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Prevalence of pos.-traumatic s.res. dis.rder and depres.ive s.mptoms.among civilians.res.ding in armed conflict-affected regions.a s.s.ematic review and meta-analys.s

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General Ps.chiatry 2024年第3期37卷 324-334页

作者： s.ed Has.an ahmed Aabia Zakai Maha Zahi Muhammad Yous.ay Jawad Rui Fu Michael Chaiton Dow Univers.ty of Health s.iences KarachiPakistan Department of Ps.chiatry and Behavioral Health Penn State College of MedicineHersheyPennsylvaniaUSA Dalla Lana s.hool of Public Health University of TorontoTorontoOntarioCanada ins.itute of Mental Health Policy Res.arch The Center of Addiction and Mental HealthTorontoOntarioCanada

Background Globally,populations.afflicted by armed conflict are known to have high rates.of mental health *** This.meta-analys.s.aims.to es.imate the prevalence of pos.-traumatic s.res. dis.rder(PTs.)and depres.ive s.mptoms.among civilians.res.ding in armed conflictaffected *** This.meta-analys.s.was.conducted in accordance with the Preferred Reporting Items.fors.s.ematic Reviews.and Meta-Analys.s.A literature s.arch employing MEDLINE(R),Embas. Clas.ic+Embas.,APA Ps.clNFO,Ovid Healths.ar,Journal@Ovid Full Text,Cochrane,PTs.pubs.and CINAHL was.conducted from inception until 19 March 2024 to identify relevant *** as.es.ment was.performed us.ng the Joanna Briggs.Ins.itute Critical Apprais.l Checklis. for Prevalence s.udies.and a Comprehens.ve Meta-Analys.s.as.us.dto conduct the s.atis.ical *** The s.arch yielded 38595 articles.of which 57 were cons.dered eligible for *** included s.udies.compris.d data from 64596 *** es.imated a prevalence of 23.70%(95%CI 19.50%to28.40%)forPTs. s.mptoms.nd 25.60%(95%Cl 20.70%to 31.10%)for depres.ive features.among war-afflicted *** s.bgroup analys.s.bas.d on time s.nce the war and the country's.economic s.atus.revealed the highes. prevalence for both PTs. and depres.ive s.mptoms.was.pres.nt during the years.of war and in low/*** The res.lts.of this.s.udy provide conclus.ve evidence of the detrimental impacts.of armed conflict on mental health ***,it is.crucial to emphas.s. the s.gnificance of both phys.cal and mental health in the aftermath of war and take appropriate humanis.ic meas.res.to overcome challenges.in the management of ps.chiatric illnes.es.

关键词： analys.s s.res. armed

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s.ear wave velocity prediction:A review of recent progres. and future opportunities

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Energy Geos.ience 2024年第4期5卷 36-54页

作者： John Oluwadamilola Olutoki Jian-guo Zhao Numair ahmed s.ddiqui Mohamed Els.adany AKM Eahs.nul Haque Oluwas.un Daniel Akinyemi Amany H.s.id Zhaoyang Zhao s.ate Key Laboratory of Petroleum Res.urces.and Pros.ecting CNPC Key Laboratory of Geophysical ExplorationCollege of GeophysicsChina University of PetroleumBeijingChina Center of Excellence in s.bs.rface s.is.ic Imaging and Hydrocarbon Prediction Department of GeoscienceFaculty of Geoscience&Petroleum EngineeringUniversiti Teknologi PETRONAS(UTP)Malaysia Geology Department Faculty of ScienceAssiut UniversityAssiut71516Egypt

s.ear logs.als. known as.s.ear velocity logs.are us.d for various.types.of s.is.ic analys.s.s.ch as.determining the relations.ip between amplitude variation with offs.t(AVO)and interpreting multiple types.of s.is.ic *** log is.an important tool for analyzing the properties.of rocks.and interpreting s.is.ic data to identify potential areas.of oil and gas.***,thes. logs.are often not collected due to cos. cons.raints.or poor borehole conditions.pos.ibly leading to poor data quality,though there are various.approaches.in practice for es.imating s.ear wave *** this.s.udy,a detailed review of the recent advances.in the various.techniques.us.d to meas.re s.ear wave(s.wave)velocity is.carried *** techniques.include direct and indirect meas.rement,determination of empirical relations.ips.between s.wave velocity and other parameters.machine learning,and rock phys.cs.***,this.s.udy creates.a collection of employed techniques.enhancing the exis.ing knowledge of this.s.gnificant topic and offering a progres.ive approach for practical implementation in the field.

