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新会陈皮中4株糖苷酶高产菌的分离鉴定、益生特性及发酵效果分析

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食品工业科技 2025年第1期46卷 171-180页

作者：沈飞王庭雨孙辉吴振强华南理工大学生物科学与工程学院广东广州510006 江门市泛亚生物工程与健康研究院广东江门529000 江门市泛亚生物工程与健康产业有限公司广东江门529000 仲恺农业工程学院农业与生物学院广东广州510006

为扩充促进新会陈皮发酵陈化的益生菌种质资源,本研究从新会陈皮中分离鉴定出4株细菌,并对其产酶能力、益生特性、安全性以及发酵新会陈皮的效果进行了评价。4株细菌均属于芽孢杆菌属,其中菌株L7具有最高的产滤纸酶、羧甲基纤维素酶、β... 详细信息

为扩充促进新会陈皮发酵陈化的益生菌种质资源,本研究从新会陈皮中分离鉴定出4株细菌,并对其产酶能力、益生特性、安全性以及发酵新会陈皮的效果进行了评价。4株细菌均属于芽孢杆菌属,其中菌株L7具有最高的产滤纸酶、羧甲基纤维素酶、β-葡萄糖苷酶和果胶酶能力,酶活分别达到1.84、0.79、1.6和1.24 U/mL。所有菌株均能在胃肠道环境下良好的存活,具有较强的抑菌性和共聚集性,无溶血性,且对多种抗生素敏感,表现出良好的益生特性和安全性。L7发酵新会陈皮效果最佳。经L7发酵后,新会陈皮结合态黄酮组分被有效地转化成游离态形式释放,特别是橙皮苷、川陈皮素和桔皮素,较未发酵新会陈皮分别提高了34.8%、93.7%以及102.7%。此外,L7发酵后的新会陈皮表现出更强的抗氧化活性,这与其具有更高的柚皮素和橙皮素含量密切相关。本研究结果为新会陈皮健康产品的开发和加速陈化技术的建立提供了参考。

关键词：新会陈皮芽孢杆菌糖苷酶益生特性发酵效果

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Bibliometric analysis of papers on mild cognitive impairment nursing in China

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International Journal of Nursing Sciences 2017年第1期4卷 73-79页

作者： Yating ai Kaili sun hui Hu School of Nursing Hubei University of Chinese Medicine Wuhan China

Purpose: To supply further references by analyzing the status of research on mild cognitive impairment nursing in ***: Papers on mild cognitive impairment nursing published between 2005 and 2014 were collected from China National Knowledge Infrastructure,Wanfang Data,and China Biological Medicine database,while their publication dates,journals,and types were subjected to a bibliometric analysis using NoteExpress and ***: A total of 68 papers were collected from the selected *** number of papers on mild cognitive impairment nursing increased *** selected papers were published in 44 journals,55.88% of them were published in core journals,35.29% received funding support,35.29% were published by hospitals affiliated to colleges,47.06% were published by other local hospitals,author collaboration is 2.66,and 66.18% showed *** papers covered a wide range of topics,but were only conducted based on clinical *** 29.41% of these papers had a citation frequency of over 5,the highest citation frequency was 29,and the highest h-index was ***: Beijing and Shanghai established core author groups for mild cognitive impairment nursing *** studies should focus on the community and psychological nursing of such *** nursing interventions on different types of mild cognitive impairment should be adopted,new avenues for research should be opened,and various research methods should be introduced.

