检索结果-南通市图书馆

Mitochondria in colorectal cancer stem cells-a target in drug resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2023年第2期6卷 273-283页

作者： Mateus de Almeida Rainho Priscyanne Barreto Siqueira Ísis Salviano Soares de Amorim Andre Luiz Mencalha alessandra Alves thole Laboratory of Stem Cell Research Histology and Embryology DepartmentRoberto Alcantara Gomes Biology InstituteState University of Rio de JaneiroRio de Janeiro 20550-170Brazil Laboratory of Cancer Biology Biometry and Biophysics DepartmentRoberto Alcantara Gomes Biology InstituteState University of Rio de JaneiroRio de Janeiro 20550-170Brazil

Colorectal cancer(CRC)is the third most diagnosed cancer and the second most deadly type of cancer *** late diagnosis,CRC can resist therapy regimens in which cancer stem cells(CSCs)are intimately *** are a subpopulation of tumor cells responsible for tumor initiation and maintenance,metastasis,and resistance to conventional *** this scenario,colorectal cancer stem cells(CCSCs)are considered an important key for therapeutic failure and *** its turn,mitochondria is an organelle involved in many mechanisms in cancer,including chemoresistance of cytotoxic drugs due to alterations in mitochondrial metabolism,apoptosis,dynamics,and ***,it is crucial to understand the mitochondrial role in CCSCs regarding CRC drug *** has been shown that enhanced anti-apoptotic protein expression,mitophagy rate,and addiction to oxidative phosphorylation are the major strategies developed by CCSCs to avoid drug ***,new mitochondria-targeted drug approaches must be explored to mitigate CRC chemoresistance via the ablation of CCSCs.

关键词： Cancer stem cells mitochondria colorectal cancer drug resistance mitophagy

Effect of first thinning and pruning on the individual growth of Pinus patula tree species

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2015年第4期26卷 827-831页

作者： Edward Missanjo Gift Kamanga.thole Malawi College of Forestry and Wildlife

The effect of first thinning and pruning on height, diameter at breast height （DBH）, and volume growth was studied in individual trees of Pinus patula Schiede and Deppe in Chongoni Plantation, using four plots for thinning trials. Each of the plots was 0.5 ha and subjected to one of the fol- lowing silvicultural treatments： first thinning and pruning, first thinning and no pruning, pruning and no thinning, and control （no pruning and no thinning）. The silvicultural treatments were randomized in four replicates. Fourteen years after planting, the following parameters were measured including total height, DBH, and volume. The highest DBH and volume growth was observed in thinning and pruning, while the highest growth in height was observed where there was pruning and no thinning. Clearly, both thinning and pruning are an important manage- ment option in pine species plantations in Malawi to maximize the increase in volume productivity.

关键词： Pinus patula Thinning and pruning Diameter growth Height growth Volume

在线全文

学校读者我要写书评

暂无评论

撞车模拟的不稳定性分析(英文)

工程数学学报 2002年第2期19卷 47-51,56页

作者：梅立泉 thole C A. Fraunhofer-Institute of Algorithms and Scientific Computing D53754 St.Augustin Germany

众所周知 ,在并行机器上多次执行同一应用会产生不同的撞击数值模拟结果。为了研究这一问题 ,我们开发了一个工具 ,它可从PAM CRASH读取多个结果文件 ,计算各种统计量并可利用可视化工具产生这些量的输出以用于分析。

关键词：数值模拟软件稳定性分析撞车模拟并行机器撞击

The Habitat Structure of Lukanga Ramsar Site in Central Zambia: An Understanding of Wetland Ecological Condition

在线全文

学校读者我要写书评

暂无评论

Open Journal of Ecology 2017年第6期7卷 406-432页

作者： Harry Chabwela Chansa Chomba Loyd thole Department of Biological Sciences University of Zambia Lusaka Zambia School of Agriculture and Natural Resources Disaster Management Training Centre Mulungushi University Kabwe Zambia Zambia Environmental Management Authority Ministry of Lands and Natural Resources Lusaka Zambia

A field survey was carried out to determine the vegetation structure of the Lukanga Swamp Ramsar site in central Zambia. The aim of the study was to identify the different vegetation communities, species composition and distribution patterns for improved habitat management. Sampling was conducted in all recognizable vegetation communities. The results of the survey showed that the swamp was a littoral palustrine wetland predominantly characterized by the dominance of Leersia hexandria Swartz (42.02%), Typha capensis Rohrb (62.43%), Phragmites australis (Cav.) Trin. ex Steud (33.61%), Aeschynomeme fluitans Peter (31.58%) and Polygonum senegalense Meisn (48.8%). The occurrence of Vossia cuspidata Griff and Cyperus papyrusL was restricted to small and isolated locations. Short Termitaria was generally covered by Acrocerus macrum Stapf (35.25%) while tall Termitaria was dominated by Panicum maximum Jacq. (26.00%). The most important woody plant species included Combretum ghasalense Engl. et Diels (I. V = 62.88), Pseudolachnostylis maprouneifolia Pax ((I. V = 90.48), Albizia adianthifolia (Schmacher) W.F. Wight (I. V = 135.63) Isoberlinia angolensis Hyle and Brenan (I. V = 87.25). The current structure of the hydrophytes composition observed in this study was an indication of a generally silting wetland, while the dominant occurrence of understorey woody plants in the surrounding vegetation signified degraded miombo vegetation. It was concluded that the ecological status of wetland habitat was potentially threatened by mainly anthropogenic activities such as;wildfires, and unsustainable exploitation of surrounding vegetation. Further research is required to examine water flows, eutrophication and the long-term effects of deforestation on the ecological functioning of the wetland.

