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单剂量阿奇霉素的沙眼集体治疗

世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 12-12页

作者： Solomon A.W. Holland M.J. alexander n.d.e. 杨建刚 Clinical Research Unit London Sch. of Hyg. and Trop. Med. Keppel St. London WC1E 7HT United Kingdom Dr

BACKGROUnd: Trachoma, caused by repeated ocular infection with Chlamydia trach omatis, is an important cause of blindness. Current recommended dosing intervals for mass azithromycin treatment for trachoma are based on a mathematical model. MeTHOdS: We collected conjunctival swabs for quantitative polymerase chain re action assay of C. trachomatis before and 2, 6, 12, 18, and 24 months after mass treatment with azithromycin in a Tanzanian community in which trachoma was ende mic. For ethical reasons, at 6, 12, and 18 months, we gave tetracycline eye oint ment to residents who had clinically active trachoma. ReSULTS: At baseline, 956 of 978 residents (97.8 percent) received either one oral dose of azithromycin or (if azithromycin was contraindicated) a course of tetracycline eye ointment. Th e prevalence of infection fell from 9.5 percent before mass treatment to 2.1 per cent at 2 months and 0.1 percent at 24 months. The quantitative burden of ocular C. trachomatis infection in the community was 13.9 percent of the pretreatment level at 2 months and 0.8 percent at 24 months. At each time point after baselin e, over 90 percent of the total community burden of C. trachomatis infection was found among subjects who had been positive the previous time they were tested. COnCLUSIOnS: The prevalence and intensity of infection fell dramatically and rem ained low for two years after treatment. One round of very high cover age mas s treatment with azithromycin, perhaps aided by subsequent periodic use of tetra cycline eye ointment for persons with active disease, can interrupt the transmis sion of ocular C. trachomatis infection.

关键词：四环素眼膏定量检查医学伦理学拭子数学模型感染强度

elucidating elusive quaternary selenide euCeCuSe3:Synthesis,crystal structure,properties and theoretical studies

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Journal of Rare earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev Anna V.Ruseikina Maxim S.Molokeev Vladimir A.Chernyshev Aleksandr S.Aleksandrovsky alexander S.Krylov Svetlana n.Krylova nikolai P.Shestakov dmitriy A.Velikanov alexander A.Garmonov Alexey V.Matigorov evgeny A.Ostapchuk Thomas Schleid damir A.Safin Laboratory of Theory and Optimization of Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation department of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of natural Sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation department of Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute for Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scientific and educational and Innovation Center for Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide euCeCuSe3,the fabrication of which has been a challenge until this *** structure of the reported selenide was elucidated from the powder X-ray diffraction data,which revealed the formation of euCeCuSe3with excellent yield(96.7%)accompanied with a minor fraction of CeSe2(3.3%),and was best solved in orthorhombic space group Pnma with the BaLaCuS3structural ***,the crystal structure of the title compound completes the row of the heterometallic quaternary selenides euReCuSe3(Re=La,Pr,nd,Sm,eu,Gd,Tb,dy,Ho,er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belongs to the BaLaCuS3structural *** distortion of the CuSe4polyhedron was compared for the whole series of euReCuSe3compounds using theτ4-descriptor for four coordinated ions,which revealed the highest degree of distortion for the Ce3+-containing selenide,followed by the La3+-based ***,the crystallographic and geometrical parameters of the reported selenide were discussed in comparison to the Ce3+-based sulfides SrCeCuS3and *** initio calculations of the crystal structure,a phonon spectrum and elastic constants for the crystal of euCeCuSe3were also *** types and wavenumbers of fundame ntal modes were determined and the involvement of ions participating in the phonon modes was *** experimental IR spectrum of the reported selenide was interpreted and found to be in agreement with the calculated *** experimental direct band gap of euCeCuSe3was measured to be 1.36 eV that is consistent with the concept of its origin.d.e.to interband transitions between orbitals emerging mainly from 4f(valence band)and 5d(conduction band)levels of the eu2+*** dependence of the Young’s modulus on the direction demonstrates the anisotropy of the elastic properties,while the Vickers hardness for euCeCuSe3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide Synthesis Crystal structure Ab initio calculations Magnetic measurements Spectroscopy

