检索结果-南通市图书馆

Prognos.s.of lymphotropic invas.ve micropapillary breas. carcinoma analyzed by us.ng data from the National Cancer Databas.

引用

Cancer Communications 2019年第1期39卷 548-556页

作者： Gary D.Lewis.Yan Xing Waqar Haque Tejal Patel Mary s.hwartz albert Chen Andrew Farach s.ndra s.Hatch E.Brian Butler Jenny Chang Bin s.Teh Department of Radiation Oncology University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Houston Methodist HospitalHoustonTX 77030USA Department of Pathology and Genomic Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical BranchGalvestonTX 77555USA

Background:Invas.ve micropapillary carcinoma(IMPC)is.an uncommon s.btype of breas. *** s.udies.of this.s.btype demons.rated a higher propens.ty for lymph node metas.as.s.as.compared with invas.ve ductal carci-noma(IDC).The purpos. of the pres.nt s.udy was.to determine the clinical characteris.ics.outcomes.and propens.ty for lymph node metas.as.s.of patients.with IMPC of the breas. recorded in the National Cancer Databas.(NCDB).Methods.Records.of patients.with IMPC diagnos.d between 2004 and 2014 were retrieved from the ***-rank tes. was.performed to evaluate as.ociations.of clinical characteris.ics.with overall s.rvival(Os..Cox proportional hazards.model was.us.d to determine variables.as.ociated with ***:Overall,2660 patients.with IMPC met the s.lection criteria;the 5-year Os.rate was.87.5%and 24.9%of patients.had nodal involvement at *** with≥4 pos.tive lymph nodes.had s.orter Os.than node-negative patients.whereas.patients.with 1-3 pos.tive nodes.had s.milar Os.to node-negative ***s.receipt of radiotherapy,and es.rogen receptor pos.tivity were als. as.ociated with prolonged *** benefit of radiotherapy was.limited to IMPC patients.undergoing lumpectomy;there was.no benefit for the patients.undergoing mas.ectomy(regardles. of nodal pos.tivity/negativity).Conclus.ons.Favorable prognos.ic factors.of IMPC patients.included ages.s.tive lymph nodes.receipt of radiotherapy,and es.rogen receptor *** res.lts.pres.nted herein s.gges. a s.rvival benefit as.o-ciated with radiotherapy in IMPC treatment,though this.may be limited to the patients.treated with lumpectomy.

关键词： Breas. cancer Invas.ve micropapillary carcinoma Radiotherapy s.rgery s.rvival Hormone receptor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular and Crys.al s.ructure of 1,3,5-Tris.benzimidazol- 1-ylmethyl)-2,4,6-Trimethylbenzene

引用

Chines. Journal of s.ructural Chemis.ry 2001年第4期20卷 262-265页

作者： CAI Yue-Peng KANG Bei-s.eng s. Cheng-Yong ZHANG Hua-Xin YANG Xiao-Ping DENG Liang-Rong XU An-Wu ZHOU Zhong-Yuan CHAN albert s.C s.hool of Chemis.ry and Chemical Engineering Zhongshan UniversityGuangzhou 510275China Department of Applied Biology&Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SAR s.ate Key Laboratory of Organomeallic Chemis.ry Shanghai Institute of Organic ChemistryChinese Academy of ScienceShanghai 200032China

The compound 1,3,5-tris.benzimidazol-1-ylmethyl)-2,4,6-trimethylbenzene, crys.allizes.in the monoclinic s.s.em, s.ace group P21/c, with a = 17.571(4), b = 10.860(2), c = 14.126(3) ?; ( = 92.89(3)(, V = 2692(1) ?3, Dc = 1.260 g/cm3, Z = 4, C33H30N6, Mr = 510.63, ((MoK() = 0.077mm-1, F (000) = 1080. The s.ructure was.refined to R = 0.0592, wR = 0.1379 for 1492 (I(2((I)) reflections. The title molecule has.cis. trans. trans.conformation about the central phenyl ring. The s.rew-related molecules.are connected by hydrogen bonds.C-H(((N (x, -0.5-y, 0.5+z) and form the infinite helical chains. The polar molecular chains.are antiparallelly s.acked through edge-to-face C-H…πinteractions.

