy Materials and TechnologyCollege of PhysicsJilin UniversityChangchun 130012JilinChina MSN Mohamed VI Polytechnic UniversityLot 660Hay Moulay RachidBen Guerir 43150Morocco CELLS-ALBA Synchrotron E-08290 Cerdanyola del VallesBarcelonaSpain Technology Development Cell(Techcell) Technology Transfer Office(TTO)Mohamed VI Polytechnic UniversityLot 660Hay Moulay RachidBen Guerir 43150Morocco

The structure evolution and electrochemical performance of Na SICON-type Ca_(0.5)Ti_(2)(PO_(4))_(3) for sodium batteries are *** phosphate was synthesized by a solid-state method,and the obtained particles were coated with carbon using *** compound crystallizes in the rhombohedral system with space group *** presence of carbon in the Ca_(0.5)Ti_(2)(PO_(4))_(3)/C composite was confirmed by Raman and Thermogravimetric *** electrochemical performance of Ca_(0.5)Ti_(2)(PO_(4))_(3)/C was investigated in the potential window 1.5–3.0 v *** metal at different scan *** compound is able to initially intercalate/deintercalate 1.6/1.15 Na per formula unit,*** operando synchrotron diffraction was done in the potential window 0.02–3.0 v ***|Na+and revealed the occurrence of several reaction regions upon first *** to 4 Na+ion per formula unit can be inserted during the first *** intensive refinement of the synchrotron X-ray diffraction(SXRD)patterns of discharged Ca_(0.5)Ti_(2)(PO_(4))_(3) evidenced the existence of five regions depending on the sodium content while the crystal structures of new phases were elucidated for the first time where sodium insertion occurs in the unusual M3 and M’3 sites of the Na SICON structure.

关键词： Sodium-ion batteries Phosphates Synchrotron Mechanism Energy storage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pyroptosis is a drug target for prevention of adverse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy

引用

The Journal of Biomedical Research 2022年第6期36卷 375-389页

作者： Natalia v.Naryzhnaya Leonid N.Maslov Sergey v.Popov alexandr v.Mukhomezyanov vyacheslav v.Ryabov Boris K.Kurbatov alexandra E.Gombozhapova Nirmal Singh Feng Fu Jian-Ming Pei Sergey v.Logvinov Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Pharmaceutical Sciences and Drug Research Punjabi UniversityPatiala 147002India Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic MedicineFourth Military Medical UniversityXi'anShaanxi 710032China Department of Histology Embryology and CytologySiberian State Medical UniversityTomskTomsk Region 634055Russia

Acute myocardial infarction(AMI)is one of the main reasons of cardiovascular disease-related *** introduction of percutaneous coronary intervention to clinical practice dramatically decreased the mortality rate in *** cardiac remodeling is a serious problem in *** increase in the effectiveness of AMI treatment and prevention of adverse cardiac remodeling is difficult to achieve without understanding the mechanisms of reperfusion cardiac injury and cardiac *** of pyroptosis prevents the development of postinfarction and pressure overload-induced cardiac remodeling,and mitigates cardiomyopathy induced by diabetes and metabolic ***,it is reasonable to hypothesize that the pyroptosis inhibitors may find a role in clinical practice for treatment of AMI and prevention of cardiac remodeling,diabetes and metabolic syndrome-triggered *** was demonstrated that pyroptosis interacts closely with apoptosis and *** could be inhibited by nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 inhibitors,caspase-1 inhibitors,microRNA,angiotensin-converting enzyme inhibitors,angiotensinⅡreceptor blockers,and traditional Chinese herbal medicines.

关键词： pyroptosis apoptosis autophagy cardiac remodeling diabetes metabolic syndrome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Social structure and space use of Amur tigers(Panthera tigris altaica)in Southern Russian Far East based on GPS telemetry data

引用

Integrative Zoology 2015年第4期10卷 365-375页

作者： Jose A.HERNANDEZ-BLANCO Sergei v.NAIDENKO Maria D.CHISTOPOLOvA victor S.LUKAREvSKIY Alexey KOSTYRYA alexandr RYBIN Pavel A.SOROKIN Mikhail N.LITvINOv Andrey K.KOTLYAR Dale G.MIQUELLE viatcheslav v.ROZHNOv A.N.Severtsov Institute of Ecology and Evolution Russian Academy of ScienceMoscowRussia v.L.Komarov Ussuriskii State Nature Reserve Far Eastern BranchRussian Academy of ScienceUssuriskRussia Institute of Biology and Soil Sciences Far Eastern BranchRussian Academy of ScienceVladivostokRussia Wildlife Conservation Society VladivostokRussia

