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Variable range hopping transport and dielectric relaxation mechanism in GdCrO_(3) rare-earth orthochromite perovskite

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Journal of Rare Earths 2024年第7期42卷 1304-1316,I0004页

作者： Muhammad Javed Ayaz Arif khan Jamal Kazmi Naeem Akbar Said Nasir Khisro Amanullah Dar aleem Dad khan Tareen Mohd Ambri Mohamed Department of Physics The University of Azad Jammu and KashmirMuzaffarabad13100Pakistan Department of Physics University of Kotli Azad Jammu and KashmirKotli11100Pakistan Institute of Microengineering and Nanoelectronics Universiti Kebangsaan Malaysia43600BangiSelangorMalaysia Department of Mathematics University of Kotli Azad Jammu and KashmirKotli11100Pakistan

The polycrystalline GdCrO_(3)(GCO)perovskite orthochromite was synthesized by the sol-gel auto-combustion *** Rietveld refined X-ray diffraction(XRD)profile of GCO confirms that the orthorhombic phase crystallizes in perovskite crystal structure with space group *** transmission electron microscopy and selected area electron diffraction divulge the polycrystalline nature of the perovskite *** field emission scanning electron microscopy(FESEM)images reveal the microstructural polyhedral growth of grains separated by sharp grain *** chemical states of the ions present in the compound were investigated by X-ray photoelectron spectroscopy(XPS)studies,and the electrical pathways were *** impedance studies were carried out in the experimental frequency and temperature ranges of 40 Hz-4 MHz and 178-408 K,*** equivalent circuit model(RGQG)(RGBQGB)resolves the impedance response into two contributions originating from the intra-grain and inter-granular micro-constituents of the *** electrical conduction mechanism is based on the Mott variable range hopping *** complex electric modulus studies demonstrate the short-and long-range mobility of the charge carriers and rule out the presence of electrode effects on the dielectric relaxation mechanism of the *** decreasing pattern of dielectric permittivity with frequency is explained by the Maxwell-Wagner type of *** frequency dependence of the loss factor exhibits the presence of thermally activated relaxation time distribution in the material.

关键词： Auto-combustion Perovskite Electro-ceramic Dielectric Electrical transport Impedance

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Presentation delay in breast cancer patients and its association with sociodemographic factors in North Pakistan

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Chinese Journal of Cancer Research 2015年第3期27卷 288-293页

作者： Muhammad aleem khan Sheharyar Hanif Sundas Iqbal Muhammad Faheem Shahzad Sehrish Shafique Muhammad Taha khan Department of Nuclear Medicine Nuclear MedicineOncology and Radiotherapy Institute Department of Medicine Ziauddin Medical University Armed Forces Institute of Cardiology Department of Physiology Rawal Institute of Health Sciences Nuffield Brentwood Hospital

Background： There is strong evidence that delayed diagnosis of breast cancer is associated with poor survival. The objectives were to determine the frequency of breast cancer patients with delayed presentation, the reasons of delay and its association with different socio-demographic variables in our ***： We interviewed 315 histologically confirmed breast cancer patients. Delay was defined as more than 3 months from appearance of symptoms to the consultation from doctor. Questions were asked from each patient which could reflect their understanding about the disease and which could be the likely reasons for their delayed ***： A total of 39.01%（n=123） of patients presented late and out of those, 40.7% wasted time using alternative medicines; 25.2% were not having enough resources; 17.1% presented late due to painless lump; 10.6% felt shyness and 6.5% presented late due to other reasons. Higher age, negative family history, 〈8 school years of education and low to middle socio-economic status were significantly associated with delayed presentation（P〈0.05）. Education and socioeconomic status were two independent variables related to the delayed presentation after adjustment for others [odds ratios（OR） of 2.26, 2.29 and 95% confidence intervals（CI） was 1.25-4.10, 1.06-4.94 respectively].Conclusions： Significant percentage of women with breast cancer in North Pakistan is experiencing presentation delay due to their misconceptions about the disease. Coordinated efforts with public health department are needed to educate the focused groups and mitigating the barriers identified in the study. Long term impact will be reduced overall burden of the disease in the region.

