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Supercritical fluid-assisted fabrication of C-doped Co_(3)O_(4) nanoparticles based on polymer-coated metal salt nanoreactors for efficient enzyme-mimicking and glucose sensor properties

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Nano Research 2023年第5期16卷 7431-7442页

作者： Ze-Wen Kang Jun-Yu Zhang Ze-Zhen Li Ranjith Kumar Kankala Shi-Bin Wang ai-zheng chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen 361021China Instrumental Analysis Center Laboratory and Equipment Management DepartmentHuaqiao UniversityXiamen 361021China

Nanomaterials doped with non-metallic C have attracted tremendous attention as potential nano-artificial enzymes due to their ability to change the energy band structure to improve their intrinsic ***,we report a green,facile,efficient,fast strategy to access high-performance nanozymes via supercritical CO_(2)fluid technology-fabricated polymer nanoreactor of poly-(methyl vinyl ether-co-maleic anhydride)(PVM/MA)coated Co(NO_(3))_(2)into C-doped Co_(3)O_(4)(C-Co_(3)O_(4))nanozyme by a onestep calcination *** PVM/MA to C doping into Co_(3)O_(4)shortens the entire lattice constant of the crystal structure,and the overall valence band energy level below the Fermi level shifts toward the lower energy *** as-prepared CCo_(3)O_(4)demonstrated significant peroxidase-like catalytic activity,significantly greater than the undoped Co_(3)O_(4)nanoparticle *** following density functional theory(DFT)calculations revealed that the doped nano-enzyme catalytic site displayed a unique electronic structure,altering the material surface with more electrons to fill the anti-bond of the two molecular orbitals,significantly improving the peroxidase-like enzyme catalytic and glucose sensor *** resultant enzymatic glucose sensing in a linear range of 0.1–0.6 mM with a detection limit of 3.86μM is in line with standard Michaelis–Menten ***,this work demonstrates that converting polymers into nanozymes of C-doped form by supercritical CO_(2)fluid technology in a step is an effective strategy for constructing high-performance glucose sensor *** cost-effective,reliable,precise system offers the potential for rapid analyte detection,facilitating its application in a variety of fields.

关键词： supercritical fluid poly-(methyl vinyl ether-co-maleic anhydride)(PVM/MA) C-doped Co_(3)O_(4) nanozymes density functional theory(DFT)calculation

Preparation of aripiprazole-poly(methyl vinyl ether-co-maleic anhydride)nanocomposites via supercritical antisolvent process for improved antidepression therapy

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Regenerative Biomaterials 2022年第1期9卷 917-927页

作者： Lin-Fei chen Ying chen You-Yu Duan Man-Man Zhang Pei-Yao Xu Ranjith Kumar Kankala Shi-Bin Wang ai-zheng chen College of Chemical Engineering Huaqiao UniversityXiamen 361021PR China Institute of Biomaterials and Tisszue Engineering Huaqiao UniversityXiamen 361021PR China Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao UniversityXiamen 361021PR China

Aripiprazole(ARI),a second-generation atypical antipsychotic drug approved for schizophrenia treatment,shows good efficacy against ***,the poorly aqueous solubility of ARI leads to low bioavailability and increased dose-related side effects,seriously limiting its application in ***,we demonstrated the fabrication of ARI and poly(methyl vinyl etherco-maleic anhydride)(PVMMA)composite nanoparticles(PA NPs)using the supercritical antisolvent(SAS)process for enhancing its water-solubility and curative anti-depressant ***,the optimal experimental conditions(ARI/PVMMA mass ratio of 1:6,pressure of 10MPa,and solution flow rate of 0.75ml min^(-1))were determined by a 23 factorial experimental design,resulting in the PA NPs with an excellent particle *** vitro cell experiments showed that PA NPs significantly inhibited the inflammatory response caused by the microglia activation induced by lipopolysaccharide(LPS).Similarly,mice behavioral tests demonstrated that PA NPs significantly improved LPS-induced depression-like ***,compared with free ARI,the LPS-induced activation of microglia in the mouse brain and the expression of inflammatory factors in serum were significantly reduced after treatment with PA ***,the innovative PA NPs designed by SAS processmight provide a candidate for developing new ARI-based nano-formulations.