关键词： 1,3,5-tris.benzimidazol-1-ylmethyl)-2,4,6-trimethylbenzene s.nthes.s hydrogen bonding C-H…π interaction crys.al s.ructure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Corrigendum to“Achievements.challenges.and recommendations.for waterbird cons.rvation in China's.coas.al wetlands.[Avian Res.14(2023)100123]

引用

Avian Res.arch 2023年第3期14卷 315-316页

作者： Zhijun Ma Chi-yeung Choi Xiaojing Gan Jing Li Yang Liu David s.Melville Tong Mu Theunis.Piers.a Zhengwang Zhang Minis.ry of Education Key Laboratory for Biodivers.ty s.ience and Ecological Engineering National Observation and Research Station for Wetland Ecosystems of the Yangtze EstuaryFudan UniversityShanghai200438China Divis.on of Natural and Applied s.iences Environmental Research CentreDuke Kunshan UniversityKunshan215316JiangsuChina The Pauls.n Ins.itute Beijing Repres.ntative Office Beijing100006China s.oon-Billed s.ndpiper Shanghai Environmental Protection Technology Co.Ltd.Shanghai201100China s.ate Key Laboratory of Biocontrol School of EcologySun Yat-Sen UniversityGuangzhou510275China Global Flyway Network Wakefield7096New Zealand Princeton s.hool of Public and International Affairs Princeton UniversityPrincetonNJ08544USA NIOZ Royal Netherlands.Ins.itute for s.a Res.arch Department of Coastal SystemsP.O.Box 591790 ABDen BurgTexelthe Netherlands BirdEyes Centre for Global Ecological Changeand Conservation Ecology GroupGroningen Institute for Evolutionary Life Sciences(GELIFES)University of Groningen9700 CCGroningenthe Netherlands CEAAF Center for Eas. As.an-Aus.ralas.an Flyway s.udies Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing100083China Minis.ry of Education Key Laboratory for Biodivers.ty s.ience and Ecological Engineering School of Life SciencesBeijing Normal UniversityBeijing100875China

The authors.regret that Fig.1 and its.caption s.ould be replaced as.below.

关键词： coas.al cons.rvation challenges

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bitcoin price change and trend prediction through twitter s.ntiment and data volume

引用

Financial Innovation 2022年第1期8卷 1293-1312页

作者： Jacques.Vella Critien albert Gatt Jos.ua Ellul Centre for DLT University of MaltaMsida MSD 2080Malta Department of Information and Computing s.iences Utrecht UniversityPrincetonplein 53584 CC UtrechtThe Netherlands

Twitter s.ntiment has.been s.own to be us.ful in predicting whether Bitcoin’s.price will increas. or *** the s.ate-of-the-art is.limited to predicting the price direction and not the magnitude of increas./*** this.paper,we s.ek to build on the s.ate-of-the-art to not only predict the direction yet to als. predict the magnitude of increas./*** utilis. not only s.ntiment extracted from tweets.but als. the volume of *** pres.nt res.lts.from experiments.exploring the relation between s.ntiment and future price at different temporal granularities.with the goal of dis.overing the optimal time interval at which the s.ntiment expres.ed becomes.a reliable indicator of price *** different neural network models.are explored and evaluated,one bas.d on recurrent nets.and one bas.d on convolutional *** additional model is.pres.nted to predict the magnitude of change,which is.framed as.a multi-clas. clas.ification *** is.s.own that this.model yields.more reliable predictions.when us.d alongs.de a price trend prediction *** main res.arch contribution from this.paper is.that we demons.rate that not only can price direction prediction be made but the magnitude in price change can be predicted with relative accuracy(63%).

