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The role of natural killer cells in the uterine microenvironment during pregnancy

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Cellular & Molecular Immunology 2018年第11期15卷 941-943页

作者： Julia P.Andreotti Ana E.Paiva Pedro H.D.M.Prazeres Daniel A.P.Guerra Walison N.Silva Rogerio S.Vaz akiva mintz Alexander Birbrair Department of Pathology Federal University of Minas GeraisBelo HorizonteMGBrazil Department of Biotechnology and Bioprocess Engineering Federal University of ParanaCuritibaPRBrazil Department of Radiology Columbia University Medical CenterNew YorkNYUSA

Pregnancy is a choreographed physiological phenomenon that involves maternal-fetal *** the cellular and molecular mechanisms involved in this communication will allow us to develop therapies for gestational *** is known about the role of natural killer(NK)cells in the uterine *** a recent study,Fu et al.(2017)used state-of-art technologies and showed that NK cells stimulate fetal growth via growth-promoting factors.

关键词： killer fetal uterine

A Blade Altering Toolbox for Automating Rotor Design Optimization

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Communications on Applied Mathematics and Computation 2024年第1期6卷 688-704页

作者： akiva Wernick Jen-Ping Chen Mechanical and Aerospace Engineering The Ohio State University201 W.19th Ave.ColumbusOH43210USA

The Blade Altering Toolbox(BAT)described in this paper is a tool designed for fast reconstruction of an altered blade geometry for design optimization *** BAT algorithm is capable of twisting a given rotor’s angle of attack and stretching the chord length along the span of the *** test cases were run using the BAT’s *** BAT code’s twisting,stretching,and mesh reconstruction capabilities proved to be able to handle reasonably large geometric alterations to a provided input rotor *** test examples showed that the toolbox’s algorithm could handle any stretching of the blade’s chord as long as the blade remained within the original bounds of the unaltered *** algorithm appears to fail when the net twist angle applied the geometry exceeds approximately 30 degrees,however this limitation is dependent on the initial geometry and other input ***,the algorithm is a very powerful tool for automating a design optimization procedure.

关键词： Mesh reconstruction Mesh alteration Rotor alteration Design optimization

Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm Edwin J.Yoo Ariel Isser Vivek P.Jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan P.Schneck Jordan J.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

Towards Disaggregate Dynamic Travel Forecasting Models

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Tsinghua Science and Technology 2007年第2期12卷 115-130页

作者： Moshe Ben-akiva Jon Bottom Song Gao Haris N. Koutsopoulos Yang Wen Massachusetts Institute of Technology 77 Massachusetts Avenue Room 1-181 Cambridge MA 02139 USA CRA International 200 Clarendon Street T-33 Boston MA 02116 USA Caliper Corporation 1172 Beacon Street Newton MA 02461 USA Northeastern University 437 Snell Engineering Center Boston MA 02115 USA

The authors argue that travel forecasting models should be dynamic and disaggregate in their representation of demand, supply, and supply-demand interactions, and propose a framework for such models. The proposed framework consists of disaggregate activity-based representation of travel choices of individual motorists on the demand side integrated with disaggregate dynamic modeling of network performance, through vehicle-based traffic simulation models on the supply side. The demand model generates individual members of the population and assigns to them socioeconomic characteristics. The generated motorists maintain these characteristics when they are loaded on the network by the supply model. In an equilibrium setting, the framework lends itself to a fixed-point formulation to represent and resolve demand-supply interactions. The paper discusses some of the remaining development challenges and presents an example of an existing travel forecasting model system that incorporates many of the proposed elements.

关键词： disaggregate dynamic travel forecasting

Sustainability and Its Constraints in the Global Tourist Industry： Exploring the Dark Side in the Growth of International Tourism

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Journal of Tourism and Hospitality Management 2014年第5期2卷 183-197页

作者： Keith akiva Lehrer York University Toronto Canada

This paper provides a brief overview of three problematic aspects of the trend towards globalization in the tourist industry： sex tourism, exploitation of minors, and environmental degradation in both the physical and social environments. This paper draws on the experience of fast-expanding tourist centres in Central America, in addition to worldwide compilations of published data. It suggests that underlying the specific problems of each of these three major aspects of globalized tourism, there exists a deeper malaise： its potential contribution to a deeper rift between ＂haves＂ and ＂have-nots＂. Income inequality has clearly always existed; however, the awareness of such inequality may spread through the globalizing nature of intemational tourism. Such consciousness may lead to increasing resentment, despite the injection of tourist income into the local economy. One-way exploitation is thus distinguished from mutual exploitation, and in that context, ＂gringoitis＂ and social degradation are discussed. The possibility is explored that growth in global tourism is ultimately beneficial. However, the dark side of that growth needs further exposure. That is the aim of this paper.