关键词： aripiprazole supercritical fluid technology antidepression new nano-formulation

Immune-regulating camouflaged nanoplatforms:A promising strategy to improve cancer nano-immunotherapy

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Bioactive Materials 2023年第3期21卷 1-19页

作者： Biao-Qi chen Yi Zhao Yang Zhang Yu-Jing Pan Hong-Ying Xia Ranjith Kumar Kankala Shi-Bin Wang Gang Liu ai-zheng chen Institute of Biomaterials and Tissue Engineering Fujian Provincial Key Laboratory of Biochemical TechnologyHuaqiao UniversityXiamen361021PR China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen361102PR China

Although nano-immunotherapy has advanced dramatically in recent times,there remain two significant hurdles related to immune systems in cancer treatment,such as(namely)inevitable immune elimination of nanoplat-forms and severely immunosuppressive microenvironment with low immunogenicity,hampering the perfor-mance of *** address these issues,several immune-regulating camouflaged nanocomposites have emerged as prevailing strategies due to their unique characteristics and specific *** this review,we emphasize the composition,performances,and mechanisms of various immune-regulating camouflaged nano-platforms,including polymer-coated,cell membrane-camouflaged,and exosome-based nanoplatforms to evade the immune clearance of nanoplatforms or upregulate the immune function against the ***,we discuss the applications of these immune-regulating camouflaged nanoplatforms in directly boosting cancer immunotherapy and some immunogenic cell death-inducing immunotherapeutic modalities,such as chemo-therapy,photothermal therapy,and reactive oxygen species-mediated immunotherapies,highlighting the cur-rent progress and recent ***,we conclude the article with interesting perspectives,suggesting future tendencies of these innovative camouflaged constructs towards their translation pipeline.

关键词： Biological camouflage Immunogenic cell death Prolonged blood circulation Immune-regulating Nanovaccine

Reliability ensemble averaging reduces surface wind speed projection uncertainties in the 21st century over China

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Advances in Climate Change Research 2024年第2期15卷 222-229页

作者： zheng-Tai ZHANG Chang-ai XU Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China

Accurate prediction of future surface wind speed(SWS)changes is the basis of scientific planning for wind *** studies have projected SWS changes in the 21st century over China on the basis of the multi-model ensemble(MME)of the 6th Coupled Model Intercomparison Project(CMIP6).However,the simulation capability for SWS varies greatly in CMIP6 multi-models,so the MME results still have large *** this study,we used the reliability ensemble averaging(REA)method to assign each model different weights according to their performances in simulating historical SWS changes and project the SWS under different shared socioeconomic pathways(SSPs)in *** results indicate that REA considerably improves the SWS simulation capacity of CMIP6,eliminating the overestimation of SWS by the MME and increasing the simulation capacity of spatial *** spatial correlations with observations increased from 0.56 for the MME to 0.85 for ***,REA could eliminate the overestimation of the SWS by 33%in *** for southeastern China,the SWS generally decreases over China in the near term(2020-2049)and later term(2070-2099),particularly under high-emission *** SWS reduction projected by REA is twice as high as that by the MME in the near term,reaching-4%to-3%.REA predicts a larger area of increased SWS in the later term,which expands from southeastern China to eastern *** study helps to reduce the projected SWS uncertainties.

关键词： Surface wind speed Uncertainty Multi-model ensemble Reliability ensemble averaging CMIP6

Wellbore Cleaning Degree and Hydraulic Extension in Shale Oil Horizontal Wells

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Fluid Dynamics & Materials Processing 2024年第3期20卷 661-670页

作者： Xin ai Mian chen College of Petroleum Engineering China University of Petroleum(Beijing)BeijingChina Daqing Oil Field Company Limited DaqingChina

The efficient development and exploitation of shale oil depends on long-distance horizontal wells. As the degreeof cleaning of the wellbore plays a key role in these processes, in this study, this problem is investigated experimentallyby focusing on the dimensionless cuttings bed height. A method is proposed to calculate the horizontalwellhydraulic extension taking into account the influence of the wellbore cleaning degree on the wellborepressure distribution and assess the effect of a variety of factors such as the bottom hole pressure, the circulatingpressure drop, the drilling pump performance and the formation properties. The analysis shows that the hydraulicextension of horizontal wells decreases with an increase in the cuttings bed height, and the higher the displacementof drilling fluid, the faster the hydraulic extension declines. The annular pressure drop of the horizontalsection increases with the increase of the cuttings bed height, resulting in a higher bottom-hole pressure. Severalarguments are provided to guide the safe drilling of shale oil horizontal wells and overcome the limits of currenttechnological approaches.