关键词： Mild cognitive impairment Nursing Bibliometric

MOFs和COFs在选择性富集及色谱分离中药活性成分中的应用进展

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分析测试学报 2025年第1期44卷 82-90页

作者：司甜甜赵薇孙启慧容蓉孙敏山东中医药大学药学院山东济南250355 济南大学化学与化工学院山东济南250022

金属有机框架材料(MOFs)和共价有机框架材料(COFs)具有超大比表面积和可调节的孔径等结构特点,可以实现目标化合物的选择性富集和分离,在中药活性成分领域表现出广泛的应用前景。该文综述了MOFs、COFs的常用制备方法,阐述了MOFs、COFs... 详细信息

金属有机框架材料(MOFs)和共价有机框架材料(COFs)具有超大比表面积和可调节的孔径等结构特点,可以实现目标化合物的选择性富集和分离,在中药活性成分领域表现出广泛的应用前景。该文综述了MOFs、COFs的常用制备方法,阐述了MOFs、COFs及其复合材料在选择性富集、色谱分离不同中药基质活性成分方面的应用,并结合网络药理学探讨了其在靶向中药活性成分方面的发展前景,为新型有机框架材料在中药有效成分领域的研究提供了思路。

关键词：金属有机框架共价有机框架中药活性成分选择性富集色谱分离

Combined radiochemotherapy in patients with locally advanced pancreatic cancer: A meta-analysis

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World Journal of Gastroenterology 2013年第42期19卷 7461-7471页

作者： Yue Chen Xian-Jun sun Ting-hui Jiang ai-Wu Mao Department of Radiology Renji Hospital of Shanghai Jiaotong University School of Medicine Department of Combined Traditional Chinese and Western Medicine for Liver Gallbladder and Pancreas DiseasesMinhang BranchFudan University Shanghai Cancer Center Intervention Center Tongren BranchRenji Hospital of Shanghai Jiaotong University School of Medicine

aiM:To compare the long-term clinical efficacy of chemotherapy plus radiotherapy(CRT)with that of radiotherapy alone(RT)or chemotherapy alone(CT)for locally advanced pancreatic carcinoma(LAPC).METHODS:Using manual and computer-aided methods,we searched the data through the databases,including PubMed/EmBase/CNKI/CQVIP/China Journals Full Text Database and websites and proceedings of major annual meetings such as ASCO and *** methodological quality of the included studies was assessed using the Jadad scoring *** English and Chinese publications were *** collected data from controlled clinical trials on CRT vs RT or CT for LAPC,and conducted a meta-analysis of 15 included ***-analysis was performed using RevMan4.2Software according to the method recommended by Cochrane ***:Fifteen eligible randomized controlled trials including a total of 1128 patients were *** score was 2 in only one article,and 3-4 in the remaining 14 *** meta-analysis showed that CRT was superior in the 6-and 12-mo survivals to the RT alone group or CT alone group(P=0.0001 and P=0.02,respectively),whereas the 18-mo survival showed no significant difference(P=0.23).Subgroup analysis showed that the 6-,12-,and 18-mo survivals were not significantly different between the CRT group and CT group(P=0.07,P=0.23,and P=0.91,respectively).Notably,the CRT group had significantly better 6-,12-,and 18-mo survivals than the RT group(all P<0.01).CRT group had significantly more grade 3-4 treatmentrelated hematologic and non-hematologic toxicities than the CT group or RT group(all P<0.01).CONCLUSION:Compared with CT or RT,CRT can benefit the long-term survival of LAPC patients,although it may also increase treatment-related toxicities.

关键词： Pancreatic cancer Chemotherapy Radiotherapy Meta-analysis Survival

Removal of residual nitrate ion from bioactive calcium silicate through soaking

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Chinese Chemical Letters 2016年第4期27卷 579-582页

作者： Yong-Sen sun ai-Ling Li hui-hui Ren Xin-Ping Zhang Chao Wang Dong Qiu Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100190 China

Bioactive calcium silicates prepared by sol–gel routes mainly use calcium nitrate as the calcium precursor. However, the toxic nitrate ions are usually removed by calcination（i.e. 550 8C or over）, which poses great challenge for the in situ preparation of inorganic/polymer composites, as polymer moieties could not survive such temperatures. In this study, we prepared 70Si30Ca（70 mol% Si O_2 and 30 mol%Ca O） bioactive glass at low temperatures where polymer could survive（i.e. 200 8C and 350 8C）, and proposed to remove the residual nitrate ions through soaking. Deionized water and simulated body fluid（SBF） were employed as the soaking medium. The results showed that the residual nitrate ions could be removed as quickly as 0.5 h while maintain the bioactivity of the samples. This technique may open the possibility of preparing sol–gel derived bioactive glass/polymer hybrids in situ with reduced potential toxicity.

