检索结果-南通市图书馆

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei ai-hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo hui Bojing sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

Mapping Properties of Certain Oscillatory Integrals on Modulation Spaces

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2017年第12期33卷 1647-1658页

作者： Mei Fang CHENG hui hui LIU ai Wen sun School of Mathematical and Computer Sciences Anhui Normal University Wuhu 241002 P. R. China

Suppose β1 〉 α1 ≥ 0, β2 〉 α2 ≥ 0 and （k,j） ∈ R^2. In this paper, we mainly investigate the mapping properties of the operator Tα,βf（x,y,z）=∫Q^2f（x-t,y-s,z-t^ks^j）e^-2πit-β1s-β2t^-1-α1s^-1-α2 dtd... 详细信息

关键词： Modulation space singular integral operator Wiener amalgam space

在线全文

学校读者我要写书评

暂无评论

正常人和肝病患者肝血流图的临床观察

新疆医学院学报 1983年第3期 192-198页

作者：翟琦王吉爱孙惠敏新疆医学院第一附属医院传染科

本文报告了乌鲁木齐地区210名正常成人和135名各种肝病的肝血流图改变,为该地区提供了肝血流图正常值。讨论了肝血流图在各种肝病中的临床意义。

关键词：肝血流图肝阻抗图正常人肝病患者锯齿波收缩波肝硬变慢性间质性肝炎肝疾病肝癌肝脏肿瘤探查电极

RF Optimizer Model for Predicting Compressive Strength of Recycled Concrete

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期 215-223页

作者：刘琳王柳燕 WANG hui sun Huayue School of Civil Engineering and Architecture Shenyang University

Traditional machine learning （ML） encounters the challenge of parameter adjustment when predicting the compressive strength of reclaimed *** address this issue,we introduce two optimized hybrid models:the Bayesian optimization model （B-RF） and the optimal model （Stacking model）.These models are applied to a data set comprising 438 observations with five input variables,with the aim of predicting the compressive strength of reclaimed ***,we evaluate the performance of the optimized models in comparison to traditional machine learning models,such as support vector regression （SVR）,decision tree （DT）,and random forest （RF）.The results reveal that the Stacking model exhibits superior predictive performance,with evaluation indices including R2=0.825,MAE=2.818 and MSE=14.265,surpassing the traditional ***,we also performed a characteristic importance analysis on the input variables,and we concluded that cement had the greatest influence on the compressive strength of reclaimed concrete,followed by water. Therefore,the Stacking model can be recommended as a compressive strength prediction tool to partially replace laboratory compressive strength testing,resulting in time and cost savings.

关键词：

Thermal performance analysis of non-uniform height rectangular fin based on constructal theory and entransy theory

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2016年第12期59卷 1882-1891页

作者： YANG ai Bo CHEN Lin Gen XIE Zhi hui FENG hui Jun sun Feng Rui Institute of Thermal Science and Power Engineering Military Key Laboratory for Naval Ship Power EngineeringCollege of Power EngineeringNaval University of Engineering

A model of non-uniform height rectangular fin, in which the variation of base's thickness and width are taken into account, is established in this paper. The dimensionless maximum thermal resistance(DMTR) and the dimensionless equivalent thermal resistance(DETR) defined based on the entransy dissipation rate(EDR) are taken as performance evaluation indexes. According to constructal theory, the variations of the two indexes with the geometric parameters of the fin are analyzed by using a finite-volume computational fluid dynamics code, the effects of the fin-material fraction on the two indexes are analyzed. It is found that the two indexes decrease monotonically as the ratio between the front height and the back height of the fin increases subjected to the non-uniform height rectangular fin. When the model is reduced to the uniform height fin, the two indexes increase first and then decrease with increase in the ratio between the height of the fin and the fin space. The fin-material fraction has no effect on the change rule of the two indexes with the ratio between the height of the fin and the fin space. The sensitivity of the DETR to the geometric parameters of the fin is higher than that of the DMTR to the geometric parameters. The results obtained herein can provide some theoretical support for the thermal design of rectangular fins.

