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Nursing Communications 2024年第2期8卷 1-5页

作者： Reham Suliman al Kharyef aisha ali al harbi Mohammed Abdelhamied Genedy Mohamed K.M.Khalil Suliman Mohamed al Eidi Ministry of Health Riyadh 13352Saudi Arabia Consultant Public Health and Research Development.Cairo 11728 Egypt

Background:This study aimed to assess the occupational risks encountered by Healthcare Workers(HCWs)in Saudi Arabia during the COVID-19 ***:A cross-sectional survey was carried out from May to October *** a multi-stage stratified random sampling technique,an online questionnaire was sent to the recruited HCWs,across Saudi ***:Of the 768 HCWs recruited,702 participated in the survey.A significant majority(over 80%)reported working beyond 8 hours ***-19 infection,confirmed via PCR,was identified in 25%of the ***,infection was significantly correlated with direct or close contact(p=0.0007).Psychological distress was reported by 81%,with anxiety being the most prevalent(33%),followed by stress(19%),depression(17%),and insomnia(12%).Around 20%experienced headaches post-PPE use,while 14%reported adverse skin reactions,predominantly allergy and dermatitis.A concerning one-third of respondents reported exposure to ***:High infection rate,physical and psychological risks among HCWs especially those in direct contact with patients,reflect the need for enhancing the entirety of outbreak preparedness and response,specifically *** surveillance system,is crucial to adequately monitor and support HCWs during pandemic scenarios.

关键词： COVID-19 pandemic healthcare worker risk Saudi Arabia

Highly selective adsorption of rhenium by amyloid-like protein material

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Science China(Technological Sciences) 2024年第5期67卷 1417-1430页

作者： MUHAMMAD Arif YANG QingMin KANWal aisha ZHAO Jian NAWAZ Mohsan REN Hao YANG Peng Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Xi’an Key Laboratory of Polymeric Soft Matter International Joint Research Center on Functional Fiber and Soft Smart TextileSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an710119China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an710072China

Rhenium separation from molybdenum in molybdenite minerals and waste leachate has become an emerging *** this challenge,we prepared a set of protein-based alkylamine/alkylammonium salts complexes as extractants for selective uptake of rhenium from molybdenum,where the protein component turned into the insoluble amyloid-like structure when its internal disulfide bonds were reduced,namely phase-transition *** them,the phase-transited lysozyme and methyletrioctyleammonium chloride complex(PTL-N263)exhibited the most efficient adsorption at the alkaline condition for the electrostatic interaction between negatively charged metal ions with positively charged center(R_(4)N^(+))in N263,where negatively charged protein residues hindered the ion exchange of Cl^(-)in N263 for larger size Mo species(Mo_(7)O_(24)^(6-))than smaller size Re species(ReO^(4-)).The adsorption follows the Freundlich model and pseudo-second-order kinetics,which exhibits toplevel adsorption performance with a maximum adsorption capacity of 124 mg/g and a separation factor(β_(Re/Mo))of 2.78×10^(3)for *** adsorption capacity per unit area(57.2 mg/(g m^(2)))is 1.6–41 times higher than previously reported adsorbents,and the cost for adsorbing 1 g of Re(VII)is$1.07,indicating its industrial *** adsorption strategy can be applied to separating Re from Mo in binary solutions and industrial wastewater with other competing ions.

关键词： amyloid phase-transited lysozyme selective adsorption rhenium waste leachate solution

Unique Azolyl Acylhydrazonyl Hybridization of aloe Emodins to Access Potential Antibacterial Agents

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Chinese Journal of Chemistry 2024年第15期42卷 1741-1758页

作者： Yi-Xin Wang Zhao Deng aisha Bibi Bo Fang Cheng-He Zhou Institute of Bioorganic&Medicinal Chemistry Key Laboratory of Applied Chemistry of Chongqing MunicipalitySchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsChongqing Key Laboratory of Kinase Modulators as Innovative MedicineChongqing University of Arts and SciencesChongqing 402160China

A type of unique azole-hybridized acylhydrazonyl aloe emodins(AAEs)were developed as new antibacterial agents for combating bacterial *** target AAEs showed strong antibacterial activities,especially,tetrazolylthioether AAE 27a exhibited broad antibacterial spectrum with 16-256 folds and 8-64 folds more active antibacterial efficacy than the reference drugs aloe emodin and norfloxacin,*** AAE 27a also gave low hemolysis and cytotoxicity,as well as favorable *** mechanism explorations revealed that tetrazolylthioether AAE 27a could cause bacterial membrane depolarization and damage the cell membrane,resulting in nucleic acid ***,compound 27a could intercalate into DNA to impede its replication and form supramolecular 27a-DNA gyrase complex to disturb the function of DNA *** findings would provide valuable insights for the further exploration of azolyl acylhydrazonyl aloe emodins as new potential antibacterial candidates.

