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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

Bone Research 2024年第1期12卷 180-198页

作者： Morten S.Hansen Kaja Madsen Maria price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research(IMSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane proteins and Receptors(COMpARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNps,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GpR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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Innate IgM antibodies to mannose in patients with gastric cancer

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Cancer Biology & Medicine 2024年第3期21卷 193-197页

作者： Maxim petrovich Nikulin Nadezhda Vladimirovna Shilova alexander Dmitrievich Lipatnikov Ivan Sokratovich Stilidi Alexandra Vladimirovna Semyanikhina Nikolai Vladimirovich Bovin Nikolai Nikolaevich Tupitsyn Federal State Budgetary Institution"National Medical Research Center for Oncology Named After N.N.Blokhin"of the Ministry of Health of Russia MoscowRussia State Research Center"Institute of Bioorganic Chemistry Named After Academicians M.M.Shemyakin and Yu.A.Ovchinnikov"of the Russian Academy of Sciences MoscowRussia National Medical Research Center for Obstetrics Gynecology and Perinatology Named After Academician VI.Kulakov of the Ministry of Health of Russian FederationMoscowRussia

Gastric cancer(GC) remains one of the most common lethal diseases. Every year, about 1 million people fall ill and almost 800 thousand people die worldwide~1. Surgical treatment has reached its limit. The current advances in immunology and detection of epidermal growth factor molecules(EGFR) in gastric cancer cells allowed to improve the treatment results;however, the metastatic form of this disease is still incurable.

关键词： Gastric cancer gastric

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Enigmatic thymus: Variations in anatomical localisation of thymic tissue as an easily misdiagnosed congenital anomaly in surgical practice

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World Journal of Clinical Cases 2024年第25期12卷 5646-5652页

作者： alexander Mayer Jaroslav Voller Ivan Varga Fourth Department of Surgery Faculty of MedicineComenius University and University Hospital BratislavaBratislava 81372Slovakia Faculty of Health Care Studies University of Western BohemiaPilsen 30100Czech Republic Institute of Histology and Embryology Faculty of MedicineComenius University in BratislavaBratislava 81372Slovakia

We point out the issue of differential diagnosis regarding the finding of ectopically localised thymic tissue(a thymic cyst)in the *** tissue can be found anywhere along its developmental tract of descent,from the angle of the mandible to the upper *** of the thymic descent can result in ectopically/abnormally localised islets of accessory thymic tissue,which may undergo cystic changes,as described in a case report by Sun et *** anatomical variation of the thymus may be clinically misinterpreted as a neoplasm or other congenital anomalies as a branchial cyst,lymphatic malformation or cystic *** present editorial focuses on the challenge of establishing a diagnosis of ectopically localised tissue of thymus often presented as a lateral cervical mass,especially in the case of cystic variation/degeneration of this thymic *** summarise hypotheses on the origin of such congenital cervical thymic cysts from the point of view of evolutionary history and *** also discuss lesser-known facts about the anatomy,histopathology and developmental biology of the thymus as one of the most enigmatic organs in the human body.

关键词： Thymus Thymic anomalies Thymic ectopy Congenital cervical thymic cyst Embryonic development

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Self-powered UVC detectors based on α-Ga_(2)O_(3) with enchanted speed performance

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Journal of Semiconductors 2024年第8期45卷 74-80页

作者： Aleksei Almaev alexander Tsymbalov Bogdan Kushnarev Vladimir Nikolaev Alexei pechnikov Mikhail Scheglov Andrei Chikiryaka Laboratory of Metal Oxide Semiconductors Research and Development Center for Advanced Technologies in MicroelectronicsNational Research Tomsk State UniversityTomsk 634050Russia Fokon LLC Kaluga 248035Russia Department of Semiconductor Electronics and physics of Semiconductors National University of Science and Technology MISISMoscow 119049Russia perfect Crystals LLC Saint Petersburg 194223Russia

Detectors were developed for detecting irradiation in the short-wavelength ultraviolet(UVC)interval using high-quality single-crystallineα-Ga_(2)O_(3) films with pt interdigital *** films ofα-Ga_(2)O_(3) were grown on planar sapphire substrates with c-plane orientation using halide vapor phase *** spectral dependencies of the photo to dark current ratio,responsivity,external quantum efficiency and detectivity of the structures were investigated in the wavelength interval of 200−370 *** maximum of photo to dark current ratio,responsivity,external quantum efficiency,and detectivity of the structures were 1.16×10^(4) ***.,30.6 A/W,1.65×10^(4)%,and 6.95×10^(15) Hz^(0.5)·cm/W at a wavelength of 230 nm and an applied voltage of 1 *** high values of photoelectric properties were due to the internal enhancement of the photoresponse associated with strong hole ***α-Ga_(2)O_(3) film-based UVC detectors can function in self-powered operation mode due to the built-in electric field at the pt/α-Ga_(2)O_(3) *** a wavelength of 254 nm and zero applied voltage,the structures exhibit a responsivity of 0.13 mA/W and an external quantum efficiency of 6.2×10^(−2)%.The UVC detectors based on theα-Ga_(2)O_(3) films demonstrate high-speed performance with a rise time of 18 ms in self-powered mode.

