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In.racellular Cholesterol Reten.ion.n.w Target for Direct An.i-Atherosclerotic Therapy

Open.Journ.l of En.ocrin. an. Metabolic Diseases 2013年第4期3卷 9-17页

作者： alexander n. orekhov In.titute for Atherosclerosis Research Skolkovo Innovative Center Moscow Russia

Accumulation.of cholesterol in.arterial cells, in.racellular cholesterol reten.ion. may be respon.ible for all major man.festation. of atherosclerosis on.a cellular level. Previously we have shown.that in.racellular cholesterol reten.ion.is the prin.ipal even. in.the gen.sis of atherosclerotic lesion.. This allows us to con.ider cellular reten.ion.of cholesterol as a n.vel target for an.i-atherosclerotic therapy. In.this case the target is n.t the level of blood cholesterol but the level of cholesterol in.vascular cells. This review describes our approach based on.the use of cultured human.arterial cells for the developmen. of direct an.i-atherosclerotic therapy. We use n.tural products as the basis of promisin. drugs for an.i-atherosclerotic therapy. Usin. n.tural products, we have developed an.approach to preven. in.racellular cholesterol reten.ion.in.cultured cells. Our kn.wledge of the mechan.sms of atherosclerosis is the foun.ation.on.which we have developed drugs that have a direct an.i-atherosclerotic effect, n.mely Allicor on.the basis of garlic powder, an.i-in.lammatory drug In.lamin.t (calen.ula, elder, an. violet) possessin. an.i-cytokin. activity an. phytoestrogen.rich drug Karin.t (garlic powder, extract of grape seeds, green.tea leaves, hop con.s, β-caroten., α-tocopherol, an. ascorbic acid). Treatmen. with allicor or in.lamin.t has a direct an.i-atherosclerotic effect on.carotid atherosclerosis in.asymptomatic men. Karin.t preven.s the developmen. of carotid atherosclerosis in.postmen.pausal women. Thus, the main.fin.in.s of our basic research have been.successfully tran.lated in.o clin.cal practice. As a result, this tran.lation. a n.vel approach to the developmen. of an.i-atherosclerotic therapy, has been.established. Our clin.cal trials have con.irmed the suitability of in.ovative approach an. the efficacy of n.vel drugs developed on.the basis our methodology.

关键词： Allicor An.i-Atherosclerotic Therapy Atherosclerosis Cell Culture Drugs Imagin. n.tural Products

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Direct an.i-atherosclerotic therapy preven.in. in.racellular cholesterol reten.ion

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Health 2013年第7期5卷 11-18页

作者： alexander n. orekhov In.titute for Atherosclerosis Research Skolkovo Innovative Center Moscow Russia

The key in.tiatin. process in.atherogen.sis is the suben.othelial cholesterol reten.ion. which is both n.cessary an. sufficien. to provoke lesion.in.tiation. Reten.ion.of cholesterol tran.ported by low den.ity lipoprotien.(LDL) in.suben.othelial cells of arterial wall, is an.absolute requiremen. for lesion.developmen.. This allows us to con.ider in.racellular cholesterol reten.ion.as a n.vel target for an.i-atherosclerotic therapy. In.this case, the target is n.t the level of blood cholesterol but the level of cholesterol in.vascular cells. This review summarizes the results of our basic studies sheddin. light on.the mechan.sms of in.racellular cholesterol reten.ion. We describe our cellular models to search for an.i-atherosclerotic agen.s an. demon.trate the use of these models for the developmen. of an.i-atherosclerotic drugs. We use n.tural products as the basis of an.i-atherosclerotic drugs because an.i-atherosclerotic therapy should be lon.-term or even.lifelon.. Usin. cellular models an. n.tural products, we have developed an.approach to preven. in.racellular cholesterol reten.ion.in.cultured suben.othelial aortic cells. We have developed drugs that reduce in.racellular cholesterol reten.ion. n.mely Allicor on.the basis of garlic powder, an.i-in.lammatory drug In.lamin.t (calen.ula, elder, an. violet) possessin. an.i-cytokin. activity an. phytoestrogen.rich drug Karin.t (garlic powder, extract of grape seeds, green.tea leaves, hop con.s, β-caroten., α-tocopherol, an. ascorbic acid). Treatmen. with Allicor or In.lamin.t caused regression.of carotid atherosclerosis in.asymptomatic men. Karin.t preven.ed the developmen. of n.w atherosclerotic plaques in.postmen.pausal women. Thus, the main.fin.in.s of our basic research have been.successfully tran.lated in.o clin.cs. As a result, this tran.lation. a n.vel approach to the developmen. of an.i-atherosclerotic therapy, has been.established. Our clin.cal trials have con.irmed the suitability of in.ovative approach an.

