Immune-regulating camouflaged nanoplatforms:A promising strategy to improve cancer nano-immunotherapy
作者机构：Institute of Biomaterials and Tissue EngineeringFujian Provincial Key Laboratory of Biochemical TechnologyHuaqiao UniversityXiamen361021PR China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen361102PR China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2023年第21卷第3期
页 面：1-19页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学]
基 金：Financial support from the National Key Research&Development Program of China(2019YFE0113600) National Natural Science Foundation of China(NSFC,81971734,and 32071323) Program for Innovative Research Team in Science and Technology in Fujian Province University,and the Scientific Research Funds of Huaqiao University(20BS104)
主 题：Biological camouflage Immunogenic cell death Prolonged blood circulation Immune-regulating Nanovaccine
摘 要：Although nano-immunotherapy has advanced dramatically in recent times,there remain two significant hurdles related to immune systems in cancer treatment,such as(namely)inevitable immune elimination of nanoplat-forms and severely immunosuppressive microenvironment with low immunogenicity,hampering the perfor-mance of *** address these issues,several immune-regulating camouflaged nanocomposites have emerged as prevailing strategies due to their unique characteristics and specific *** this review,we emphasize the composition,performances,and mechanisms of various immune-regulating camouflaged nano-platforms,including polymer-coated,cell membrane-camouflaged,and exosome-based nanoplatforms to evade the immune clearance of nanoplatforms or upregulate the immune function against the ***,we discuss the applications of these immune-regulating camouflaged nanoplatforms in directly boosting cancer immunotherapy and some immunogenic cell death-inducing immunotherapeutic modalities,such as chemo-therapy,photothermal therapy,and reactive oxygen species-mediated immunotherapies,highlighting the cur-rent progress and recent ***,we conclude the article with interesting perspectives,suggesting future tendencies of these innovative camouflaged constructs towards their translation pipeline.
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