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A review on valorization of different byproducts of mango(Mangifera indica L.)for functional food and human health

Food Bioscience 2022年第4期48卷 665-692页

作者： Alok kumar Gupta Pawan Singh Gurjar Karma Beer Alemwati Pongener S.C.Ravi Smita Singh Anil verma Abha Singh Mamta Thakur Soubhagya Tripathy Deepak kumar verma Division of Post-harvest Management ICAR-Central Institute for Subtropical Horticulture(Ministry of Agriculture and Farmers WelfareGovernment.of India)LucknowUP226101India ICAR-Central Institute for Arid Horticulture BikanerRajasthanIndia ICAR-Indian Agricultural Research Institute AssamIndia Department of Nutrition and Dietetics University Institute of Applied Health SciencesChandigarh UniversityChandigarh140413PunjabIndia Department of Food Technology School of SciencesITM UniversityGwalior474001Madhya PradeshIndia Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpur721302West BengalIndia

Mango(Mangifera indica)is one of the most popular fruits in the *** processing,the byproducts such as peel,seed and kernel are produced,which are high in bioactive *** is a need to utilize them to formulate food products or extract the functional *** paper provides an overview about the nutritional composition of mango byproducts besides discussing the bioactive compounds(BACs).The manuscript also explores the existing evidences on the biological activity of BACs and the potential of mango peel and seed kernel to develop value-added foods and *** kernel is a great source of macronutrients and micronutrients with a relatively high antioxidant and polyphenolic content,whereas mango peels are rich in protocatechuic acids,mangiferin andβ-*** BACs demonstrate numerous biological activities including anti-oxidant antimicrobial,anti-diabetic,anti-cancer and anti-inflammatory *** of the promising strategies to utilize these byproducts is the development of different value-added food products such as bakery products,meat products,and dairy-based products for improving their phenolic compounds,fiber content,carotenoids,and antioxidant *** review thus illustrates the nutraceutical and pharmacological properties of mango byproducts and their appropriate use to enhance nutrition and health.

关键词： Mango peel and kernel Nutritional composition Bioactive compounds Flavonoids Mangiferin Carotenoids Food utilization Biological properties

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Study of morphologic variability of incudostapedial angle and its relation with temporal bone pneumatization

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Journal of Otology 2020年第2期15卷 50-53页

作者： Anup Singh David Victor kumar Irugu Rajeev kumar Hitesh verma Anandita Gupta Abha kumari Department of Otorhinolaryngology and Head and Neck Surgery All India Institute of Medical SciencesNew Delhi110029India Department of Otorhinolaryngology and Head and Neck Surgery Army College of Medical SciencesBase Hospital Delhi CantonmentKotwali RoadNew Delhi110010India Department of Otorhinolaryngology Command HospitalKolkata700027India

Introduction:Optimal sound transmission across the ossicular chain is dependent on the appropriate alignment of the middle ear *** joint(ISJ)is conventionally considered to be at right ***:We intended to study the ISJ anatomy and the impact of temporal bone pneumatization on the ***:In a cadaveric study comprising of 47 human temporal bones,canal wall down mastoidectomy was carried out under microscopic guidance keeping the ossicular chain *** morphology of ISJ was recorded and analysed with respect to the pneumatization status of the temporal *** data analysis was performed using statistical software Stata version ***:The mean ISJ angle for the 47 bones was 90.5^0(SD-15^0;range:54^0-122^0).The mean angle in well pneumatized bones was 93.7^0(SD-16.5;Range:54°-122^0)and in sclerotic mastoids was 88.7^0(SD-14;Range:68°-118^0).The difference in the ISJ angle in these two conditions was not statistically significant(p=0.27).The mean angle was found to be significantly more obtuse in the cases with partially eroded ISJ(111.4^0{SD-8.8;range:100.3^0-221.9^0};p=0.0001)and in the cases with an‘adherent/tilted morphology’of the stapes suprastructure with the promontory(mean-95.8^0(SD-13.8;range:70.7^0-120.4^0);p-<0.00001).Conclusion:The ISJ angle shows considerable *** variability needs to be taken into account when undertaking middle ear reconstructive procedures,specifically the ones involving the stapes *** mastoid pneumatization does not appear to have an impact on the ISJ angle.

