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Extracellular vesicles as tools and targets in therapy for diseases

Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.Baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir ajaz a.bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

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Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy

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Cancer Communications 2022年第8期42卷 689-715页

作者： ajaz a.bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha Laboratory of Molecular and Metabolic Imaging Cancer Research DepartmentSidra MedicineDoha 26999Qatar Department of Medical Oncology Dr.B.R.Ambedkar Institute Rotary Cancer HospitalAll India Institute of Medical Sciences(AIIMS)New Delhi 110029India Department of Biotechnology School of Life SciencesCentral University of KashmirGanderbalJammu&Kashmir 191201India Division of Translational Medicine Research BranchSidra MedicineDoha 26999Qatar Genomics Core Facility QBRIQatar FoundationDoha 34110Qatar Department of Pathology Sher-I-Kashmir Institute of Medical SciencesSrinagarJammu&Kashmir 190011India Department of Diagnostic Imaging St.Jude Children’s Research HospitalMemphisTN 38105USA Center for Advanced Metabolic Imaging in Precision Medicine Department of RadiologyPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA Academic Health System Hamad Medical CorporationDoha 3050Qatar Translational Research Institute Hamad Medical CorporationDoha 3050Qatar Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE 68198USA Laboratory Animal Research Center Qatar UniversityDoha 2713Qatar Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaJammu&Kashmir 192122India

Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of *** inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth *** complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease *** evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive *** cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for ***,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC *** also outlined the potential of this crosstalk as a novel therapeutic target for *** major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review.

关键词： chemokine colorectal cancer cytokine drug resistance epithelial-mesenchymal transition immunosuppression immunotherapy inflammation metastasis tumor microenvironment

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Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

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Signal Transduction and Targeted Therapy 2021年第2期6卷 324-338页

作者： ajaz a.bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael EI-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha Functional and Molecular Imaging Laboratory Cancer Research DepartmentSidra MedicineDohaQatar Department of Zoology School of Life SciencesCentral University of KashmirGanderbalJammu&KashmirIndia Department of Nephrology All India Institute of Medical SciencesNew DelhiIndia Department of Biochemistry All India Institute of Medical SciencesNew DelhiIndia Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaJammu&KashmirIndia Laboratory of Cancer Immunogenomics Cancer Research DepartmentSidra MedicineDohaQatar Department of Surgery University of MiamiMiamiFLUSA Academic Health System Hamad Medical CorporationDohaQatar Department of Biochemisty and Molecular Biology University of Nebraska Medical CenterOmahaNEUSA Eppley Institute for Research in Cancer and Alied Diseases University of Nebraska Medical CenterOmahaNEUSA Buffet Cancer Center University of Nebraska Medical CenterOmahaNEUSA Laboratory Animal Research Center Qatar UniversityDohaQatar

Head and neck squamous cell carcinoma(HNSCC)is a very aggressive disease with a poor prognosis for advanced-stage *** clinical,genomic,and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of *** signifcant advances in multimodal therapeutic interventions,failure to cure and recurrence are common and account for most *** is becoming increasingly apparent that tumor microenvironment(TME)plays a critical role in HNSCC tumorigenesis,promotes the evolution of aggressive tumors and resistance to therapy,and thereby adversely affects the prognosis.A complete understanding of the TME factors,together with the highly complex tumor-stromal interactions,can lead to new therapeutic interventions in ***,different molecular and immune landscapes between HPV^(+ve) and HPV^(-ve)(human papillomavirus)HNSCC tumors offer new opportunities for developing individualized,targeted chemoimmunotherapy(CIT)*** review highlights the current understanding of the complexity between HPV^(+ve) and HPV^(-ve) HNSCC TME and various tumor-stromal cross-talk modulating processes,including epithelial-mesenchymal transition(EMT),anoikis resistance,angiogenesis,immune surveillance,metastatic niche,therapeutic resistance,and development of an aggressive tumor ***,we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV^(+ve) and HPV^(-ve) HNSCC.

关键词： targeted squamous thereby

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Multiplicity dependence of the freezeout parameters in high energy hadron-hadron collisions

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Chinese Physics C 2024年第5期48卷 124-133页

作者： Muhammad ajaz Majid Shehzad Muhammad Waqas Haifa I.Alrebdi Mohammad Ayaz Ahmad Antalov Jagnandan Shawn Jagnandan Murad Badshah Jalal Hasan Baker Abdul Mosawir Quraishi Department of Physics Abdul Wali Khan University MardanMardan 23200Pakistan School of Mathematics Physics and Optoelectronic EngineeringHubei University of Automotive TechnologyShiyan 442002China Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Mathematics Physics and StatisticsFaculty of Natural SciencesUniversity of Guyana101110 GeorgetownGuyananSouth America Department of Physics Faculty of ScienceUniversity of TabukTabukKingdom of Saudi Arabia Department of Electrical Engineering College of EngineeringQassim UniversityUnaizahSaudi Arabia