关键词： Allicor An.i-Atherosclerotic Therapy Atherosclerosis Cell Culture Drugs Imagin. In.racellular Cholesterol Reten.ion n.tural Products

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Impact of Con.exin. on.Atherogen.sis: A Brief Review

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Journ.l of In.egrative Medicin.（双语） 2018年第2期7卷 12-19页

作者： Veron.ka A. Myasoedova Don.wei Zhan. Rein.ard Wetzker An.rey V. Grechko alexander n. orekhov Laboratory of An.iopathology Institute of General Pathology and PathophysiologyMoscow 125315Russia Dabetes Research Cen.er Traditional Chinese Medicine SchoolBeijing University of Chinese MedicineBeijing 100029China Klin.k für An.sthesiologie un. In.en.ivmedizin.Un.versitatsklin.kum Jen. Austria Federal Scien.ific Clin.cal Cen.er for Resuscitation.an. Rehabilitation MoscowRussia In.titute for Atherosclerosis Research Skolkovo Innovative CenterMoscow 121609Russia Cen.re of Collective Use Institute of Gene BiologyMoscow 121552Russia

Con.exin. family in.human. con.ists of 21 highly con.erved protein. that are respon.ible for con.act formation.between.cells. On.the cell surface, con.exin. form hemichan.els, or con.exon.. Two hemichan.els brought together form a gap jun.tion. a form of in.ercellular con.act that allows for direct tran.fer of material an. sign.ls between.the adjacen. cells. Gap jun.tion. serve for tran.portin. ion. an. other soluble, low molecular weight molecules therefore syn.hron.zin. the microen.iron.en. of the con.actin. cells an. main.ain.n. cell an. tissue homeostasis. Impairmen. of gap jun.tion. is associated with differen. pathological con.ition.. Importan.ly, it has been.described in.atherosclerosis, which causes local cellular dysfun.tion.in.the arterial wall tissues followed by the developmen. of atherosclerotic plaque. There are 3 main.con.exin. expressed in.human.cardiovascular system: Cx37, Cx40, an. Cx43. Alteration. in.the arterial wall cells observed in.atherosclerosis in.lude chan.es in.the expression.pattern.of the main.con.exin. an. impairmen. of in.ercellular con.acts an. commun.cation. Accordin. to the curren.ly available data, Cx37 an. Cx40 have an.i-atherogen.c an. vasculoprotective properties, while Cx43 appears to be more pro-atherogen.c. However, the effects of con.exin. are cell type-depen.en. an. in.man. cases, remain.to be studied in.detail. In.this review, we summarize the available kn.wledge on.con.exin. of the arterial wall cells in.olved in.atherosclerosis developmen..

关键词： Con.exin Con.exon Gap jun.tion Atherosclerosis Vascular wal

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Gradewise Properties of Subgroups an. Their Application.

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Algebra Colloquium 2017年第2期24卷 255-266页

作者： Wen.in.Guo alexander n. Skiba Departmen. of Mathematics University of Science and Technology of China Hefei 230026 China Departmen. of Mathematics Francisk Skorina Gomel State University Gomel 246019 Belarus

For each fin.te group E, let O（E） be a bin.ry relation.on.the set of all subgroups of E. If A an. B are subgroups of a fin.te group G, then.we say that the pair （A, B） en.oys the gradewise property （resp., gen.ralized gradewise property） in.G if G has a n.rmal series Г：1=G0≤G1≤Gt=Gsuch that for each i=1,...,t,we have （（A∩Gi）Gi-1/BGi-1/Gi-1）∈θ（G/Gi-1）（resp., we have （（A∩Gi）Gi-1/BGi-1/Gi-1）∈θ（G/Gi-1）Usin. these con.epts, we obtain.some n.w characterization. for solubility an. supersolubility of fin.te groups an. gen.ralize some kn.wn.results.

关键词： fin.te group subgroup fun.tor subgroup bifun.tor gradewise property

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Fin.te groups whose n.maximal subgroups are σ-subn.rmal

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Scien.e Chin. Mathematics 2019年第7期62卷 1355-1372页

作者： Wen.in.Guo alexander n. Skiba School of Mathematical Scien.es University of Science and Technology of China Hefei 230026 China Departmen. of Mathematics an. Techn.logies of Programmin. Francisk Skorina Gomel State University Gomel 246019 Belarus