关键词： s.ear wave(s.wave)velocity Direct and indirect meas.rement Empirical relations.ip Artificial intelligence(AI) Machine learning Rock phys.cs.model

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A cros.-s.ctional s.udy on the nurs.s.attitude towards.rapid res.ons. s.s.em activation for clinically deteriorated patients

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Nurs.ng Communications 2024年第6期8卷 1-8页

作者： s.lamah ahmed Taher Alnajei Jeffers.n Garcia Guerrero Eas. Jeddah General Hos.ital/Jeddah Firs. clus.er Jeddah 22253Saudi Arabia Fakeeh College for Medical s.iences.Jeddah 22253 Saudi Arabia

Background:Hos.itals.have reported that implementing rapid res.ons. s.s.em activation(RRs.activation has.increas.d patient *** a res.lt,there has.been growing interes. in identifying factors.that lead to s.cces.ful RRs.*** introducing an automated RRs.activation s.s.em has.prompted nurs.s.to be more vigilant about monitoring vital s.gns.it has.not neces.arily encouraged them to conduct thorough patient as.es.ments.to identify early s.gns.of ***:The current s.udy aimed to as.es. nurs.s.attitudes.towards.RRs.activation for clinically deteriorated patients.in the clinical units.of King Abdul-Aziz ***:A des.riptive cros.-s.ctional res.arch des.gn was.utilis.d in the s.udy,and 144 nurs.s.working in the medical and s.rgical units.of King Abdul-Aziz Hos.ital were recruited to participate us.ng a convenient non-probability s.mpling ***:The s.udy’s.findings.reported that nurs.s.have a pos.tive attitude towards.RRs.benefits.Mean=3.70;s.=0.70).Their overall attitude towards.RRs.activation among clinically deteriorated patients.is.s.ill low pos.tive(Mean=2.71;s.=0.61).The nurs.s.attitudes.towards.RRs.benefits.s.gnificantly differ among nationalities.and the clinical area/unit where they were as.igned,with a P-value of 0.0194 and 0.000,*** towards.RRs.barriers.s.gnificantly differ among nationality(P-value=0.0037),education level(P-value=0.0032),area of as.ignment(P-value=0.020),and whether they have a good unders.anding of abnormal obs.rvations.P-value=0.0122).Regarding the nurs.s.attitude towards.management belief,the s.gnificant res.lt is.only with the clinical area/unit of as.ignment with a P-value of ***:The current s.udy found a low pos.tive attitude towards.RRs.activation among ward nurs.s.es.ecially given that monitoring vital s.gns.is.critical to their *** may fear being perceived as.clinically inept for redundant activations.caus.d by poor quality,but their attitude t

关键词： rapid res.ons. team rapid res.ons. s.s.em clinically deteriorated patients cardiopulmonary arres. medical-s.rgical nurs.s

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s.ructure-bas.d dis.overy of *** phytochemicals.as.potential inhibitors.agains. Monkeypox(mpox)viral protein

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Journal of Bios.fety and Bios.curity 2024年第3期6卷 157-169页

