检索结果-南通市图书馆

Possible Roles of Diet in the Etiology of Rheumatoid Arthritis:A Systematic Review

World Journal of Traditional Chinese Medicine 2016年第3期2卷 25-35页

作者： Chi Zhang Ka-Miu Chan ai-ping lu School of Chinese Medicine Hong Kong Baptist University Hong Kong Chinese Medicine Clinical study Center Hong Kong Baptist University Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences

Background:There is a growing interest in the possible role of diet in the prevention of rheumatoid arthritis(RA).However,the evidence for diet having a role in the etiology of RA is inconsistent,sometimes ***:To critically appraise the literature to pool the results of studies to clarify the relation between diet risk and ***:We performed a systematic review using guideline-recommended methodology to evaluate the association between pre-illness diet or diet pattern and the risk of subsequent RA ***:A total of 25 studies met the inclusion *** include 13 cohort studies,10 case-control studies and 2 nested case-control studies,with a total of 1279810 *** were new evidences of a protective effect of long term consumption of *** sodium intake was associated with an increased risk of *** intake has consistently been shown to have no effect on the development of *** diet pattern,Vitamin D intake,and the consumption of long-chain omega-3 acids were not associated with an increased/decreased risk of RA in every two *** were non-statistically significant association between RA and sugar-sweetened soda,red meat,vegetable and fruits in each single *** association between coffee,tea and RA was consistent,and here exists an inverse relationship between olive oil and *** to the heterogeneity of study designs and analyses,the results could not be ***:The results of this SR indicate that alcohol consumption and sodium intake may be associated with RA risk,especially evidence from recent *** of some discordant results,the debate continues on whether some other dietary intakes increase or decrease RA risk.

关键词： Diet Rheumatoid Arthritis Systematic review

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pushing the Boundaries of Molecular Property Prediction for Drug Discovery with Multitask Learning BERT Enhanced by SMILES Enumeration

引用

Research 2023年第3期2022卷 157-170页

作者： Xiao-Chen Zhang Cheng-Kun Wu Jia-Cai Yi Xiang-Xiang Zeng Can-Qun Yang ai-ping lu Ting-Jun Hou Dong-Sheng Cao Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013Hunan P.R.China Shangqiu Normal University School of Information TechnologyShangqiu 476000HenanP.R.China College of Computer National University of Defense TechnologyChangsha 410005HunanP.R.China Department of Computer Science Hunan UniversityChangsha 410082.HunanP.R.China institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077P.R.China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University.College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058ZhejiangP.R.China

Accurate prediction of pharmacological properties of small molecules is becoming increasingly important in drug *** feature-engineering approaches heavily rely on handcrafted descriptors and/or fingerprints,which need extensive human expert *** the rapid progress of artificial intelligence technology,data-driven deep learning methods have shown unparalleled advantages over feature-engineering-based ***,existing deep learning methods usually suffer from the scarcity of labeled data and the inability to share information between different tasks when applied to predicting molecular properties,thus resulting in poor generalization ***,we proposed a novel multitask learning BERT(Bidirectional Encoder Representations from Transformer)framework,named MTL-BERT,which leverages large-scale pre-training,multitask learning,and SMILES(simplified molecular input line entry specification)enumeration to alleviate the data scarcity ***-BERT first exploits a large amount of unlabeled data through self-supervised pretraining to mine the rich contextual information in SMILES strings and then fine-tunes the pretrained model for multiple downstream tasks simultaneously by leveraging their shared ***,SMILES enumeration is used as a data enhancement strategy during the pretraining,fine-tuning,and test phases to substantially increase data diversity and help to learn the key relevant patterns from complex SMILES *** experimental results showed that the pretrained MTL-BERT model with few additional fine-tuning can achieve much better performance than the state-of-the-art methods on most of the 60 practical molecular ***,the MTL-BERT model leverages attention mechanisms to focus on SMILES character features essential to target properties for model interpretability.