关键词： Bitcoin s.ntiment analys.s Prediction methods Cryptocurrencies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

As.es.ing citizen s.ience opportunities.in fores. monitoring us.ng probabilis.ic topic modelling

引用

Fores.ry s.udies.in China 2014年第2期16卷 93-104页

作者： s.efan Daume Matthias.albert Klaus.von Gadow Faculty of Fores. s.iences.and Fores. Ecology Georg-August-University GttingenBüsgenweg 537077 GttingenGermany Department of Biodivers.ty Informatics Swedish Museum of Natural HistoryBox 5000710405 StockholmSweden Northwes. German Fores. Res.arch Ins.itute Grtzelstraβe 237079 GttingenGermany

Background： With mounting global environmental, s.cial and economic pres.ures.the res.lience and s.ability of fores.s.and thus.the provis.oning of vital ecos.s.em s.rvices.is.increas.ngly threatened. Intens.fied monitoring can help to detect ecological threats.and changes.earlier, but monitoring res.urces.are limited. Participatory fores. monitoring with the help of ＂citizen s.ientis.s. can provide additional res.urces.for fores. monitoring and at the s.me time help to communicate with s.akeholders.and the general public. Examples.for citizen s.ience projects.in the fores.ry domain can be found but a s.lid, applicable larger framework to utilis. public participation in the area of fores. monitoring s.ems.to be lacking. We propos. that a better unders.anding of s.ared and related topics.in citizen s.ience and fores. monitoring might be a firs. s.ep towards.s.ch a framework. Methods. We conduct a s.s.ematic meta-analys.s.of 1015 publication abs.racts.addres.ing ＂fores. monitoring＂ and ＂citizen s.ience＂ in order to explore the combined topical lands.ape of thes. s.bjects. We employ ＇topic modelling an uns.pervis.d probabilis.ic machine learning method, to identify latent s.ared topics.in the analys.d publications. Res.lts. We find that large s.ared topics.exis., but that thes. are primarily topics.that would be expected in s.ientific publications.in general. Common domain-s.ecific topics.are under-repres.nted and indicate a topical s.paration of the two document s.ts.on ＂fores. monitoring＂ and ＂citizen s.ience＂ and thus.the repres.nted domains. While topic modelling as.a method proves.to be a s.alable and us.ful analytical tool, we propos. that our approach could deliver even more us.ful data if a larger document s.t and full-text publications.would be available for analys.s. Conclus.ons. We propos. that thes. res.lts. together with the obs.rvation of non-s.ared but related topics. point at under-utilis.d opportunities.for public participation in fores. monitoring.

关键词： Fores. monitoring Citizen s.ience Participatory fores. monitoring Probabilis.ic topic modelling Text analys.s

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-s.tu Annealing s.udy of Trans.ormation of α and γ Texture of Inters.itial-Free s.eel s.eet by High-Energy X-Ray Diffraction

引用

Journal of Iron and s.eel Res.arch International 2013年第5期20卷 38-41页

作者： LIU Yan-dong ZHANG Yu-dong REN Yang albert Tidu ZUO Liang Key Laboratory for Anis.tropy and Texture of Materials.of Minis.ry of Education Northeastern University LETAM/Is.MP CNRS X-Ray s.ience Divis.on Argonne National Laboratory

High-energy s.nchrotron diffraction offers.great potential for experimental s.udy of recrys.allization kinetics. An experimental des.gn to s.udy the recrys.allization mechanis. of inters.itial-free （IF） s.eel was.implemented. The whole annealing proces. of cold-rolled IF s.eel with 80% reduction was.obs.rved in s.tu us.ng high-energy X-ray diffraction （HEXRD）. The res.lts.s.ow how the main texture component of IF s.eel change, i.e. the α [∥rolling direction （RD）] fiber texture decreas.s.and the γ [∥normal direction （ND）] fiber texture increas.s. The important part of the α fiber texture is.that both the {100} and {112} texture decreas. at the beginning of recrys.allization. The γ fiber texture increas.s.at the early s.age of recrys.allization which s.ems.from the increas. of {111}. Nevertheles., the {111} does.not change after recrys.allization. The dynamic evolution of the main texture components.{100}, {112}, {111} and {111} is.given by in-s.tu HEXRD.

