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Comparison of different lymph node staging systems in prognosis of gastric cancer:a bi-institutional study from Hungary

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Chinese Journal of Cancer research 2017年第4期29卷 323-332页

作者： Dezso Toth adrienn bfra Zsolt Vargal Miklos Torok Peter peter Akosy Department of General Surgery Kenezy Gyula Teaching Hospital Debrecen 4031 Hungary Department of General Thoracic and Vascular Surgery Kaposi M6r Teaching Hospital Kaposv~r 7400 Hungary Department of Pathology Ken6zy Gyula Teaching Hospital Debrecen 4031 Hungary Department of Oncology Kan6zy Gyula Teaching Hospital Debrecen 4031 Hungary

Objective： The Union for International Cancer Control （UICC） Node （N） classification is the most common used staging method for the prognosis of gastric cancer. It demands adequate, at least 16 lymph nodes （LNs） to be dissected; therefore different staging systems were invented. Methods： between March 2005 and March 2010, 164 patients were evaluated at the Department of General Surgery in the Ken^zy Gyula Hospital and at the Department of General, Thoracic and Vascular Surgery in the Kaposi M6r Hospital. The 6th, 7th and 8th UICC N-staging systems, the number of examined LNs, the number of harvested negative LNs, the metastatic lymph node ratio （MLr） and the log odds of positive LNs （LODDS） were determined to measure their 5-year survival rates and to compare them to each other. results： The overall 5year survival rate for all patients was 55.5% with a median overall survival time of 102 months. The tumor stage, gender, UICC N-stages, MLr and the LODDS were significant prognostic factors for the 5-year survival with univariate analysis. The 6th UICC N-stage did not follow the adequate risk in comparing N2 vs. NO and N3 vs. NO with multivariate investigation. Comparison of performances of the residual N classifications proved that the LODDS system was first in the prediction of prognosis during the evaluation of all patients and in cases with less than 16 harvested LNs. The MLr gave the best prognostic prediction when adequate （more than or equal to 16） lymphadenectomy was performed. Conclusions： We suggest the application of LODDS system routinely in western patients and the usage of MLr classification in cases with extended lymphadenectomy.

关键词： Gastric cancer lymph node metastasis prognosis staging system survival

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Wnt pathway inhibitors are upregulated in XLH dental pulp cells in response to odontogenic differentiation

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International Journal of Oral Science 2023年第1期15卷 127-135页

作者： Elizabeth Guirado Cassandra Villani adrienn Petho Yinghua Chen Mark Maienschein-Cline Zhengdeng Lei Nina Los Anne George Department of Oral biology University of Illinois ChicagoChicagoILUSA research Informatics Core University of Illinois at ChicagoChicagoILUSA bioinformatics Scientist Ⅲ Ambry GeneticsAlisoCAUSA Genome research Core University of Illinois at ChicagoChicagoILUSA

X-linked hypophosphatemia(XLH)represents the most common form of familial *** significant advances have been made in the treatment of bone pathology,patients undergoing therapy continue to experience significantly decreased oral health-related quality of *** following study addresses this persistent oral disease by further investigating the effect of DMP1 expression on the differentiation of XLH dental pulp *** pulp cells were isolated from the third molars of XLH and healthy controls and stable transduction of full-length human DMP1 were *** sequencing was performed to evaluate the genetic changes following the induction of odontogenic *** data shows the upregulation of inhibitors of the canonical Wnt pathway in XLH cells,while constitutive expression of full-length DMP1 in XLH cells reversed this effect during odontogenic *** results imply that inhibition of the canonical Wnt pathway may contribute to the pathophysiology of XLH and suggest a new therapeutic strategy for the management of oral disease.