关键词： Breast cancer delayed diagnosis survival

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Helicobacter pylori and other Helicobacter species DNA in human bile samples from patients with various hepato-biliary diseases

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World Journal of Gastroenterology 2006年第14期12卷 2181-2186页

作者： Santosh K Tiwari aleem a khan Mohd Ibrahim Mohd Aejaz Habeeb C M Habibullah Center for Liver Research and Diagnostics Deccan College of Medical Sciences KanchanbaghHyderabad 500 058Andhra PradeshIndia Center for Liver Research and Diagnostics Deccan College of Medical Sciences KanchanbaghHyderabad 500 058Andhra PradeshIndia Department of GastroenterologyDeccan College of Medical Sciences Hyderabad 500 058Andhra PradeshIndia

AIM： To investigate the presence of Helicobacter species by nested PCR of 16S rRNA genes followed by the presence of Flelicobacter pylori （H pylori） 16S rRNA, ureA, cagA genes in bile obtained at endoscopic retrograde cholangio-pancreatography （ERCP） from 60 Indian subjects. METHODS： Sixty bile samples were obtained from patients diagnosed with various hepato-biliary diseases and control subjects at ERCP. PCR analysis was carried out using primers for Helicobacter genus 16S rRNA gene and H pylori （16S rRNA, urea and cagA） genes. Gastric H pylori status was also assessed from biopsies obtained at endoscopy from patients with various hepatobiliary diseases and controls. The control group mainly consisted of subjects with gastric disorders. Sequencing analysis was performed to confirm that PCR products with 16S rRNA and cagA primers were derived from H pylori. RESULTS No Helicobacters were grown in culture from the bile samples. Helicobacter DNA was detected in bile of 96.7% and 6.6% of groups Ⅰ and Ⅱ respectively. Ten from group Ⅰ were positive for 16S rRNA and ureA and 9 were positive for cagA gene. In contrast of the 2 from the control, 1 amplified with 16S rRNA, ureA and cagA primers used. The sequences of the 16S rRNA genes and cagA were 99% similar to Helicobacter pylori. CONCLUSION： Helicobacters are associated with the pathogenesis of various hepato-biliary disorders.

关键词： Helicobacter pylori Bile Hepato-biliary diseases PCR, Sequence analysis

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Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker

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World Journal of Gastroenterology 2007年第16期13卷 2319-2323页

作者： Parveen Nyamath Ayesha Alvi Aejaz Habeeb Sanjeev Khosla aleem a khan CM Habibullah Center for Liver Research and Diagnostics Deccan College of Medical Sciences and Allied Hospitals Kanchanbagh Hyderabad-58 Andhra Pradesh India Centre for DNA Fingerprinting and Diagnostics Nacharam Hyderabad 500072 India

AIM: To enrich putative hepatic progenitors from the developing human fetal liver using CD34 as a marker. METHODS: Aborted fetuses of 13-20 wk were used for the isolation of liver cells. The cells were labeled with anti CD34; a marker used for isolating progenitor population and the cells were sorted using magnetic cell sorting. The positive fractions of cells were assessed for specific hepatic markers. Further, these cells were cultured in vitro for long term investigation. RESULTS: Flow cytometric and immunocytochemical analysis for alphafetoprotein (AFP) showed that the majority of the enriched CD34 positive cells were positive for AFP. Furthermore, these enriched cells proliferated in the long term and maintained hepatic characteristics in in vitro culture. CONCLUSION: The study shows that aborted human fetal liver is a potential source for isolation of hepatic progenitors for clinical applications. The study also demonstrates that CD34 can be a good marker for the enrichment of progenitor populations.