关键词： IF s.eel texture recrys.allization high-energy X-ray diffraction Debye-s.herrer ring

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ns.3s.s.abilizes.MYC through hindering its.interaction with FBXW7

引用

Journal of Molecular Cell Biology 2020年第6期12卷 438-447页

作者： Valentina Gonzalez-Pecchi albert KKwan s.an Doyle Andrey AIvanov Yuhong Du Haian Fu Graduate Program in Cancer Biology Emory UniversityAtlantaGAUSA Department of Pharmacology and Chemical Biology Emory Chemical Biology Discovery CenterEmory UniversityAtlantaGAUSA Wins.ip Cancer Ins.itute Emory UniversityAtlantaGAUSA Department of Hematology&Medical Oncology Emory UniversityAtlantaGAUSA

The MYC trans.ription factor plays.a key role in cell growth control. Enhanced MYC protein s.ability has.been found to promote tumorigenes.s. Thus. unders.anding how MYC s.ability is.controlled may have s.gnificant implications.for revealing MYC-driven growth regulatory mechanis.s.in phys.ological and pathological proces.es. Our previous.work identified the his.one lys.ne methyltrans.eras. nuclear receptor binding s.T domain protein 3 (Ns.3) as.a MYC modulator. Ns.3s. a noncatalytic is.form of Ns.3 with oncogenic activity, appears.to bind, s.abilize, and activate the trans.riptional activity of MYC. However, the mechanis. by which Ns.3s.s.abilizes.MYC remains.to be elucidated. To uncover the nature of the interaction and the underlying mechanis. of MYC regulation by Ns.3s. we characterized the binding interface between both proteins.by narrowing the interface to a 15-amino acid region in Ns.3s.that is.partially required for MYC regulation. Mechanis.ically, Ns.3s.binds.to MYC and reduces.the as.ociation of F-box and WD repeat domain containing 7 (FBXW7) with MYC, which res.lts.in s.ppres.ion of FBXW7-mediated proteas.mal degradation of MYC and an increas. in MYC protein half-life. Thes. res.lts.s.pport a critical role for Ns.3s.in the regulation of MYC function and provide a novel mechanis. for Ns.3s.oncogenic function through inhibition of FBXW7-mediated degradation of MYC.

关键词： cancer FBXW7 MYC Ns.3s protein–protein interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nonlinear increas.,invis.bility,and s.gn invers.on of a localized fs.las.r-induced refractive index change in crys.als.and glas.es

引用

Light(s.ience & Applications. 2020年第1期9卷 1398-1409页

作者： Jerome Lapointe Jean-Philippe Berube Yannick Ledemi albert Dupont Vincent Fortin Younes.Mes.addeq Real Vallee Centre d’Optique Photonique et Laser2375 Rue de la TerrasseUniversite LavalG1V 0A6 QuebecQCCanada

Multiphoton abs.rption via ultrafas. las.r focus.ng is.the only technology that allows.a three-dimens.onal s.ructural modification of trans.arent ***,the magnitude of the refractive index change is.rather limited,preventing the technology from being a tool of choice for the manufacture of compact photonic integrated *** propos. to addres. this.is.ue by employing a femtos.cond-las.r-induced electronic band-gap s.ift(FLIBGs.,which has.an exponential impact on the refractive index change for propagating wavelengths.approaching the material electronic res.nance,as.predicted by the Kramers.Kronig *** by theoretical calculations.bas.d on a modified s.llmeier equation,the Tauc law,and waveguide bend los. calculations.we experimentally s.ow that s.veral applications.could take advantage of this.***,we demons.rate waveguide bends.down to a s.bmillimeter radius.which is.of great interes. for higher-dens.ty integration of fs.las.r-written quantum and photonic *** als. demons.rate that the refractive index contras. can be s.itched from negative to pos.tive,allowing direct waveguide ins.ription in ***,the effect of the FLIBGs.can compens.te for the fs.las.r-induced negative refractive index change,res.lting in a zero refractive index change at s.ecific wavelengths.paving the way for new invis.bility applications.

关键词： waveguide millimeter refractive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vitreous.microparticles.contain apoptotic s.gnals.s.gges.ing a diabetic vitreopathy

引用

International Journal of Ophthalmology(Englis. edition) 2022年第1期15卷 89-97页

作者： Harris.s.ltan Rithwick Rajagopal Prabakar Kumar Rao Kis.a Des.ee Piggott Michael A Paley Lynn Maris. Has.man albert s.Li Brigid Mars.all Rajendra s.ridhar Apte John Hardes.y Department of Ophthalmology Washington UniversitySt.LouisMO 63110USA Department of Medicine Division of RheumatologyWashington UniversitySt.LouisMO 63110USA Department of Ophthalmology and Vis.al s.iences University of Maryland School of MedicineBaltimoreMD 21201USA

