检索结果-南通市图书馆

UPLC-Q-TOF/MS-based metabolomic studies on the toxicity mechanisms of traditional Chinese medicine Chuanwu and the detoxification mechanisms of Gancao, Baishao, and Ganjiang

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2015年第9期13卷 687-698页

作者： DONG hui YAN Guang-Li HAN Ying sun hui ZHANG ai-Hua LI Xian-Na WANG Xi-Jun National TCM Key Laboratory of Serum Pharmacochemistry Laboratory of Metabolomics and Chinmedomics Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine

Chuanwu(CW), a famous traditional Chinese medicine(TCM) from the mother roots of Aconitum carmichaelii Debx..(Ranunculaceae), has been used for the treatment of various diseases. Unfortunately, its toxicity is frequently reported because of its narrow therapeutic window. In the present study, a metabolomic method was performed to characterize the phenotypically biochemical perturbations and potential mechanisms of CW-induced toxicity. Meanwhile, the expression level of toxicity biomarkers in the urine were analyzed to evaluate the detoxification by combination with Gancao(Radix Glyeyrrhizae, CG), Baishao(Radix Paeoniae Alba, CS) and Ganjiang(Rhizoma Zingiberis, CJ), which were screened from classical TCM prescriptions. Urinary metabolomics was performed by UPLC-Q-TOF-HDMS, and the mass spectra signals of the detected metabolites were systematically analyzed using pattern recognition methods. As a result, seventeen biomarkers associated with CW toxicity were identified, which were associated with pentose and glucuronate interconversions, alanine, aspartate, and glutamate metabolism, among others. The expression levels of most toxicity biomarkers were effectively modulated towards the normal range by the compatibility drugs. It indicated that the three compatibility drugs could effectively detoxify CW. In summary, our work demonstrated that metabolomics was vitally significant to evaluation of toxicity and finding detoxification methods for TCM.

关键词： Metabolomics Aconitum Chuanwu Detoxification Compatibility

An eikonal equation based path planning method using polygon decomposition and curve evolution

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2020年第5期16卷 1001-1018页

作者： Zheng sun Zhu-Feng Shao hui Li School of Mechanical and Electrical Engineering Zaozhuang UniversityZaozhuang277160China Department of Mechanical Engineering School of Mechanical EngineeringTsinghua UniversityBeijing100084China

Path planning is a key technique of autonomous navigation for robots,and the velocity field is an important *** velocity field in a complex workspace is still *** this paper,an inner normal guided segmentation algorithm in a complex polygon is proposed to decompose the complex workspace in this *** artificial potential field model based on probability theory is then used to calculate the potential field of the decomposed workspace,and the velocity field is obtained by utilizing the potential field of this *** optimization is implemented by curve evolution,during which the internal force generated in the smoothing process of the initial path by a mean filter and the external force is obtained from the gradient of the workspace potential *** parameter selection principle is deduced by analyzing the influence of several parameters on the path length and *** results show that the designed polygon decomposition algorithm can effectively segment complex workspace and that the path optimization algorithm can shorten and smoothen paths.

关键词： Level set Path planning Artificial potential field Polygon decomposition Path optimization Curve evolution

NiO-Doped Fe_(2)O_(3)/MgO Properties for the Chemical Looping Oxidative Dehydrogenation of Ethane

在线全文

学校读者我要写书评

暂无评论

China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 27-33页

作者： Liang Hao Chen Junjie sun Jie sun hui Shenyang Ligong University Shenyang 110159China Fushun Ecology Environment Bureau Qingyuan County Branch Fushun 113399China

Ethane chemical looping oxidative dehydrogenation(CL-ODH)to ethylene is a new technology for ethylene ***_(2)O_(3)/MgO oxygen carrier was prepared using the co-precipitation *** influence of added NiO and its different loadings on Fe_(2)O_(3)/MgO were ***,a series of oxygen carriers were applied in the CL-ODH of the ethane cycle ***-Emmett-Teller(BET),X-ray diffractometry(XRD),X-ray photoelection spectroscopy(XPS),and H2-temperature programmed reduction(TPR)were used to characterize the physicochemical properties of these oxygen *** was confirmed that an interaction between NiO and Fe_(2)O_(3) occurred based on the XPS and H2-TPR *** on the CL-ODH activity performance tests conducted in a fixed-bed reactor,it was revealed that ethylene selectivity was significantly improved after NiO ***_(2)O_(3)-10%NiO/MgO showed the best activity performance with 93%ethane conversion and 50%ethylene selectivity at a reaction temperature of 650℃,atmospheric pressure,and space velocity of 7500 mL/(g·h).

关键词： chemical looping oxidative dehydrogenation oxygen carrier Fe_(2)O_(3)/MgO NiO

Liver-resident NK cells and their potential functions

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2017年第11期14卷 890-894页

作者： hui Peng Rui sun Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Sciences and Medical CenterUniversity of Science and Technology of ChinaHefeiAnhui 230027China

Natural killer(NK)cells represent a heterogeneous population of innate lymphocytes with phenotypically and functionally distinct *** particular,recent studies have identified a unique subset of NK cells residing within the liver that are maintained as tissue-resident cells,confer antigen-specific memory responses and exhibit different phenotypical and developmental characteristics compared with conventional NK(cNK)*** findings have encouraged researchers to uncover tissue-resident NK cells at other sites,and detailed analyses have revealed that these tissue-resident NK cells share many similarities with liver-resident NK cells and tissue-resident memory T ***,we present a brief historical perspective on the discovery of liver-resident NK cells and discuss their relationship to cNK cells and other emerging NK cell subsets and their potential functions.

