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Chinese Medical Journal 2018年第11期131卷 1357-1364页

作者： Wei-Cheng Xu Ge Qian ai-qun liu Yong-Qiang Li He-qun Zou Department of Nephrology Institute of Nephrology and Urology The Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong 510630 China

Objective： Diabetic kidney disease （DKD） has become one of the major causes of end-stage renal disease. Urinary extracellular vesicles （uEVs） contain rich biological information which could be the ideal source for noninvasive biomarkers of DKD. This review discussed the potential early diagnostic and therapeutic values of proteins and microRNAs in uEVs in DKD. Data Sources： This review was based articles published in PubMed, Embase, Cochrane, and Google Scholar databases up to November 20, 2017, with the following keywords：＂Diabetic kidney disease＂, ＂Extracellular vesicle＂, and ＂Urine＂. Study Selection： Relevant articles were carefully reviewed, with no exclusions applied to tile study design and publication type. Results： There is no ＂gold standard＂ technology to separate and/or purify uEVs. The uEVs contain a variety of proteins and RNAs and participate in the physiological and pathological processes of the kidney. UEVs, especially urinary exosomes, may be useful biomarkers for early diagnosis and treatment to DKD. Furthermore, the uEVs has been used as a therapeutic target for DKD. Conclusion： Proteins and nucleic acids in uEVs represent promising biomarker for the diagnosis and treatment of DKD.

关键词： Biomarker Diabetic Kidney Disease Diagnosis Extracellular Vesicles Therapy

Rapid tooth movement through distraction osteogenesis of the periodontal ligament in dogs

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Chinese Medical Journal 2008年第5期121卷 455-462页

作者： ai Hong XU Qing-feng LU Hong-fei Mai Zhi-hui AN ai-qun liu Guo-ping Department of Stomatology Affiliated Hospital Guangzhou Sun Yat-sen University Third Guangdong 510630 China

Background Animal models are needed for the study of rapid tooth movement into the extraction socket through distraction osteogenesis of the periodontal ligament. Methods Modified distraction devices were placed on eight dogs between the first and third mandibular premolars on the left sides; similar placement of traditional straight wise appliances on the right sides served as the control. The experimental distractors were activated （0.25 mm/d） twice a day and the control devices were activated （100 g） for two weeks with consolidation periods at weeks two, three, six, and ten. Two dogs were sacrificed at each consolidation time point; rates and patterns of tooth movement, loss of anchorage, and periapical films were evaluated, and the affected premolars and surrounding periodontal tissues were decalcified and examined histologically. General observations, X-ray periapical filming and histology examination were performed. Results Distal movement （（3.66±0.14） mm） measured two weeks after modified distraction exceeded that achieved using the traditional device （（1.15±0.21） mm; P 〈0.05）. Loss of anchorage was minimally averaged （0.34±0.06） mm and （0.32±0.07） mm in the experimental and control sides, respectively. By radiography, apical and lateral surface root resorptions on both sides were minimal. Alveolar bone lesions were never evident. Fibroblasts were enriched in periodontal ligaments and bone spicules formed actively along directions of distraction. Conclusions The canine model is suitable for the study of rapid tooth movement through distraction osteogenesis of the periodontal ligament. The technique accelerates tooth movement, periodontal remodeling, alveolar bone absorption, and may induce fibroblast formation, as compared to the traditional orthodontic method, without adversely affecting root absorption, bone loss, tooth mobility and anchorage loss.

关键词： animal model distraction osteogenesis periodontal ligament rapid tooth movement bone formation

Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation

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Light(Science & Applications) 2020年第1期9卷 1418-1429页

作者： Yuzhi Shi Tongtong Zhu Tianhang Zhang Alfredo Mazzulla Din Ping Tsai Weiqiang Ding ai qun liu Gabriella Cipparrone Juan Jose Saenz Cheng-Wei Qiu School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalian 116024China School of Physics Harbin Institute of TechnologyHarbin 150001China CNR-NANOTEC LiCryL and Centre of Excellence CEMIF.CALPonte P.BucciCubo 33B87036 Rende(CS)Italy Department of Electronic and Information Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Physics University of CalabriaPonte P.BucciCubo 33B87036 Rende(CS)Italy Donostia International Physics Center 20018 Donostia-San SebastianSpain

Lateral optical forces induced by linearly polarized laser beams have been predicted to deflect dipolar particles with opposite chiralities toward opposite transversal ***“chirality-dependent”forces can offer new possibilities for passive all-optical enantioselective sorting of chiral particles,which is essential to the nanoscience and drug ***,previous chiral sorting experiments focused on large particles with diameters in the geometrical-optics ***,we demonstrate,for the first time,the robust sorting of Mie(size~wavelength)chiral particles with different handedness at an air–water interface using optical lateral forces induced by a single linearly polarized laser *** nontrivial physical interactions underlying these chirality-dependent forces distinctly differ from those predicted for dipolar or geometrical-optics *** lateral forces emerge from a complex interplay between the light polarization,lateral momentum enhancement,and out-of-plane light refraction at the particle-water *** sign of the lateral force could be reversed by changing the particle size,incident angle,and polarization of the obliquely incident light.

