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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa abd El-Salam El-Sayed Mohamed Z.Sayed-ahmed Shaimaa ahmed Awad ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

Comprehensive evaluation and sensitivity analysis of regeneration energy for acid gas removal plant using single and activated-methyl diethanolamine solvents

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1684-1693页

作者： Ammar ali abd Samah Zaki Naji ahmed Barifcani Water Resources Engineering College Al-Qasim Green UniversityBabylonIraq Petroleum Engineering Department Kerbala UniversityKerbalaIraq Chemical Engineering Department Curtin University of TechnologyPerthAustralia.

The absorption of acid gas using reactive amines is among the most widely used types of capturing ***,the absorption process requires intensive energy expenditure majorly in the solvent regeneration *** study simultaneously evaluated the regeneration energy of MDEA and PZ/MDEA solvents in terms of heat of absorption,sensible heat,and vaporization *** Hysys version 8.8 simulation tool is applied to model the full acid gas removal plant for the chemical absorption *** new energy balance technique presents around the absorption and desorption columns to bring a new perspective of energy distribution in the capturing of acid gas *** analysis of regeneration energy and its three contributors is performed at several operation parameters such as absorber and stripper pressures,lean amine circulation rate,solvent concentration,reflux ratio,and CO2 and H2 S *** results show that the heat of absorption of PZ/MDEA system is higher than that for MDEA system for the same operating *** sensible heat is the main contributor in the required regeneration energy of MDEA solvent *** simulation results have been validated against data taken from real plant and *** product specifications of our simulation corroborate with real plant data in an excellent approach;additionally,the profile temperature of the absorber and the stripper columns are in good agreement with *** overall results highlight the direction of the effects of each parameter on the heat of absorption,sensible heat,and vaporization heat.

关键词： Heat of absorption Sensible heat Vaporization heat Regeneration energy Acid gases capturing Piperazine Activated-Methyl diethanolamine

Response of seed yield and fatty acid compositions for some sunflower genotypes to plant spacing and nitrogen fertilization

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Information Processing in Agriculture 2017年第3期4卷 241-252页

作者： Mohamed ali abd EL-Satar Asmaa abd-EL-Halime ahmed Tamer Hassan ali Hassan Oil Crops Research Department Field Crops Research InstituteAgricultural Research Center9 El-Gamaa St.GizaEgypt

A field experiment was conducted at the experiment Farm of Kafr-El-Hamam Research Station,Zagazig,Sharkia Governorate,Agricultural Research Center,Egypt during the two successive summer seasons of 2015 and 2016 to achieve the highest yield and good oil quality of three tested sunflower *** both seasons,the experiment was conducted using the split split plot design in randomized complete block design with three replicates arrangement keeping plant spaces(15,20 and 25 cm apart between hills)in main plots,nitrogen fertilization levels(15,30 and 45 N fad.^-1)in sub plots and sunflower genotypes(Giza 102,Sakha 53 and promising line of L120)in sub sub *** and quality traits were significantly influenced by plant spaces,nitrogen fertilization levels and genotypes as well as interactions in both seasons and their combined *** wider plant spacing of 25 cm seems to be a good compromise between the highest seed yield fad.^-1 and good acid composition of *** increasing of nitrogen fertilization level had a positive reflected on yield and desirable acid composition of *** 53 was ranked in the first order in stem diameter,head diameter,100-seed weight,seed weight plant^-1,flowered late and hence seed yield fad.^-1 as well as seed oil content whereas,Giza 102 characterized with its contained the highest proportion of oleic and linoleic unsaturated fatty *** highest values of head diameter,100-seed weight,seed weight plant^-1 and hence seed yield fad.^-1 as well as the highest proportion of oleic and linoleic unsaturated fatty acids composition were obtained by grown sunflower *** 53 at wider spacing of 25 cm with application of nitrogen fertilization levels of 45 N fad.^-*** and path analyses revealed that 100-seed weight and head diameter had the highest direct and indirect influence on seed weight plant1,at the same time also,oleic acid content and linoleic acid content had the highest direct and indirect effect inf

关键词： Sunflower Plant spacing Nitrogen fertilization Genotypes Seed yield Fatty acids

Functional activity of the rectum:A conduit organ or a storage organ or both?