关键词： Progenitor cells Fetal liver Magnetic cell sorting Flow cytometry Immunohistochemistry

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Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer,gastric carcinoma,and non-ulcer dyspepsia subjects with histological changes

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World Journal of Gastroenterology 2005年第43期11卷 6815-6822页

作者： Mahaboob Ali aleem a khan Santosh K Tiwari Niyaz Ahmed L Venkateswar Rao CM Habibullah Center for Liver Research and Diagnostics Pathogen Evolution Group Department of Microbiology

AIM： To investigate the presence of the cag-pathogenicity island and the associated histological damage caused by strains with complete cag-PAI and with partial deletions in correlation to the disease status. METHODS： We analyzed the complete cag-PAI of 174 representative Helicobacter pylori （H pylori ） clinical isolates obtained from patients with duodenal ulcer, gastric ulcer, gastric cancer, and non-ulcer dyspepsia using eight different oligonucleotide primers viz cagA1, cagA2, cagAP1, cagAP2, cagE, cagT, LEC-1, LEC-2 spanning five different loci of the whole cag-PAI by polymerase chain reaction （PCR）. RESULTS： The complete screening of the genes comprising the cag-PAI showed that larger proportions of subjects with gastric ulcer （97.8%） inhabited strains with complete cag-PAI, followed by gastric cancer （85.7%）, non-ulcer dyspepsia （7.1%）, and duodenal ulcer （6.9%）, significant differences were found in the percentage distribution of the genes in all the clinical groups studied. It was found that strains with complete cag-PAI were able to cause severe histological damage than with the partially deleted ones. CONCLUSION： The cag-PAI is a strong virulent marker in the disease pathogenesis as it is shown that a large number of those infected with strain with complete cag-PAI had one or the other of the irreversible gastric pathologies and interestingly 18.5% of them developed gastric carcinoma. The presence of an intact cag- PAI correlates with the development of more severe pathology, and such strains were found more frequently in patients with severe gastroduodenal disease. Partial deletions of the cag-PAI appear to be sufficient to render the organism less pathogenic.

关键词： Helicobacter pylori cag-pathogenicity island Genetic diversity Gastro-duodenal diseases

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Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies

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World Journal of Gastroenterology 2006年第44期12卷 7136-7142页

作者： Mohammed Ibrahim aleem a khan Santosh K Tiwari Mohammed Aejaz Habeeb MN Khaja CM Habibullah Centre for Liver Research and Diagnostics Deccan college of Medical Sciences and Allied Hospitals Kanchanbagh Hyderabad India

AIM： To evaluate the antibacterial activity of Sapindus mukorossi （S. mukorossl） and Rheum emodi （R. emodl）. METHODS： Powders of S. mukorossi and R. emodi were extracted successively with petroleum ether, benzene, chloroform and ethanol and were concentrated in vacuum. The disk diffusion method was used for in vitro studies and in vivo studies were performed on male Wister rats. Thirty resistant clinical isolates of H pylon, as determined by their antibiotic sensitivity patterns by E-test, along with two Gram ＋ve （S. aureus, B. subtilis） and two Gram -ve （E. coli, P. vugaris） organisms were screened for their susceptibility patterns against these extracts. RESULTS： In our screening, all 30 resistant isolates and the other four organisms （two Gram ＋ve S. aureus, B. subtilis and two Gram -ve, E. coli, P. vugaris） were sensitive to the test compounds. It was found that ethanol and chloroform extracts of S. mukorossi and ethanol and benzene extracts of R. emodi inhibited Hpylori at very low concentrations, In the in vitro study, the isolates showed a considerable zone of inhibition at very low concentrations （10 μg/mL） for both the extracts. In the in vivo study, the H pylori infection was cleared with minimal doses of extracts of S. mukorossi （2.5 mg/mL） and R. emodi （3.0 mg/mL） given orally for seven days. CONCLUSION： We can conclude from this study that the extracts of S. mukorossi and R. emodi inhibited the growth of pylori in vitro and, in in vivo studies, the H pylori infection cleared within seven days at very low concentrations. We also found that H pylori did not acquire resistance against these herbal extracts even after 10 consecutive passages.

