检索结果-南通市图书馆

Investigation of SARS-CoV-2 main Protease Potential Inhibitory Activities of Some Natural Antiviral Compounds Via molecular Docking and Dynamics Approaches

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2022年第5期91卷 1089-1104页

作者： Nada m.mostafa muhammad I.Ismail Amr m.El-Araby Dina m.Bahgat ahmed m.Elissawy ahmed m.mostafa Omayma A.Eldahshan Abdel Nasser B.Singab Department of Pharmacognosy Faculty of PharmacyAin Shams UniversityCairo11566Egypt Department of Pharmaceutical Chemistry Faculty of PharmacyThe British University in EgyptCairo11837Egypt Department of Pharmaceutical Chemistry Faculty of PharmacyAin Shams UniversityCairo11566Egypt Department of Biochemistry Faculty of PharmacyAin Shams UniversityCairo11566Egypt Center for Drug Discovery and Development Research Ain Shams UniversityCairo11566Egypt

Coronaviruses caused an outbreak pandemic disease characterized by a severe acute respiratory distress syndrome leading to the infection of more than 200 million patients and the death of more than 4 million *** primary treatment is either supportive or *** products have an important role in the development of various ***,screening of natural compounds with reported antiviral activities can lead to the discovery of potential inhibitory entities against *** the current study,an in-silico molecular docking experiment was conducted on the effects of some of these natural antiviral phytoconstituents,(e.g.,procyanidin B2,theaflavin,quercetin,ellagic acid,caffeoylquinic acid derivatives,berginin,eudesm-1β,6α,11-triol and arbutin),on the crystal structure of SARS-CoV-2 main protease(PDB ID:6w63)using AutoDock-Vina *** of the docked compounds revealed good binding affinity,with procyanidin B2(–8.6 Kcal/mol)and theaflavin(–8.5 Kcal/mol)showing a better or similar binding score as the ligand(–8.5 Kcal/mol).molecular dynamics simulations were carried out at 100 ns and revealed that procyanidin B2 forms a more stable complex with SARS-CoV-2 main protease than *** B2,theaflavin,and 4,5-dicaffeoylquinic acid were evaluated for toxicity by ProTox-II webserver and were non-toxic according to the predicted LD50 values and safe on different organs and ***,these phytoconstituents showed good ADmE properties and acceptable lipophilicity,as evaluated using *** the tested compounds,procyanidin B2 showed the highest lipophilic *** is worth mentioning that these natural inhibitiors of SARS-CoV-2 main protease are components of green and black tea that can be used as a supporting supplement for COVID patients or as potential nuclei for further drug design and development campaigns.

关键词： Coronavirus natural products SARS-CoV-2 main protease molecular docking molecular dynamics tea

Surface activation of viscose textiles via air,argon,and oxygen dielectric barrier discharge plasma:influence of peak voltage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2024年第7期26卷 134-147页

作者： Shrouk ELASHRY Usama m.RASHED mostafa A.WAHBA Hend m.ahmed Nabil m.ELSIRAGY Plasma Laboratory Physics DepartmentFaculty of scienceTanta UniversityTanta 31527Egypt Physics Department Faculty of Science(Male)Al-Azhar UniversityCairo 11651Egypt Textile Research Industrial Division National Research CentreDokkiGiza 12622Egypt

This paper discusses the use of atmospheric pressure dielectric barrier discharge(DBD)plasma treatment to enhance the surface qualities of viscose *** study explores the effects of different plasma gases,discharge voltages,and exposure times on the treated *** findings emphasize the importance of optimizing the plasma's peak voltage to achieve the desired surface treatment *** document also presents data on colour strength,wettability,colour fastness,and tensile strength of the treated fabrics,as well as scanning electron microscopy(SEm)analysis of surface morphology and chemical analysis using fouriertransition infrared spectroscopy(FTIR)and energy dispersive X-ray(EDX).The results show that treatment at a peak voltage of 11.83 k V is more efficient,except for the tensile strength which is enhanced at a peak voltage of 8.92 k *** oxygen plasma treatment significantly improves the colour strength,which exhibits an increase from 11 to *** intensified colour was attributed to the significant influence of electrostatic interactions between the charged hydroxyl groups of the oxygen plasma treated viscose textiles and the dye molecules,which enhance the *** oxygen DBD plasma exhibits a higher ability to enhance the properties of textiles when compared to air and argon *** study presents a sustainable,economical,secure,and ecologically friendly approach to explore new fabrics for specific uses.