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World Journal of Gastroenterology 2006年第28期12卷 4549-4552页

作者： ahmed Shafik Randa M Mostafa Ismail Shafik Olfat ei-Sibai ali A Shafik Department of Surgery and Experimental Research Faculty of MedicineCairo UniversityCairoEgypt Department of Physiology Faculty of MedicineSharkia UniversityBanha-ZagazigEgypt Department of Surgery Faculty of MedicineMenoufia UniversityShebin El-KomEgypt

AIM： To investigate whether the degree of rectal distension could define the rectum functions as a conduit METHODS： Response of the rectal and anal pressure to 2 types of rectal balloon distension, rapid voluminous and slow gradual distention, was recorded in 21 healthy volunteers （12 men, 9 women, age 41.7 ± 10.6 years）. The test was repeated with sphincteric squeeze on urgent sensation. RESULTS： Rapid voluminous rectal distension resulted in a significant rectal pressure increase （P 〈 0.001）, an anal pressure decline （P 〈 0.05） and balloon expulsion. The subjects felt urgent sensation but did not feel the 1^st rectal sensation. On urgent sensation, anal squeeze caused a significant rectal pressure decrease （P 〈 0.001） and urgency disappearance. Slow incremental rectal filling drew a rectometrogram with a ＂tone＂ limb representing a gradual rectal pressure increase during rectal filling, and an ＂evacuation limb＂ representing a sharp pressure increase during balloon expulsion. The curve recorded both the ist rectal sensation and the urgent sensation. CONCLUSION： The rectum has apparently two functions： transportation （conduit） and storage, both depending on the degree of rectal filling. If the fecal material received by the rectum is small, it is stored in the rectum until a big volume is reached that can affect a degree of rectal distension sufficient to initiate the defecation reflex. Large volume rectal distension evokes directly the rectoanal inhibitory reflex with a resulting defecation.

关键词： Anal pressure Rectal pressure Rectometry First rectal sensation

Efficacy of octreotide in the prevention of complications after pancreaticoduodenectomy in patients with soft pancreas and non-dilated pancreatic duct: A prospective randomized trial

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 59-63页

作者： Ayman El Nakeeb ahmed El Gawalby Mahmoud A.ali ahmed Shehta Hosam Hamed Mohamed El Refea ahmed Moneer ahmed abd El Rafee Gastroenterology Surgical Center Mansoura University

Background: The efficacy of octreotide to prevent postoperative pancreatic fistula(POPF) of pancreaticoduodenectomy(PD) is still controversial. This study aimed to evaluate the effect of postoperative use of octreotide on the outcomes after ***: This is a prospective randomized controlled trial for postoperative use of octreotide in patients undergoing PD. Patients with soft pancreas and pancreatic duct eive postoperative octreotide. Group II received postoperative octreotide. The primary end of the study is to compare the rate of ***: A total of 104 patients were included in the study and were divided into two randomized *** were no significant difference in overall complications and its severity. POPF occurred in 11 patients(21.2%) in group I and 10(19.2%) in group II, without statistical significance(P = 0.807). Also, there was no significant differences between both groups regarding the incidence of biliary leakage(P = 0.083), delayed gastric emptying(P = 0.472), and early postoperative mortality(P = 0.727).Conclusions: Octreotide did not reduce postoperative morbidities, reoperation and mortality rate. Also, it did not affect the incidence of POPF and its clinically relevant variants.