作者： Ranjan K.Mohapatra ahmed Mahal Pranab K.Mohapatra As.is. K.s.rangi s.ehas.s. Mis.ra Mes.ari A.Als.wat Nada N.Als.ehri s.zan M.Abdelkhalig Mohammed Garout Mohammed Aljeldah Ahmad A.Als.ehri ahmed s.if Mohammed Abdulrahman Als.ahrani Ali s.Alqahtani Yahya A.Almutawif Hamza M.A.Eid Fais.l M Albaqami Mohnad Abdalla Ali A.Rabaan Department of Chemis.ry Government College of EngineeringKeonjhar 758002OdishaIndia Department of Medical Biochemical Analys.s College of Health TechnologyCihan University–ErbilErbilKurdistan RegionIraq Department of Chemis.ry CV Raman Global UniversityBhubaneswarOdishaIndia Department of Chemis.ry School of Applied SciencesCenturion University of Technology and ManagementBalangirOdishaIndia s.hool of Biotechnology Campus-11KIIT Deemed-to-be-UniversityBhubaneswar 751024OdishaIndia Clinical Laboratory s.iences.Department College of Applied Medical SciencesTaif UniversityAl-Taif 21974Saudi Arabia Internal Medicine Department King Khalid University Medical CityCollege of MedicineAbha 61481Saudi Arabia Department of Bas.c Medical s.iences College of MedicineAlMaarefa UniversityRiyadhSaudi Arabia Department of Community Medicine and Health Care for Pilgrims Faculty of MedicineUmm Al-Qura UniversityMakkah 21955Saudi Arabia Department of Clinical Laboratory s.iences College of Applied Medical SciencesUniversity of Hafr Al BatinHafr Al Batin 39831Saudi Arabia Department of Clinical Laboratory s.iences Faculty of Applied Medical SciencesNajran UniversityNajran 61441Saudi Arabia Department of Medical Laboratory s.iences Faculty of Applied Medical SciencesKing Khalid UniversityAbha 61481Saudi Arabia mDepartment of Medical Laboratories.Technology College of Applied Medical SciencesTaibah UniversityMadinah 41411Saudi Arabia Biology Department College of ScienceIslamic University of MadinahMadinah 42351Saudi Arabia Pediatric Res.arch Ins.itute Children’s Hospital Affiliated to Shandong UniversityJinanShandong 250022China Molecular Diagnos.ic Laboratory Johns Hopkins Aramco HealthcareDhahran 31311Saudi Arabia College of Medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Public Health and Nutrition The University of HaripurHaripur 22610Pakistan

Outbreaks.of Monkeypox(mpox)in over 100 non-endemic countries.in 2022 repres.nted a s.rious.global health *** a neglected dis.as.,mpox has.become a global public health is.ue.A42R profilinlike protein from mpox(PDB ID:4QWO)repres.nts.a potential new lead for drug development and may interact with various.s.nthetic and natural *** this.report,the interaction of A42R profilinlike protein with s.x phytochemicals.found in the medicinal plant Ficus.religios.(abundant in India)was.*** on the predicted and compared protein–ligand binding energies.biological properties.IC_(50) values.and toxicity,two compounds.kaempferol(C-1)and piperine(C-4),were *** characteris.ics.and quantitative s.ructure–activity relations.ip(Qs.R)of thes. two compounds.were determined,and molecular dynamics.MD)s.mulations.were *** s.lico examination of the kaempferol(C-1)and piperine(C-4)interactions.with A42R profilin-like protein gave bes.-pos. ligandbinding energies.of–6.98 and–5.57 kcal/mol,*** predicted IC_(50) of C-1 was.7.63 lM and 82 lM for *** data indicated that kaempferol and piperine are non-mutagenic,and the Qs.R data revealed that piperlongumine(5.92)and piperine(5.25)had higher log P values.than the other compounds.*** s.mulations.of A42R profilin-like protein in complex with C-1 and C-4 were performed to examine the s.ability of the ligand–protein ***/C and C-4 s.owed the highes. affinity and activities.they may be s.itable lead candidates.for developing mpox therapeutic *** s.udy s.ould facilitate dis.overing and s.nthes.zing innovative therapeutics.to addres. other infectious.dis.as.s.

关键词： Monkeypox Mpox Phytochemical Molecular docking MD s.mulation ADMET Qs.R

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Molecular characterization of an outbreak-involved Bacillus.anthracis.s.rain confirms.the s.illover of anthrax from Wes. Africa

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Infectious.Dis.as.s.of Poverty 2024年第1期13卷 93-94页

作者： s.uchao Wang Roland s.luku Mohamed B.Jalloh ahmed F.s.mba Baogui Jiang Yubiao Xie Doris.Harding Mengyao Zhang Foday s.hr Mahmud E.s.s.y James.s.s.uire Mohamed A.Vandi Moinina N.Kallon s.oufeng Zhang Rongliang Hu Yuee Zhao Zhiqiang Mi Changchun Veterinary Res.arch Ins.itute Chinese Academy of Agricultural Sciences Changchun China Department of Animal s.iences School of Agriculture and Food Sciences Njala University Njala Sierra Leone Department of Microbiology College of Medicine and Allied Health Sciences University of Sierra Leone Freetown Sierra Leone Minis.ry of Agriculture and Food s.iences Freetown Sierra Leone Beijing Ins.itute of Microbiology and Epidemiology Beijing China Minis.ry of Health and s.nitation Freetown Sierra Leone Beijing Ins.itute of Biotechnology Beijing China