Malargüe Site Remediation:A Successful Solution for Uranium Mill Tailings

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原子能科学技术 2024年第10期58卷 2088-2094页

作者： BARARI e díAZ J G GIOMIA KeMPF R A national Atomic energy Commission Av.Del Libertador 8250Ciudad Autónoma de Buenos AiresC1429BNPArgentina

Comisión nacional de energía Atómica (CneA) has the responsibility for restoring uranium mining facilities once the operations have ***,within its environmental Program and in compliance with its legal responsibilities,decides to implement a restoration project for all sites related to the mining and processing of uranium *** Malargüe Site is located within the Province of Mendoza in the city of Malargü*** is the first site to successfully complete its *** activities consist of relocation of tailings to an engineering *** tailings management(encapsulation) and rehabilitation of the area was finished in June *** remediation alternative for the ore tailings was selected after conducting comparative studies and submitted the project to the society for *** objective of the encapsulation of the mineral tails is to isolate them from the environment,also proceeding with the decontamination and rehabilitation of the area (landscaping,post-closure monitoring and 20 years monitoring period).encapsulation consisted of the construction of a containment cell for the mine tailings,to isolate them and prevent pollutants from entering the environment through the transfer *** clean the impacted areas,the soil was removed,it was incorporated into the encapsulation,and the filling was carried out with natural soils from the *** prevents radon transfer to the environment,as ^(222)Ra is an alpha emitter with a half-life of four days,which produces its own radioactive *** progeny are solids,and when a ^(222)Ra nucleus emits an alpha particle into the air,the resulting ^(218)Po nucleus,momentarily electrically charged,adheres to any dust *** prevents the discharge into the air containing radon and also containing dust particles charged with intensely radioactive radon *** tasks mentioned make it possible to decrease radon emanation,reduce radiological risks to the public and pre

关键词： remediation radionuclide transfer tailings encapsulation solution sustainable

Removal of As(V)in the presence of Cr(VI)in contaminated water from the Bajio region of Mexico using ferrihydrite-functionalized graphene oxide(GOFH):A case study

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emerging Contaminants 2024年第3期10卷 134-144页

作者： d.R.Joya-Cardenas J.P.Rodríguez-Caicedo M.A.Corona-Rivera n.Saldana-Robles C.e.damian-Ascencio A.Saldana-Robles Graduate Program in Biosciences University of GuanajuatoIrapuato36500Mexico Facultad de Ingenierías y Tecnologías Instituto XeriraUniversidad de SantanderBucaramanga680003Colombia Chemical engineering Unit Academic Multidisciplinary Region Altiplano UAMRA.Autonomous University of San Luis PotosíMatehualaSan Luis Potosí78000Mexico department of Agricultural engineering University of GuanajuatoIrapuato36500Mexico department of Mechanical engineering University of GuanajuatoSalamanca36800Mexico Mechanical engineering department Virginia TechBlacksburgVA24061USA

The presence of heavy metals such as arsenic(As)and chromium(Cr)can be considered one of the most toxic heavy *** study aims to develop and evaluate a graphene oxide(GO)based material functionalized with ferrihydrite for the removal of As(V)in the presence of Cr(VI).The adsorbent ferrihydrite-functionalized graphene oxide(GOFH)was characterized by SeM,FTIR,XRd,XPS,surface charge,BeT and *** adsorption capacities for As(V)and Cr(VI)were 160 and 66 mg g^(-1)respectively at pH 4 and 298 K,fitting the Langmuir *** binary systems,GOFH adsorbed As(V)with an adsorption capacity of 137 mg g^(-1)in the presence of 20 mg L^(-1)Cr(VI)at room *** analysis revealed an exothermic and spontaneous ***,GOFH effectively removed several coexisting anions from groundwater,including SO_(4)^(2-),CO_(3)^(2-)and Cl^(-).This work evidences the potential of GOFH for competitive adsorption of priority pollutants from complex *** GOFH material represents a technically and economically viable technology for application in groundwater decontamination,as it requires inexpensive precursors and ambient conditions during synthesis and operation.