关键词： constructal design entransy theory maximum thermal resistance equivalent thermal resistance rectangular fin generalized thermodynamic optimization

Bibliometric analysis of papers on mild cognitive impairment nursing in China

在线全文

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2017年第1期4卷 73-79页

作者： Yating ai Kaili sun hui Hu School of Nursing Hubei University of Chinese Medicine Wuhan China

Purpose: To supply further references by analyzing the status of research on mild cognitive impairment nursing in ***: Papers on mild cognitive impairment nursing published between 2005 and 2014 were collected from China National Knowledge Infrastructure,Wanfang Data,and China Biological Medicine database,while their publication dates,journals,and types were subjected to a bibliometric analysis using NoteExpress and ***: A total of 68 papers were collected from the selected *** number of papers on mild cognitive impairment nursing increased *** selected papers were published in 44 journals,55.88% of them were published in core journals,35.29% received funding support,35.29% were published by hospitals affiliated to colleges,47.06% were published by other local hospitals,author collaboration is 2.66,and 66.18% showed *** papers covered a wide range of topics,but were only conducted based on clinical *** 29.41% of these papers had a citation frequency of over 5,the highest citation frequency was 29,and the highest h-index was ***: Beijing and Shanghai established core author groups for mild cognitive impairment nursing *** studies should focus on the community and psychological nursing of such *** nursing interventions on different types of mild cognitive impairment should be adopted,new avenues for research should be opened,and various research methods should be introduced.

关键词： Mild cognitive impairment Nursing Bibliometric

Unraveling brain aging through the lens of oral microbiota

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu Guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

Combined radiochemotherapy in patients with locally advanced pancreatic cancer: A meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第42期19卷 7461-7471页

作者： Yue Chen Xian-Jun sun Ting-hui Jiang ai-Wu Mao Department of Radiology Renji Hospital of Shanghai Jiaotong University School of Medicine Department of Combined Traditional Chinese and Western Medicine for Liver Gallbladder and Pancreas DiseasesMinhang BranchFudan University Shanghai Cancer Center Intervention Center Tongren BranchRenji Hospital of Shanghai Jiaotong University School of Medicine

aiM:To compare the long-term clinical efficacy of chemotherapy plus radiotherapy(CRT)with that of radiotherapy alone(RT)or chemotherapy alone(CT)for locally advanced pancreatic carcinoma(LAPC).METHODS:Using manual and computer-aided methods,we searched the data through the databases,including PubMed/EmBase/CNKI/CQVIP/China Journals Full Text Database and websites and proceedings of major annual meetings such as ASCO and *** methodological quality of the included studies was assessed using the Jadad scoring *** English and Chinese publications were *** collected data from controlled clinical trials on CRT vs RT or CT for LAPC,and conducted a meta-analysis of 15 included ***-analysis was performed using RevMan4.2Software according to the method recommended by Cochrane ***:Fifteen eligible randomized controlled trials including a total of 1128 patients were *** score was 2 in only one article,and 3-4 in the remaining 14 *** meta-analysis showed that CRT was superior in the 6-and 12-mo survivals to the RT alone group or CT alone group(P=0.0001 and P=0.02,respectively),whereas the 18-mo survival showed no significant difference(P=0.23).Subgroup analysis showed that the 6-,12-,and 18-mo survivals were not significantly different between the CRT group and CT group(P=0.07,P=0.23,and P=0.91,respectively).Notably,the CRT group had significantly better 6-,12-,and 18-mo survivals than the RT group(all P<0.01).CRT group had significantly more grade 3-4 treatmentrelated hematologic and non-hematologic toxicities than the CT group or RT group(all P<0.01).CONCLUSION:Compared with CT or RT,CRT can benefit the long-term survival of LAPC patients,although it may also increase treatment-related toxicities.

关键词： Pancreatic cancer Chemotherapy Radiotherapy Meta-analysis Survival