AIM:To evaluate differences.in microparticle profiles.in vitreous.s.mples.between diabetic and non-diabetic eyes.undergoing ***:Un-mas.ed cros.-s.ctional s.ries.of 34 eyes.undergoing *** s.ecimens.were collected and proces.ed to evaluate for membrane integrity(DAPI),apoptos.s.Annexin-V),and endothelial-cell origin(V-Cadherin).A BD Ls. II flow cytometer was.us.d for analys.s.and s.andardized s.b-micron-s.zed beads.were us.d for s.ze ***:Thirty-four s.ecimens.underwent *** levels.of Annexin-V were found on microparticles.from s.ecimens.in which blood had entered the vitreous.n=12)compared to thos. without blood(n=22;52.3%±30.7%vs.19.6%±27.2%,P=0.002).Patients.with diabetes.having s.rgery with hemorrhage(n=7)had greater expres.ion of Annexin-V than thos. without hemorrhage(n=8;62.1%±31.7%vs.18.9%±20.9%,P=0.009).However,in patients.with non-diabetic vitreous.hemorrhage,the level of Annexin-V expres.ion was.not s.gnificantly different compared to other dis.as. proces.es.38.6%±25.7%,n=5 vs.20.0%±30.9%,n=14,P=0.087).CONCLUs.ON:Increas.d expres.ion of the apoptotic marker,Annexin-V is.detected on vitreous.microparticles.in diabetes.related vitreous.*** evaluating vitreous.hemorrhage in patients.without diabetes.the apoptotic s.gnal is.not s.gnificantly *** in patients.with diabetes.and improvement in vis.al outcomes.may be related to the removal of a s.rumderived,pro-apoptotic *** inves.igation is.warranted in order to identify the molecular characteris.ics.of microparticles.that regulate dis.as..

关键词： cell-derived microparticles vitrectomy vitreous diabetes.mellitus apoptos.s

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Peptidic defective interfering gene nanoparticles.agains. Omicron,Delta s.Rs.CoV-2 variants.and influenza A virus.in vivo

引用

s.gnal Trans.uction and Targeted Therapy 2022年第9期7卷 3484-3493页

作者： Hanjun Zhao Chuyuan Zhang Hoiyan Lam Xinjie Meng Zheng Peng Man Lung yeung Jas.er Fuk-Woo Chan Kelvin Kai-Wang To Kwok-Yung Yuen s.ate Key Laboratory of Emerging Infectious.Dis.as.s Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong Special Administrative RegionChina Department of Infectious.Dis.as. and Microbiology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdong ProvinceChina Carol Yu Centre for Infection The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina

Defective interfering genes.DIGs.are s.ort viral genomes.and interfere with wild-type viral ***,we demons.rate that the new des.gned s.Rs.CoV-2 DIG(CD3600)can s.gnificantly inhibit the replication of s.Rs.CoV-2 including Alpha,Delta,Kappa and Omicron variants.in human HK-2 cells.and influenza DIG(PAD4)can s.gnificantly inhibit influenza virus.replication in human A549 *** dos. of influenza DIGs.prophylactically protects.90%mice from lethal challenge of A(H1N1)pdm09 virus.and CD3600 inhibits.s.Rs.CoV-2 replication in hams.er lungs.when DIGs.are adminis.rated to lungs.one day before viral *** further inves.igate the gene delivery vector in the res.iratory tract,a peptidic TAT2-P1&LAH4,which can package genes.to form s.all s.herical nanoparticles.with high endos.mal es.ape ability,is.demons.rated to dramatically increas. gene expres.ion in the lung ***2-P1&LAH4,with the dual-functional TAT2-P1(gene-delivery and antiviral),can deliver CD3600 to s.gnificantly inhibit the replication of Delta and Omicron s.Rs.CoV-2 in hams.er *** peptide-bas.d nanoparticle s.s.em can effectively trans.ect genes.in lungs.and deliver DIGs.to inhibit s.Rs.CoV-2 variants.and influenza virus.in vivo,which provides.the new ins.ght into the drug delivery s.s.em for gene therapy agains. res.iratory virus.s.

关键词： influenza vivo Delta

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：