关键词： Competition Ions Contamination Groundwater Adsorption capacity

Luminescent Composite Films Based on Mechanically Strong Ladder-like Polyphenylsilsesquioxane and Oligophenyleuropiumsiloxane

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Chinese Journal of Polymer Science 2024年第11期 1793-1801页

作者： e.e.Kim T.O.ershova A.S.Belova d.A.Khanin e.V.Bashkova G.G.nikiforova Yu.n.Kononevich A.A.Anisimov O.I.Shchegolikhina A.M.Muzafarov A.n.nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences Tula State Lev Tolstoy Pedagogical University V.Topchiev Institute of Petrochemical Synthesis Russian Academy of Sciences Moscow Institute of Physics and Technology (national Research University) n.S.enikolopov Institute of Synthetic Polymeric Materials Russian Academy of Sciences

nowadays organosilicon luminescent materials are of increasing interest due to the variety of their synthetic or modification techniques and application fields. Ladder polyphenylsilsesquioxanes(L-PPSQ) are a unique class of organosilicon polymers, which can be ideal matrices for the luminescent composites due to their high thermal stability, optical transparency and mechanical strength. In this work, new mechanically strong, heat-resistant, transparent and sensitive to ammonia vapor luminescent composite films based on L-PPSQ have been obtained. As the source of europium ions oligophenyleuropiumsiloxane was used, demonstrating perfect compatibility to the matrix due to the similar *** improve luminescent properties of the films, new organosilicon ligands were introduced into the composites and their influence on the properties of the materials was studied. Valuable properties of described composites may allow their further application as multifunctional coatings.

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Key features of numerical models for the Fe-simulation of deep tunnel advance by the nATM

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Underground Space 2024年第1期14卷 357-376页

作者： Peter Gamnitzer Matthias neuner Magdalena Schreter-Fleischhacker alexander dummer Thomas Mader Stefan Smaniotto Gunter Hofstetter Unit of Strength of Materials and Structural Analysis Institute of Basic Sciences in Engineering SciencesUniversitat InnsbruckTechnikerstraβe 13Innsbruck A-6020Austria

In the present work,important aspects of time-dependent nonlinear 3d finite element(Fe)models for deep tunnel advance by the new Austrian Tunneling Method(nATM),characterized by repeated sequences of excavation,securing,and idle periods,are discussed on the example of a 3d finite element model of a stretch of the Brenner Base Tunnel,which is currently constructed between Austria and *** material models are utilized for representing the surrounding rock mass and the shotcrete *** on the finite element model,strategies for the efficient implementation into a parallel distributed memory numerical code are *** are essential to achieve reasonable computation times for numerical simulations of tunneling based on large 3d Fe *** particular,the implementation of the construction procedure,parallel computing and communication specific details,and efficient linear solvers for the global equation system within the incremental-iterative newton–Raphson scheme are ***,possible extensions of the material models for rock mass and shotcrete,used in the 3d Fe model,are *** concern(i)a gradient-enhanced model for transversely isotropic rock and rock mass,taking into account hardening and softening behavior and(ii)the extension of the shotcrete model to nonlinear creep and damage due to *** possible benefits of the model extensions in numerical simulations of tunneling by the nATM are discussed.

关键词： nATM Finite element model Rock Shotcrete damage-plasticity model

Generating Baikal-GVd high energy cascade-like neutrino events with a GeAnT4-based simulation toolkit

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Chinese Physics C 2024年第10期48卷 256-263页

作者： Zike Wang A.d.Avrorin Zhen Cao Mingjun Chen Peiyuan Chu Zh.-A.M.dzhilkibaev Bo Gao Tianqi Huang Jiali Liu Ying Qi Xiaohao You d.n.Zaborov Key Laboratory of Particle Astrophysics experimental Physics division&Institute of High energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Institute for nuclear Research of the Russian Academy of Sciences Moscow 117312Russia TIAnFU Cosmic Ray Research Center Chengdu 610213China School of Science Tibet UniversityLhasa 850000China

Using the GeAnT4 and Cosmic Ray Monte Carlo(CRMC)software packages,we developed a new simulation toolkit for astrophysical neutrino *** configuring the Baikal-GVd detector and comparing the vertex position and direction of incident particles,as well as the channel-by-channel signals,to the events detected by Baikal-GVd,we successfully generated 13 high-energy cascade neutrino events with the *** analysis revealed a systematic offset between the reconstructed shower position and the true interaction position,with a distance close to the scale of the shower maximum of−0.54±1.29 *** achieved a good linear relationship between the photoelectron number of neutrino events obtained by simulation and the real data measured by *** simulation toolkit could serve as a reliable basis for studying the performance of astrophysical neutrino telescopes.