We examined the transverse momentum(pT)spectra of various identified particles,encompassing both light-flavored and strange hadrons(π++π−,K++K−,p+p¯,ϕ,K0s,Λ+Λ¯,Ξ−+Ξ¯+,andΩ−+Ω¯+),across different multiplicity classes in proton-proton collisions(p-p)at a center-of-mass energy of s√=7 *** the Tsallis and Hagedorn models,parameters relevant to the bulk properties of nuclear matter were *** models exhibit good agreement with experimental *** our analyses,we observed a consistent decrease in the effective temperature(T)for the Tsallis model and the kinetic or thermal freeze-out temperature(T0)for the Hagedorn model,as we transitioned from higher multiplicity(class-I)to lower multiplicity(class-X).This trend is attributed to the diminished energy transfer in higher multiplicity ***,we observed that the transverse flow velocity(βT)experiences a decline from class-I to *** normalization constant,which represents the multiplicity of produced particles,was observed to decrease as we moved toward higher multiplicity *** the effective and kinetic freeze-out temperatures,as well as the transverse flow velocity,show a mild dependency on multiplicity for lighter particles,this dependency becomes more pronounced for heavier *** multiplicity parameter for heavier particles was observed to be smaller than that of lighter particles,indicating a greater abundance of lighter hadrons compared to heavier *** particle species were observed to undergo decoupling from the fireball at distinct temperatures:lighter particles exhibit lower temperatures,while heavier ones show higher temperatures,thereby supporting the concept of multiple freeze-out ***,we identified a positive correlation between the kinetic freeze-out temperature and transverse flow velocity,a scenario where particles experience stronger collective motion at a higher freeze-out *** reason for this positive correlation is th

关键词： multiplicity dependence collective properties thermal energy

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Correction: Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

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Signal Transduction and Targeted Therapy 2021年第3期6卷 1069-1069页

作者： ajaz a.bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael El-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha Functional and Molecular Imaging Laboratory Cancer Research Department Sidra Medicine Doha Qatar Department of Zoology School of Life Sciences Central University of Kashmir Ganderbal Jammu & Kashmir India Department of Biotechnology School of Life Sciences Central University of Kashmir Ganderbal Jammu & Kashmir India Department of Nephrology All India Institute of Medical Sciences New Delhi India Department of Biochemistry All India Institute of Medical Sciences New Delhi India Watson-Crick Centre for Molecular Medicine Islamic University of Science and Technology Awantipora Jammu & Kashmir India Laboratory of Cancer Immunogenomics Cancer Research Department Sidra Medicine Doha Qatar Department of Surgery University of Miami Miami FL USA Academic Health System Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Biology University of Nebraska Medical Center Omaha NE USA Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center Omaha NE USA Buffett Cancer Center University of Nebraska Medical Center Omaha NE USA Laboratory Animal Research Center Qatar University Doha Qatar

Correction to:Signal Transduction and Targeted Therapy https://***/10.1038/s41392-020-00419-w,published online 12 January 2021 After online publication of the article1,the authors noticed an error in affiliation of co-authors *** *** is erroneously linked to Sidra Medicine,Doha,Qatar who is actually working at the Department of Biotechnology,School of Life Sciences,Central University of Kashmir,Ganderbal,Jammu&Kashmir,***,the department name"Cancer Research Department"for the first author ajaz *** is missing.

关键词： Cancer squamous targeted

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Enhanced photocatalytic degradation of organic dyes from aqueous environment using neodymium-doped mesoporous layered double hydroxide

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Journal of Rare Earths 2022年第10期40卷 1554-1563页

作者： ajaz Ahmad Wani Amjad Mumtaz Khan Yahiya Kadaf Manea Mansour A.S.Salem Department of Chemistry Aligarh Muslim UniversityAMUAligarh202002India

Neodymium-doped Zn-Al layered double hydroxide(Nd/Zn-Al LDH) with excellent photocatalytic activity was prepared by a one-step hydrothermal method. The morphology and physicochemical properties of as-synthesized photocatalysts were well analyzed by Fourier transform infrared(FT-IR), X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), photoluminescence(PL), UV-diffuse reflectance spectroscopy(UV-DRS), and Brunauer-Emmett-Teller(BET)surface analysis. Doping Nd^(3+) into Zn-Al LDH enhances the overall catalytic activity of the nanocomposite, like better electron-hole pair separation, increase in interplanar distance, fast electron transfer, and large surface area. The as-prepared nanocomposite shows excellent degradation of three different dyes under visible light irradiation. The degradation efficiency of these dyes follows the order of Congo red > rose Bengal > fast green. Furthermore, liquid chromatography-mass spectrometry(LC-MS)was employed to propose a possible photocatalytic degradation pathway for Congo Red and Rose Bengal dyes by Nd/Zn-Al LDH. With the help of radical trapping experiments, it is revealed that during the photoexcitation process, the primary reactive intermediates are hydroxyl radicals.

