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MiCPhot:A prime-focus multicolor CCD photometer on the 85-cm Telescope

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Chinese Journal of Astronomy and Astrophysics 2009年第3期9卷 349-366页

作者： ai-ying zhou Xiao-Jun Jiang Yan-Ping Zhang Jian-Yan Wei National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Department of Astronomy Beijing Normal University Beijing 100875 China

We describe a new BVRI multicolor CCD photometric system situated at the prime focus of the 85-cm telescope at the Xinglong Station of NAOC. Atmospheric extinction effects, photometric accuracy and color calibration dependence of the system are investigated. Additional attention was paid to giving observers guidance in estimating throughput, detection limit, signal-to-noise ratio and exposure time.

关键词： instrumentation photometers CCD photometer- techniques photometric

Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing zhou Mei-ying Zhang ai-ai Gao Cheng Zhu Tao He James G Herman Ming-zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both P<0.05).However,no significant associations were observed between promoter region methylation and age,gender,smoking,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity

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World Journal of Diabetes 2024年第7期15卷 1589-1602页

作者： Wei Luo Yue zhou Li-ying Wang Lei ai Department of Sports and Health Sciences Nanjing Sport InstituteNanjing 210014Jiangsu ProvinceChina Department of Exercise Physiology Beijing Sport UniversityBeijing 100084China Department of Sports Physiology Research Jiangsu Research Institute of Sports ScienceNanjing 210033Jiangsu ProvinceChina

BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skeletal muscle regulated the inflammation and regeneration of skeletal ***,despite of the decades of research,whether macrophages infiltration and polarization in skeletal muscle under high glucose(HG)milieus results in the development of IR is yet to be elucidated.C2C12 myoblasts are well-established and excellent model to study myogenic regulation and its responses to *** exploration of macrophages'role in myoblasts IR and the dynamics of their infiltration and polarization is *** To evaluate interactions between myoblasts and macrophages under HG,and its effects on inflammation and IR in skeletal *** We detected the polarization status of macrophages infiltrated to skeletal muscles of IR mice by hematoxylin and eosin and immunohistochemical ***,we developed an in vitro co-culture system to study the interactions between myoblasts and macrophages under HG *** effects of myoblasts on macrophages were explored through morphological observation,CCK-8 assay,Flow Cytometry,and enzyme-linked immunosorbent *** mediation of macrophages to myogenesis and insulin sensitivity were detected by morphological observation,CCK-8 assay,Immunofluorescence,and 2-NBDG *** The F4/80 and co-localization of F4/80 and CD86 increased,and the myofiber size decreased in IR group(P0.8).In McM+HG group,F4/80+CD86+CD206-cells,monocyte chemoattractant protein 1,TNFα,IL-1βand IL-6 were increased,and F4/80+CD206+CD86-cells and IL-10 were decreased compared with Mc+HG group and McM group(P0.8).Compered to M group,myotube area,myotube n

关键词： Macrophages phenotype Myoblasts Cross-talk Glucose toxicity Chronic inflammation Insulin sensitivity

1RXS J232953.9+062814: a New SU UMa Dwarf Nova below the Period Minimum

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Chinese Journal of Astronomy and Astrophysics 2001年第6期1卷 483-486页

作者： Jian-Yan Wei, Xiao-Jun Jiang, Da-Wei Xu, ai-ying zhou and Jing-Yao Hu National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

RXS 1232953.9+062814 was identified as a cataclysmic variable by Wei et al. (1999). Four low-resolution spectra of 1RXS J232953.9+062814 were obtained with the 2.16-rn telescope of the National Astronomical Observatories, of which two were at outburst, and two were at quiescence. The system is about 16.8 B and 16.5 V at quiescence, and 12.6 B and 12.6 V at outburst. The quiescent spectra were dominated by double-peaked Balmer emissions, which indicates a hydrogen-rich system with a high-inclination accretion disc. MgH and TiO absorption bands appeared in the quiescent spectrum which implies a companion with a spectral type of early M dwarf. If we take it as a MO dwarf, then the system is located at a distance of 350 pc with a proper motion velocity 150 km s-1. The superhump period of 0.046311 days was confirmed by our V photometry. The short period and the hydrogen-rich nature reveal that this system is another SU Ursae Majoris-type dwarf nova below the period minimum after V485 Centauri. 1RXS J23 2953.9+062814 is one of the most important systems for studying the evolutionary scenario of cataclysmic variables since it is much brighter than V485 Cen.

