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Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 234-239页

作者： Nabil abdel Salam ahmed Hasona Mohammed ahmed Qumani Turki ahmed Alghassab Muath Abdulrahman Alghassab Abdullah Ali Alghabban Department of Biochemistry College of MedicineHa'il UniversityHa'ilSaudi Arabia Department of Chemistry Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Department of Pharmacology College of MedicineHa'il UniversityHa'ilSaudi Arabia

Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L.(T. foenum-graecum) seeds and Punica granatum L.(P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea ***: Sixty guinea pigs were divided into six groups(10 guinea pigs per group).Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, *** animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were ***: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters(blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters ***: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs.

关键词： Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin

Human recombinant soluble ACE2(hrsACE2)shows promise for treating severe COVID19

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Signal Transduction and Targeted Therapy 2020年第1期5卷 303-304页

作者： Tarek Mohamed Abd El-aziz ahmed Al-Sabi James D.Stockand Department of Cellular and Integrative Physiology University of Texas Health Science Center at San AntonioSan AntonioTX 78229-3900USA Zoology Department Faculty of ScienceMinia UniversityEl-Minia 61519Egypt College of Engineering and Technology American University of the Middle EastKuwaitKuwait

A recent study by Zoufaly et *** in The Lancet Respiratory Medicine describes encouraging data from the first severe COVID-19 patient successfully treated with human recombinant soluble angiotensin-converting enzyme-2(hrsACE2).1 The published data document upon treatment of an adaptive immune response,the disappearance of the virus swiftly from the serum,the nasal cavity and lungs,and a reduction of inflammatory cytokine levels that are critical for COVID-19 ***,the use of hrsACE2 did not impede the generation of neutralizing antibodies,leading to a significant clinical improvement of the treated patient.

关键词： ACE2 al cavity

Synergistic renoprotective effect of a compiled branched-chain amino acids and Cymbopogon schoenanthus extract against experimentally induced oxido-nitrosative renal insult

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Asian Pacific Journal of Tropical Medicine 2018年第5期11卷 342-349页

作者： Omar abdel-Hamed ahmed-Farid Bosy Azmy Abd El-Motelp Enaam abdel-Mohsen Essa Mohamad Warda Physiology Department National Organization for Drug Control and Research Zoology Department-Faculty of Women for Arts Science and EducationAin Shams University Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary Medicine Cairo University

Objective: To better investigate the protective role of branched-chain amino acids(BCAAs)and Cymbopogon schoenanthus(CS) extract against the potassium dichromate(PDC)-induced oxido-nitrosative nephrotoxic insult in the experimental rat model. Methods: Thirty male rats were randomly divided into five equal groups: The 1 st group served as control; the 2^(nd)was injected with a single dose of PDC(15 mg/kg b.w i.p.);the 3^(rd), 4^(th), and 5^(th) groups were respectively treated with BCAAs, CS, and their combination for 15 d prior to induction of renal insult via PDC single dose(15 mg/kg b.w s.c.). The experimental period was terminated in all groups 2 d after induction of renal insult. The harvested kdney samples were divided for biochemical assays and histological examination. Results: The PDC-induced nephrotoxic effect caused a depletion of renal oxidative scavengers glutathione, superoxide dismutase with consequent lipo-oxidative cellular membrane deterioration manifested by a rise in malonaldehyde, oxidized glutathione, myeloperoxidase and the concomitant increase in inflammatory response elements tumor necrosis factor α, nitric oxide, and interleukin 1 β.Moreover, the comet assay and increased 8-hydroxy-2-deoxyguanosine proved an accelerated apoptotic DNA fragmentation. These local renal changes were met with global altered blood biochemistry. The BCAAs and CS or their compiled administration showed an ameliorative effect against PDC-induced nephrotoxic in a synergistic pattern. Conclusions: Both BCAAs and CS or their combined administration afford potential competitors against renal insult induced by polyvalent anion pollutants in experimentally studied animals model. As a route for novel drug discovery, further investigation should be attempted to optimize their augmenting reno-protecting potential.

关键词： Branched chain amino acids Cymbopogon schoenanthus Nephrotoxicity Comet assay Rats

PERIODIC MOTIONS OF SPINNING RIGID SPACECRAFT UNDER INFLUENCE OF GRAVITATIONAL AND MAGNETIC FIELDS

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Applied Mathematics and Mechanics(English Edition) 2006年第8期27卷 1061-1069页

作者： Yehia A.abdel-aziz M.H.Yehia F.A.Abd El-Salam M.Radwan National Research Institute of Astronomy and Geophysics Helwan. Cairo Egypt Mathematics Department Faculty of Science Mansoura University MansouraEgypt Astronomy Department Faculty of ScienceCairo UniversityCairo12613Egypt

The motion of a magnetized axisymmetric spacecraft about its center of mass in a circular orbit is considered, taking the gravitational and magnetic effects of the central body into account. Equations of motion of the reduced system are transformed to equations of plane motion of a charged particle under the action of electric and magnetic fields. Stationary motions of the system are determined and periodic motions near to them are constructed using the Lyapounoff theorem of the holomorphic integral.