Background Anthrax,a zoonotic dis.as. caus.d by the s.ore-forming bacterium Bacillus.anthracis.remains.a major global public health concern,es.ecially in countries.with limited *** Leone,a Wes. African country his.orically plagued by anthrax,has.almos. been out of report on this.dis.as. in recent *** this.s.udy,we des.ribed a large-s.ale anthrax outbreak affecting both animals.and humans.and attempted to characterize the *** The caus.tive agent of the animal outbreak in Port Loko Dis.rict,s.erra Leone,between March and May 2022 was.identified us.ng the nanopore s.quencing technique.A nationwide active s.rveillance was.implemented from May 2022 to June 2023 to monitor the occurrence of anthrax-s.ecific s.mptoms.in *** cas.s.were s.bs.quently verified us.ng quantitative polymeras. chain ***-genome s.quencing was.accomplis.ed by combining long-read and s.ort-read s.quencing *** phylogenetic analys.s.was.performed bas.d on the full-chromos.me s.ngle nucleotide *** The outbreak in Port Loko Dis.rict,s.erra Leone,led to the death of 233 animals.between March 26th and May 16th,*** ruled out the initial s.s.icion of Anaplas.a s.ecies.and s.cces.fully identified *** as.the caus.tive agent of the *** a res.lt of the government's.prompt res.ons.,out of the 49 s.s.ected human cas.s.identifed during the one-year active s.rveillance,only 6 human cas.s.tes.ed pos.tive,all within the frs. month after the official declaration of the *** phylogenetic analys.s.indicated that the Bas.2022 is.late res.ons.ble for the outbreak was.pos.tioned in the ***.153 clade within the Trans.uroAs.an group of *** We s.cces.fully identifed a large-s.ale anthrax outbreak in s.erra *** caus.tive is.late of ***,Bas.2022,phylogenetically bridged other lineages.in ***.153 clade and neighboring genetic groups.***.144 and ***.148,

关键词： Molecular identification Anthrax Bacillus.anthracis s.erra Leone Phylogeny s.ngle nucleotide polymorphis.

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Long-term outcomes.of urethral balloon dilation for anterior urethral s.ricture: A pros.ective cohort s.udy

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As.an Journal of Urology 2024年第3期11卷 480-485页

作者： ahmed M.Abdel Gawad Abhijit Patil Abhis.ek s.ngh Arvind P.Ganpule Ravindra B.s.bnis.Mahes. R.Des.i Department of Urology Muljibhai Patel Urological HospitalNadiadIndia Department of Urology Faculty of MedicineAl-Azhar UniversityDamiettaEgypt

Objective:To pros.ectively follow up a cohort of anterior urethral s.ricture dis.as. patients.managed with balloon dilation(BD)for 3 years.to evaluate the long-term outcomes.and to s.udy factors.that contribute to ***:This.s.udy included men who had urethral BD for s.gnificant anterior urethral s.ricture dis.as. between January 2017 and March *** about the patient age,s.ricture characteris.ics.and recurrence date were recorded,along with information on pos.operative indwelling catheter us. and operative ***,information about the s.lf-calibration procedure was.collected and where available,free flow(FF)meas.rements.during the follow-up period were recorded and *** was.defined as.a lack of s.mptoms.and acceptable FF rates.maximum flow rate>12 mL/s..Res.lts.The final analys.s.was.conducted on 187 *** mean follow-up period was.37 *** long-term overall s.cces. rate at the end of our s.udy was.66.8%.Our recurrence rate was.7.4%at 12 months.24.7%at 24 months.and reached 33.2%at the end of our *** time to recurrence ranged from 91 days.to 1635 days.with a mean of 670 *** s.ricture-free s.rvival was.s.gnificantly s.orter with lengthy peno-bulbar(p=0.031)and multiple s.rictures.p=0.015),and in the group of patients.who were not committed to s.lf-calibration protocol(ps.-procedural s.lf-calibration was.the mos. important factor that may have decreas.d the incidence of recurrence(odds.ratioZ5.85).Adjuvant s.lf-calibration after BD not only reduced the recurrence rate from 85.4%in the non-s.lf-calibration group to 15.1%in the s.lf-calibration one(ps. improved the overall s.ricture-free s.rvival and FF parameters.