To better understand the spatial structure of Amur tigers(Panthera tigris altaica)at the southern edge of their range we fitted 14 tigers(6♀♀and 8♂♂)with 15 GPS-Argos collars between 2008 and 2011 in 2 study sites:the Ussuriskii Reserve of southern Sikhote-Alin and the Land of the Leopard National Park in southwest Primorye,Russian Far *** kernel estimates of male home ranges were larger than those of female home ranges(Pvaried greatly,but on average was similar to estimates derived from earlier work further *** overlap of adjacent home ranges suggested that females retained exclusive *** core areas of females overlapped only slightly,and remained stable over multiple *** home ranges of adult males were smaller than those of males to the north,and in contrast to previous studies,high overlap among males indicated the absence of ***,real core areas of males did not overlap,suggesting some spatial *** comparison to other tiger populations and other areas of the Russian Far East,the sex ratio in our 2 study areas was highly skewed towards *** believe this skewed sex ratio resulted in the dissolution of territoriality of males due to an inability to defend individual females,with males resorting to scramble competition for *** monitoring of these sites to determine whether shifts in the sex ratio might result in a return to male territoriality would provide confirmation of our tentative hypothesis.

关键词： Amur tiger GPS-Argos telemetry home range overlap Panthera tigris altaica space use social structure sex ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

引用

The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： Leonid N.Maslov Natalia v.Naryzhnaya Sergey v.Popov alexandr v.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey v.Krylatov Feng Fu Jianming Pei vyacheslav v.Ryabov Evgenii v.vyshlov Svetlana v.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MvO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MvO in patients with acute myocardial ***,the major events preceding the appearance of MvO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MvO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MvO,with L-type Ca2+channel blockers appearing the most effective in treating MvO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Erosion processes in karst landscapes of the Russian plain northern taiga,based on digital elevation modeling

引用

Journal of Mountain Science 2016年第4期13卷 569-580页

作者： Elena POLYAKOvA Mikhail GOFAROv Yuriy KUTINOv vladimir BELJAEv Zinaida CHISTOvA Nikolay NEvEROv vadim STARITSYN alexandr MINEEv Sergey DURYNIN Institute of Ecological Problems of the North Ural Branch of Russian Academy of SciencesGeological Structure and Dynamics of the Lithosphere Laboratory Space Monitoring of the Arctic Centre of the Northern Arctic Federal University namedafter M.v.Lomonosov Arkhangelsk163000Russia Institute of Ecological Problems of the North Ural Branch of Russian Academy of SciencesMolecular Ecology and Biogeography LaboratoryArkhangelsk163000Russia Institute of Ecological Problems of the North Ural Branch of Russian Academy of SciencesGeological Structure and Dynamics of the Lithosphere LaboratoryArkhangelsk163000Russia

This paper considers the problems of the potential development of erosion processes in the natural landscapes of northern taiga in the Russian plain. It is considered that in forest ecosystems, erosion processes are slow and are weakly reflected in the terrain. However, the situation changes radically if the vegetation cover integrity is violated, which is inevitable with the modern methods of developing northern territories. Furthermore, global changes in average annual temperatures and the occurrence of karst processes may be the reason behind the development of erosion processes. The authors suggest a method for determining territories with a varying occurrence probability of erosional processes, based on digital elevation modelling. The territory of the Pinezhsky Nature Reserve(Arkhangelsk region) was chosen as the test plot. Direct field studies were previously used to detect exogenous geological processes in this territory. The authors were the first to suggest digital elevation modelling as a method that allows determining the potential danger of erosion in karst landscapes of the northern taiga. The geomorphometric studies resulted in the determination of areas with the greatest and lowest occurrence probability of erosion processes in the Pinezhsky Nature Reserve. It was established that the most significant erosion type was linear erosion, represented by incised river valleys and karst ravines. Sheet erosion is less significant and occurs as sinkholes, local declines, and chasms over the valleys of subterranean rivers.

关键词： Russian plain Erosion processes Karst Northern taiga Digital elevation model Geomorphometric parameters

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Do reactive oxygen species damage or protect the heart in ischemia and reperfusion?Analysis on experimental and clinical data

引用

The Journal of Biomedical Research 2023年第4期37卷 255-267页

作者： Leonid N.Maslov Natalia v.Naryzhnaya Maria Sirotina alexandr v.Mukhomedzyanov Boris K.Kurbatov Alla A.Boshchenko Huijie Ma Yi Zhang Feng Fu Jianming Pei viacheslav N.Azev vladimir A.Pereverzev Cardiology Research Institute Tomsk National Research Medical Centerthe Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China The Branch of the Institute of Bioorganic Chemistry Russian Academy of SciencesPushchinoMoscow Oblast 142290Russia Department of Normal Physiology Belarusian State Medical UniversityMinsk 220083Belarus

The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 *** has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated *** were found to have the ability to mitigate I/R injury of the ***,it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial *** high doses and high concentrations of antioxidants were experimentally used,it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other *** has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic ***,there is evidence that ROS protect the heart against the I/R injury.

关键词： reactive oxygen species free radicals antioxidants heart reperfusion patients

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：