Liver-resident NK cells and their potential functions
作者机构：Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Life Sciences and Medical CenterUniversity of Science and Technology of ChinaHefeiAnhui 230027China
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2017年第14卷第11期
页 面：890-894页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：by the Natural Science Foundation of China(#81761128013,81571522,91642105,81361120388,31300727,91542114,91442112,91542000 and 81330071) the Ministry of Science and Technology of China(973 Basic Science Project 2013CB944902)
主 题：potential maintained finding
摘 要：Natural killer(NK)cells represent a heterogeneous population of innate lymphocytes with phenotypically and functionally distinct *** particular,recent studies have identified a unique subset of NK cells residing within the liver that are maintained as tissue-resident cells,confer antigen-specific memory responses and exhibit different phenotypical and developmental characteristics compared with conventional NK(cNK)*** findings have encouraged researchers to uncover tissue-resident NK cells at other sites,and detailed analyses have revealed that these tissue-resident NK cells share many similarities with liver-resident NK cells and tissue-resident memory T ***,we present a brief historical perspective on the discovery of liver-resident NK cells and discuss their relationship to cNK cells and other emerging NK cell subsets and their potential functions.
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