关键词： simplified generalization tuning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer

引用

World Journal of Gastroenterology 2009年第12期15卷 1499-1505页

作者： Ni Dai ai-ping lu Cheng-Chao Shou Ji-You Li Department of Pathology Peking University School of Oncology Beijing Cancer Hospital Beijing 100036 China Department of Biochemistry & Molecular Biology Peking University School of Oncology Beijing Cancer Hospital Beijing 100036 China

aiM： To investigate the prognostic significance of phosphatase regenerating liver 3 （PRL-3） protein expression in gastric cancer.METHODS： PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. Nonoclonal antibody specifically against PRL-3, 3B6, was obtained with hybridoma technique.RESULTS： Positive PRL-3 expression was detected in 43.3% （227 of 293） of gastric cancer cases. High expression of PRL-3 was positively correlated with tumor size, depth of invasion, vascular/lymphatic invasion, lymph node metastasis, high TNM stage and tumor recurrence. Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression （28.3% vs 52.9%, P 〈 0.0001）. Patients who received curative surgery, and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression （hazard ratio of 16.7 and 16.6, respectively; P 〈 0.0001 for both）. Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients, particularly for survival in TNM stage Ⅲ patients. CONCluSION： PRL-3 expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection,

关键词： Phosphatase regenerating liver 3 Gastriccancer Prognosis Recurrence Antibody

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The 2nd World Integrative Medicine Congress(2002)(WIMCO 2002) First Announcement

引用

Chinese Journal of Integrative Medicine 2001年第2期7卷 157-159页

作者： Ke-ji Chen ai-ping lu

The 2nd World Integrative Medicine Congress (2002) (WIMCO 2002) First Announcement

关键词： World WIMCO 2002 The 2nd World Integrative Medicine Congress First Announcement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The 2nd World Integrative Medicine Congress(WIMCO)2nd Announcement:Call for Abstract

引用

Chinese Journal of Integrative Medicine 2001年第4期7卷 312-314页

作者： Ke-ji Chen ai-ping lu

Date 22-24 Sept 2002(Sunday-Tuesday)Venue Beijing International Convention CenterSponsor Chinese Association of Integrative MedicineSupporters China Association for Science and Technology State Administration of Traditional Chinese Medicine, China State Drug Administration, China Development Center for Medical Science and Technology, Ministry of Health, ChinaCo-Sponsors China Academy of Traditional Chinese Medicine Chinese Academy of Medical Sciences China-Japan Friendship Hospital Medical Center of Peking University Beijing University of Traditional Chinese Medicine Hong Kong Huada Group Co. Ltd. Institute of Life Science and Engineering, Tsinghua University Modern Research Center of Chinese Medicine, Peking University Sanjiu Medical Trade Inc Ltd. Hong Kong Association for Health Care Hong Kong Association for Integration of Chinese-Western MedicineMain Themes

关键词： World WIMCO)2nd Announcement The 2nd World Integrative Medicine Congress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Special Expression of Thy-1 in Different Malignant Tumors

引用

Chinese Journal of Cancer Research 2010年第1期22卷 73-79页

作者： Jin-feng Chen ai-ping lu Nan Wu Li-jian Zhang Yue Yang Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education Department of Thoracic Surgery Department of Pathology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective： To investigate the expression status of Thy-1 in malignant cancerous tissues and to evaluate whether Thy-1 could be a potential tumor marker. Methods： Immunohistochemistry method was used to examine Thy-1 expressions in different malignant tumor tissues. We used a monoclonal antibody specific for Thy-1 and the indirect Catalysis Signal Amplification method. With the help of tissue microarray （TMA）, we examined expression the status of Thy-1 in 1451 different types of malignant tumor tissues, 144 normal tissues and benign lesions. Results： All the malignant tumor cells were grouped as one group （malignant cells group） and normal or benign tumor tissue cells as another group （normal cells group）. Among the entire 1451 malignant cases group, positive Thy-1 expression with diffuse and strong staining was observed in 734 （734/1451; 50.59%） cases. In the benign cases only 6 chronic cervicitis cases showed weak staining for Thy-1. All the normal tissue showed negative staining. One-Way ANVOA analysis showed F value between these two groups was 147.229 （P〈0.0001）. Conclusion： A significantly stronger expression of Thy-1 in malignant tumors was observed. Special overexpression of Thy-1 in malignant tumors suggests that Thy-1 might be a potential novel tumor marker with respect to cancer progression. Chronic cervicitis has some relationship with cervix carcinoma. When it develops into atypical hyperplasia, it will be a precancerous lesion for cervix carcinoma. In this research we found weak staining for Thy-1 in chronic cervicitis lesion, so Thy-1 may play a crucial role in carcinogenesis for cervix carcinoma. The research about the relationship between Thy-1 expressions in cancer cells and in precancerous lesion will provide some clues to understand the mechanism for carcinogenesis process.