关键词： high-energy neutrino cascade event simulation Cherenkov

explainability and Interpretability in electric Load Forecasting Using Machine Learning Techniques–A Review

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energy and AI 2024年第2期16卷 483-496页

作者： Lukas Baur Konstantin ditschuneit Maximilian Schambach Can Kaymakci Thomas Wollmann alexander Sauer Fraunhofer Institute for Manufacturing engineering and Automation IPA Nobelstraße 12Stuttgart70569Germany Institute for energy efficiency in Production(eeP) University of StuttgartNobelstraße 12Stuttgart70569Germany Merantix Momentum GmbH Max-Urich-Straße 3Berlin13355Germany

electric Load Forecasting(eLF)is the central instrument for planning and controlling demand response programs,electricity trading,and consumption *** to the increasing automation of these processes,meaningful and transparent forecasts become more and more ***,at the same time,the complexity of the used machine learning models and architectures *** there is an increasing interest in interpretable and explainable load forecasting methods,this work conducts a literature review to present already applied approaches regarding explainability and interpretability for load forecasts using Machine *** on extensive literature research covering eight publication portals,recurring modeling approaches,trends,and modeling techniques are identified and clustered by properties to achieve more interpretable and explainable load *** results on interpretability show an increase in the use of probabilistic models,methods for time series decomposition and the use of fuzzy logic in addition to classically interpretable *** explainable approaches are Feature Importance and Attention *** discussion shows that a lot of knowledge from the related field of time series forecasting still needs to be adapted to the problems in *** to other applications of explainable and interpretable methods such as clustering,there are currently relatively few research results,but with an increasing trend.

关键词： electric load forecasting explainability InterpretabilityStructured review

Antibacterial HA-coatings on bioresorbable Mg alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1965-1985页

作者： K.V.nadaraia d.V.Mashtalyar M.A.Piatkova A.I.Pleshkova I.M.Imshinetskiy M.S.Gerasimenko e.A.Belov V.V.Kumeiko d.n.Kozyrev K.A.Fomenko V.V.Mostovaya B.R.Torpanov A.R.Biktimirov I.S.Osmushko S.L.Sinebryukhov S.V.Gnedenkov Institute of Chemistry FeB RAS 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far eastern Federal University 10 Ajax BayRussky IslandVladivostok 690922Russia A.V.Zhirmunsky national Scientific Center of Marine Biology FeB RAS 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical dermatovenerological dispensary 18 V St.GamarnikaVladivostok 690033Russia nMIC“Treatment and Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this study,a calcium-phosphate coating was formed on a Mg-Mn-Ce alloy by the plasma electrolytic oxidation(PeO).The antibiotic vancomycin,widely used in the treatment of infections caused by Staphylococcus aureus(***),was impregnated into the *** with vancomycin showed high bactericidal activity against *** mechanical and electrochemical properties of the formed coatings were studied,as well as in vitro cytotoxicity tests and in vivo tests on mature male rats were *** to SeM,edS,XRd and XPS data,coatings had a developed morphology and contained hydroxyapatite,which indicates high *** analysis of roughness of coatings without and with vancomycin did not reveal any differences,confirming the high roughness of the *** electrochemical tests,an increase in corrosion resistance by more than two times after the application of PeO coatings was *** to the results of an in vivo study,after 28 days of the implantation of samples with calcium phosphate PeO coating and vancomycin,no signs of inflammation were observed,while an inflammatory reaction developed in the area of implantation of bare alloy,followed by *** release tests from the coatings show a sharp decrease in the concentration of the released antibiotic on day 7 and then a gradual decrease until day *** the experiment,no significant deviations in the condition and behavior of the animals were observed;clinical tests did not reveal a systemic toxic reaction.

关键词： Bioactive coatings Biocompatibility Mg alloy Plasma electrolytic oxidation Hydroxyapatite Vancomycin