关键词： stars: dwarf novae - stars: cataclysmic variables: individual: 1RXS J232953.9 +062814

Resilience and response:Unveiling the impacts of extreme droughts on forests through integrated dendrochronological and remote sensing analyses

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Forest Ecosystems 2024年第4期11卷 491-501页

作者： Han Shi Xi Peng Yong-Jiao zhou ai-ying Wang Xue-Kai Sun Na Li Quan-Sheng Bao Gude Buri Guang-You Hao CAS Key Laboratory of Forest Ecology and Silviculture Institute of Applied EcologyChinese Academy of SciencesShenyang110016China Daqinggou Ecological Research Station Institute of Applied EcologyChinese Academy of SciencesShenyang110016China University of Chinese Academy of Sciences Beijing100049China School of Life Science and Engineering Shenyang UniversityShenyang110044China Wudantala Forestry Forestry and Grassland Administration of Horqin Northeast CountyTongliao028100China

Extreme droughts are anticipated to have detrimental impacts on forest ecosystems,especially in water-limited regions,due to the influence of climate ***,considerable uncertainty remains regarding the patterns in species-specific responses to extreme ***,we conducted a study integrating dendrochronology and remote sensing methods to investigate the mosaic-distributed maple-oak(native)natural forests and poplar plantations(introduced)in the Horqin Sandy Land,Northeast *** assessed the impacts of extreme droughts on tree performances by measuring interannual variations in radial growth and vegetation *** results showed that precipitation and self-calibrated palmer drought severity index(scPDSI)are the major factors influencing tree-ring width index(RWI)and normalized difference vegetation index(NDVI).The severe droughts between 2000 and 2004 resulted in reduced RWI in the three studied tree species as well as led to NDVI reductions in both the maple-oak natural forests and the poplar *** RWI reached the nadir during the2000-2004 severe droughts and remained at low levels two years after the severe drought,creating a legacy *** contrast to the lack of significant correlation between RWI and scPDSI,NDVI exhibited a significant positive correlation with scPDSI indicating the greater sensitivity of canopy performance to droughts than radial ***,interspecific differences in RWI and NDVI responses were observed,with the fast-growing poplar species experiencing a more significant RWI decrease and more negative NDVI anomaly during severe droughts than native species,highlighting the species-specific trade-offs between drought resilience and growth *** study emphasizes the importance of combining tree-level radial growth with landscape-scale canopy remote sensing to understand forest resilience and *** study improves our understanding of forest responses to extreme drought and highlights species di

关键词： Introduced tree species Native tree species NDVI Severe drought Tree-ring width

Cogeneration of Innovative Audio-visual Content: A New Challenge for Computing Art

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Machine Intelligence Research 2024年第1期21卷 4-28页

作者： Mengting Liu ying zhou Yuwei Wu Feng Gao Advanced Institute of Information Technology Peking UniversityHangzhou311215China School of Electronic and Computer Engineering Shenzhen Graduate SchoolPeking UniversityShenzhen 518000China Peng Cheng Laboratory Shenzhen 518000China School of Arts Peking UniversityBeijing 100871China

In recent years,computing art has developed rapidly with the in-depth cross study of artificial intelligence generated con-tent(aiGC)and the main features of ***-visual content generation has gradually been applied to various practical tasks,including video or game score,assisting artists in creation,art education and other aspects,which demonstrates a broad application *** this paper,we introduce innovative achievements in audio-visual content generation from the perspective of visual art genera-tion and auditory art generation based on artificial intelligence(Al).We outline the development tendency of image and music datasets,visual and auditory content modelling,and related automatic generation *** objective and subjective evaluation of generated samples plays an important role in the measurement of algorithm *** provide a cogeneration mechanism of audio-visual content in multimodal tasks from image to music and display the construction of specific stylized *** are still many new op-portunities and challenges in the field of audio-visual synesthesia generation,and we provide a comprehensive discussion on them.

关键词： Artificial intelligence(ai)art audio-visual artificial intelligence generated content(aiGC) multimodal artistic evalu-ation

Relative peripheral refraction in school children with different refractive errors using a novel multispectral refraction topographer

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1477-1482页

作者： Hui-Ling Hu Serena Zhe-Chuang Li ai-ying Feng Hao-Xi Zhong Jing-Feng Mu Mei-zhou Liu Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina NIMO Ophthalmology Research Institute Beijing 100176China