关键词： Pancreaticoduodenectomy Postoperative pancreatic fistula Octreotide Periampullary tumor

Spectrofluorimetric and Spectrophotometric Stability- Iwndicating Methods for the Analysis of Veralipride in Presence of Its Degradants and in Spiked Human Plasma

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Chinese Journal of Chemistry 2012年第1期30卷 183-189页

作者： Salama,Nahla Nour El Din ahmed Salem,Maissa Yacoub abd El Halim,Lobna Mohammed abdel Fattah,Laila ei-Sayed National Organization for Drug Control and Research(NODCAR) 6 Abu Hazem StreetPyramids AveP.O.Box 29GizaEgypt Analytical Chemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Analytical Chemistry Department Faculty of PharmacyMisr University for Science and Technology6th of OctoberEgypt

Spectrofluorimetric and spectrophotometric stability-indicating methods were developed and validated for analysis of veralipride （Ver） in presence of its hydrolytic and oxidative degradants. The spectrofluorimetric method was based on direct measurement of the intrinsic fluorescence of Ver at 366 nm after excitation at 299 nm using sodium lauryl sulfate （SLS） as micelle enhancer. The fluorescence intensity plot was linear over the concentration range 1.0-10.0 ***-1. The high sensitivity of the method allowed its successful application to the analysis of Ver in spiked human plasma. Two other methods were developed. They are based on the oxidative coupling reac- tion of Vet with 3-methyl benzothiazolin-2-one hydrazone （MBTH） hydrochloride in presence of ceric ammonium sulphate in an acidic medium. The first method depends on spectrophotometric measurement of the stable green colored oxidative coupling product at 660 nm. The different experimental parameters affecting the reaction were optimized. Linearity range is 10.0--100.0 ~tgomL-1. The second method depends on a fluorescence quenching effect of Vet on the fluorescence of Ce3＋. The difference in fluorescence intensity was measured at 380 nm after excitation at 300 nm. This method is applicable over the concentration ranges 0.25-2.50 pg-mL-1. The methods were validated according to the ICH guidelines. They were successfully applied for the analysis of Ver in drug substance, drug product and in laboratory prepared mixtures containing different percentages of hydrolytic and oxidative degradants.

关键词： veralipride micelle-enhanced fluorescence MBTH validation stability fluorescence quenching Ce3+

Analysis of BrainMRI: AI-Assisted Healthcare Framework for the Smart Cities

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Intelligent Automation & Soft Computing 2023年第2期35卷 1843-1856页

作者： Walid El-Shafai Randa ali ahmed Sedik Taha El-Sayed Taha Mohammed abd-Elnaby Fathi E.abd El-Samie Department Electronics and Electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenoufia32952Egypt Department of ROBOTICS and Intelligent Machines Faculty of Artificial IntelligenceKafrelsheikh UniversityKafrelsheikhEgypt Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

The use of intelligent machines to work and react like humans is vital in emerging smart ***-aided analysis of complex and huge MRI(Mag-netic Resonance Imaging)scans is very important in healthcare *** AI(Artiﬁcial Intelligence)driven healthcare applications,tumor detection is one of the contemporary researchﬁelds that have become attractive to *** are several modalities of imaging performed on the brain for the pur-pose of tumor *** paper offers a deep learning approach for detecting brain tumors from MR(Magnetic Resonance)images based on changes in the division of the training and testing data and the structure of the CNN(Convolu-tional Neural Network)*** proposed approach is carried out on a brain tumor dataset from the National Centre of Image-Guided Therapy,including about 4700 MRI images of ten brain tumor cases with both normal and abnormal *** dataset is divided into test,and train subsets with a ratio of the training set to the validation set of 70:*** main contribution of this paper is introdu-cing an optimum deep learning structure of CNN *** simulation results are obtained for 50 epochs in the training *** simulation results reveal that the optimum CNN architecture consists of four layers.

关键词： Healthcare smart cities clinical automation CNN machine learning brain tumor medical diagnosis

Effect of Al_(2)O_(3) Nanoparticles on the Compression Ignition Performances and Emitted Pollutants of a Diesel Engine

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Fluid Dynamics & Materials Processing 2023年第11期19卷 2847-2861页

作者： Noora S.Ekab ahmed Q.Salam ali O.abd Miqdam T.Chaichan Electromechanical Engineering Department University of Technology-IraqBaghdad65035Iraq Environment Research Center University of Technology-IraqBaghdad65035Iraq Applied Science Department University of Technology-IraqBaghdad65035Iraq Energy and Renewable Energies Technology Center University of Technology-IraqBaghdad65035Iraq