关键词： Thy-1/CD90 Malignant tumor Tumor marker

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice

引用

World Journal of Gastroenterology 2016年第23期22卷 5374-5383页

作者： Hai-Mei Zhao Rong Xu Xiao-Ying Huang Shao-Min Cheng Min-Fang Huang Hai-Yang Yue Xin Wang Yong Zou ai-ping lu Duan-Yong Liu School of Basic Medical Sciences Jiangxi University of Traditional Chinese Medicine Department of postgraduate Jiangxi University of Traditional Chinese Medicine Key Laboratory of Modern preparation of Traditional Chinese Medicine Ministry of EducationJiangxi university of Traditional Chinese Medicine School of Chinese Medicine Hong Kong Baptist University Science and Technology College Jiangxi University of Traditional Chinese Medicine

aiM: To explore the probable pathway by which curcumin(Cur) regulates the function of Treg cells by observing the expression of costimulatory molecules of dendritic cells(DCs).METHODS: Experimental colitis was induced by administering 2, 4, 6-trinitrobenzene sulfonic acid(TNBS)/ethanol solution. Forty male C57BL/6 mice were randomly divided into four groups: normal, TNBS + Cur, TNBS + mesalazine(Mes) and TNBS groups. The mice in the TNBS + Cur and TNBS +Mes groups were treated with Cur and Mes, respectively, while those in the TNBS group were treated with physiological saline for 7 d. After treatment, the curative effect of Cur was evaluated by colonic weight, colonic length, weight index of the colon, and histological observation and score. The levels of CD4+CD25+Foxp3+ T cells(Treg cells) and costimulatory molecules of DCs were measured by flow cytometry. Also, related cytokines were analyzed by enzyme-linked immunosorbent assay. RESULTS: Cur alleviated inflammatory injury of the colonic mucosa, decreased colonic weigh and histological score, and restored colonic length. The number of Treg cells was increased, while the secretion of TNF-α, IL-2, IL-6, IL-12 p40, IL-17 and IL-21 and the expression of costimulatory molecules(CD205, CD54 [ICAM-1], TLR4, CD252[OX40 L], CD256 [RANK] and CD254 [RANK L]) of DCs were notably inhibited in colitis mice treated with ***: Cur potentially modulates activation of DCs to enhance the suppressive functions of Treg cells and promote the recovery of damaged colonic mucosa in inflammatory bowel disease.

关键词： Curcumin Regulatory T cells Dendritic cells Costimulatory molecules

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative network analysis: bridging the gap between Western medicine and traditional Chinese medicine

引用

Journal of Integrative Medicine 2015年第3期13卷 133-135页

作者： Bing He Ge Zhang ai-ping lu School of Chinese Medicine Hong Kong Baptist University

There is a global movement calling for the integration of Western medicine（WM）and traditional Chinese medicine（TCM）[1].The World Health Organization suggests that health care would be improved by integrating traditional and complementary medicines into the practices of health care service delivery and self-health care[1].The WM and TCM are commonly integrated in the contemporary practice of medicine in China.

关键词： integrated TCM WM traditional Chinese medicine compounds(TCD) health care omics net work pharmacology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Gui Zhi decoction on enteric mucosal immune in mice with collagen-induced arthritis

引用

World Journal of Gastroenterology 2005年第34期11卷 5373-5376页

作者： Gui-Qin Zhou Ning Zhao Hao Zhang Hong-Wei Jia Wan-Dong Zhang Lin-Hua Zhao Cheng lu Ying-Hui He ai-ping lu Institute of Basic Theory China Academy of Traditional Chinese Medicine Beijing 100700 China National Pharmaceutical Engineering Centre for HerbalPreparations 347 Fuzhou Road Nanchang 330077 Jiangxi ProvinceChina