Let σ={σi | i ∈ I} be some partition.of the set of all primes P. A set H of subgroups of G is said to be a complete Hall σ-set of G if every member ≠ 1 of H is a Hall σi-subgroup of G, for some i ∈ I, an. H con.ain. exactly on. Hall σi-subgroup of G for every σi ∈σ(G). A subgroup H of G is said to be:σ-permutable or σ-quasin.rmal in.G if G possesses a complete Hall σ-set H such that HAx= AxH for all A ∈ H an. x ∈ G:σ-subn.rmal in.G if there is a subgroup chain.A = A0≤A1≤···≤ At = G such that either Ai-1■Ai or Ai/(Ai-1)Ai is a fin.te σi-group for some σi ∈σ for all i = 1,..., *** Mn.n.1 n. then.Mn.is said to be an.n.maximal subgroup of G. If each n.maximal subgroup of G is σ-subn.rmal(σ-quasin.rmal,respectively) in.G but, in.the case n.> 1, some(n.1)-maximal subgroup is n.t σ-subn.rmal(n.t σ-quasin.rmal,respectively) in.G, we write mσ(G)= n.mσq(G)= n. respectively).In.this paper, we show that the parameters mσ(G) an. mσq(G) make possible to boun. the σ-n.lpoten. len.th lσ(G)(see below the defin.tion. of the terms employed), the ran. r(G) an. the n.mber |π(G)| of all distin.t primes dividin. the order |G| of a fin.te soluble group G. We also give the con.ition. un.er which a fin.te group is σ-soluble or σ-n.lpoten., an. describe the structure of a fin.te soluble group G in.the case when.mσ(G)=|π(G)|. Some kn.wn.results are gen.ralized.

关键词： fin.te group n.maximal subgroup σ-subn.rmal subgroup σ-quasin.rmal subgroup σ-soluble group σ-n.lpoten. group

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Therapeutic effects of garlic in.cardiovascular atherosclerotic disease

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Chin.se Journ.l of n.tural Medicin.s 2019年第10期17卷 721-728页

作者： Igor A.Soben.n.Veron.ka A.Myasoedova Maria I.Iltchuk ZHAn. Don.-Wei alexander n.orekhov n.tion.l Medical Research Cen.er of Cardiology 121552 MoscowRussian Federation In.titute of Gen.ral Pathology an. Pathophysiology 125315 MoscowRussian Federation Research In.titute of Threpsology an. Healthy Lo n.evity Plekhanov Russian University of Economics117997 MoscowRussian Federation Diabetes Research Cen.er Traditional Chinese Medicine SchoolBeijing University of Chinese MedicineBeijing 100029China In.titute of Human.Morphology 117418 MoscowRussian Federation

Garlic(Allium sativum) is a widely kn.wn.medicin.l plan., poten.ial of which remain. to be fully evaluated. Its wide-ran.e ben.ficial effects appear to be relevan. for treatmen. an. preven.ion.of atherosclerosis an. related diseases. It is gen.rally believed that garlic-based preparation. are able to improve lipid profile in.human., in.ibit cholesterol biosyn.hesis, suppress low den.ity lipoprotein.oxidation. modulate blood pressure, suppress platelet aggregation. lower plasma fibrin.gen.level an. in.rease fibrin.lytic activity, thus providin. clin.cally relevan. cardioprotective an. an.i-atherosclerotic effects. It is importan. to assess the level of eviden.e available for differen. protective effects of garlic an. to un.erstan. the un.erlyin. mechan.sms. This in.ormation.will allow adequate in.egration.of garlic-based preparation. to clin.cal practice. In.this review, we discuss the mechan.sms of an.i-atherosclerotic effects of garlic preparation., focusin. on.an.ihyperlipidemic, hypoten.ive, an.i-platelet an. direct an.i-atherosclerotic activities of the medicin.l plan.. We also provide an.overview of available meta-an.lyses an. a n.mber of clin.cal trials that assess the ben.ficial effects of garlic.

关键词： Atherosclerosis Dyslipidemia Cardiovascular disease n.tural medicin.s Garlic

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n.n.hydrostatic versus hydrostatic modelin.s of free surface flows

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Journ.l of Hydrodyn.mics 2014年第4期26卷 512-522页

作者：张景新 SUKHODOLOV alexander n. 刘桦 MOE Key Laboratory of Hydrodyn.mics Shanghai Jiao Tong University Key Laboratory of Estuarin. an. Coastal En.in.erin. Ministry of Transport School of n.val Architecture Ocean and Civil EngineeringShanghai Jiao Tong University Departmen. of Ecohydrology Institute of Fresh-water Ecology and Inland Fisheries MOE Key Laboratory of Hydrodyn.mics Shanghai Jiaotong University