关键词： momentum chiral optics

Combined analysis of imaging tumor capsule with imaging tumor size guides the width of resection margin for solitary hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 551-558页

作者： Jia-Shuo Chao Qi Zhu De-Sheng Chen Gui-Ming Chen Xue-Qian Xie ai-qun liu Sen-Lin Zhao Hong-Cheng Sun Department of General Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China

Background:The optimal width of resection margin(RM)for hepatocellular carcinoma(HCC)remains *** study aimed to investigate the value of imaging tumor capsule(ITC)and imaging tu-mor size(ITS)in guiding RM width for patients with ***:Patients who underwent hepatectomy for HCC in our center were retrospectively ***(complete/incomplete)and ITS(≤3 cm/>3 cm)were assessed by preoperative magnetic resonance imaging(MRI).Using subgroup analyses based on ITC and ITS,the impact of RM width[narrow RM(3 cm and complete ITC,the narrow RM group exhibited comparable RFS,OS,and incidence of RM recurrence with the wide RM group(P=0.606,0.916,and 0.649,respectively).However,in patients with ITS>3 cm and incomplete ITC,the wide RM group showed better RFS and OS and a lower incidence of RM recurrence compared with the narrow RM group(P=0.037,0.018,and 0.046,respectively).Conclusions:As MRI-based preoperative markers,conjoint analysis of ITC with ITS aids in determining RM width for solitary HCC *** RM is applicable in patients with ITS≤3 cm regardless of ITC status and in those with ITS>3 cm and complete *** RM is preferred in those with ITS>3 cm and incomplete ITC.

关键词： Hepatocellular carcinoma Resection Hepatectomy Magnetic resonance imaging Preoperative imaging

Smart ring resonator–based sensor for multicomponent chemical analysis via machine learning

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Photonics Research 2021年第2期9卷 I0031-I0037页

作者： ZHENYU LI HUI ZHANG BINH THI THANH NGUYEN SHAOBO LUO PATRICIA YANG liu JUN ZOU YUZHI SHI HONG Cai ZHENCHUAN YANG YUFENG JIN YILONG HAO YI ZHANG ai-qun liu National Key Laboratory of Science and Technology on Micro/Nano Fabrication Institute of MicroelectronicsPeking University Quantum Science and Engineering Centre Nanyang Technological University Institute of Microelectronics A*STAR Agency for ScienceTechnology and Research School of Mechanical and Aerospace Engineering Nanyang Technological University

We demonstrate a smart sensor for label-free multicomponent chemical analysis using a single label-free ring resonator to acquire the entire resonant spectrum of the mixture and a neural network model to predict the composition for multicomponent analysis. The smart sensor shows a high prediction accuracy with a low rootmean-squared error ranging only from 0.13 to 2.28 mg/m L. The predicted concentrations of each component in the testing dataset almost all fall within the 95% prediction bands. With its simple label-free detection strategy and high accuracy, the smart sensor promises great potential for multicomponent analysis applications in many fields.

关键词： Smart neural smart

Clinical Analysis and Mental Health Survey of Hemophilia Carriers:a Cross-sectional Study

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Current Medical Science 2024年第2期44卷 435-440页