关键词： HVpE gallium oxide solar-blind ultraviolet detector self-powered mode

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Self-assembled high-entropy nitride multilayer coating

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Rare Metals 2024年第6期43卷 2876-2883页

作者： Xiang-Yu Zhang Yan Liu Vasiliy pelenovich Xiao-Mei Zeng Jie Liu Qiang Wan alexander pogrebnjak Long-Jian Xue Zhi-Wen Chen Yan Lei Bing Yang School of power and Mechanical Engineering Wuhan UniversityWuhan 430072China Hubei JiuFengShan Future Science and Technology Laboratory Wuhan 420000China Institute of Technological Sciences of Wuhan University Wuhan 430072China Hubei Key Laboratory of Electronic Manufacturing and packaging Integration Wuhan UniversityWuhan 430072China College of Engineering Huazhong Agricultural UniversityWuhan 430070China Sumy State University Sumy 40007Ukraine Institute of Materials Science Slovak University of Technology in BratislavaJána Bottu2591724 TrnavaSlovak Republic Shenzhen Research Institute of Wuhan University Shenzhen 518057China

The development of advanced materials and construction of multilayer structure contribute to enhancing the performance of protective coatings,further improving the industrial productivity and conserving *** this paper,the self-assembled high-entropy nitride(HEN)AlCrNbSiTiN multilayer coating was designed by harnessing the plasma distribution characteristics and depos-ited by arc ion plating using single target.

关键词： coating energy multilayer

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Deformation,structure and potential hazard of a landslide based on InSAR in Banbar county,Xizang(Tibet)

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China Geology 2024年第2期7卷 203-221页

作者： Guan-hua Zhao Heng-xing Lan Hui-yong Yin Lang-ping Li alexander Strom Wei-feng Sun Chao-yang Tian College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Key Laboratory of Ecological Geology and Disaster prevention Ministry of Natural ResourcesXi’an 710054China University of Chinese Academy of Sciences Beijing 100049China JSC“Hydroproject Institute” Moscow 125993Russia

The Tibetan plateau is characterized by complex geological conditions and a relatively fragile ecological *** recent years,there has been continuous development and increased human activity in the Tibetan plateau region,leading to a rising risk of *** landslide in Banbar County,Xizang(Tibet),have been perturbed by ongoing disturbances from human engineering activities,making it susceptible to instability and displaying distinct *** this study,small baseline subset synthetic aperture radar interferometry(SBAS-InSAR)technology is used to obtain the Line of Sight(LOS)deformation velocity field in the study area,and then the slope-orientation deformation field of the landslide is obtained according to the spatial geometric relationship between the satellite’s LOS direction and the ***,the landslide thickness is inverted by applying the mass conservation *** results show that the movement area of the landslide is about 6.57×10^(4)m^(2),and the landslide volume is about 1.45×10^(6)m^(3).The maximum estimated thickness and average thickness of the landslide are 39 m and 22 m,*** thickness estimation results align with the findings from on-site investigation,indicating the applicability of this method to large-scale earth *** deformation rate of the landslide exhibits a notable correlation with temperature variations,with rainfall playing a supportive role in the deformation process and displaying a certain *** activities exert the most substantial influence on the spatial heterogeneity of landslide deformation,leading to the direct impact of several prominent deformation areas due to human ***,utilizing the long short-term memory(LSTM)model to predict landslide displacement,and the forecast results demonstrate the effectiveness of the LSTM model in predicting landslides that are in a continuous development and movement *** landslide is still active,and based

关键词： Landslide InSAR Human activity Deformation Structure LSTM model Engineering construction Thickness Neural network Machine learning prediction and prevention Tibetan plateau Geological hazards survey engineering

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Atherosclerosis originating from childhood:Specific features

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Journal of Biomedical Research 2024年第3期38卷 233-240页

作者： Anastasia V.poznyak Alexey A.Yakovlev MikhailА.popov Elena B.Zhigmitova Vasily N.Sukhorukov alexander N.Orekhov Institute for Atherosclerosis Research Moscow 121609Russia Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology Moscow 109240Russia Department of Cardiac Surgery Moscow Regional Research and Clinical InstituteMoscow 129110Russia Laboratory of Angiopathology Institute of General Pathology and PathophysiologyMoscow 125315Russia

Atherosclerosis is extremely ***,it is considered a disease of older people,who most often experience problems with the heart and blood *** much attention from the scientific community has been paid to studying the association between aging and atherosclerosis,as well as its consequences,there is evidence that atherosclerosis occurs at an early *** may form both during intrauterine development and in *** plays an important role in childhood atherosclerosis,along with previous infectious diseases and excess weight of both the child and the *** the present review,we examined the development of atherosclerosis and the prerequisites in childhood.