关键词： pulp pathology reversed

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beyond the rPA and GW methods with adiabatic xc-kernels for accurate ground state and quasiparticle energies

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npj Computational Materials 2019年第1期5卷 202-224页

作者： Thomas Olsen Christopher E.Patrick Jefferson E.bates adrienn ruzsinszky Kristian S.Thygesen Computational Atomic-Scale Materials Design(CAMD) Department of PhysicsTechnical University of DenmarkKongens LyngbyDenmark Department of Physics University of WarwickCoventry CV47ALUK A.r.Smith Department of Chemistry and Fermentation Sciences Appalachian State UniversityBooneNC 28607USA Department of Physics Temple UniversityPhiladelphiaPA 19122USA Center for Nanostructured Graphene(CNG) Department of PhysicsTechnical University of DenmarkKongens LyngbyDenmark

We review the theory and application of adiabatic exchange–correlation(xc)-kernels for ab initio calculations of ground state energies and quasiparticle excitations within the frameworks of the adiabatic connection fluctuation dissipation theorem and Hedin’s equations,*** different xc-kernels,which are all rooted in the homogeneous electron gas,are introduced but hereafter we focus on the specific class of renormalized adiabatic kernels,in particular the rALDA and *** kernels drastically improve the description of short-range correlations as compared to the random phase approximation(rPA),resulting in significantly better correlation *** effect greatly reduces the reliance on error cancellations,which is essential in rPA,and systematically improves covalent bond energies while preserving the good performance of the rPA for dispersive *** quasiparticle energies,the xc-kernels account for vertex corrections that are missing in the GW *** this context,we show that the short-range correlations mainly correct the absolute band positions while the band gap is less affected in agreement with the known good performance of GW for the *** renormalized xc-kernels offer a rigorous extension of the rPA and GW methods with clear improvements in terms of accuracy at little extra computational cost.

关键词： adiabatic kernels quasi

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Auxetic two-dimensional transition metal selenides and halides

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npj Computational Materials 2020年第1期6卷 387-392页

作者： Jinbo Pan Yan-Fang Zhang Jingda Zhang Huta banjade Jie Yu Liping Yu Shixuan Du adrienn ruzsinszky Zhenpeng Hu Qimin Yan Department of Physics Temple UniversityPhiladelphiaPA 19122USA Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physics Nankai UniversityTianjin 300071China Department of Physics and Astronomy University of MaineOronoME 04469USA

Auxetic two-dimensional(2D)materials provide a promising platform for biomedicine,sensors,and many other applications at the *** this work,utilizing a hypothesis-based data-driven approache,we identify multiple materials with remarkable in-plane auxetic behavior in a family of buckled monolayer 2D *** materials are transition metal selenides and transition metal halides with the stoichiometry MX(M=V,Cr,Mn,Fe,Co,Cu,Zn,Ag,and X=Se,Cl,br,I).First-principles calculations reveal that the desirable auxetic behavior of these 2D compounds originates from the interplay between the buckled 2D structure and the weak metal-metal interaction determined by their electronic *** observe that the Poisson’s ratio is sensitive to magnetic order and the amount of uniaxial stress applied.A transition from positive Poisson’s ratio(PPr)to negative Poisson’s ratio(NPr)for a subgroup of MX compounds under large uniaxial stress is *** work provides a guideline for the future design of 2D auxetic materials at the nanoscale.

关键词： materials transition dimensional

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Elevated birth rates in CD62L (L-Selectin)-Deficient bALb/c Mice: Potential Involvement of NK Cells

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Open Journal of Immunology 2014年第4期4卷 148-156页

作者： balint Farkas Jozsef bodis Aaron r. Mangold adrienn Angyal Ferenc boldizsar Katalin Mikecz Tibor T. Glant Department of Obstetrics and Gynecology University of Pecs Clinical Center Pécs Hungary Section of Molecular Medicine Department of Orthopedic Surgery Biochemistry Internal Medicine (Section of Rheumatology) at Rush University Medical Center Chicago USA Janos Szentagothai research Centre University of Pecs Pécs Hungary Department of Dermatology Mayo Clinic Scottsdale USA Department of Cardiovascular Science University of Sheffield Sheffield UK Department of Immunology and biotechnology University of Pecs Pécs Hungary

