Efficacy of octreotide in the prevention of complications after pancreaticoduodenectomy in patients with soft pancreas and non-dilated pancreatic duct: A prospective randomized trial

作     者：Ayman El Nakeeb Ahmed El Gawalby Mahmoud A.Ali Ahmed Shehta Hosam Hamed Mohamed El Refea Ahmed Moneer Ahmed Abd El Rafee 

作者机构：Gastroenterology Surgical Center Mansoura University 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2018年第17卷第1期

页      面：59-63页

核心收录：

学科分类：10[医学] 

主　　题：Pancreaticoduodenectomy Postoperative pancreatic fistula Octreotide Periampullary tumor 

摘      要：Background: The efficacy of octreotide to prevent postoperative pancreatic fistula(POPF) of pancreaticoduodenectomy(PD) is still controversial. This study aimed to evaluate the effect of postoperative use of octreotide on the outcomes after ***: This is a prospective randomized controlled trial for postoperative use of octreotide in patients undergoing PD. Patients with soft pancreas and pancreatic duct 3 mm were randomized to 2 *** I did not receive postoperative octreotide. Group II received postoperative octreotide. The primary end of the study is to compare the rate of ***: A total of 104 patients were included in the study and were divided into two randomized *** were no significant difference in overall complications and its severity. POPF occurred in 11 patients(21.2%) in group I and 10(19.2%) in group II, without statistical significance(P = 0.807). Also, there was no significant differences between both groups regarding the incidence of biliary leakage(P = 0.083), delayed gastric emptying(P = 0.472), and early postoperative mortality(P = 0.727).Conclusions: Octreotide did not reduce postoperative morbidities, reoperation and mortality rate. Also, it did not affect the incidence of POPF and its clinically relevant variants.