关键词： Nitrate ion Bioactive Calcium silicate Soaking FTIR

Deep learning-based software engineering: progress,challenges, and opportunities

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Science China(Information Sciences) 2025年第1期68卷 57-144页

作者： Xiangping CHEN Xing HU Yuan HUANG He JIANG Weixing JI Yanjie JIANG Yanyan JIANG Bo LIU hui LIU Xiaochen LI Xiaoli LIAN Guozhu MENG Xin PENG Hailong sun Lin SHI Bo WANG Chong WANG Jiayi WANG Tiantian WANG Jifeng XUAN Xin XIA Yibiao YANG Yixin YANG Li ZHANG Yuming ZHOU Lu ZHANG School of Journalism and Communication Sun Yat-sen University School of Software Technology Zhejiang University School of Software Engineering Sun Yat-sen University School of Software Dalian University of Technology School of Computer Science and Technology Beijing Institute of Technology Key Laboratory of High Confidence Software Technologies (Peking University) Ministry of EducationSchool of Computer Science Peking University State Key Laboratory for Novel Software Technology Nanjing University School of Computer Science and Engineering Beihang University Institute of Information Engineering Chinese Academy of Sciences School of Computer Science Fudan University State Key Laboratory of Complex & Critical Software Environment (CCSE) School of Software Beihang University School of Computer and Information Technology Beijing Jiaotong University School of Computer Science and Technology Harbin Institute of Technology School of Computer Science Wuhan University Huawei Technologies

Researchers have recently achieved significant advances in deep learning techniques, which in turn has substantially advanced other research disciplines, such as natural language processing, image processing, speech recognition, and software engineering. Various deep learning techniques have been successfully employed to facilitate software engineering tasks, including code generation, software refactoring, and fault localization. Many studies have also been presented in top conferences and journals, demonstrating the applications of deep learning techniques in resolving various software engineering tasks. However,although several surveys have provided overall pictures of the application of deep learning techniques in software engineering,they focus more on learning techniques, that is, what kind of deep learning techniques are employed and how deep models are trained or fine-tuned for software engineering tasks. We still lack surveys explaining the advances of subareas in software engineering driven by deep learning techniques, as well as challenges and opportunities in each subarea. To this end, in this study, we present the first task-oriented survey on deep learning-based software engineering. It covers twelve major software engineering subareas significantly impacted by deep learning techniques. Such subareas spread out through the whole lifecycle of software development and maintenance, including requirements engineering, software development, testing, maintenance, and developer collaboration. As we believe that deep learning may provide an opportunity to revolutionize the whole discipline of software engineering, providing one survey covering as many subareas as possible in software engineering can help future research push forward the frontier of deep learning-based software engineering more systematically. For each of the selected subareas,we highlight the major advances achieved by applying deep learning techniques with pointers to the available datasets i

关键词： deep learning software engineering software benchmark software artifact representation survey

Sperm chromatin structure assay results after swim-up are related only to embryo quality but not to fertilization and pregnancy rates following IVF

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Asian Journal of Andrology 2011年第6期13卷 862-866页

作者： Zhi-Hong Niu hui-Juan Shi hui-Qin Zhang ai-Jun Zhang Yi-Juan sun Yun Feng IVF Unit Department of Obstetrics and Gynecology Ruijin Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200025 China Shanghai Institute of Planned Parenthood Research Shanghai 200032 China