关键词： Aquatic Macrophytes Wetland Habitat Brachystegia Woodland Palustrine Swamp Sedimentation Environmental Flows Wetland Fires and Overexploitation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

石膏刨花板生产的工艺设计

木材工业 1990年第2期4卷 13-19页

作者： L.Mehlhorn V.thole 陈士英联邦德国弗劳霍夫研究所中国林科院木材工业研究所

由联邦德国科技部(BMFT)资助中国的项目“利用木质纤维生产人造板”,是由联邦德国弗劳霍夫木材研究所(WKI)和中国林科院木材工业研究所(CRIWI)承担。现进行了半干法生产石膏刨花板的工艺设计。为了确认原材料的适用性,中国派遣一名科技... 详细信息

由联邦德国科技部(BMFT)资助中国的项目“利用木质纤维生产人造板”,是由联邦德国弗劳霍夫木材研究所(WKI)和中国林科院木材工业研究所(CRIWI)承担。现进行了半干法生产石膏刨花板的工艺设计。为了确认原材料的适用性,中国派遣一名科技人员在WKI用中国原材料进行了试验。根据当地实际情况确定该厂的年生产能力。全部生产设备可分成热能生产、石膏煅烧和板生产三部分。

关键词：石膏刨花板山杨石膏工艺设计

在线全文

学校读者我要写书评

暂无评论

刨花板生产质量指标的优化

木材工业 1994年第4期8卷 1-5页

作者：陈士英 V.thole L.Mehlhorn 德国弗劳霍夫木材研究所中国林科院木工所

本文以中国一家刨花板厂为例，用该厂目前使用的原料在德国弗劳霍夫木材研究所进行系统的工艺试验。试验设计和数据计算采用数理统计方法。试验结果表明，在生产过程中某些工段采用相应措施可降低原材料消耗和改善产品质量，提高经济效... 详细信息

本文以中国一家刨花板厂为例，用该厂目前使用的原料在德国弗劳霍夫木材研究所进行系统的工艺试验。试验设计和数据计算采用数理统计方法。试验结果表明，在生产过程中某些工段采用相应措施可降低原材料消耗和改善产品质量，提高经济效益，保持一定的工艺条件，可降低施胶量３０％。

关键词：刨花板质量指标最佳化工艺

在线全文

学校读者我要写书评

暂无评论

一年生植物作为石膏刨花板原料的适应性

木材工业 1993年第1期7卷 15-24页

作者： V.thole D.Weiss 陈士英德国弗劳霍夫木材研究所中国林科院木材工业研究所北京100091

本文叙述了使用德国及中国建筑石膏和甘蔗渣、竹材、棉秆、麦秸、稻草等一年生植物生产石膏刨花板的适应性,分析了石膏的成分和性能,测定了缓凝剂和植物原料对石膏水化的影响。制板时采用不同的配方和板的密度,以评价一年生植物的使用... 详细信息

本文叙述了使用德国及中国建筑石膏和甘蔗渣、竹材、棉秆、麦秸、稻草等一年生植物生产石膏刨花板的适应性,分析了石膏的成分和性能,测定了缓凝剂和植物原料对石膏水化的影响。制板时采用不同的配方和板的密度,以评价一年生植物的使用价值。在所使用的原料中,甘蔗渣是良好的石膏刨花板原料。

关键词：一年生植物石膏刨花板适应性

Last line therapy with sorafenib in colorectal cancer: A retrospective analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第23期22卷 5400-5405页

作者： Ksenia Martchenko Irene Schmidtmann Thomas Thomaidis Verena.thole Peter R Galle Marc Becker Markus Mohler Thomas C Wehler Carl C Schimanski Department of Internal Medicine Marienhospital 64285 Darmstadt Germany Institute of Medical Biostatistics Epidemiology and Informatics Johannes Gutenberg University Hospital of Mainz 55131 Mainz Germany First Department of Internal Medicine Johannes Gutenberg University Hospital of Mainz 55131 Mainz Germany Department of Internal Medicine Katholische Kliniken Mainz 55131 Mainz Germany Institute of Pathology Saarland University Medical Center 66421 Homburg Germany Third Department of Internal Medicine Johannes Gutenberg University Hospital of Mainz 55131 Mainz Germany

AIM: To analyze the efficacy of last line sorafenib treatment in colorectal cancer patients. METHODS: All patients receiving chemotherapy for colorectal cancer in the outpatient clinic of the University of Mainz since 2006 were retrospectively analyzed for last line sorafenib exposure. Charts of identified patients were analyzed for clinic-pathological parameters, like data on gender, age, date of initial diagnosis, UICC stage, number and kind of the pretherapies, therapy start and end of sorafenib, sorafenib mediated treatment cessation, side effects, response rates, time to progression and overall survival. RESULTS: Ten patients with a median of 3.0 prior chemotherapy lines had received a last line sorafenib therapy either alone(10%) or in combination with 5-fluorouracil derivates(90%). All patients suffered from colorectal cancer stage UICC 4 and were routinely seen in 2-wk intervals in the oncology outpatient clinic. Median duration of treatment was 142.0 d. At 8 wk 80% of patients showed stable disease but we did not observe any remissions. Median time to progression was 140.5 d(4.7 mo), while median overall survival reached 176.5 d. One patient ceased treatment due to side effects. Reason for treatment stop was bleeding complication in one case and non-specified sorafenib intolerance in another case. Due to the retrospective approach we did not further quantify side ***: This retrospective analysis encourages further investigation of sorafenib in colorectal cancer last line therapy.

关键词： Colorectal cancer Sorafenib Regorafenib Chemotherapy Last line