关键词： Shale oil horizontal well hydraulic extension wellbore cleaning degree pressure distribution mechanism analysis

Disturbance Observer-based Pointing Control of Leighton Chajnantor Telescope

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Research in Astronomy and Astrophysics 2024年第1期24卷 135-150页

作者： Weirui chen zheng Wang School of Automation Southeast UniversityNanjing 210096China Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of EducationSoutheast UniversityNanjing 210096China

Leighton Chajnantor Telescope(LCT), i.e., the former Caltech Submillimeter Observatory telescope, will be refurbished at the new site in Chajnantor Plateau, Chile in 2023. The environment of LCT will change significantly after its relocation, and the telescope will be exposed to large wind disturbances directly because its enclosure will be completely open during observation. The wind disturbance is expected to be a challenge for LCT's pointing control since the existing control method cannot reject this disturbance very well. Therefore, it is very necessary to develop a new pointing control method with good capability of disturbance rejection. In this research, a disturbance observer—based composite position controller(DOB-CPC) is designed, in which an H∞feedback controller is employed to compress the disturbance, and a feedforward linear quadratic regulator is employed to compensate the disturbance precisely based on the estimated disturbance signal. Moreover, a controller switching policy is adopted, which applies the proportional controller to the transient process to achieve a quick response and applies the DOB-CPC to the steady state to achieve a small position error. Numerical experiments are conducted to verify the good performance of the proposed pointing controller(i.e., DOB-CPC) for rejecting the disturbance acting on LCT.

关键词： instrumentation:miscellaneous methods:analytical methods:numerical telescopes

Feasible strategy for the nitrogen fixation and humification quality improvement by spent mushroom substrate as conditioning agent

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 235-240页

作者： Shuang ai Yuanbei Zhang Guoxiang zheng College of Engineering Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Swine Facilities Engineering Ministry of Agriculture and Rural AffairsHarbin 50030China Heilongjiang Key Laboratory of Technology and Equipment for the Utilization of Agricultural Renewable Resources Harbin 150030China

There is an overlooked problem which increasing microbial abundance while reducing nitrogen loss during *** study investigated the viability of spent mushroom substrate(SMS)as conditioners in the aerobic composting of kitchen waste(KW)with cattle manure(CM).The variation of temperature,pH,C/N,organic matter,cellulose,hemicelluloses,germination index(GI),and microflora structure were explored to evaluate the potential in accelerating maturity and nitrogen fixation by SMS *** results showed that the addition of SMS accelerated the heating rate,prolonged the high temperature time,and decreased organic matter,hemicellulose,and cellulose by 17.49%,23.61%,and 18.62%,*** GI reached 105.86%with SMS addition,while 74.17%was found in control treatment after *** changed the microbial community composition and increased the species ***,Clostridium XI and Azomonas were dominant bacteria,which increased the retention of nitrogen,promoted organic matter degradation and reduce compost *** study can provide a feasible strategy for nitrogen fixation in the field of organic waste recycling.

关键词： spent mushroom substrate conditioning agent nitrogen fixation humification quality aerobic composting

Numerical Study of Water Transport and Operating Strategy for Fuel Cells with Segmented Water Management Flow Fields

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Journal of Thermal Science 2024年第4期33卷 1577-1589页

作者： chen chengdai WANG Changhong zheng Zijun School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China

The effective cathode flow field design can realize the internal water balance and higher current density output of proton exchange membrane fuel cells(PEMFC).Therefore,a segmented water management flow field is proposed in this study,i.e.a half separated-half coupled cathode(HSHC)flow field which has two inlets but just one outlet.A 3D numerical PEMFC model is applied to study the effect of the HSHC flow field on PEMFC performance and its operating strategy in terms of operating *** study results are shown as follows:Compared with the two conventional cathode flow fields,the HSHC flow field improves the water balance along the channel and increases the current density by 17.1%at a cathode stoichiometry of *** is because the HSHC flow field can overcome the water loss at channels upstream and the water accumulation at channels *** draw water phenomenon(DWP)in the HSHC flow field is observed,which is mainly affected by the water vapor pressure of *** on the DWP,cooling channel inlet flow rates can be used to adjust water balance,but severe water loss should be *** addition,the inlet temperature control in HSHC flow field should be that cell temperature>cathode channel inlet temperature>cooling channel inlet temperature>ambient temperatures for better water balance.

关键词： proton exchange membrane fuel cells channel design segmented water management water balance operating strategy

Nanoscale Reorganization of Glutamate Receptors Underlies Synaptic Plasticity and Pathology

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Neuroscience Bulletin 2024年第6期40卷 840-844页

作者： Jia-Hui chen ai-Hui Tang Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research Center and Biomedical Sciences and Health Laboratory of Anhui ProvinceUniversity of Science and Technology of ChinaHefei230027China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei230088China

Excitatory synapses serve as the primary sites for information transmission between neurons in the *** work over the past decades has identified and revealed multiple compositions and functions of the synaptic proteome in the postsynaptic density(PSD),including receptors,scaffold proteins,and signaling molecules,which work together to ensure stable and effective synaptic transmission.

关键词： Receptor scale Glutamate