background: L-selectin (CD62L) is a cell surface adhesion molecule recently shown to play a critical role in determining endometrial receptivity and implantation in humans. by contrast, the L-selectin ligand is missing from the rodent endometrium. Interestingly, CD62L (L-selectin)-deficient bALb/c mice delivered significantly higher numbers of viable offspring than wild type controls via mechanisms yet to be defined. Methods: Nulliparous CD62L-deficient (8-10-week-old, n = 25) or wild type (n = 18) females were mated with 43 age-matched males. Animals were sacrificed at gestational day (GD) 9.5. Tissue samples were analyzed by immunostaining and flow cytometry. results: Mating wild type and CD62L-deficient bALb/c mice revealed that the increased birth rate was due to the CD62L deficiency in females. Flow cytometric analysis demonstrated significant differences in the number of natural killer (NK) cells present in the uterus of pregnant CD62L- deficient mice compared to controls. Immunohistochemistry confirmed NK cell accumulation at the fetal-maternal interface. Discussion: Uterine NK cells have been shown to peak at GD 8-10 at the fetal-maternal interface. NK cells might regulate mouse fertility rates by facilitating development of the maternal spiral arteries, thereby stimulating the formation of larger vessels that facilitate intrauterine survival, however, their role is not obligate to spiral artery development. Conclusions: Diminished CD62L expression modified immune cell trafficking into the uterus of pregnant mice generating a microenvironment primarily dominated by NK cells resulting in improved embryonic survival rates.

关键词： L-Selectin Pregnancy bALb/c CD62L NK Cells Lymphocyte Homing

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Systematic Evaluation of Current Possibilities to Determine Left Ventricular Volumes by Echocardiography in Patients after Myocardial Infarction

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Open Journal of Medical Imaging 2012年第2期2卷 68-75页

作者： Stephan Stoebe adrienn Tarr Tudor Trache Jens-Gerrit Kluge Dietrich Pfeiffer Department of Cardiology-Angiology University of Leipzig Leipzig German Department of Internal Medicine & Cardiology Center Faculty of Medicine University of Szeged Szeged Hungary

Purpose: The aim of the present study was to evaluate the diagnostic accuracy for quantification of left ventricular (LV) volumes and LV ejection fraction (LVEF) with current echocardiographic methods of planimetry for analysis of LV remodeling after myocardial infarction in daily clinical routine. Methods: 26 patients were investigated directly after interventional therapy at hospital pre-discharge and at 6 month follow-up. Standardized 2D transthoracic native and contrast echocardiography were performed in all patients. Due to methodological aspects the results of LV volumes and LVEF using native echocardiography were compared to the results of LV opacification (LVO) imaging for analysis in mono-, bi- and triplane data sets using the Simpson’s rule. In addition corresponding multidimensional data sets were analyzed. results: The assessment of LV volumes and LVEF is more accurate with contrast echocardiography. The comparison of LV volumes and LVEF shows significant increases using contrast echocardiography (p rger left ventricular end-diastolic volumes (LVEDV) are measured at follow up (p rences (p re found for the determination of LVEDV and LVEF relating to apical mono-, bi-, tri- and multiplane data sets. Standard deviations of the triplane approach, however, are significantly lower than using other modalities. Conclusion: Depending on the localization of the myocardial infarction LV volumes and LVEF are less reliably evaluated using the mono- or biplane approach. According to standardization and simultaneous acquisition of all LV wall segments the triplane approach is currently the best approach to determine LV systolic function. In addition, contrast echocardiography is indicated to improve endocardial border delineation in patients using the triplane or multiplane approach. To our knowledge the present study is the first systematic evaluation of all current possibilities for determination of LV volumes and LVEF

关键词： Contrast Echocardiography Left Ventricular Systolic Function Left Ventricular Volumes remodeling Myocardial Infarction LVO Imaging

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“Exercise as the Human body’s Conductor”or the Significance of Exercise in Early Childhood

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Sino-US English Teaching 2018年第8期15卷 410-414页

作者： baloghnébakk adrienn University of Sopron SopronHungary

The focus of our topic is doing regularly physical exercises,regarding healthy way of life,which is also the basis of development of kindergarten aged *** children of consecutive generations are growing fat and the number of overweight children in the generation change has *** not all fat children will become fat adults,but this is very *** should be started as early as the age of *** activity must play an outstanding role in ensuring healthy development of children’s organisms.

关键词： early childhood kindergarten obesitas physical exercises(PE)

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Migration of nutrients dissolved by precipitation and their role in soil erosion

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Chinese Journal Of Geochemistry 2006年第B8期25卷 5-5页

作者： adrienn Toth Gergely Jakab balazs Madarasz Zoltan Szalai Erzsebet Meszaros Geographical research Institute Hungarian Academy of Sciences/Budapest Hungary

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