Combined radiochemotherapy in patients with locally advanced pancreatic cancer: A meta-analysis

作     者：Yue Chen Xian-Jun Sun Ting-Hui Jiang Ai-Wu Mao 

作者机构：Department of RadiologyRenji Hospital of Shanghai Jiaotong University School of Medicine Department of Combined Traditional Chinese and Western Medicine for LiverGallbladder and Pancreas DiseasesMinhang BranchFudan University Shanghai Cancer Center Intervention CenterTongren BranchRenji Hospital of Shanghai Jiaotong University School of Medicine 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第42期

页      面：7461-7471页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Shanghai Science and Technology Development Fund No.10JC1412902 

主　　题：Pancreatic cancer Chemotherapy Radiotherapy Meta-analysis Survival 

摘      要：AIM:To compare the long-term clinical efficacy of chemotherapy plus radiotherapy(CRT)with that of radiotherapy alone(RT)or chemotherapy alone(CT)for locally advanced pancreatic carcinoma(LAPC).METHODS:Using manual and computer-aided methods,we searched the data through the databases,including PubMed/EmBase/CNKI/CQVIP/China Journals Full Text Database and websites and proceedings of major annual meetings such as ASCO and *** methodological quality of the included studies was assessed using the Jadad scoring *** English and Chinese publications were *** collected data from controlled clinical trials on CRT vs RT or CT for LAPC,and conducted a meta-analysis of 15 included ***-analysis was performed using RevMan4.2Software according to the method recommended by Cochrane ***:Fifteen eligible randomized controlled trials including a total of 1128 patients were *** score was 2 in only one article,and 3-4 in the remaining 14 *** meta-analysis showed that CRT was superior in the 6-and 12-mo survivals to the RT alone group or CT alone group(P=0.0001 and P=0.02,respectively),whereas the 18-mo survival showed no significant difference(P=0.23).Subgroup analysis showed that the 6-,12-,and 18-mo survivals were not significantly different between the CRT group and CT group(P=0.07,P=0.23,and P=0.91,respectively).Notably,the CRT group had significantly better 6-,12-,and 18-mo survivals than the RT group(all P0.01).CRT group had significantly more grade 3-4 treatmentrelated hematologic and non-hematologic toxicities than the CT group or RT group(all P0.01).CONCLUSION:Compared with CT or RT,CRT can benefit the long-term survival of LAPC patients,although it may also increase treatment-related toxicities.