作者： Wen WANG Li-juan JIANG Dong-yan CUI ai ZHANG Xiong WANG ai-guo liu qun HU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Hemophilia carriers(HCs),who are heterozygous for mutations in the clotting factor VIII/clotting factor IX gene(F8 or F9),may have a wide range of clotting factor levels,from very low,similar to afflicted males,to the upper limit of normal,and may experience mental health *** purpose of this study was to provide genetic information on mothers of hemophilia patients and to understand the clotting factor activity and phenotype of ***,we aimed to investigate the mental health status of HCs in ***:A total of 127 hemophilia mothers,including 93 hemophilia A(HA)mothers and 34 hemophilia B(HB)mothers,were enrolled in this *** distance PCR,multiplex PCR,and Sanger sequencing were used to analyze mutations in F8 or *** factor activity was detected by a one-stage clotting *** Symptom Checklist 90(SCL-90,China/Mandarin version)was given to HCs at the same time to assess their mental ***:A total of 90.6%of hemophilia mothers were diagnosed genetically as carriers,with inversion in intron 22 and missense mutations being the most common mutation types in HA and HB carriers,*** median clotting factor level in carriers was 0.74 IU/mL(ranging from 0.09 to 1.74 IU/mL)compared with 1.49 IU/mL(ranging from 0.93 to 1.89 IU/mL)in noncarriers,of which 14.3%of HCs had clotting factor levels of 0.40 IU/mL or below.A total of 53.8%(7/13)of HA carriers with low clotting factor levels(less than 0.50 IU/mL)had a history of bleeding,while none of the HB carriers displayed a bleeding *** total mean score and the global severity index of the SCL-90 for surveyed HCs were 171.00(±60.37)and 1.78(±0.59),respectively.A total of 67.7%of the respondents had psychological symptoms,with obsessive-compulsive disorder being the most prevalent and *** pooled estimates of all nine factors were significantly higher than those in the general population(P<0.05).Conclusions:The detection rate of gene mutations

关键词： hemophilia A hemophilia B mutation carrier mental health

Advances in lithium niobate photonics:development status and perspectives

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Advanced Photonics 2022年第3期4卷 40-82页

作者： Guanyu Chen Nanxi Li Jun Da Ng Hong-Lin Lin Yanyan Zhou Yuan Hsing Fu Lennon Yao Ting Lee Yu Yu ai-qun liu Aaron J.Danner National University of Singapore Department of Electrical and Computer EngineeringSingapore A*STAR(Agency for Science Technology and Research)Institute of MicroelectronicsSingapore Huazhong University of Science and Technology School of Optical and Electronic InformationWuhan National Laboratory for OptoelectronicsWuhanChina Nanyang Technological University Quantum Science and Engineering CentreSingapore

Lithium niobate(LN)has experienced significant developments during past decades due to its versatile properties,especially its large electro-optic(EO)*** example,bulk LN-based modulators with high speeds and a superior linearity are widely used in typical fiber-optic communication ***,with everincreasing demands for signal transmission capacity,the high power and large size of bulk LN-based devices pose great challenges,especially when one of its counterparts,integrated silicon photonics,has experienced dramatic developments in recent *** long ago,high-quality thin-film LN on insulator(LNOI)became commercially available,which has paved the way for integrated LN photonics and opened a hot research area of LN photonics *** allows a large refractive index contrast,thus light can be confined within a more compact *** with other properties of LN,such as nonlinear/acousto-optic/pyroelectric effects,various kinds of high-performance integrated LN devices can be demonstrated.A comprehensive summary of advances in LN photonics is *** LN photonics has experienced several decades of development,our review includes some of the typical bulk LN devices as well as recently developed thin film LN *** this way,readers may be inspired by a complete picture of the evolution of this *** first introduce the basic material properties of LN and several key processing technologies for fabricating photonics *** that,various kinds of functional devices based on different effects are ***,we give a short summary and perspective of LN *** hope this review can give readers more insight into recent advances in LN photonics and contribute to the further development of LN related research.

关键词： lithium niobate etching photonics integrated optics nanotechnology devices.

Efficient option pricing with a unary-based photonic computing chip and generative adversarial learning

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Photonics Research 2023年第10期11卷 1703-1712页

作者： HUI ZHANG LINGXIAO WAN SERGI RAMOS-CALDERER YUANCHENG ZHAN Wai-KEONG MOK HONG Cai FENG GAO XIANSHU LUO GUO-QIANG LO LEONG CHUAN KWEK JOSÉIGNACIO LATORRE ai qun liu Institute of Quantum Technologies(IQT) The Hong Kong Polytechnic UniversityHong KongChina Quantum Science and Engineering Centre(QSec) Nanyang Technological UniversitySingaporeSingapore Departament de Fisica Quantica i Astrofisica and Institut de Ciencies del Cosmos(ICCUB) Universitat de BarcelonaBarcelonaSpain Quantum Research Centre Technology Innovation InstituteAbu DhabiUAE Centre for Quantum Technologies National University of SingaporeSingaporeSingapore Institute of Microelectronics A*STAR(Agency for ScienceTechnology and Research)SingaporeSingapore Advanced Micro Foundry SingaporeSingapore National Institute of Education Nanyang Technological UniversitySingaporeSingapore

In the modern financial industry system,the structure of products has become more and more complex,and the bottleneck constraint of classical computing power has already restricted the development of the financial ***,we present a photonic chip that implements the unary approach to European option pricing,in combination with the quantum amplitude estimation algorithm,to achieve quadratic speedup compared to classical Monte Carlo *** circuit consists of three modules:one loading the distribution of asset prices,one computing the expected payoff,and a third performing the quantum amplitude estimation algorithm to introduce *** the distribution module,a generative adversarial network is embedded for efficient learning and loading of asset distributions,which precisely captures market *** work is a step forward in the development of specialized photonic processors for applications in finance,with the potential to improve the efficiency and quality of financial services.