关键词： periodic motions routhian rigid spacecraft

Naringenin suppresses NLRP3 inflammasome activation via the mRNA-208a signaling pathway in isoproterenol-induced myocardial infarction

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Asian Pacific Journal of Tropical Biomedicine 2023年第10期13卷 443-450页

作者： Ayman Eldourghamy Toka Hossam Mohammed Abdalla Hussein Amal abdel-aziz Samir A.El-masry Environmental Biotechnology Department Genetic Engineering and Biotechnology Research InstituteSadat UniversityEgypt Department of Medical Labs Faculty of Applied Medical Sciences TechnologyOctober 6 UniversityEgypt Department of Biotechnology Faculty of Applied Health Sciences TechnologyOctober 6 UniversityEgypt Molecular Biology Department Genetic Engineering and Biotechnology Research InstituteSadat UniversityEgypt

Objective:To investigate the cardioprotective effect of naringenin against isoproterenol(ISO)-induced cardiotoxicity in ***:Rats were divided into five groups:the normal group,the ISO group(85 mg/kg b.w.);the ISO+naringenin(50 mg/kg b.w.)group,the ISO+naringenin(100 mg/kg b.w.)group and the ISO+propranolol(10 mg/kg b.w.)*** creatine kinase-MB(CK-MB),cardiac troponin T,lactate dehydrogenase,brain natriuretic peptide(BNP),and IL-10,as well as cardiac transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF)and malondialdehyde(MDA)were *** addition,NLRP3 and mRNA-208a expressions were evaluated by RT-PCR *** examination was also performed to assess cardiac ***:Naringenin treatment significantly decreased plasma lactate dehydrogenase,CK-MB,cardiac troponin T,BNP,and IL-10,as well as cardiac TGF-β1,VEGF,and MDA while increasing p-Akt and superoxide dismutase in ISO-administered *** also reduced NLRP3 and mRNA-208a gene expression ***,naringenin improved ISO-induced cardiac ***:Naringenin attenuates myocardial dysfunction in ISO-treated rats by decreasing oxidative stress and increasing cardiac endogenous antioxidant system,which may be modulated partly by improvement of NLRP3 and mRNA-208a gene expression.

关键词： Naringenin Isoproterenol Myocardial infarction Antioxidants NLRP3 mRNA-208a

Improvement of Selected Morphological, Physiological, and Biochemical Parameters of Banana (Musa acuminata L.) Using Potassium Silicate under Drought Stress Condition Grown in vitro

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Phyton-International Journal of Experimental Botany 2023年第4期92卷 1019-1036页

作者： Hosny abdel aziz Mohamed Sharaf Magdy Omar ahmed Abou El-Yazied Nada Ibrahim AlJwaizea Shaimaa Ismail Mohamed M.A.Omar Khadiga Alharbi Amr Elkelish Moataz Tawfik Department of Horticulture Faculty of AgricultureAl-Azhar UniversityCairo11651Egypt Department of Biochemistry Faculty of AgricultureAl-Azhar UniversityCairo11651Egypt Department of Biochemistry and Molecular Biology College of Marine Life SciencesOcean University of ChinaQingdao266003China Department of Agricultural Botany Faculty of AgricultureAl-Azhar UniversityNasr CityCairo11751Egypt Department of Horticulture Faculty of AgricultureAin Shams UniversityCairo11566Egypt Department of Biology College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Biochemistry Faculty of AgricultureAin Shams UniversityCairo11566Egypt Biology Department College of ScienceImam Mohammad ibn Saud Islamic University(IMSIU)Riyadh11623Saudi Arabia Botany Department Faculty of ScienceSuez Canal UniversityIsmailia41522Egypt Botany Department Faculty of SciencePort Said UniversityPort Said42511Egypt

Drought stress has become more common in recent years as a result of climate change impacts on the production of banana crops and other fruit *** growth and productivity of Musa spp are severely impacted by the gradual degradation of water resources and the erratic distribution pattern of annual precipitation *** aim of the work includes increased drought tolerance in light of water scarcity in the world as a result of the bananas’being gluttonous for water *** investigation was carried out from 2019 to 2020 to study the effect of potassium silicate on morphological growth and biochemical parameters of Musa acuminata L under drought stress by *** a result,drought stress reduced the morphological characteristics such as shoots number,shoot length,roots number,and survival percentage and biochemical characteristics such as chlorophyll a,b,carotenoids,stomatal status,and *** proline content increased in the leaf of *** *** complemented with K2SiO3(2 to 6 mM)either individually or in combination with PEG led to an improvement in all morphological and biochemical *** activities of CAT,POD,and PPO enzymes increased significantly compared to ***,the lowest PPO,CAT,and POD activity were ***,K2SiO3 treatments under drought stress successfully enhanced the leaf stomatal *** results suggest that K2SiO3 can help to maintain plant integrity in the tested cultivar under drought stress.