关键词： atherosclerosis childhood pediatrics cardiovascular disease

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Biological perspectives in geotechnics:Application and monitoring

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2854-2878页

作者： partha Narayan Mishra Surabhi Jain Thierry Bore Ilhan Chang Yeong-Man Kwon Yijie Wang Hirak Ranjan Dash Ashutosh Kumar Satyam Tiwari Ningjun Jiang Sarat Kumar Das alexander Scheuermann Department of Civil Engineering Indian Institute of Technology KanpurKanpur208016India School of Civil Engineering University of QueenslandSt LuciaQLD4072Australia Department of Civil Engineering Indian Institute of Technology DhanbadDhanbad826004India Department of Civil System Engineering Ajou UniversitySuwon-si16499Republic of Korea School of Engineering and IT University of New South WalesCanberraACT2600Australia Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIL60208USA Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina National Forensic Sciences University New Delhi110085India Southeast University Nanjing211189China

This paper builds on exploring the applications of biomediated pathways to solve geotechnical ***,the state of the art of biological remediation strategies including microbial remediation and phytoremediation have been introduced and critically reviewed in the context of decontaminating the ***,biopolymerisation,biomineralisation and bioneutralisation processes have been depicted with a special emphasis on the applications including but not limited to soil stabilisation,soil erosion prevention,anti-desertification and pH *** of these methods have their own limitations and bottlenecks while scaling up,and these challenges have been summarised and some possible paths to overcome the challenges have also been *** state of the art of electromagnetic(EM)monitoring methods to capture the effects of biomediation on spatio-temporal soil properties are then highlighted as a non-invasive and rapid pathway to track the progress of biomediated soil ***,each of the technologies discussed have been evaluated for their maturity level using the principles of technology readiness level(TRL).A majority of the technologies amounting to around 77%are still in the TRL 4e7,*** the valley of *** is thus evident that development of these technologies needs to be supported with appropriate funding for improving their maturity to a level of industrial deployment.

关键词： Biogeotechnics Bioremediation phytoremediation Biopolymers Biomineralisation Electromagnetic(EM)methods technology readiness level(TRL)

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A new perspective on intervertebral disc calcification—from bench to bedside

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Bone Research 2024年第1期12卷 50-61页

作者： Emanuel J.Novais Rajkishen Narayanan Jose A.Canseco Koen van de Wetering Christopher K.Kepler Alan S.Hilibrand alexander R.Vaccaro Makarand V.Risbud Department of Orthopaedic Surgery Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de Saúde do Litoral Alentejano Orthopedic DepartmentSantiago do CacémPortugal Rothman Orthopedic Institute at Thomas Jefferson University PhiladelphiaPAUSA

Disc degeneration primarily contributes to chronic low back and neck ***,there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis,ectopic calcification,herniation,or mixed *** these phenotypes,disc calcification is the least *** calcification,by definition,is the pathological mineralization of soft tissues,widely studied in the context of conditions that afflict vasculature,skin,and ***,disc calcification is associated with poor surgical outcomes and back pain refractory to conservative *** is frequently seen as a consequence of disc aging and progressive degeneration but exhibits unique molecular and morphological characteristics:hypertrophic chondrocyte-like cell differentiation;TNAp,ENpp1,and ANK upregulation;cell death;altered pi and ppi homeostasis;and local *** studies in mouse models have provided a better understanding of the mechanisms underlying this *** is essential to recognize that the presentation and nature of mineralization differ between AF,Np,and Ep ***,the combination of anatomic location,genetics,and environmental stressors,such as aging or trauma,govern the predisposition to ***,the systemic regulation of calcium and pi metabolism is less important than the local activity of ppi modulated by the ANK-ENpp1 axis,along with disc cell death and differentiation *** there is limited understanding of this phenotype,understanding the molecular pathways governing local intervertebral disc calcification may lead to developing disease-modifying drugs and better clinical management of degeneration-related pathologies.

关键词： degeneration metabolism intervertebral

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Improved training framework in a neural network model for disruption prediction and its application on EXL-50

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plasma Science and Technology 2024年第5期26卷 29-39页

作者：蔡剑青梁云峰 alexander KNIEpS 齐东凯王二辉向皓明廖亮黄杰阳杰黄佳刘建文 philipp DREWS 徐帅顾翔高轶琛罗宇李直 the EXL-50 Team Institute of plasma physics Chinese Academy of SciencesHefei 230031People’s Republic of China Forschungszentrum Jülich GmbH Institut für Energie-und Klimaforschung-PlasmaphysikPartner of the Trilateral Cluster(TEC)Jülich 52425Germany ENN Science and Technology Development Co. LtdLangfang 065001People’s Republic of China

A neural network model with a classical annotation method has been used on the EXL-50tokamak to predict impending ***,the results revealed issues of overfitting and overconfidence in predictions caused by inaccurate *** mitigate these issues,an improved training framework has been *** this approach,soft labels from previous training serve as teachers to supervise the further learning process;this has lead to a significant improvement in predictive model ***,this enhancement is primarily attributed to the coupling effect of the soft labels and correction *** improved training framework introduces an instance-specific label smoothing method,which reflects a more nuanced model assessment on the likelihood of a *** presents a possible solution to effectively address the challenges associated with accurate labeling across different machines.

关键词： neural network disruption soft label EXL-50 tokamak

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