关键词： aloe emodin Hydrazone Heterocycle Antibacterial Membrane damage

Enhancing Patient Safety in the Operating Room: A Comprehensive Guide from a Nurse’s Perspective

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Open Journal of Nursing 2024年第6期14卷 252-266页

作者： aisha Mohamed Hussein Operating Room Nurse Dr. Sulaiman Al-Habib Medical Group Bone Joint and Spine Hospital Riyadh Saudi Arabia

Ensuring patient safety within the operating room is a paramount concern in contemporary healthcare, and this guide aims to provide an in-depth exploration of this crucial aspect from the perspective of nurses. Nurses play a pivotal role in supporting surgeons and maintaining a safe environment for patients undergoing various medical procedures.

关键词： Operating Room Patient Safety Nurses

Low testing rates and high BRCA prevalence: Poly (ADP-ribose) polymerase inhibitor use in Middle East BRCA/homologous recombination deficiency-positive cancer patients

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World Journal of Clinical Oncology 2024年第7期15卷 848-858页

作者： Naveed Syed Ashish Vittalrao Chintakuntlawar Deepti Vilasini aisha Mohamed al Salami Riad al Hasan Imrana Afrooz Kanishka Uttam Chandani Ashok Uttam Chandani Aref Chehal Department of Hematology and Oncology Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Oncology Mayo ClinicRochesterNY 790339United States Department of Oncology Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Clinical Research Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Internal Medicine Landmark Medical CenterRhode IslandRI 02895United States

BACKGROUND Poly(ADP-ribose)polymerase inhibitors(PARPis)are approved as first-line therapies for breast cancer gene(BRCA)-positive,human epidermal growth factor receptor 2-negative locally advanced or metastatic breast *** are also effective for new and recurrent ovarian cancers that are BRCA-or homologous recombination deficiency(HRD)-***,data on these mutations and PARPi use in the Middle East are *** To assess BRCA/HRD prevalence and PARPi use in patients in the Middle East with breast/ovarian *** This was a single-center retrospective study of 57 of 472 breast cancer patients tested for BRCA mutations,and 25 of 65 ovarian cancer patients tested for *** adult patients participated in at least four visits to the oncology service at our center between August 2021 and May *** were summarized using descriptive statistics and compared using counts and *** to treatment was assessed using Response Evaluation Criteria in Solid Tumors *** Among the 472 breast cancer patients,12.1%underwent BRCA testing,and 38.5%of 65 ovarian cancer patients received HRD *** mutations were found in 25.6%of the tested patients:26.3%breast cancers had germline BRCA(gBRCA)mutations and 24.0%ovarian cancers showed ***,40.0%of gBRCA-positive breast cancers and 66.0%of HRD-positive ovarian cancers were Middle Eastern and Asian patients,*** treatment was used in 5(33.3%)gBRCA-positive breast cancer patients as first-line therapy(n=1;7-months progression-free),for maintenance(n=2;>15-months progression-free),or at later stages due to compliance issues(n=2).Four patients(66.6%)with HRD-positive ovarian cancer received PARPi and all remained *** Lower testing rates but higher BRCA mutations in breast cancer were *** reflected United Arab Emirates demographics,with breast cancer in Middle Eastern and ovarian cancer in Asian patients.

