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Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

Neural Regeneration Research 2024年第4期19卷 846-854页

作者： Willian Orlando castillo-Ordoñez Nohelia cajas-Salazar Mayra alejandra Velasco-Reyes Facultad de ciencias Naturales-Exactas y de la Educación Departamento de Biología.Universidad del Cauca Departamento de Estudios Psicológicos Universidad Icesi

Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older *** factors,such as oxidative stress,an increase in acetylcholinesterase activity,mitochondrial dysfunction,genotoxicity,and neuroinflammation are present in this syndrome,which leads to *** pathologies such as Alzheimer’s disease are considered late-onset diseases caused by the complex combination of genetic,epigenetic,and environmental *** are two main types of Alzheimer’s disease,known as familial Alzheimer’s disease(onsetc Alzheimer’s disease(onset≥65 years).Patients with familial Alzheimer’s disease inherit the disease due to rare mutations on the amyloid precursor protein(APP),presenilin 1 and 2(PSEN1 and PSEN2)genes in an autosomaldominantly fashion with closely 100%*** contrast,a different picture seems to emerge for sporadic Alzheimer’s disease,which exhibits numerous non-Mendelian anomalies suggesting an epigenetic component in its ***,the fundamental pathophysiological mechanisms driving Alzheimer’s disease are interfaced with epigenetic ***,the dynamic nature of epigenetics seems to open up new avenues and hope in regenerative neurogenesis to improve brain repair in Alzheimer’s disease or following injury or stroke in *** recent years,there has been an increase in interest in using natural products for the treatment of neurodegenerative illnesses such as Alzheimer’s *** epigenetic mechanisms,such as DNA methylation,non-coding RNAs,histone modification,and chromatin conformation regulation,natural compounds appear to exert neuroprotective *** we do not purport to cover every in this work,we do attempt to illustrate how various phytochemical compounds regulate the epigenetic effects of a few Alzheimer’s disease-related genes.

关键词： Alzheimer’s disease epigenetics genes methylation natural products

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Metallography of an Underground Oil Pipeline

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Open Journal of Metal 2018年第3期8卷 35-54页

作者： Francisco casanova-del-Angel alejandra córdova-castillo Sección de Estudios de Posgrado e Investigación Escuela Superior de Ingeniería y Arquitectura Unidad Profesional Adolfo López Mateos Instituto Politécnico Nacional Mexico City Mexico

The purpose of this article is to show a metallographic analysis of an underground pipeline taken out of operation upon failure. The pipeline had an 8.89 cm (3.5”) diameter and a 7 mm thickness. The study was based on a 45 cm long pipe sample, visibly and entirely corroded, with a fish-mouth crack along its length. The work contributes to finding new ways to prevent structural failure, which has high-impact consequences from the point of view of production, damage to property, pollution, and risks to human live. Through this analysis the knowledge on behavior of failures in terrestrial ducts has been extended. Development of the research included metallographic, chemical, and mechanical tests on the sample in order to know the composition of the material, its strength and its physical conditions upon taking it out of operation. After the analysis of the laboratory tests, the physical and chemical features were compared to existing national and international regulations, which allowed a specific characterization of the conditions of the sample. In accordance with the regulations, the grade of the pipe was between ×65 and ×70. Tensile testing was carried out to obtain mechanical properties in order to corroborate the grade of pipeline steel and complement the metallographic analysis.

关键词： Metallography Microscopy Oil Pipeline Failure Tensile Testing

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Finite Element Structural Analysis of Buried Pipelines

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Modern Mechanical Engineering 2022年第2期12卷 27-44页

作者： casanova-del-Angel Francisco córdova-castillo alejandra Escuela Superior de Ingeniería y Arquitectura UP ALM SEPI of the Instituto Politécnico Nacional Mexico City Mexico

This document uses previous results (which we call the first stage), for the development of a computer model based on finite elements under the FEAP programmer, to carry out a structural analysis of a pipeline. For this purpose, we used environmental variables that we believe influence the failure of buried pipelines such as the internal pressure of fluid, the type of support used, the temperature at which the pipelines work, the type of soil and the stiffness of the soil acting on it. Once the model was finalized, analyses were made with each of the variables separately and combined to observe the behavior of the pipeline, finding the most unfavorable case that indicates the main causes that led to its failure.