关键词： potential maintained finding

Polarised radio emission associated with HESS J1912+101

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2019年第3期19卷 123-130页

作者： Wolfgang Reich Xiao-hui sun Max-Planck-Institut für Radioastronomie Department of Astronomy Yunnan Universityand Key Laboratory of Astroparticle Physics of Yunnan Province

The shell-type TeV source HESS J1912+101 was tentatively identified as an old supernova remnant, but is missing counterparts at radio and other frequencies. We analysed the Sino-German Urumqiλ6 cm survey and the Effelsberg λ11 cm and λ21 cm surveys to identify radio emission from HESS J1912+101 to clarify the question of a supernova origin. We find a partial shell of excessive polarisation at λ6 cm at the periphery of HESS J1912+101. At λ11 cm, its polarised emission is faint and suffers from depolarisation, while at λ21 cm, no related polarisation is seen. We could not separate the shell's total intensity signal from the confusing intense diffuse emission from the inner Galactic plane. However, a high percentage of polarisation in the shell's synchrotron emission is indicated. Our results support earlier suggestions that HESS J1912+101 is an old supernova remnant. The synchrotron emission is highly polarised,which is typical for evolved supernova remnants with low surface brightness.

关键词： radio continuum ISM-ISM individual objects HESS J1912+101-ISM magnetic fields

Total Synthesis of Syringin and Its Natural Analogues via C—C Bond Activation of Aryl Ketones

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第24期41卷 3587-3592页

作者： Zhen-Yu Wang Yi sun Guo-Dong sun hui Xu hui-Xiong Dai School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjingJiangsu210023 China CAS Key Laboratory of Receptor Research State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203 China University of Chinese Academy of Sciences Beijing100049 China

Syringin is found in the root of Acanthopanax senticosus(***.)Harms and belongs to the lignin chemical compound with many biological *** this study,we employed commercially available starting materials and accomplished the total synthesis of syringin in 5 steps with an overall yield of 58%.Palladium-catalyzed C(O)–C bond activation and subsequent cross coupling reaction is the key to construct syringin and its natural analogues.

关键词： Syringin Total synthesis Cross-coupling C—C activation Syringin analogues

Microstructure and properties of joint for stirring brazing of dissimilar Al/Mg alloy during heating processes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2015年第4期34卷 245-250页

作者： hui-Bin Xu hui-Bin sun hui Yang Lu-Xin Chi Jun Chen School of Materials Science and Engineering Chongqing University of Technology

In this paper, 2024 Al alloy and AZ31B Mg alloy were brazed with aid of stirring without flux in air. The effects of the brazing temperature on microstructure and shear strength of the joint were investigated. The diffusion zone is found at joint interface near Al base metal, which consists of Al-Zn-Sn solid solution. At the same time, continuous intermetallic compounds （IMCs） phase and broken ones are found at joint interface near Mg base metal, which mainly consists of the Mg2Sn phase. With the increase of the brazing temperature, the shear strength at the joint interface near A1 base metal rises gradually. On the contrary, that of the joint interface near Mg base metal obviously decreases.

关键词： Stirring brazing 2024 Al alloy AZ31B Mg alloy Temperature

Twisting Sliding Mode Control of an Electrostatic MEMS Micromirror for a Laser Scanning System

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2019年第4期6卷 1060-1067页

作者： hui Chen Zhendong sun Weijie sun John Tze Wei Yeow the School of Computer and Information Engineering Henan UniversityKaifeng 475000China the Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190 China the College of Automation Science and Engineering South China University of TechnologyGuangzhou 510641China the Systems Design Engineering University of WaterlooWaterloo N2L3G1Canada IEEE

In this paper,we present a twisting control scheme with proportional-integral-derivative(PID)sliding surface for a two-axis electrostatic torsional micromirror,and the utilization of the proposed scheme in a laser scanning *** experimental results of set-point regulation verify that the proposed scheme provides enhanced transient response and positioning performance as compared to traditional sliding mode *** evaluate the tracking performance of the closed-loop system,triangular waves with different frequencies are used as desired *** the proposed scheme the experimental results verified that the closed-loop controlled micromirror follows the given triangular trajectories precisely.A micromirror-based laser scanning system is developed to obtain *** compared with open-loop control,the experimental results demonstrated that the proposed scheme is able to reduce the distortion of the raster scan,and improve the imaging performance in the presence of cross-coupling effect.

关键词： Electrostatic micromirror imaging microelectromechanical system(MEMS) twisting algorithm

Cumulative prospect theory-based user equilibrium model with stochastic perception errors

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2016年第9期23卷 2465-2474页

作者： WANG Wei sun hui-jun Key Laboratory of Urban Transportation Complex Systems Theory and Technology of Ministry of Education Beijing Jiaotong University Beijing 100044 China

The cumulative prospect theory(CPT) is applied to study travelers' route choice behavior in a degradable transport network. A cumulative prospect theory-based user equilibrium(CPT-UE) model considering stochastic perception error(SPE) within travelers' route choice decision process is developed. The SPE is conditionally dependent on the actual travel time distribution, which is different from the deterministic perception error used in the traditional logit-based stochastic user equilibrium. The CPT-UE model is formulated as a variational inequality problem and solved by a heuristic solution algorithm. Numerical examples are provided to illustrate the application of the proposed model and efficiency of the solution algorithm. The effects of SPE on the reference point determination, cumulative prospect value estimation, route choice decision and network performance evaluation are investigated.

关键词： cumulative prospect theory user equilibrium stochastic perception error variational inequality