关键词： computing loading estimation

Genetic Analysis of Two Novel GPI Variants Disrupting H Bonds and Localization Characteristics of 55 Gene Variants Associated with Glucose-6-phosphate Isomerase Deficiency

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Current Medical Science 2024年第2期44卷 426-434页

作者： Bi-xin XI Si-ying liu Yu-ting XU De-dong ZHANG qun HU ai-guo liu Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Glucose-6-phosphate isomerase(GPI)deficiency is a rare hereditary nonspherocytic hemolytic anemia caused by GPI gene *** disorder exhibits wide heterogeneity in its clinical manifestations and molecular characteristics,often posing challenges for precise diagnoses using conventional *** this end,this study aimed to identify the novel variants responsible for GPI deficiency in a Chinese ***:The clinical manifestations of the patient were summarized and analyzed for GPI deficiency phenotype *** compound heterozygous variants of the GPI gene,c.174C>A(***58Lys)and c.1538G>T(***513Leu),were identified using whole-exome and Sanger *** AlphaFold program and Chimera software were used to analyze the effects of compound heterozygous variants on GPI ***:By characterizing 53 GPI missense/nonsense variants from previous literature and two novel missense variants identified in this study,we found that most variants were located in exons 3,4,12,and 18,with a few localized in exons 8,9,and *** study identified novel compound heterozygous variants associated with GPI *** pathogenic variants disrupt hydrogen bonds formed by highly conserved GPI amino ***:Early family-based sequencing analyses,especially for patients with congenital anemia,can help increase diagnostic accuracy for GPI deficiency,improve child healthcare,and enable genetic counseling.

关键词： glucose-6-phosphate isomerase deficiency whole-exome sequencing compound heterozygous variants genetic characterization hydrogen bond

Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation

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World Journal of Gastroenterology 2019年第37期25卷 5630-5640页

作者： Jia-Shuo Chao Sen-Lin Zhao Si-Wen Ou-yang Yong-Bing Qian ai-qun liu Hua-Mei Tang Lin Zhong Zhi-Hai Peng Jun-Ming Xu Hong-Cheng Sun Department of General Surgery Shanghai Organ Transplantat Medical CenterShanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Colorectal Surgery Fudan UniversityShanghai Cancer CenterShanghai 200032China Division of Critical Care Department of Liver SurgeryRenji HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200127China Department of Radiology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Pathology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China

BACKGROUND Tumor recurrence after orthotopic liver transplantation(OLT)remains a serious threat for long-term survival of the recipients with hepatocellular carcinoma(HCC),since very few factors or measures have shown impact on overcoming HCC recurrence after *** infection suppresses tumor recurrence and improves patient survival in lung cancer and malignant glioma probably via stimulating the immune ***-transplant infection(PTI),a common complication,is deemed to be harmful for the liver transplant recipients from a short-term ***,whether PTI inhibits HCC recurrence after OLT and prolongs the long-term survival of HCC patients needs to be *** To investigate the potential influence of PTI on the survival and tumor recurrence of patients with HCC after *** A total of 238 patients with HCC who underwent OLT between August 2002 and July 2016 at our center were retrospectively included and accordingly subdivided into a PTI group(53 patients)and a non-PTI group(185 patients).Univariate analyses,including the differences of overall survival(OS),recurrence-free survival(RFS),and post-recurrence survival(PRS),between the PTI and non-PTI subgroups as well as survival curve analysis were performed by the Kaplan-Meier method,and the differences were compared using the log rank *** variables with a P-value<0.1 in univariate analyses were included in the multivariate survival analysis by using a Cox proportional-hazards *** The 1-,3-,and 5-year OS and RFS rates of the whole cohort were 86.6%,69.0%,and 63.6%,and 75.7%,60.0%,and 57.3%,*** 1-,3-,and 5-year OS rates for the PTI patient group(96.0%,89.3%,and 74.0%)were significantly higher than those for the non-PTI group(84.0%,63.4%,and 60.2%)(P=0.033).The absence of PTI was an independent risk factor for dismal OS(relative risk[RR]=2.584,95%CI:1.226-5.449)and unfavorable RFS(RR=2.683,95%CI:1.335-5.390).Subgroup analyses revealed that PTI remark

关键词： Liver transplantation Liver cancer Infection Survival Tumor recurrence