关键词： Human Ear ossicles Anatomic variation Stapes surgery

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Secure Rotation Invariant Face Detection System for Authentication

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Computers, Materials & Continua 2022年第1期70卷 1955-1974页

作者： Amit verma Mohammed Baljon Shailendra Mishra Iqbaldeep Kaur Ritika Saini Sharad Saxena Sanjay kumar Sharma Department of Computer Science&Engineering Chandigarh Group of CollegesMohali140317India Department of Computer Engineering College of Computer&Information ScienceMajmaah University11952Saudi Arabia Department of Computer Science and Engineering Thapar Institute of Engineering&TechnologyPatiala147004India Department of Computer Centre&Campus Network Facility Science Complex PO Central UniversityGachibowliHyderabad500046TelanganaIndia

Biometric applications widely use the face as a component for recognition and automatic *** rotation is a variable component and makes face detection a complex and challenging task with varied angles and *** problem has been investigated,and a novice algorithm,namely RIFDS(Rotation Invariant Face Detection System),has been *** objective of the paper is to implement a robust method for face detection taken at various *** to achieve better results than known algorithms for face *** RIFDS Polar Harmonic Transforms(PHT)technique is combined with Multi-Block Local Binary Pattern(MBLBP)in a hybrid *** MBLBP is used to extract texture patterns from the digital image,and the PHT is used to manage invariant rotation *** this manner,RIFDS can detect human faces at different rotations and with different facial *** RIFDS performance is validated on different face databases like LFW,ORL,CMU,MIT-CBCL,JAFFF Face Databases,and Lena *** results show that the RIFDS algorithm can detect faces at varying angles and at different image resolutions and with an accuracy of 99.9%.The RIFDS algorithm outperforms previous methods like Viola-Jones,Multi-blockLocal Binary Pattern(MBLBP),and Polar HarmonicTransforms(PHTs).The RIFDS approach has a further scope with a genetic algorithm to detect faces(approximation)even from shadows.

关键词： Pose variations face detection frontal faces facial expressions emotions

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Targeting biosignatures of hyperglycemia and oxidative stress in diabetes comorbid depressive rats: effectiveness of hydroethanolic extract of the whole plant of Ludwigia octovalvis

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Traditional Medicine Research 2023年第2期8卷 13-20页

作者： Stuti Pandey Pawan kumar Pandey Alakh Niranjan Sahu Himanshu verma Manmath kumar Nandi Department of Medicinal Chemistry Faculty of AyurvedaInstitute of Medical SciencesBanaras Hindu UniversityVaranasi 221005Uttar PradeshIndia Department of Pharmaceutical Engineering&Technology Indian Institute of Technology Banaras Hindu UniversityVaranasi 221005Uttar PradeshIndia

Background:The prime objective of the current research was to evaluate the whole plant hydroalcoholic extract of Ludwigia octovalvis(HLO)against hyperglycemia,and oxidative stress biomarkers in rats induced with diabetes comorbid depression,diabetes comorbid depression(streptozotocin-nicotinamide+electric footshocks).Methods:2,2-Diphenyl-1-picrylhydrazyl assay of HLO versus ascorbic acid was *** of 200 and 400 mg/kg body weight/day HLO doses versus 25 mg/kg body weight/day metformin was studied through insulin,glucose,superoxide dismutase,lipid peroxidation,catalase,and behavioral assessment(forced swim and open field tests).Results:IC50 values of HLO and ascorbic acid were 33.52 and 27.86μg/mL *** the HLO doses showed intended results with respect to oxidative stress biomarkers in diabetes comorbid depression rats in comparison to *** field test showed better results for HLO in diabetes comorbid depression ***,hypoglycemic effects,and forced swim test performance of metformin was slightly higher than the 400 mg dose,followed by the 200 mg dose of *** gallate,gallic acid,β-sitosterol,and quercetin in HLO might resulted in attenuating diabetic as well as depression ***:Inhibition of glucosidase and lipase activity,and AMP-activated protein kinase phosphorylation might be the possible biochemical changes occurred in HLO treated rats.

关键词： 2,2-diphenyl-1-picrylhydrazyl assay brain homogenate insulin superoxide dismutase content catalase activity lipid peroxidation

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Use of hydroxychloroquine and azithromycin combination to treat the COVID-19 infection

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World Journal of Experimental Medicine 2022年第3期12卷 44-52页

作者： Jyoti Bajpai Akshyaya Pradhan Ajay kumar verma Surya Kant Department of Respiratory Medicine King George's Medical UniversityLukcnowLucknow 226003Uttar PradeshIndia Department of Cardiology King George's Medical UniversityLukcnowLucknow 226003Uttar PradeshIndia Department of Respiratory Medicine King George Medical UniversityLucknow 226003Uttar PradeshIndia

Coronavirus disease 2019(COVID-19)infection is unequivocally the worst crisis in recent decades,which is caused by a severe acute respiratory virus ***,there is no effective therapy for the COVID-19 *** countries have different guidelines for treating COVID-19 in the absence of an approved therapy for ***,there is an imminent need to identify effective treatments,and several clinical trials have been conducted *** hydroxychloroquine[HCQS],chloroquine,and azithromycin(AZ)have been widely used for management based on in vitro studies favoring antiviral effects against the COVID-19 ***,there is evidence both in favor and against the use of hydroxychloroquine and azithromycin(HCQS+AZ)combination therapy to manage the COVID-19 *** combination of hydroxychloroquine and azithromycin was significantly associated with increased adverse ***,the inference of these findings was from observational ***,large randomized trials are imperative to show the future path for the use of HCQS+AZ combination ***,owing to the ban on HCQS use in COVID-19,this may no longer be *** review is on the pharmacology,trials,regimens,and side effects of hydroxychloroquine and azithromycin combination therapy.