关键词： Organic pollutants Degradation Multifunctional Mesoporous LC-MS Rare earths

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Metal-Doped Brushite Cement for Bone Regeneration

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Journal of Bionic Engineering 2023年第6期20卷 2716-2731页

作者： Muhammad Aqib Aneela Anwar Humayun ajaz Samina Akbar Ahsan Manzoor Maham Abid Zohaib Waheed Qudsia Kanwal Department of Chemistry University of Engineering and TechnologyGT RoadLahore54890Pakistan Department of Chemistry University of LahoreLahore5400Pakistan

For the past several years,calcium phosphate cement was used in the biomedical *** biocompatibility,good bioactivity,self-setting qualities,minimum setting degree,appropriate toughness,and simple shape to accommodate any difficult geometry are among their most notable *** phosphate has some types and brushite is one of the most attractive mineral for bone repair *** is extensively employed in filling fractures and trauma treatments as a bone substituted *** kind of material can potentially be used as a medicine delivery *** replacement of metal,such as magnesium,zinc,and strontium ions,into the calcium phosphate structure is a major research topic these *** cement has low mechanical strength and quick setting *** is possible to produce biomaterials with higher mechanical *** adding metal that are great potential in controlling cellular density when included into *** a result,it is a successful method to develop quite well regenerative *** paper provides a detailed summary of the present achievements of metal-doped brushite cement for bone repair and healing *** major purpose of this work is to give a simple but thorough analysis of current successes in brushite cement doped with Zn,Mg,Sr,and other ions as well as to highlight new advancements and *** impact of metal replacement on cement physical and chemical properties,including microstructure,setting time,injectability,mechanical property,and ion release,is *** metal-doped cement has osteogenesis,angiogenesis,and antibacterial properties,as well as their prospective utility as drug carriers,also considered.

关键词： Calcium phosphate Brushite Bone cement Metal dopants Bone regeneration

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A case of neurosyphilis with psychosis and hippocampal atrophy

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General Psychiatry 2022年第1期35卷 57-60页

作者： Mohammed Murtza Ayesha Bangash ajaz-Ur Rehman Amjadali Pervaiz Adeena Imran General Psychiatry South West Yorkshire Partnership NHS Foundation TrustHalifaxUK Old Age Psychiatry South West Yorkshire Partnership NHS Foundation TrustHalifaxUK

Neurosyphilis can mimic many neurological and psychiatric *** several of its varied central nervous system manifestations can be measured clinically and by neuroimaging,they are ***,this mimicry and the relative rarity of the illness in the present era make the diagnosis ***,neurosyphilis is readily treatable;therefore,it must be considered a diagnostic possibility in the routine workup of early-onset *** case report is of a young man presenting with psychosis and cognitive *** brain scan showed hippocampal atrophy,a finding not often seen in neurosyphilis but more common in Alzheimer’s *** awareness of the various causes of mesiotemporal atrophy,clinicians may erroneously diagnose cases such as this one as a neurodegenerative disorder.

关键词： atrophy routine diagnosis

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Genesis of Graphite in Betul Belt, Madhya Pradesh, India: Inferences Based on Petrographic and Other Studies

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Open Journal of Geology 2022年第11期12卷 983-1012页

作者： Rajendra Kumar Sharma Biswajeet Lenka Syed ajaz Ahmed A-55 Anand Vihar Jagatpura Jaipur Rajsathan India Geological Survey of India Bhubaneswar India Geological Survey of India Jaipur India

Betul belt is known for its volcanic massive sulphide type of mineralization in the geological circles of India. But here the betul belt has been presented with a different qualification, which is graphite mineralization. The graphite mineralization is popularly known within the proterozoic sediments of Aravalli Supegroup of rocks in South Rajasthan and in its extension in the Jhabua and Alirajpur districts of Madhaya Pradesh. The graphite mineralization in Betul belt is confined to the supracrustals enclosed within the granite gneisses and has been brought on the national map after the recently explored blocks by geological survey of India, which were auctioned for the commercial exploitation. This paper briefly discuses the possible mechanism of formation and the nature of mineralization of graphite here in this belt, essentially based on the inferences drawn from petrography supported by scanning electron microscopic and XRD data. It is concluded that major proportion of the graphite mineralization here is accumulated due to progressive metamorphism of the organic matter deposited along with various sediments, while a considerable component has been contributed by the precipitation from super critical graphite rich fluids.

关键词： Betul Belt Graphite Graphitization Lensoid Organic Matter

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Effect of the jet production on pseudorapidity, transverse momentum and transverse mass distributions of charged particles produced in pp-collisions at Tevatron energy

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Chinese Physics C 2015年第7期39卷 6-11页

作者： Ali Zaman Mais Suleymanov Muhammad ajaz Kamal Hussain Khan Department of Physics COMSATS Institute of Information Technology Department of Physics Abdul Wali Khan University Mardan

We investigate the effects of jet production on the following parameters： pseudorapidity, transverse momentum and transverse mass distributions of secondary charged particles produced in pp-collisions at 1.8 Te V,using the HIJING code. These distributions are analyzed for the whole range and for six selected regions of the polar angle as a function of the different number of jets. The obtained simulation results for these parameters are interpreted and discussed in connection to the increase observed in the multiplicity of secondary charged particles as a result of its multi-jet dependence, and are also discussed in comparison with the experimental results from the CDF Collaboration.

关键词： jet production charged particles in pp-interactions HIJING pseudorapidity transverse momentum transverse mass

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