The aim of this study was to investigate whether the sperm chromatin structure assay （SCSA） results after swim-up are related to fertilization rates, embryo quality and pregnancy rates following in vitrofertilization （IVF）. A total of 223 couples undergoing IVF in our hospital from October 2008 to September 2009 were included in this study. Data on the IVF process and sperm chromatin structure assay results were collected. Fertilization rate, embryo quality and IVF success rates of different DNA fragmentation index （DFI） subgroups and high DNA stainability （HDS） subgroups were compared. There were no significant differences in fertilization rate, clinical pregnancy or delivery rates between the DFI and HDS subgroups. However, the group with abnormal DFI had a lower good embryo rate. So, we concluded that the SCSA variables, either DFI or HDS after swim-up preparation, were not valuable in predicting fertilization failure or pregnancy rate, but an abnormal DFI meant a lower good embryo rate following IVF.

关键词： embryo fertilization in-vitro fertilization sperm chromatin structure assay

Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern China？

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Frontiers of Medicine 2014年第1期8卷 113-117页

作者： Lizhe ai Yaqin Yu Xiaoli Liu Chong Wang Jieping Shi hui sun Qiong Yu Department of Epidemiology and Biostatistics School of Public Health Jilin University Changchun 130021 China Jilin Provincial Key Laboratory of Surgical Translational Medicine Department of Thyroid and Parathyroid Surgery China-Japan Union Hospital Jilin University Changchun 130033 China

Papillary thyroid carcinoma （PTC） is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 （located at the 14q13.3 locus）, which was probably the genetic risk factor of PTC. This study aimed to examine the association of this gene with PTC in Chinese. A total of 354 patients with PTC and 360 healthy control subjects from the Han population of Northern China were recruited in the study. These individuals were genotyped to determine rs12589672, rs12894724, rs2076751, and rs944289. The association of rs944289 with PTC was obtained （C vs. T, P= 0.027, OR= 1.264, 95% CI = 1.026-1.557; and C/C-C/T vs. T/T, P= 0.034, OR= 1.474, 95% CI = 1.028-2.112）. Conducting a subgroup analysis, we found a marginal difference in the allele frequency distribution of rs944289 （adjusted P = 0.062） between the patients with PTC and multi-nodular goiter and the control subjects. We also observed an interaction （P= 0.029; OR = 2.578, 95% CI=1.104-6.023） between rs944289 and diabetes in patients with PTC. In conclusion, rs944289 was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.

关键词： NKX2-1 papillary thyroid carcinoma the Han population of Northern China association

Construction of Ni single-atom coordinated with doped N and S elements for mild hydrogenation of methyl acrylate to methyl propionate

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Nano Research 2025年第1期18卷 217-224页

作者： Taolue sun Chen Jian Gang Wang hui Zhao Guoliang Zhang Zengxi Li Chunshan Li State Key Laboratory of Mesoscience and Engineering CAS Key Laboratory of Green Process and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China huizhou Institute of Green Energy and Advanced Materials Huizhou 516081China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516081China

Although the nickel-based catalyst is able toexhibit comparative catalytic activity to noble metal formethyl acrylate hydrogenation,it requires strict reactioncondition,which can be improved by regulation ofcoordination *** this study,we constructed akind of Ni single-atom coordinated with N and S(Ni-NSC)through the pyrolysis of organic Ni-based precursors at600℃.The existence and fine structure of Ni single-atom were confirmed by the spherical electron microscopicobservation in combination with the X-ray absorption spectroscopy(XAS)*** addition,the catalytichydrogenation assessment suggested that the as-prepared Ni-NSC catalyst exhibited higher activity and stability than theNi/NSC supported catalyst prepared by incipient wetness impregnation *** remarkable catalytic activity was dueto the high dispersion and density of Ni single-atom and weak adsorption energy of intermediates on these Ni sites.

关键词： methyl acrylate mild hydrogenation Ni single-atom coordination environment adsorption energy