关键词： Lissajous diagrams printability wettability tensile strength SEm EDX FTIR

Comparative study between three carbonaceous nanoblades and nanodarts for antimicrobial applications

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 594-605页

作者： mohamed S.Selim ahmed m.Azzam mohamed A.Shenashen Shimaa A.Higazy Bayaumy B.mostafa Sherif A.El-Safty National Institute for materials Science(NImS) 1-2-1 SengenTsukuba-ShiIbaraki-Ken 305-0047Japan Petroleum Application Department Egyptian Petroleum Research InstituteNasr City 11727Egypt Department of Environmental Research Theodor Bilharz Research InstituteGizaEgypt

The design of nanostructured materials occupies a privileged position in the development and management of affordable and effective technology in the antibacterial ***,we discuss the antimicrobial properties of three carbonaceous nanoblades and nanodarts materials of graphene oxide(GO),reduced graphene oxide(RGO),and single-wall carbon nanotubes(SWCNTs)that have a mechano-bactericidal effect,and the ability to piercing or slicing bacterial *** demonstrate the significance of size,morphology and composition on the antibacterial activity mechanism,the designed nanomaterials have been *** minimum inhibitory concentration(mIC),standard agar well diffusion,and transmission electron microscopy were utilized to evaluate the antibacterial activity of GO,RGO,and *** on the evidence obtained,the three carbonaceous materials exhibit activity against all microbial strains tested by completely encapsulating bacterial cells and causing morphological disruption by degrading the microbial cell membrane in the order of RGO>GO>*** of the external cell wall structure and outer membrane proteins,the synthesized carbonaceous nanomaterials exhibited higher antibacterial activity against Gram-positive bacterial strains than Gram-negative and fungal *** had the lowest mIC values(0.062,0.125,and 0.25 mg/mL against ***,***,and ***,respectively),as well as minimum fungal concentrations(0.5 mg/mL for both *** and ***).At 12 hr,the cell viability values against tested microbial strains were completely *** lysis and death occurred as a result of severe membrane damage caused by microorganisms perched on RGO *** work gives an insight into the design of effective graphene-based antimicrobial materials for water treatment and remediation.

关键词： Antimicrobial properties Nanoblades mechano-bactericidal effect RGO nanosheets Gram-positive bacteria Cell viability

A Comprehensive Review on Charging Topologies and Power Electronic Converter Solutions for Electric Vehicles

在线全文

学校读者我要写书评

暂无评论

Journal of modern Power Systems and Clean Energy 2024年第3期12卷 675-694页

作者： Abdelfatah Ali Hossam H.H.mousa mostafa F.Shaaban maher A.Azzouz ahmed S.A.Awad the Department of Electrical Engineering American University of Sharjah26666 SharjahUnited Arab Emirates the Department of Electrical Engineering South Valley University83523 QenaEgypt the Department of Electrical and Computer Engineering University of WindsorWindsorON N9B 3P4 Canada Electrical Engineering Department Qatar UniversityDoha 2713Qatar Department of Electrical and Computer Engineering Sultan Qaboos UniversityMuscat123Oman

Electric vehicles(EVs)are becoming more popular worldwide due to environmental concerns,fuel security,and price *** performance of EVs relies on the energy stored in their batteries,which can be charged using either AC(slow)or DC(fast)***,EVs can also be used as mobile power storage devices using vehicle-to-grid(V2G)*** electronic converters(PECs)have a constructive role in EV applications,both in charging EVs and in ***,this paper comprehensively investigates the state of the art of EV charging topologies and PEC solutions for EV *** examines PECs from the point of view of their classifications,configurations,control approaches,and future research prospects and their impacts on power *** can be classified into various topologies:DC-DC converters,AC-DC converters,DC-AC converters,and AC-AC *** address the limitations of traditional DC-DC converters such as switching losses,size,and high-electromagnetic interference(EmI),resonant converters and multiport converters are being used in high-voltage EV ***,power-train converters have been modified for high-efficiency and reliability in EV *** paper offers an overview of charging topologies,PECs,challenges with solutions,and future trends in the field of the EV charging station applications.