aiM:To compare relative peripheral refraction(RPR)in Chinese school children with different refractive errors using multispectral refraction topography(MRT).METHODS:A total of 713 eyes of primary school children[172 emmetropia(E),429 low myopia(LM),80 moderate myopia(MM),and 32 low hypermetropia(LH)]aged 10 to 13y were *** were measured using MRT without *** results showed RPR at 0-15°(RPR 0-15),15°-30°(RPR 15-30),and 30°-45°(RPR 30-45)annular in the inferior(RPR-I),superior(RPR-S),nasal(RPR-N),and temporal(RPR-T)*** equivalent(SE)was detected and calculated using an ***:There were significant differences of RPR 15-30 between groups MM[0.02(-0.12;0.18)]and LH[-0.13(-0.36;0.12)](P<0.05),MM and E[-0.06(-0.20;0.10)](P<0.05),and LM[-0.02(-0.15;0.15)]and E(P<0.05).There were also significant differences of RPR 30-45 between groups MM[0.45(0.18;0.74)]and E[0.29(-0.09;0.67)](P<0.05),and LM[0.44(0.14;0.76)]and E(P<0.001).RPR values increased from the hyperopic to medium myopic group in each *** were significant differences of RPR-S between groups MM[-0.02(-0.60;0.30)]and E[-0.44(-0.89;-0.04)](P<0.001),and LM[-0.28(-0.71;0.12)]and E(P<0.05).There were also significant differences of RPR-T between groups MM[0.37(0.21;0.78)]and LH[0.14(-0.52;0.50)](P<0.05),LM[0.41(0.06;0.84)]and LH(P<0.05),and LM and E[0.29(-0.10;0.68),P<0.05].A Spearman’s correlation analysis showed a negative correlation between RPR and SE in the 15°-30°(P=0.005),30°-45°(P<0.05)annular(P=0.002),superior(P<0.001),and temporal(P=0.001)***:Without pupil dilation,values for RPR 15-30,30-45,RPR-S,and T shows significant differences between myopic eyes and emmetropia,and the differences are negatively correlated with SE.

关键词： relative peripheral refraction myopia school children multispectral refraction topography

Rapid and Sensitive Biosensing of Salmonella Using Mechanical Step Rotation and Gold@platinum Nanozymatic Amplification

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Journal of Analysis and Testing 2024年第3期8卷 262-269页

作者： Meixuan Li Lei Wang ai Xu ying Ding Fengzhen Yang Yanbin Li Jianhan Lin Key Laboratory of Agricultural Information Acquisition Technology Ministry of Agriculture and Rural AffairsChina Agricultural University Center of Excellence for Poultry Science University of Arkansas

Inspired by ballpoint pen, an optical biosensor is developed for detection of Salmonellausing a mechanical step rotator with a dropper to greatly simplify operation, a high gradient magnetic field with immune magnetic nanobeads to specifically separate bacteria, and immune gold@platinum nanozymes with a smartphone to sensitively detect bacteria. First, the preloaded bacterial sample is drawn by the dropper to react with the immune magnetic nanobeads through repeated squeezing and releasing of the dropper, and the rotator is successively rotated and the dropper is repeatedly squeezed and released to achieve mixing of the bacteria, magnetic nanobeads and gold@platinum nanozymes, followed by magnetic separation to remove the background. Then, the conjugates are eff ectively washed with skim milk and ultrapure water, and the substrate are rapidly catalyzed into the product. Finally, the blue product is photographed and analyzed using a smartphone to obtain the Salmonella concentration. This biosensor could detect Salmonellaas low as 56 CFU/mL in～25 min.

关键词： gold@platinum nanozyme magnetic grid separation mechanical step rotator optical biosensor Salmonella detection

A quantitative study of disruptive technology policy texts:An example of China’s artificial intelligence policy

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Journal of Data and Information Science 2024年第3期9卷 155-180页

作者： ying zhou Linzhi Yan Xiao Liu School of Management Anhui UniversityHefei 230601China

Purpose:The transformative impact of disruptive technologies on the restructuring of the times has attracted widespread global *** study aims to analyze the characteristics and shortcomings of China’s artificial intelligence(ai)disruptive technology policy,and to put forward suggestions for optimizing China’s ai disruptive technology ***/methodology/approach:Develop a three-dimensional analytical framework for“policy tools-policy actors-policy themes”and apply policy tools,social network analysis,and LDA topic model to conduct a comprehensive analysis of the utilization of policy tools,cooperative relationships among policy actors,and the trends in policy theme settings within China’s innovative ai technology ***:We find that the collaborative relationship among the policy actors of ai disruptive technology in China is insufficiently *** subjects exhibit low participation in the cooperation network and overly rely on central subjects,forming a“center-periphery”network *** tool usage is predominantly focused on supply and environmental types,with a severe inadequacy in demand-side policy tool *** themes are diverse,encompassing topics such as“Intelligent Services”“Talent Cultivation”“Information Security”and“Technological Innovation”,which will remain focal *** the themes of“Intelligent Services”and“Intelligent Governance”,policy tool usage is relatively balanced,with close collaboration among policy ***,the theme of“ai Theoretical System”lacks a comprehensive understanding of tool usage and necessitates enhanced cooperation with other policy *** limitations:The data sources and experimental scope are subject to certain limitations,potentially introducing biases and imperfections into the research results,necessitating further validation and *** implications:The study introduces a three-dimensional analysis framework for disruptive technology p

关键词： Disruptive technologies Artificial intelligence Synergies Policy tools Thematic evolution