关键词： H pylori Sapindus mukorossi Rheum emodi

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Phylogeography and diversification of Oriental weaverbirds(Ploceus spp.):A gradual increase of eurytopy

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Avian Research 2023年第4期14卷 511-522页

作者： Abdul Razaq Giovanni Forcina Urban Olsson Qian Tang Robert Tizard Naing Lin Nila Pwint aleem Ahmed khan Institute of Pure&Applied Biology Zoology DivisionBahauddin Zakariya UniversityMultanPakistan Universidad de Alcala(UAH) Global Change Ecology and Evolution Research Group(GloCEE)Departamento de Ciencias de La Vida28805Alcala de HenaresSpain CIBIO Centro de Investigaçao em Biodiversidade e Recursos GenaeticosInBIO Laborataorio AssociadoUniversidade do PortoCampus de Vairao4485-661VairaoPortugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de Vairao4485-661VairaoPortugal Department of Biology and Environmental Science University of GothenburgBox 463SE-40530GothenburgSweden Gothenburg Global Biodiversity Centre Box 461SE-40530GothenburgSweden Department of Biological Sciences National University of Singapore16 Science Drive 4Republic of Singapore Wildlife Conservation Society Global Conservation ProgramBronxNYUSA Nature and Wildlife Conservation Division Ministry of Natural Resources and Environmental ConservationNaypyidawMyanmar

Weaverbirds are a speciose group of colorful passerines inhabiting the Old World ***,the Oriental weaverbirds(Ploceus spp.),widespread across southern Asia,are much less diverse and restricted to a few ecological niches compared to their African *** investigate their phylogeography,we retrieved 101 samples of Baya Weaver(***),Streaked Weaver(***),Black-Throated Weaver(***)and Asian Golden Weaver(***)along with GenBank sequences of Finn's Weaver(***).We reconstructed the first molecular phylogeny based on a dataset consisting of both mitochondrial and nuclear genes,dating the most recent common ancestor of Oriental Ploceus to~11 *** speciation appears to have been a combination of divergence within the Indian subcontinent and dispersal across a barrier situated between the Indian subcontinent and the Indochinese region,which provided habitats with a varying degree of isolations and ultimately promoted divergences in *** descendants of the earliest nodes,*** and ***,are both rare and local,often found near large river systems,which perhaps reflects niche conservatism and a lack of adaptive *** three smaller species are all widespread,common and less habitat *** most recent divergence,between western and eastern *** populations,is supported by both phylogenetic and morphological evidence,pointing toward limited gene flow between ***,a zone of intergradation may exist in Myanmar and Brahmaputra flood plains,thus preventing a recommendation for species level recognition without further study.

关键词： Avian phylogenetics Indian subcontinent Indochinese region Multilocus analyses Ploceidae

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Characterization of hepatic progenitors from human fetal liver during second trimester

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World Journal of Gastroenterology 2008年第37期14卷 5730-5737页

作者： Mekala Subba Rao aleem Ahmed khan Nyamath Parveen Mohammed Aejaz Habeeb Chittoor Mohammed Habibullah Gopal Pande Centre for Cellular and Molecular Biology Uppal Road Hyderabad 500007 India Centre for Liver Research and Diagnostics Kanchanbagh Hyderabad 500058 India

AIM： To enrich hepatic progenitors using epithelial cell adhesion molecule （EpCAM） as a marker from human fetal liver and investigate the expression of human leukocyte antigen （HLA） and their markers associated with hepatic progenitor cells. METHODS： EpCAM ＋ve cells were isolated using magnetic cell sorting （MACS） from human fetuses （n = 10） at 15-25 wk gestation. Expression of markers for hepatic progenitors such as albumin, alpha-fetoprotein （AFP）, CD29 （integrin ~1）, CD49f （integrin c^6） and CD90 （Thy 1） was studied by using flow cytometry, immunocytochemistry and RT-PCR; HLA class Ⅰ （A, B, C） and class Ⅱ （DR） expression was studied by flow cytometry only. RESULTS： FACS analysis indicated that EpCAM ＋ve cells were positive for CD29, CD49f, CD90, CD34, HLA class I, albumin and AFP but negative for HLA class Ⅱ （DR） and CD45. RT PCR showed that EpCAM ＋ve cells expressed liver epithelial markers （CK18）, biliary specific marker （CK19） and hepatic markers （albumin, AFP）. On immunocytochemical staining, EpCAM ＋ve cells were shown positive signals for CK18 and albumin. CONCLUSION： Our study suggests that these EpCAM ＋ve cells can be used as hepatic progenitors for cell transplantation with a minimum risk of alloreactivity and these cells may serve as a potential source for enrichment of hepatic progenitor.