关键词： Charging station charging topology electric vehicle power electronic converter vehicle-to-grid

Standardization of meibomian gland dysfunction in an Egyptian population sample using a non-contact meibography technique

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第1期17卷 61-65页

作者： ahmed mohamed Karara Zeinab El-Sanabary mostafa Ali El-Helw Tamer ahmed macky mohamad Amr Salah Eddin Abdelhakim Department of Ophthalmology Kasr Al-Ainy HospitalCairo UniversityCairo 11431Egypt

AIm:To develop normative data for meibomian gland dysfunction(mGD)parameters,using non-contact meibography technique of Sirius Costruzione Strumenti Oftalmici(CSO)machine,in an Egyptian population ***:Observational,cross-sectional,analytic study,in which 104 Egyptian volunteers were *** upper lids were examined,using“Sirius CSO”*** eyelid was given a degree of meibomian gland loss(mGL),which was calculated by the software of the ***:mean percentage mGL in right upper lid was of 30.9%±12.6%,and that of left upper lid was 32.6%±11.8%.Thirty-four volunteers(32.7%)had first-degree mGL in their right upper lid,and 67.3%had second-degree *** volunteer(1%)had zero-degree mGL in left upper lid,28(26.9%)had first-degree loss,and 75(72.1%)had second-degree *** of mGL in right upper eyelid was not related to age,but degree of mGL in left upper eyelid increased with *** was statistically significant difference between both genders for degree of mGL in right eye(P=0.036)and in left eye(P=0.027).CONCLUSION:Noncontact meibography is a useful non-invasive tool for diagnosing *** is diagnosed in 100%of apparently normal individuals;26.9%-32.7%of which have first-degree mGL,and 67.3%-72.1%have second-degree mGL.

关键词： Egyptian population meibomian gland dysfunction non-contact meibography standardization upper lid

EDSUCh:A robust ensemble data summarization method for effective medical diagnosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第1期10卷 182-189页

作者： mohiuddin ahmed A.N.m.Bazlur Rashid School of Science Edith Cowan UniversityPerthAustralia

Identifying rare patterns for medical diagnosis is a challenging task due to heterogeneity and the volume of *** summarization can create a concise version of the original data that can be used for effective *** this paper,we propose an ensemble summarization method that combines clustering and sampling to create a summary of the original data to ensure the inclusion of rare *** the best of our knowledge,there has been no such technique available to augment the performance of anomaly detection techniques and simultaneously increase the efficiency of medical *** performance of popular anomaly detection algorithms increases significantly in terms of accuracy and computational complexity when the summaries are ***,the medical diagnosis becomes more effective,and our experimental results reflect that the combination of the proposed summarization scheme and all underlying algorithms used in this paper outperforms the most popular anomaly detection techniques.

关键词： Data summarization Ensemble medical diagnosis Sampling

Improving the Transmission Security of Vein Images Using a Bezier Curve and Long Short-Term memory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, materials & Continua 2024年第6期79卷 4825-4844页

作者： ahmed H.Alhadethi Ikram Smaoui ahmed Fakhfakh Saad m.Darwish Computer Science and School of Electronics and Telecommunications University of SfaxSfax3029Tunisia LETI Laboratory University of SfaxSfax3029Tunisia Digital Research Center of Sfax Technopark of SfaxSfax3029Tunisia Department of Information Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandriaEgypt

The act of transmitting photos via the Internet has become a routine and significant *** the security measures to safeguard these images from counterfeiting and modifications is a critical domain that can still be further *** study presents a system that employs a range of approaches and algorithms to ensure the security of transmitted venous *** main goal of this work is to create a very effective system for compressing individual biometrics in order to improve the overall accuracy and security of digital photographs by means of image *** paper introduces a content-based image authentication mechanism that is suitable for usage across an untrusted network and resistant to data loss during *** employing scale attributes and a key-dependent parametric Long Short-Term memory(LSTm),it is feasible to improve the resilience of digital signatures against image deterioration and strengthen their security against malicious ***,the successful implementation of transmitting biometric data in a compressed format over a wireless network has been *** applications involving the transmission and sharing of images across a *** suggested technique utilizes the scalability of a structural digital signature to attain a satisfactory equilibrium between security and picture *** effective adaptive compression strategy was created to lengthen the overall lifetime of the network by sharing the processing of *** scheme ensures a large reduction in computational and energy requirements while minimizing image quality *** approach employs multi-scale characteristics to improve the resistance of signatures against image *** proposed system attained a Gaussian noise value of 98%and a rotation accuracy surpassing 99%.