关键词： Duct Finite Element Buried Pipeline Material creep Thermal conditions Soil Springs

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Vegetation Response To Soil And Morphological Properties In An Arid Region Alluvial Fan Landscape. Pre-Andes Of San Juan， Argentina

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Journal of Earth Science 2024年

作者： FLORES Daniel Germán OcA?A Raúl Emmanuel MELIáN Edgardo ORTEG Andrés ESPER ANGILLIERI María Yanina PITTALUGA María alejandra cIGEOBIO (cONIcET-UNSJ) Av.José I.de la Roza y Meglioli Gabinete de Geología Ambiental INGEO Universidad Nacional de San Juan Av.José I.de la Roza y Meglioli

The Monte Desert is characterized by a great diversity of landforms created with fluvial， alluvial which the vegetation patterns are related to. The present work has the following objectives: 1: determine whether topographical attributes， surface characteristics， soil properties and vegetation patterns vary between alluvial landforms， and 2: define whether morphometric， soil and surface properties influence vegetation patterns along alluvial landscape. Morphometric data were obtained by processing a 5 m digital elevation model. The coverage of rock fragments， fine sediments and mulch was quantified. Observations and descriptions of the soil profiles were restricted to the uppermost 50 cm. Vegetation properties were calculated using a Point Quadrat Method. The relationship between variables was evaluated through multivariate statistical analysis. The main results show the presence of 45 plant species distributed in 19 families， where shrubs are dominant. The wind effect， topographic wetness and dissection of the landscape are limiting factors of diversity. The coverage of superficial rock fragments influence vegetation coverage through the distribution and availability of rainwater. Furthermore， the different soil textures reveal that the silt content favors an increase in vegetation coverage. The presence of V horizon could condition the installation and development of vegetation in the early stages of growth.

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Effects of Phytoremediation on Soil contaminated with Pb and cd in Tolerant Bacterial Populations

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Journal of Environmental Science and Engineering(A) 2024年第4期13卷 122-127页

作者： alejandra Vásquez María Montes Melissa cervantes María Alvarado Pedro García Victor Aguilar Department of Environmental Engineering Institute for EngineeringUniversity of VeracruzBoca del RioVer.94294Mexico Department chemical Engineering Faculty of Chemical SciencesUniversity of VeracruzBoca del RíoVer.94294Mexico Faculty of Environmental Engineering Popular Autonomous University of the State of PueblaBarrio de Santiago 72410PueblaPueMexico Department of Administration Open Education SystemUniversity of VeracruzBoca del RioVer.94294Mexico

Bacterial populations isolated from treated soil,artificially contaminated with lead(Pb)and cadmium(cd)and undergoing a phytoremediation process were studied to determine their potential application in soil *** physicochemical parameters evaluated in the soil varied *** bacterial strains were selected from each polluted soil to test tolerance and growth in contaminated *** concentrations of heavy metals tested were 1,000 ppm for lead and 850 ppm for *** strains were morphologically identified through Gram *** strains showing the most significant growth in both contaminants were then selected to verify their tolerance to different concentrations of heavy *** results demonstrated that the selected bacteria have high tolerance to Pb,resisting inhibition up to 2,000 *** contrast,strains exposed to cadmium tended to slow their growth as the concentration increased.

关键词： Lead cadmium soil bacteria remediation.

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competencies in computer Security and Resolution of Technological Problems in Higher Education Students

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Journal of computer and communications 2024年第4期12卷 171-185页

作者： Esteban Pérez Flores alejandra Aldrette Malacara Sandra R. Murillo cano Vittorio Zanella Palacios Facultad de ciencias Administrativas Universidad Aut&#243noma de Baja California Mexicali M&#233xico Decanato de Ingenierí as Universidad Popular Aut&#243noma Del Estado de Puebla Puebla M&#233xico

Starting from the importance of preserving our information and protecting our devices against attacks on their vulnerabilities, this article aims to establish the level of knowledge in computer security and problem-solving of students at a university in northwest Mexico. This research has a quantitative approach where the European Framework of Digital competencies for citizenship was used as a reference to identify and establish the level of the competencies that were evaluated. The IKANOS Test was used as a data collection tool. The results show that students know the importance of keeping their devices safe and how valuable the information found on them is. On the other hand, the results also show a considerable percentage of students who do not have the knowledge and are at a basic level of knowledge to solve technical problems with their devices.