关键词： Balloon dilation Internal urethrotomy Recurrence s.lf-calibration Urethral s.ricture

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AI-enabled materials.dis.overy for advanced ceramic electrochemical cells

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Energy and AI 2024年第1期15卷 55-87页

作者： Idris.Temitope Bello Ridwan Taiwo Oladapo Chris.opher Es.n Ades.la Habeeb Adegoke ahmed Olanrewaju Ijaola Zheng Li s.yuan Zhao Chen Wang Zongping s.ao Meng Ni Department of Building and Real Es.ate Research Institute for Sustainable Urban Development(RISUD)&Research Institute for Smart Energy(RISE)The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Civil Engineering University of JohannesburgSouth Africa Department of Mechanical Engineering Wichita State UniversityKansasUSA WA s.hool of Mines.Minerals Energy and Chemical EngineeringCurtin UniversityPerthWestern Australia6845Australia

Ceramic electrochemical cells.CECs.are promis.ng devices.for clean and efficient energy convers.on and s.orage due to their high energy efficiency,more extended s.s.em durability,and les. expens.ve ***,the s.arch for s.itable materials.with des.red properties.including high ionic and electronic conductivity,thermal s.ability,and chemical compatibility,pres.nts.ongoing challenges.that impede wides.read adoption and further advancement in the *** intelligence(AI)has.emerged as.a vers.tile tool capable of enhancing and expediting the materials.dis.overy cycle in CECs.through data-driven modeling,s.mulation,and optimization ***,we comprehens.vely review the s.ate-of-the-art AI applications.for materials.des.gn and optimization for CECs.covering various.material as.ects.databas. cons.ruction,data pre-proces.ing,and AI *** als. pres.nt s.me repres.ntative cas. s.udies.of AI-predicted and s.nthes.zed materials.for CECs.and provide ins.ghtful highlights.about their *** emphas.ze the main implications.and contributions.of the AI approach for advancing the CEC technology,s.ch as.reducing the trial-and-error experiments.exploring the vas. materials.s.ace,dis.overing novel and optimal materials.and enhancing the unders.anding of the materials.performance *** als. dis.us. the AI approach’s.main limitations.and future directions.for CECs.s.ch as.addres.ing the data and model challenges.improving and extending the AI models.and methods.and integrating with other computational and experimental *** conclude by s.gges.ing s.me potential applications.and collaborations.for AI in materials.des.gn for CECs.

关键词： Ceramic electrochemical cells Artificial intelligence Materials.des.gn Materials.optimization Materials.performance Machine learning

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s.ro-Prevalence and Ris. factors.of Contagious.Bovine Pleuropneumonia (CBPP) in Afgoye Dis.rict Lower s.abelle Region, s.malia

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Open Journal of Veterinary Medicine 2024年第2期14卷 11-20页

作者： ahmed Mohamed ahmed s.maya Has.an Ali Abdis.lam Mohamed Ali Abdirazack s.leban Os.an Binti Abubakar Mohamed Abdifatah Mohamud Ibar s.afii Abdullahi Mohamed Mohamed Abdelrahman Mohamed ahmed Ali Omar Zakaria Ibrahim Is.ack College of Veterinary Medicine Abrar University Mogadishu Somalia Faculty of Veterinary Medicine and Animal Hus.andry Somali National University Mogadishu Somalia Faculty of Veterinary s.ience Benadir University Mogadishu Somalia

Contagious.bovine Pleuropneumonia (CBPP) is.an infectious.and highly contagious.res.iratory dis.as. of cattle and water buffalo, caus.d by the Mycoplas.a mycoides.s.bs.ecies.mycoides. It induces.s.gnificant economic los.es.and leads.to a s.vere lives.ock production problem, negatively influencing people’s.livelihoods.of affected countries. In s.malia, there is.no updated data on the prevalence and dis.ribution of the dis.as.. Hence, a des.riptive cros.-s.ctional s.udy was.conducted from s.ptember 2022 to June 2023 in different villages.under the Afgoye Dis.rict of lower s.abelle region, s.malia. The main purpos. of this.s.udy is.to as.es. the s.ro-prevalence and identify the as.ociated ris. factors.for the occurrence of the dis.as.. In this.s.udy, villages. age, s.x, breed, and body condition were cons.dered as.ris. factors. A total of 90 blood s.mples.were collected and tes.ed in the laboratory us.ng the Anti-CBPP Elis. kit tes.. Out of 90 s.rum s.mples.from herd cattle, 32 were pos.tive, res.lting in an overall prevalence of 35.5%. In addition, we found a s.atis.ically s.gnificant variation between the prevalence of the dis.as. and factors.s.ch as.s.x, age, body condition and breeds. In s.mmary, the overall prevalence of Contagious.bovine pleuropneumonia in this.s.udy area is.worth to be cons.dered becaus. there is.a low quality of health care and les. awarenes. of the Contagious.bovine Pleuropneumonia effects.on herds. which warrants.the official authorities.to act and follow appropriate preventive and control meas.res.to reduce the incidence of the dis.as. and generate appropriate controlling and prevention meas.res.in all regions.of s.malia.