关键词： Epithelial cell adhesion molecule Human fetal liver Hepatic progenitors Human leukocyte antigen Hepatic cell therapy

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Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies

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World Journal of Gastroenterology 2008年第16期14卷 2566-2571页

作者： Mohammed Ibrahim Mohammed Nane Khaja Anjum Aara aleem Ahmed khan Mohammed Aejaz Habeeb Yalavarthy Prameela Devi Mangamoori Lakshmi Narasu Chitoor Mohammed Habibullah Centre for Liver Research and Diagnostics Deccan college of Medical Sciences and Allied Hospitals Kanchanbagh Nizam Institute of Pharmacy Deshmukhi pochampally (Mandal) Near Ramoji Film City Centre for Biotechnology Jawaharlal Nehru Technological University Kukatpally

AIM: To study the hepatoprotective capacity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi) extracts in CCl4 treated male rats. METHODS: The dried powder of S. mukorossi and R. emodi was extracted successively with petroleum ether, benzene, chloroform, and ethanol and concentrated in vacuum. Primary rat hepatocyte monolayer cultures were used for in vitro studies. In vivo, the hepatoprotective capacity of the extract of the fruit pericarp of S. mukorossi and the rhizomes of R. emodi was analyzed in liver injured CCl4-treated male rats. RESULTS: In vitro: primary hepatocytes monolayer cultures were treated with CCl4 and extracts of S. mukorossi & R. emodi. A protective activity could be demonstrated in the CCl4 damaged primary monolayer culture. In vivo : extracts of the fruit pericarp of S. mukorossi (2.5 mg/mL) and rhizomes of R. emodi (3.0 mg/mL) were found to have protective properties in rats with CCl4 induced liver damage as judged from serum marker enzyme activities. CONCLUSION: The extracts of S. mukorossi and R. emodi do have a protective capacity both in vitro on primary hepatocytes cultures and in in vivo in a rat model of CCl4 mediated liver injury.

关键词： Hepatoprotective activity Sapindus mukorossr Rheum emodi

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Bioengineered humanized livers as better three-dimensional drug testing model system

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World Journal of Hepatology 2018年第1期10卷 22-33页

作者： Sandeep Kumar Vishwakarma Avinash Bardia Chandrakala Lakkireddy Raju Nagarapu Md Aejaz Habeeb aleem Ahmed khan Central Laboratory for Stem Cell Research and Translational Medicine Centre for Liver Research and Diagnostics Deccan College of Medical Sciences

AIM To develop appropriate humanized three-dimensional ex-vivo model system for drug testing. METHODS Bioengineered humanized livers were developed in this study using human hepatic stem cells repopulation within the acellularized liver scaffolds which mimics with the natural organ anatomy and physiology. Six cytochrome P-450 probes were used to enable efficient identification of drug metabolism in bioengineered humanized livers. The drug metabolism study in bioengineered livers was evaluated to identify the absorption, distribution, metabolism, excretion and toxicity *** The bioengineered humanized livers showed cellular and molecular characteristics of human livers. The bioengineered liver showed three-dimensional natural architecture with intact vasculature and extra-cellular matrix. Human hepatic cells were engrafted similar to the human liver. Drug metabolism studies provided a suitable platform alternative to available ex-vivo and in vivo models for identifying cellular and molecular dynamics of pharmacological *** The present study paves a way towards the development of suitable humanized preclinical model systems for pharmacological testing. This approach may reduce the cost and time duration of preclinical drug testing and further overcomes on the anatomical and physiological variations in xenogeneic systems.

关键词： Acellularization Repopulation Drug testing Humanized liver Bioengineering

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