关键词： Homologous recombination repair BRCA1 BRCA2 Homologous recombination deficiency Ovarian cancer Breast cancer Poly(ADP-ribose)polymerase inhibitors Olaparib DNA double-strand breaks

Pipeline Embolization Device for intracranial aneurysms presenting with mass effect:a large Chinese cohort

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Stroke & Vascular Neurology 2024年第1期9卷 50-58页

作者： Yang Zhao Junlin Lu Hongqi Zhang Tianxiao LI Donglei Song Sheng Guan aisha Maimaitili Yunyan Wang Wenfeng Feng Yang Wang Jieqing Wan Guohua Mao Huaizhang Shi Xinjian Yang Jianmin Liu Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuanChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Zhengzhou University People's HospitalZhengzhouHenanChina Department of Neurosurgery Shanghai Donglei Brain HospitalShanghaiChina Department of Interventional Neuroradiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurosurgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Neurosurgery Qilu Hospital of Shandong University QingdaoJinanShandongChina Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghaiChina

Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for *** study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world *** We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect *** study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect *** analyses by aneurysm location,size and form were also *** This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysmsalleviate mass effect in unruptured intracranial *** registration number NCT03831672.

关键词： aneurysm intracranial Irvine

The Impact of Simulation Education on Self-Efficacy in Pre-Registration Nursing Students

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Open Journal of Nursing 2024年第1期14卷 51-76页

作者： Ahmed A. Hakami aisha Hussin Rabie Sultan Ghormallah M. alzahrani Faisal Mohammed alnakhilan Khalid Awaidhalharbi College of Nursing Umm Al-Qura University Makkah Saudi Arabia al-Noor Specialist Hospital Makkah Saudi Arabia (MOH) Ministry of Health King Fahad Hospital Al Baha Saudi Arabia (MOH) Ministry of Health Eradah Complex Riyadh Saudi Arabia King Salman Medical City Al Madinah Saudi Arabia

This literature review primarily aims to explore and synthesise the previous studies in simulation education research conducted over the past five years related to the effects of simulation training on the self-efficacy of undergraduate pre-registration nursing students. The second aim of this study is to explore additional outcome variables that were examined in the previous studies. Five electronic databases were searched systematically. These databases were MEDLINE, CINAHL Plus, Scopus, Embase and PsycINFO. The PICO model was employed to identify the search terms, with a thesaurus being used to provide synonyms. Reference lists of relevant articles were examined and hand searches of journals were also undertaken. The quality of each study was assessed using the Simulation Research Rubric (SRR). A total of 11 studies were included. all studies explored the impact of simulation education on undergraduate pre-registration nursing. Six studies explored nursing students’ competence and performance and two papers examined their critical thinking. Problem solving, learning motivation, communication skills and knowledge acquisition were examined once. The majority of studies indicated that simulation training has a positive impact on pre-registration nursing students’ self-efficacy and other outcome variables. Furthermore, the study results indicate that simulation training is more dependable than traditional training, and students were extremely satisfied with the simulation training. However, most of the studies included in this review had several gaps, including study design, sample size and dissimilarities between the scales used. Further research with large samples, reliable and valid instruments, and outcomes measures (such as critical thinking and transferability of skills) is required to provide better insight into the effectiveness of simulation in undergraduate nursing education. .

关键词： Simulation Education Self-Efficacy Pre-Registration Nursing Students Clinical Skills Undergraduate Nursing Education Teaching Techniques Decision-Making

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员工在内部招揽投资令Meta陷入窘境

商业周刊（中文版） 2024年第10期 17-19页

作者： aisha Counts 杜然(译) 不详

Meta长期以来一直允许员工投资外部初创公司,但员工在公司内部系统里招揽投资的情况却并不常见。在Meta公司内部通讯平台的众多频道中,有一个供员工讨论房地产投资的组群。2019年,Meta洛杉矶办公中心的工程人才招募员西夫·哈法吉(Sief ... 详细信息

Meta长期以来一直允许员工投资外部初创公司,但员工在公司内部系统里招揽投资的情况却并不常见。在Meta公司内部通讯平台的众多频道中,有一个供员工讨论房地产投资的组群。2019年,Meta洛杉矶办公中心的工程人才招募员西夫·哈法吉(Sief Khafagi)开始发布关于Scoutpads的信息,这是他建立的一项服务,在用户与开发商之间建立联系,以便将资金投人房地产。

关键词：资金投人房地产投资初创公司通讯平台洛杉矶开发商

On a Novel Extended Lomax Distribution with Asymmetric Properties and Its Statistical Applications