aiM： To explore the effect of Gui Zhi decoction on enteric mucosal immune in type Ⅱ collagen-induced arthritis （CIA） in DBA mice. METHODS： Eighty DBA/1, weighing 18-22 g, were randomly divided into four groups with 20 in each group： control group, CIA group, treatment groups at high dosage and low dosage （GZH and GZL）. CIA was induced by immunization with type Ⅱ collagen （CII） emulsified with equal complete adjuvant at 0.1 mg CII each mouse. Blood lymphocyte suspension was screened for CD4 and CD8 expression using a flow cytometry, the CD4 and CD8 and secretory IgA （sIgA）-positive cells in enteric lamina propria tested with immunohistochemical staining. Tumor necrosis factor-alpha （TNF-α）, interleukin-1 （IL-1）-β, and IL-6 concentrations in serum were assayed with RIA. RESULTS： Gui Zhi decoction can lower the arthritic scores and decrease the occurrence of arthritis. The CD4, CD8, and sIgA-positive cells in CIA mice are less than in control mice, and in Gui Zhi decoction at high dosage could restore the lowered CD4- and CD8-positive cells in lamina propria, and at both high and low dosages could increase the lowered sIgA-positive cells in lamina propria, even still lower than in normal mice. In periphery, the CD4 cells in periphery are higher in CIA mice than in control mice, and Gui Zhi decoction at high and low dosages could decrease the CD4 and CD8 cells. Also, Gui Zhi decoction at high dosage could decrease the IL-6 and TNF-α concentration in serum. CONCluSION： Gui Zhi decoction can lower the arthritic scores and decrease the incidence of CIA in mice, and the mechanism is in part regulating enteric mucosal immune.

关键词： Gui Zhi decoction Mucosal immune Collageninduced arthritis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of huoxiangzhengqi liquid on enteric mucosal immune responses in mice with Bacillus dysenteriae and Salmonella typhimurium induced diarrhea

引用

World Journal of Gastroenterology 2006年第45期12卷 7346-7349页

作者： Yin-Hui He Hong-Yan Zhao Zhen-Li Liu Cheng lu Xiao-Jian luo Se-Qi Lin Xing-Wen Qian Shi-Lin Chen ai-ping lu National Pharmaceutical Engineering Research Center Jiangxi University of Traditional Chinese Medicine Nanchang 33000 Jiangxi Province China Institute of Basic Research China Academy of Traditional Chinese Medicine Beijing 100700 China State Key Laboratory of Traditional Chinese Medicine and Molecular Pharmacology Shenzhen 518057 Guangdong Province China E-institute of Shanghai Municipal Education Commission Shanghai Traditional Chinese Medicine University Shanghai China

aiM： To explore effects of huoxiangzhengqi liquid （HXZQ） on enteric mucosal immune responses in mice with Bacillus dysenteriae and Salmonella typhimurium induced diarrhea （BSD）. METHODS： BSD was induced in Balb/c mice by oral administration with Bacillus dysenteriae and Salmonella typhimurium. HXZQ was administrated from the day of diarrhea induction at dosages of 5.21 g/kg and 0.52 g/kg, respectively. The onset of diarrhea and lasting time were recorded. Peyer＇s patches and peripheral lymphocytes were prepared for flow cytometry, and levels of TNF-α in peripheral blood and enteric tissue homogenates were determined with ELISA. Student＇s t test was employed for statistics. RESULTS： Mice in BSD group started showing continuous diarrhea on the day of induction until the fourth day when they were sacrificed. Diarrhea in the mice of HXZQ high and low dose groups lasted for 36 and 54 h, respectively. There were more CD4^＋ and CD8^＋ cells in peripheral blood, fewer CD4^＋ cells in Peyer＇s patches in BSD mice compared to normal mice. Fewer CD4^＋ and CD8^＋ cells was shown in the mice in HXZQ high group compared to BSD mice. In Peyer＇s patch, there were more CD8^＋ cells in mice in HXZQ high and low dose groups and more CD4^＋ in mice in HXZQ high group. Higher levels of TNF-α in peripheral blood and intestinal tissue homogenates in BSD group were observed. Mice in HXZQ high group showed decreased levels of TNF-α in peripheral blood and enteric tissue homogenates. CONCluSION： The immune regulation of CD4^＋ and CD8^＋ cells in Peyer＇s patch and suppression of TNF-α levels in enteric homogenates may partially explain the effect of HXZQ on improvement of BSD.

关键词： Diarrhea Peyer's patches TNF-α Huoxiangzhengqi liquid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：