The hydrodyn.mics of geophysical flows in.ocean.c shelves, estuaries, an. rivers are often.studied by solvin. shallow water equation. un.er either hydrostatic or n.n.hydrostatic assumption.. Although the hydrostatic models are quite accurate an. cost-efficien. for man. practical application., there are situation. when.the fully hydrodyn.mic models are preferred despite a larger cost for computation.. The presen. n.merical model is implemen.ed by the fin.te volume method （FVM） based on.un.tructured grids. The model can.be efficien.ly switched between.hydrostatic an. n.n.hydrostatic modules. The case study shows that for waves pro- pagatin. alon. the bar a criterion.with respect to the shallown.ss alon., the ratio between.the depth an. the wave len.th, is in.ufficien. to warran. the performan.e of shallow flow equation. with a hydrostatic approach an. the n.n.in.arity in.wave dyn.mics can.be better accoun.ed with a hydrodyn.mic approach. Besides the prediction.of the flows over complex bathymetries, for in.tan.e, over asymmetrical dun.s, by a hydrodyn.mic approach is shown.to be superior in.accuracy to the hydrostatic simulation.

关键词： hydrostatic n.n.hydrostatic TVD scheme n.n.orthogon.l grid

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On.σ-semipermutable Subgroups of Fin.te Groups

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Acta Mathematica Sin.ca,En.lish Series 2018年第9期34卷 1379-1390页

作者： Wen.Bin.GUO alexander n. SKIBA Departmen. of Mathematics University of Science and Technology of China Hefei 230026 P. R. China Departmen. of Mathematics an. Techn.logies of Programmin. Francisk Skorina Gomel State University Gomel 246019 Belarus

Let a = {σi｜ i ∈ I} be some partition.of the set of all primes P, G a fin.te group an. σ（G） = {σi｜σi ∩ π （G） ≠ Ф}. A set H of subgroups of G is said to be a complete Hall or-set of G if every member ≠ 1 of H is a Hall σi-subgroup of G for some σi ∈ σ an. H con.ain. exactly on. Hall σi-subgroup of G for every σi ∈ σ（G）. A subgroup H of G is said to be： σ-semipermutablc in.G with respect to H if HHi x = Hi x H for all x ∈ G an. all x ∈ G an. all Hi ∈H such that （｜H｜, ｜Hi｜） = 1; σ-semipermutable in.G if H is σ-semipermutable in.G with respect to some complete Hall σ-set of G. We study the structure of G bein. based on.the assumption.that some subgroups of G are σ-semipermutable in.G.

关键词： Fin.te group Hall subgroup p-soluble group p-supersoluble group σ-semipermutable subgroup

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A gen.ralized CAP-subgroup of a fin.te group

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Scien.e Chin. Mathematics 2015年第10期58卷 2133-2144页

作者： GUO Wen.in.SKIBA alexander n. YAn. n.n.in. School of Mathematical Scien.es University of Science and Technology of China Departmen. of Mathematics Francisk Skorina Gomel State University School of Scien.e Jiangnan University

Let A be a subgroup of a fin.te group G. We say that A is a gen.ralized CAP-subgroup of G if for each chief factor H/K of G either A avoids H/K or the followin. holds:(1) If H/K is n.n.abelian. then.H :(A ∩H)K | is a p′-n.mber for every p ∈π((A ∩H)K/K);(2) If H/K is a p-group, then.|G : n.(K(A ∩H))| is a p-n.mber. In.this paper, we use the gen.ralized CAP-subgroup to characterize the structure of fin.te *** n.w characterization. of the hypercyclically embedded subgroups of a fin.te group are obtain.d an. a series of kn.wn.results are gen.ralized.

关键词： fin.te group gen.ralized CAP-subgroup U-embedded subgroup solubly saturated formation p-n.lpoten. group supersoluble subgroup

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On.solubility an. supersolubility of some classes of fin.te groups

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Scien.e Chin. Mathematics 2009年第2期52卷 272-286页

作者： SHUM Kar Pin. SKIBA alexander n. Departmen. of Mathematics University of Hong Kong Departmen. of Mathematics Francisk Skorina Gomel State University

AbstractLet G be a fin.te group an. H a subgroup of G. Then.H is said to be S-permutable in.G if HP = PH for all Sylow subgroups P of G. Let H sG be the subgroup of H gen.rated by all those subgroups of H which are S-permutable in.G. Then.we say that H is S-embedded in.G if G has a n.rmal subgroup T an. an.S-permutable subgroup C such that T ∩ H ? H sG an. HT = C.Our main.result is the followin.Theorem AA group G is supersoluble if an. on.y if for every n.n.cyclic Sylow subgroup P of the gen.ralized Fittin. subgroup F*(G) of G, at least on. of the followin. holds: Every maximal subgroup of P is S-embedded in.G.Every cyclic subgroup H of P with prime order or order 4 (if P is a n.n.abelian.2-group an. H ? Z ∞ (G)) is S-embedded in.G.

关键词： S-permutable subgroups S-embedded subgroups saturated formation. gen.ralized Fittin. subgroups supersoluble groups 20D10 20D20 20D25

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