关键词： Image transmission image compression text hiding Bezier curve Histogram of Oriented Gradients(HOG) LSTm image enhancement Gaussian noise rotation

Intermittent fasting and the liver: Focus on the Ramadan model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第8期16卷 1070-1083页

作者： mohamed H Emara Hanan Soliman Ebada m Said Hassan Elbatae mostafa Elazab Shady Elhefnawy Tarik I Zaher ahmed Abdel-Razik mohamed Elnadry Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of medicine Alyousif HospitalAlkhobar 34622Saudi Arabia Department of Tropical medicine and Infectious Diseases Tanta UniversityTanta 31512Egypt Department of Hepatology Gastroenterology and Infectious DiseasesBenha UniversityBenha 13511Egypt Department of Tropical medicine Zagazig UniversityZagazig 44519Egypt Department of Tropical medicine Mansoura UniversityMansoura 35516Egypt Department of Hepato-Gastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt

Intermittent fasting(IF)is an intervention that involves not only dietary modific-ations but also behavioral changes with the main core being a period of fasting alternating with a period of controlled *** duration of fasting differs from one regimen to *** fasting(RF)is a religious fasting for muslims,it lasts for only one month every one lunar *** this model of fasting,observers abstain from food and water for a period that extends from dawn to *** period of daily fasting is variable(12-18 hours)as Ramadan rotates in all seasons of the ***,longer duration of daily fasting is observed during the *** fact,RF is a peculiar type of *** is a dry IF as no water is allowed during the fasting hours,also there are no calorie restrictions during feeding hours,and the mealtime is exclusively *** three variables of the RF model are believed to have a variable impact on different liver *** was evaluated by different observational and interventional studies among patients with non-alcoholic fatty liver disease and it was associated with improve-ments in anthropometric measures,metabolic profile,and liver biochemistry regardless of the calorie restriction among lean and obese *** situation is rather different for patients with liver *** was associated with adverse events among patients with liver cirrhosis irrespective of the underlying etiology of *** patients developed new ascites,ascites were increased,had higher serum bilirubin levels after Ramadan,and frequently developed hepatic encephalopathy and acute upper gastrointestinal *** complications were higher among patients with Child class B and C cirrhosis,and some fatalities occurred due to *** transplant recipients as a special group of patients,are vulnerable to dehydration,fluctuation in blood immunosuppressive levels,likelihood of deterioration and hence observing RF without special precautions

关键词： Intermittent fasting Ramadan fasting Non-alcoholic fatty liver disease Liver cirrhosis Peptic ulcer Liver transplantation Gilbert syndrome

A critical review towards the causes of the iron-based catalysts deactivation mechanisms in the selective oxidation of hydrogen sulfide to elemental sulfur from biogas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第3期90卷 388-411,I0010页

作者： mostafa Tarek Janaina S.Santos Victor márquez mohammad Fereidooni mohammad Yazdanpanah Supareak Praserthdam Piyasan Praserthdam Center of Excellence on Catalysis and Catalytic Reaction Engineering(CECC) Department of Chemical EngineeringFaculty of EngineeringChulalongkorn UniversityBangkok 10330Thailan High-Performance Computing Unit(CECC-HCU) Center of Excellence on Catalysis and Catalytic Reaction Engineering(CECC)Chulalongkorn UniversityBangkok 10330Thailand

Hydrogen sulfide(H_(2)S) not only presents significant environmental concerns but also induces severe corrosion in industrial equipment,even at low *** various technologies,the selective oxidation of hydrogen sulfide(SOH_(2)S) to elemental sulfur(S) has emerged as a sustainable and environmentally friendly *** to its unique properties,iron oxide has been extensively investigated as a catalyst for SOH_(2)S;however,rapid deactivation has remained a significant *** causes of iron oxide-based catalysts deactivation mechanisms in SOH_(2)S,including sulfur or sulfate deposition,the transformation of iron species,sintering and excessive oxygen vacancy formation,and active site loss,are thoroughly examined in this *** focusing on the deactivation mechanisms,this review aims to provide valuable insights into enhancing the stability and efficiency of iron-based catalysts for SOH_(2)S.

关键词： Selective oxidation of H_(2)S Iron-based Catalysts mechanism of deactivation Sulfur or sulfate deposition Transformation of iron species Sintering SDG 7