关键词： Hydroxychloroquine Azithromycin Antiviral effects QT interval Randomized controlled trial

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Spontaneous closure of stoma

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Gastroenterology Report 2016年第4期4卷 325-327,I0003页

作者： Narendra Pandit Harjeet Singh Hemanth kumar Rajesh Gupta G.R.verma Division of Surgical Gastroenterology Department of General Surgery Post Graduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia

Intestinal loop stoma is a common surgical procedure performed for various benign and malignant abdominal problems,but it rarely undergoes spontaneous closure,without surgical *** male patients presented to our emergency surgical department with acute abdominal *** of them was diagnosed as having rectosigmoid perforation and underwent diversion sigmoid loop colostomy after primary closure of the *** other was a known case of carcinoma of the rectum who had already undergone low anterior resection with covering loop ileostomy;the patient underwent second loop ileostomy,this time for complicated intestinal *** our surprise,both the loop colostomy and ileostomy closed spontaneously at 8 weeks and 6 weeks,respectively,without any *** stoma closure is a rare and interesting *** exact etiology for spontaneous closure remains unknown,but it may be hypothesized to result from slow retraction of the stoma,added to the concept of a tendency towards spontaneous closure of enterocutaneous fistula.

关键词： ileostomy colostomy spontaneous closure of stoma

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Liver dysfunction during COVID-19 pandemic:Contributing role of associated factors in disease progression and severity

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World Journal of Hepatology 2022年第6期14卷 1099-1110页

作者： Tarun Sahu Babita Pande Manasa PL Henu kumar verma Department of Physiology All India Institute of Medical SciencesRaipur 492001ChhattisgarhIndia Center for Basic Sciences Pt.Ravishankar Shukla UniversityRaipur 492001ChhattisgarhIndia Department of Immunopathology Institute of Lungs Health and ImmunityMunich 85764BavariaGermany

In December 2019,a new strain of coronavirus was discovered in China,and the World Health Organization declared it a pandemic in March *** majority of people with coronavirus disease 19(COVID-19)exhibit no or only mild symptoms such as fever,cough,anosmia,and ***,approximately 15%develop a severe lung infection over the course of 10 d,resulting in respiratory failure,which can lead to multi-organ failure,coagulopathy,and *** the beginning of the pandemic,it appears that there has been consideration that preexisting chronic liver disease may predispose to deprived consequences in conjunction with ***,extensive liver damage has been linked to immune dysfunction and coagulopathy,which leads to a more severe COVID-19 *** that,people with COVID-19 frequently have abnormal liver function,with more significant elevations in alanine aminotransferase and aspartate aminotransferase in patients with severe COVID-19 compared to those with mild/moderate *** review focuses on the pathogenesis of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection in the liver,as well as the use of liver chemistry as a prognostic tool during *** also evaluate the findings for viral infection of hepatocytes,and look into the potential mechanisms behind SARS-CoV-2-related liver damage.

关键词： SARS-CoV-2 COVID-19 Liver function Hepatic injury Viral infection

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A review on synthesis of graphene,h-BN and MoS2 for energy storage applications:Recent progress and perspectives

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Nano Research 2019年第11期12卷 2655-2694页

作者： Rajesh kumar Sumanta Sahoo Ednan Joanni Rajesh kumar Singh Ram Manohar Yadav Rajiv kumar verma Dinesh Pratap Singh Wai Kian Tan Angel Perez del Pino Stanislav A.Moshkalev Atsunori Matsuda Department of Eletrical and Electronic Information Engineering Toyohashi University of Technologys1-1 HibarigaokaTempaku-chaToyohashiAichi 441-8580Japan Department of Applied Chemistry Indian Institute of Technology(ISM) Dhanbad826004JharkhandIndia Centre for Information Technology Renato Archer(CTI) Campinas 13069-901Brazil School of Physical and Material Sciences Central University of Himachal Pradesh(CUHP)KangraDharamshala 176215HR India Department of Plhysics VSSD CollegeKanpur 208002India International College Osaka University1-2 MachikaneyamachoToyonaka shiOsaka 560-0043Japan Department of Physics and Milermium Institute for Research in Optics(MIRO) University of SantiagoAvenida Ecuador 3493Estacion CentralSantiago 9170124Chile Institute of Liberal Arts and Sciences Toyohashi University of Technology1-1 HibarigaokaTempaku choToyohashiAichi 441-8580 Japan Instituto de Ciencia de Materiales de Barcelona Consejo Superior de Irvestigaciones Cientificas(ICMAB-CSIC)Campus UABBllaterra08193 BarcelonaSpain Centre for Semiconductor Components and Nanotechnology(CCS Nano) Uniersity of Campinas(UNICAMP)Campinas 13083-870Brazil