To improve the performances of diesel engines and to reduce the pollutants they emit,aluminum oxide nanopar-ticles in varying quantities(50,100,150 ppm)have been added to conventional diesel *** results of such experimental tests have revealed that the addition of nano-Al_(2)O_(3) particles to the diesel fuel reduces its consump-tion by 0.488%,1.02%,and 1.377%,respectively and increases the brake thermal efficiency by 1.4%,2.6%,and 3.8%,*** concentrations of undesired gases decrease accordingly by 1.5%,1.7%,and 2.8%for HC and by 5.88%,11.7%,and 17.6%,respectively,for *** the same percentages of nanoparticles,NO_(x) increases by 2.65,4.36,and 5.37,while the TSP(Total Suspended Particulate)decreases by 22%,34.66%,and 49.7%,*** the same conditions,sulfur dioxide pollutants increase by 4.57%,8.8%and 12.89%,and H_(2)S levels by 4.7%,7.81%and 8.9%,respectively.

关键词： Nao-Al_(2)O_(3) suspension CO NO_(x)-PM trade-off SO_(2) H_(2)

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study

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Chinese Journal of Cancer 2014年第7期33卷 356-364页

作者： Salah Mohamed El Sayed Walaa Gamal Mohamed Minnat-Allah Hassan Seddik Al-Shimaa ahmed ahmed Asmaa Gamal Mahmoud Wael Hassan Amer Manal Mohamed Helmy Nabo ahmed Roshdi Hamed Nagwa Sayed ahmed ali abdel-Rahman abd-Allah Department of Medical Oncology and Nuclear Medicine Sohag Faculty of Medicine Sohag University Department of Medical Biochemistry and Molecular biology Sohag Faculty of Medicine Sohag University Department of Surgery Sohag Cancer Center Department of Pediatrics Sohag Teaching Hospital Division of Pediatric Cardiology Department of Pediatrics Maternity and Children Hospital King Abdullah Medical City Al-Madinah Al-Munawwarah Kingdom of Saudi Arabia Department of Pathology Sohag Faculty of Medicine Sohag University

3-Bromopyruvate(3BP) is a new, promising anticancer alkylating agent with several notable functions. In addition to inhibiting key glycolysis enzymes including hexokinase II and lactate dehydrogenase(LDH), 3BP also selectively inhibits mitochondrial oxidative phosphorylation, angiogenesis, and energy production in cancer cells. Moreover, 3BP induces hydrogen peroxide generation in cancer cells(oxidative stress effect) and competes with the LDH substrates pyruvate and lactate. There is only one published human clinical study showing that 3BP was effective in treating fibrolamellar hepatocellular carcinoma. LDH is a good measure for tumor evaluation and predicts the outcome of treatment better than the presence of a residual tumor mass. According to the Warburg effect, LDH is responsible for lactate synthesis, which facilitates cancer cell survival, progression, aggressiveness, metastasis, and angiogenesis. Lactate produced through LDH activity fuels aerobic cell populations inside tumors via metabolic symbiosis. In melanoma, the most deadly skin cancer, 3BP induced necrotic cell death in sensitive cells, whereas high glutathione(GSH) content made other melanoma cells resistant to 3BP. Concurrent use of a GSH depletor with 3BP killed resistant melanoma cells. Survival of melanoma patients was inversely associated with high serum LDH levels, which was reported to be highly predictive of melanoma treatment in randomized clinical trials. Here, we report a 28-year-old man presented with stage IV metastatic melanoma affecting the back, left pleura, and lung. The disease caused total destruction of the left lung and a high serum LDH level(4,283 U/L). After ethics committee approval and written patient consent, the patient received 3BP intravenous infusions(1-2.2 mg/kg), but the anticancer effect was minimal as indicated by a high serum LDH level. This may have been due to high tumor GSH content. On combining oral paracetamol, which depletes tumor GSH, with 3BP treatment, se

关键词：黑色素瘤治疗文献综述溴代转移性乳酸脱氢酶对乙酰氨基酚 GSH含量