关键词： Musa acuminata L potassium silicate photosynthetic pigments stomata enzymatic activity

Sesame Husk as Adsorbent for Copper(II) Ions Removal from Aqueous Solution

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Journal of Geoscience and Environment Protection 2017年第7期5卷 109-152页

作者： Haitham ahmed El-Araby Abel moneim Mohamed ahmed Ibrahim ahmed Hashem Mangood Adel A.-H. abdel-Rahman Chemistry Department Faculty of Science Menoufia University Shebin El-Kom Egypt Chemistry Department Faculty of Science Alexandria University Alexandria Egypt

In this study, the adsorption behavior of copper(II) ions from aqueous solutions onto sesame husk (SH) was investigated. The effect of different parameters such as pH, contact time, adsorbent dosage, adsorbate concentration, temperature and agitation speed was studied. Thermodynamic parameters, equilibrium isotherms and kinetic data have been evaluated. The functional groups and surface morphology of SH adsorbent were characterized by FTIR and SEM. Adsorption equilibrium isotherms were expressed by Langmuir, Freundlich and Dubinin-Radushkevich (D-R) adsorption models and it was found that Langmuir adsorption model fits the experimental data better than Freundlich and D-R models. The adsorption can be best described by the pseudo second-order kinetic model.

关键词： Copper(II) Ions Adsorption Kinetics Thermodynamic Parameters

Field evaluation of some bait additives against Indian crested porcupine(Hystrix indica)(Rodentia:Hystricidae)

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Integrative Zoology 2013年第3期8卷 285-292页

作者： Muhammad MUSHTAQ Iftikhar HUSSAIN Afsar MIAN Shahid MUNIR Irfan ahmed Abdul aziz KHAN Department of Zoology PMAS Arid Agriculture UniversityRawalpindiPakistan Wildlife Management PMAS Arid Agriculture UniversityRawalpindiPakistan National Agricultural Research Centre IslamabadPakistan

This research study evaluated the effect of different additives on the bait consumption by Indian crested porcupine,a serious forest and agricultural pest,under field *** additives(saccharin,common salt,bone meal,fish meal,peanut butter,egg yolk,egg shell powder,yeast powder,mineral oil and coconut oil)at 2 and 5%each were tested for their relative preference,using groundnut-maize(1:1)as basic *** the additives were tested under a no-choice test *** control tests,no additive was mixed with the basic *** at 5%concentration significantly enhanced the consumption of bait over the basic bait,while 2%saccharin supplemented bait resulted in a non-significant bait *** other additives did not enhance the consumption of the bait material;rather,these worked as ***,the repellency was lowest with the common salt,followed by egg yolk,egg shell powder,bone meal,peanut butter,mineral oil,fish meal and yeast powder,while coconut remained the most repellent *** present study suggested that groundnut-maize(1:1)supplemented with 5%saccharin was the preferred bait combination,and can be used with different rodenticides for the management of Indian crested porcupine.

关键词： additives baits evaluation Hystrix indica Indian crested porcupine

Enhanced Heap-Based Optimizer Algorithm for Solving Team Formation Problem

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Computers, Materials & Continua 2022年第12期73卷 5245-5268页

作者： Nashwa Nageh ahmed Elshamy abdel Wahab Said Hassan Mostafa Sami Mustafa Abdul Salam Faculty of Science Suez Canal UniversityIsmailiaEgypt Faculty of Computers and Artificial Intelligence Helwan UniversityHelwanEgypt Faculty of Computers and Artificial Intelligence Benha UniversityBenha 13518Egypt Faculty of Computer Studies Arab Open UniversityCairoEgypt

Team Formation(TF)is considered one of the most significant problems in computer science and *** is defined as forming the best team of experts in a social network to complete a task with least *** real-world problems,such as task assignment,vehicle routing,nurse scheduling,resource allocation,and airline crew scheduling,are based on the TF *** has been shown to be a Nondeterministic Polynomial time(NP)problem,and high-dimensional problem with several local optima that can be solved using efficient approximation *** paper proposes two improved swarm-based algorithms for solving team formation *** first algorithm,entitled Hybrid Heap-Based Optimizer with Simulated Annealing Algorithm(HBOSA),uses a single crossover operator to improve the performance of a standard heap-based optimizer(HBO)*** also employs the simulated annealing(SA)approach to improve model convergence and avoid local minima *** second algorithm is the Chaotic Heap-based Optimizer Algorithm(CHBO).CHBO aids in the discovery of new solutions in the search space by directing particles to different regions of the search *** HBO’s optimization process,a logistic chaotic map is *** performance of the two proposed algorithms(HBOSA)and(CHBO)is evaluated using thirteen benchmark functions and tested in solving the TF problem with varying number of experts and ***,the proposed algorithms were compared to well-known optimization algorithms such as the Heap-Based Optimizer(HBO),Developed Simulated Annealing(DSA),Particle SwarmOptimization(PSO),GreyWolfOptimization(GWO),and Genetic Algorithm(GA).Finally,the proposed algorithms were applied to a real-world benchmark dataset known as the Internet Movie Database(IMDB).The simulation results revealed that the proposed algorithms outperformed the compared algorithms in terms of efficiency and performance,with fast convergence to the global minimum.

关键词： Team formation problem optimization problem genetic algorithm heap-based optimizer simulated annealing hybridization method chaotic local search