关键词： Digital Literacy cybersecurity Digcomp Digital Skills Data Protection

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The W3c Data catalog Vocabulary,Version 2:Rationale,Design Principles,and Uptake

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Data Intelligence 2024年第2期6卷 457-487页

作者： Riccardo Albertoni David Browning Simon cox alejandra N.Gonzalez-Beltran Andrea Perego Peter Winstanley Istituto di Matematica Applicata e Tecnologie Informatiche"Enrico Magenes" Consiglio Nazionale delle Ricerche(IMATI-CNR)GenoaItaly Independent consultant United Kingdom LandandWater CSiROMelbourneAustralia Scientific computing Rutherford Appleton LaboratoryScience and Technology Facilities CouncilHarwell Cam-pusOx110QXUnited Kingdom European Parliament Luxembourg Semantic Arts Fort CollinsCO80524USA

DcAT is an RDF vocabulary designed to facilitate interoperability between data catalogs published on the *** its first release in 2014 as a W3c Recommendation,DcAT has seen a wide adoption across communities and domains,particularly in conjunction with implementing the FAIR data principles(forfindable,accessible,interoperable and reusable data).These implementation experiences,besides demonstrating the fitness of DcAT to meet its intended purpose,helped identify existing issues and ***,over the last few years,additional requirements emerged in data catalogs,given the increasing practice of documenting not only datasets but also data services and *** paper illustrates the new version of DcAT,explaining the rationale behind its main revisions and extensions,based on the collected use cases and requirements,and outlines the issues yet to be addressed in future versions of DcAT.

关键词： Data catalogs Interoperability Discoverability FAIR data

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From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean Gabriel Gonzáles-Yovera María alejandra Quispe-Flores Luis Alberto concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

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A Systematic Review of cannabidiol Effects in coronary Syndromes: challenges to clinical Translation

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Journal of Biosciences and Medicines 2024年第4期12卷 246-263页

作者： Mario E. Zuñiga-Ayala alejandra Meaney-Martínez Alejandro Alcocer-chauvet Vidal Gonzalez-coronado Nestor Rubio-Infante Gerardo Garcia-Rivas Department of cardiology Instituto de Seguridad Social and Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Department of Interventional cardiology Instituto de Seguridad Social y Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Instituto Tecnó logico de Monerrey Escuela de Medicina and Ciencias de la Salud C&#225tedra de Cardiolog&#237a and Medicina Vascular Monterrey Mexico

Background: Myocardial ischemia in addition to other several cardiac syndromes represent a pathological proinflammatory state alongside a complex cellular microenvironment that can be modified by using cannabinoids. cannabidiol (cBD), a non-psychoactive compound of cannabis has been recently proposed as an immudomodulatory and cardioprotective drug. Objectives: In this systematic review we sought to clarify and summarize the clinical and preclinical evidence of potential benefit of the use of cBD in coronary syndromes. Methods: We conducted a systematic search and review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Review of Animal Data from Experimental Studies (cAMARADES) guidelines, in the electronic database from PubMed, Web of Science and Scopus up to April 2022 using predefined search terms. Pre-specified exclusion and inclusion criteria were considered, finally 11 articles were chosen to be included for this peer review. Results: currently there are no good-quality clinical trials with the use of cBD in acute or chronic coronary syndromes. A total of 11 preclinical studies where prescreened and 5 demonstrated reproducible positive cardiovascular outcomes on in-vivo models treated with cBD. Mechanisms of cBD cardioprotection observed: 1) reduction in oxidative stress and inflammation, 2) activation of adenosine receptors and 3) increased expression of angiotensin type 2-receptor. Experimental models included ischemia/reperfusion injury, myocardial infarction, arrhythmias, and metabolic syndrome-like conditions. conclusion: No clinical recommendation can be issued with the current evidence, on the use of cBD in acute and chronic coronary syndromes. Based on preclinical evidence, we considered there is enough evidence to propose the development of well-designed clinical trials that include cBD in the management of coronary syndromes.

关键词： cannabis cannabidiol Acute coronary Syndromes Myocardial Infarction Myocardial Ischemia and Oxidative Stress

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The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo alejandra carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo carmen Paradas Macarena cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(cIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain centro de Salud Utrera Sur SevillaSpain centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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