关键词： historical perspective sex tourism child exploitation mutual exploitation environmental degradation "gringoitis" consumer homogenization

Integration of Electrical Resistivity and Electromagnetic Radiation Methods for Fracture Flow System Detection

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International Journal of Geosciences 2014年第8期5卷 863-875页

作者： Jawad Hasan Shoqeir Heinz Hoetzl akiva Flexer Department of Applied Geology KIT Karlsruhe Germany Department of Earth and Environmental Sciences Al-Quds University Jerusalem Palestine Department of Geophysics and Planetary Sciences Tel Aviv University Ramat-Aviv Israel

An electrical resistivity and electromagnetic emission survey was carried out involving the use of vertical electrical soundings (VES) and natural pulse electromagnetic field of the earth (NPEMFE). The use of this new methodology managed to detect the fracture flow system rupture zones in the underground, also answered the questions about the deferent subsurface water bodies. The present study focuses on Marsaba-Feshcha sub-basin in the northeast of the Dead Sea. Due to the scarcity of boreholes in the study area, several geophysical methods were implanted. The combination of these two methods (VES and NPEMFE) with the field observations and East-West transversal faults with the coordination (624437/242888) was determined, cutting through the anticlines with their mainly impervious cores with fracture length of >400 m. These transversal faults saddle inside Nabi Musa syncline (Boqea syncline), leading to a hydraulic connection between the Lower and the Upper Aquifer. Due to the identified transversal fault, the water of the Upper and Lower Aquifer mixed and emerged as springs at Ein Feshcha group.

关键词： Vertical Electric Sounding Transversal Faults Boqea Syncline Rupture Zones Fracture Flow

Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery

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Bioactive Materials 2022年第8期7卷 152-168页

作者： Patrick Rider Zeljka Peric Kacarevic akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Emely Bortel Bernhard Hesse Frank Witte Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitatsmedizin BerlinAßmannshauser Straße 4-614197BerlinGermany Botiss Biomaterials AG Ullsteinstrasse 10812109BerlinGermany Department of Anatomy Histology EmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthUniversity of OsijekOsijek31000Croatia CMF Surgery Johannes BLA HospitalMonchengladbachGermany Dental Clinic University of StrasbourgFrance Department of Periodontology Semmelweis UniversityBudapestHungary Xploraytion GmbH Bismarkstrasse 11BerlinGermany Biotrics Bioimplants AG Ullsteinstrasse 10812109BerlinGermany

Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as *** collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second ***,biodegradable GBR membranes made of pure magnesium might be an *** this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological *** implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft *** the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect *** the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier *** the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new *** the membrane had completely resorbed,only healthy tissue *** in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen ***,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment.

关键词： Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing

Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration

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Bioactive Materials 2022年第8期7卷 15-30页

作者： Zeljka Peric Kacarevic Patrick Rider akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Till Kammerer Bernhard Hesse Emely Bortel Marco Bartosch Frank Witte Department of Anatomy Histology EmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthUniversity of OsijekOsijek31000Croatia Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitatsmedizin BerlinAßmannshauser Straße 4–614197BerlinGermany Botiss Biomaterials AG Ullsteinstrasse 10812109BerlinGermany CMF Surgery Johannes BLA HospitalMonchengladbachGermany Dental Clinic University of StrasbourgFrance Department of Periodontology Semmelweis UniversityBudapestHungary Xploraytion GmbH Bismarkstrasse 11BerlinGermany University Hospital Munich Department of Dermatology and AllergyFrauenlobstr.9-1180337MunichGermany Biotrics Bioimplants AG Ullsteinstrasse 10812109BerlinGermany

An ideal fixation system for guided bone(GBR)regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation,complete resorption when no longer needed,complete replacement by bone,as well as be biocompatible and have a good clinical *** the first time,a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these *** mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable *** demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of *** of the magnesium fixation screw was demonstrated in several in vitro and in vivo *** of the magnesium screw was investigated in in vitro and in vivo tests,where it was found that the screw is resorbed slowly and completely after 52 weeks,providing adequate fixation in the early critical healing ***,the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration(GBR)surgeries.

关键词： Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing

Surgicel Induced Intraoperative Cardiovascular Collapse in a Child with Midbrain Glioma

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Case Reports in Clinical Medicine 2015年第1期4卷 36-40页

作者： Evgeni Brotfain akiva Korn Micky Gidon Alexander Zlotnik Moti Klein Israel Melamed Department of Anesthesiology and Critical Care General Intensive Care Unit Soroka Medical Center Ben-Gurion University of the Negev Beer Sheva Israel Surgical Monitoring Service Ltd. Jerusalem Israel Department of Neurosurgery Soroka Medical Center Ben-Gurion University of the Negev Beer Sheva Israel

Introduction: Intraoperative cardiovascular complications were previously demonstrated in relation to high sympathetic nervous system outflow or stimulation of the vagal nerve nucleus during theneurosurgical procedures on brain tumors. Main Symptoms and Important Clinical Findings: We are presenting clinical case of 13-year-old girl who suffered from midbrain glioma and developed life threatening cardiovascular events during neurosurgical procedure after surgicel hemostatic agent application. Therapeutic Interventions and Outcomes: Cardiovascular stability has been restored after immediate removal of surgicel from the operating field. We believe that it might be related to direct application of the surgicel hemostatic agent.

关键词： Thalamic Glioma Pediatric Neurosurgery Cardiovascular Collapse Surgicel-Induced Hypotension Extracellular Acidosis