The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent over the last few years due to their extraordinary *** this review article we study the current progress and selected challenges in the syntheses of graphene,h-BN and MoS2 including energy storage applications as supercapacitors and *** substrates/catalysts(metals/insulator/semiconducting)have been used to obtain graphene,h-BN and MoS2 using different kinds of *** most widespread methods for synthesis of graphene,h-BN and MoS2 layers are chemical vapor deposition(CVD),plasma-enhanced CVD,hydro/solvothermal methods,liquid phase exfoliation,physical methods *** research has shown that graphene,h-BN and MoS2 layered materials modified with metal oxide can have an insightful influence on the performance of energy storage devices as supercapacitors and *** review article also contains the discussion on the opportunities and perspectives of these materials(graphene,h-BN and MoS2)in the energy storage *** expect that this witen review article including recent research on energy storage will help in generating new insights for further development and practical applications of graphene,h-BN and MoS2 layers based materials.

关键词： graphene norganic layered materials hierarchical structures energy storage supercapacitor battery

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Role of prostate cancer stem-like cells in the development of antiandrogen resistance

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Cancer Drug Resistance 2022年第2期5卷 459-471页

作者： Prem Prakash Kushwaha Shiv verma Shashank kumar Sanjay Gupta Department of Urology Case Western Reserve UniversityClevelandOH 44106USA. The Urology Institute University Hospitals Cleveland Medical CenterClevelandOH 44106USA. Molecular Signaling and Drug Discovery Laboratory Department of BiochemistryCentral University of PunjabBathinda 151401India. Department of Pathology Case Western Reserve UniversityClevelandOH 44106USA. Department of Pharmacology Case Western Reserve UniversityClevelandOH 44106USA. Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA. Divison of General Medical Sciences Case Comprehensive Cancer CenterClevelandOH 44106USA.

Androgen deprivation therapy(ADT)is the standard of care treatment for advance stage prostate *** with ADT develops resistance in multiple ways leading to the development of castration-resistant prostate cancer(CRPC).Present research establishes that prostate cancer stem-like cells(CSCs)play a central role in the development of treatment resistance followed by disease *** CSCs are capable of self-renewal,differentiation,and regenerating tumor *** stemness properties in prostate CSCs arise due to various factors such as androgen receptor mutation and variants,epigenetic and genetic modifications leading to alteration in the tumor microenvironment,changes in ATP-binding cassette(ABC)transporters,and adaptations in molecular signaling *** reprograms prostate tumor cellular machinery leading to the expression of various stem cell markers such as Aldehyde Dehydrogenase 1 Family Member A1(ALDH1A1),Prominin 1(PROM1/CD133),Indian blood group(CD44),SRY-Box Transcription Factor 2(Sox2),POU Class 5 Homeobox 1(POU5F1/Oct4),Nanog and ABC *** markers indicate enhanced self-renewal and stemness stimulating CRPC evolution,metastatic colonization,and resistance to *** this review,we discuss the role of ADT in prostate CSCs differentiation and acquisition of CRPC,their isolation,identification and characterization,as well as the factors and pathways contributing to CSCs expansion and therapeutic opportunities.

关键词： Prostate cancer second-generation antiandrogens cancer stem cells castration resistance prostate cancer androgen deprivation therapy

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Herbal antioxidant in clinical practice:A review

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Asian Pacific Journal of Tropical Biomedicine 2014年第1期4卷 78-84页

作者： Shashi Alok Sanjay kumar Jain Amita verma Mayank kumar Alok Mahor Monika Sabharwal Institute Of Pharmacy Bundelkhand University Department of Pharmaceutical Sciences Faculty of Health SciencesSam Higginbottom Institute of AgricultureTechnology and Sciences-DeemedUniversity Society of Pharmaceutical Sciences and Research

Antioxidant-the word itself is *** the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called"free-radical"reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging *** must acknowledge that such"radicals"have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and *** strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and *** paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall *** is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell *** evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totally

关键词： Antioxidant Carotenoid Free-radical Herb

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