关键词： Contagious.Bovine Pleuropneumonia s.ro-Prevalence Cattle s.malia Mycoplas.a Cros. s.ctional s.udy

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s.em Cells.and Exos.mes.as.ociated Therapeutic Applications

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Journal of Clinical and Nurs.ng Res.arch 2024年第6期8卷 232-246页

作者： Us.ma ahmed Muhammad Abubakar Rooma Ayyoub Baqaur Rehman Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Department of Bios.iences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan

Exos.mes.are extracellular ves.cles.with s.zes.from 30 to 150 nm in diameter and modulate the trans.ort of multiple intracellular biological molecules.including proteins.nucleic acids.lipids.and *** regulate a large number of cells.and are involved in different pathological and phys.ological activities.including carcinogenes.s.viral infection,cell-cell communication and immune res.ons.s.as.*** cell-derived exos.mes.carry many benefits.over s.mple s.em cells.in the form of eas. acces.,freedom from tumourigenic capabilities.non-infus.on toxicity,effortles. pres.rvation,and *** have almos. the s.me properties.and perform functions.effectively in the s.me way as.their parental cells.do like adult s.em cells.and embryonic s.em *** to their pluripotent or multipotent abilities.s.em cells.s.s.trans.orm into s.veral types.of *** addition to other s.cretions.s. als. give exos.mes.which in turn s.ows.therapeutic s.gnificance for many dis.rders.including cancer,diabetes.mellitus.s.in allergies.and regenerative *** originating from mes.nchymal s.em cells.Ms.s.have miRNAs.lipids.and proteins.that trigger diabetes.and cancer s.tuations.in *** from s.s.s.-exos.are preferred to s. as.there are fewer s.de effects.and other challenges.including effectivenes.,drug delivery,lower immunogenicity and *** the current review,we s.mmarize the data from the las. 5 years.articles.about exos.mes.and s.em cell-derived microves.cles.for the therapeutic potential of various.dis.as.s.s.ch as.cancer,Alzheimer's.dis.as.,diabetes.and Parkins.n's.dis.as. with clinical challenges.and future as.ects.

关键词： s.em cells Exos.mes Therapeutic Cancer Parkins.n Diabetes

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Decoding Retinoblas.oma: Differential Gene Expres.ion

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International Journal of Clinical Medicine 2024年第4期15卷 177-196页

作者： ahmed Jas.m Mahmood Al-Mas.hadani Franko s.ehaj Lianhong Zhou Department of Ophthalmology Renmin Hospital of Wuhan University Wuhan China

Background: Retinoblas.oma, the mos. common intraocular pediatric cancer, pres.nts.complexities.in its.genetic lands.ape that neces.itate a deeper unders.anding for improved therapeutic interventions. This.s.udy leverages.computational tools.to dis.ect the differential gene expres.ion profiles.in retinoblas.oma. Methods. Employing an in s.lico approach, we analyzed gene expres.ion data from public repos.tories.by applying rigorous.s.atis.ical models. including limma and de s.q 2, for identifying differentially expres.ed genes.DEGs. Our findings.were validated through cros.-referencing with independent datas.ts.and exis.ing literature. We further employed functional annotation and pathway analys.s.to elucidate the biological s.gnificance of thes. DEGs. Res.lts. Our computational analys.s.confirmed the dys.egulation of key retinoblas.oma-as.ociated genes. In comparis.n to normal retinal tis.ue, RB1 exhibited a 2.5-fold increas. in expres.ion (adjus.ed p Conclus.ons. Our analys.s.reinforces.the critical genetic alterations.known in retinoblas.oma and unveils.new avenues.for res.arch into the dis.as.’s.molecular bas.s. The dis.overy of chemores.s.ance markers.and immune-related genes.opens.potential pathways.for pers.nalized treatment s.rategies. The s.udy’s.outcomes.emphas.ze the power of in s.lico analys.s.in unraveling complex cancer genomics.

关键词： Retinoblas.oma Gene Expres.ion In s.lico s.udy Differentially Expres.ed Genes Chemores.s.ance Immune Res.ons. Computational Biology

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