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 2371-2403页

作者： aisha Fayomi Christophe Chesneau Farrukh Jamal ali algarni Department of Statistics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Laboratory Mathematics Nicolas Oresme Universitéde Caen NormandieCampus IICaen14032France Department of Statistics The Islamia University of BahawalpurPunjab63100Pakistan

In this article,we highlight a new three-parameter heavy-tailed lifetime distribution that aims to extend the modeling possibilities of the Lomax *** is called the extended Lomax *** considered distribution naturally appears as the distribution of a transformation of a random variable following the logweighted power distribution recently introduced for percentage or proportion data analysis *** a result,its cumulative distribution has the same functional basis as that of the Lomax distribution,but with a novel special logarithmic term depending on several *** modulation of this logarithmic term reveals new types of asymetrical shapes,implying a modeling horizon beyond that of the Lomax *** the first part,we examine several of its mathematical properties,such as the shapes of the related probability and hazard rate functions;stochastic comparisons;manageable expansions for various moments;and quantile *** particular,based on the quantile functions,various actuarial measures are *** the second part,the distribution’s applicability is investigated with the use of themaximumlikelihood *** behavior of the obtained parameter estimates is validated by a simulation *** claim data are *** show that the proposed distribution outperforms eight well-known distributions,including the Lomax distribution and several extended Lomax *** addition,we demonstrate that it gives preferable inferences from these competitor distributions in terms of risk measures.

关键词： Lomax distribution extended Lomax distribution asymmetry actuarial measures maximum likelihood estimation data analysis

Charcoal Nanoparticles as a Delivery System for Doxorubicin and Sorafenib in Treatment of Hepatocellular Carcinoma

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Advances in Nanoparticles 2024年第3期13卷 45-60页

作者： aisha Elgurashi Abdulla Toga Khalid Mohamed Gader Marvit Osman Widdatallah Omer Abdullah E. Gouda Samah Mamdouh Mohamed A. Shemis Department of Clinical Pharmacy Faculty of Pharmacy University of Medical Sciences and Technology Khartoum Sudan Department of Pharmacology Faculty of Pharmacy University of Medical Sciences and Technology Khartoum Sudan Department of Biochemistry and Molecular Biology Theodor Bilharz Research Institute Giza Egypt

Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the leading causes of cancer-related death worldwide. Advanced HCC displays strong resistance to chemotherapy, and traditional chemotherapy drugs do not achieve satisfactory therapeutic efficacy. The delivery of therapeutic compounds to the target site is a major challenge in the treatment of many diseases. Objective: This study aims to evaluate activated charcoal nanoparticles as a drug delivery system for anticancer agents (Sorafenib and Doxorubicin) in Hepatocellular Cancer Stem Cells. Method: The percent efficiency of entrapment (% EE) of the doxorubicin and sorafenib entrapped onto the activated charcoal was obtained by determining the free doxorubicin and sorafenib concentration in the supernatant-prepared solutions. Then the characterizations of nanoparticles were formed by determination of the particle size distribution, zeta potential, and polydispersity index (PDI). The anticancer activity of activated Charcoal, Doxorubicin-ACNP, sorafenib-ACNP, free doxorubicin, and free sorafenib solutions was measured based on cell viability percentage in HepG2 cell lines (ATCC-CCL 75). In vitro RBC’s toxicity of Doxorubicin/sorafenib loaded charcoal was estimated by hemolysis percentage. Results: The synthesized Doxorubicin-ACNP and Sorafenib-ACNP were evaluated and their physiochemical properties were also examined. Essentially, the percent Efficiency of Entrapment (EE %) was found to be 87.5% and 82.66% for Doxorubicin-ACNP and Sorafenib-ACNP, respectively. The loading capacity was 34.78% and 24.31% for Doxorubicin-ACNP and Sorafenib-ACNP. Using the Dynamic Light scattering [DLS] for the determination of the hydrodynamic size and surface zeta potential, a narrow sample size distribution was obtained of (18, 68, and 190 nm for charcoal, 105, 255, and 712 nm for doxorubicin, and 91, 295, and 955 nm for sorafenib), respectively. A surface charge of −13.2, −15.6 and −17 was obta

关键词： Activated Charcoal Nanoparticles (ACNP) Drug Delivery System Sorafenib and Doxorubicin Hepatocellular Cancer Stem Cells