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Effects of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis: a multi-center, randomized, placebo-controlled clinical trial

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Chinese Medical Journal 2004年第7期117卷 1029-1035页

作者：刘建立朱汉民黄琪仁张忠兰李慧林秦跃娟张颖魏道林陆敬辉刘慧陈小平刘玉娟 Abie Ekangaki 郑以漫 adolfo Diez-Perez Kristine Harper Department of Obstetrics and Gynaecology Department of Gerontology Center for Preventing and Treating Osteoporosis Eli Lilly and Company

Background Raloxifene has been approved for prevention and treatment of postmenopausal osteoporosis in Caucasian women. It also has some positive effects on serum lipids in Caucasians. The objective of this study was to determine the effect of raloxifene hydrochloride on lumbar spine and total hip bone mineral density (BMD), bone metabolism, and serum lipids in Chinese postmenopausal women with *** This was a multi-center, randomized, double-blind, placebo-controlled clinical trial in which 204 postmenopausal Chinese women with osteoporosis were assigned to receive raloxifene (60 mg) or placebo treatment daily for 12 months. BMD, serum bone metabolism markers, and serum lipids were measured before and after drug administration. BMD was measured by Dual-Energy X-Ray Absorptiometry (DEXA) and bone metabolism markers were analyzed by one-step enzyme-linked immunosorbent assay. Serum lipids were measured by enzymatic *** At the end of the 12-month study, lumbar spine BMD increased in both groups with a mean increase of (3.3±4.8) % in the raloxifene group and (1.0±4.9) % in the placebo group (P0.05). In the raloxifene group, the median decreases in the biochemical markers of bone metabolism serum osteocalcin and C-telopeptide were 41.7% and 61.5%, respectively. These changes were statistically significant compared with those in the placebo group (10.6% and 35.6%, P<0.001, respectively). Both total cholesterol and low-density lipoprotein cholesterol decreased significantly in the raloxifene group compared with those in the placebo group (P<0.001, respectively) and there was no significant effect of raloxifene on high-density lipoprotein cholesterol and triglycerides compared

关键词： raloxifene · bone density · bone metabolism markers · osteoporosis postmenopausal

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如何应对便携式系统设计中最新提出的照明要求

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中国照明 2008年第1期 70-71页

作者： adolfo Garcia

随统着设计师为用户提供前所未有且范围更广的功能，下一代便携式照明系统无疑需要增加更新的照明功能。新一代纵向集成的系统级器件将在设计师研发更低成本、更高性能系统的过程中扮演至关重要的作用。

关键词：便携式系统照明功能设计师高性能系统照明系统低成本

Dizziness : a practical approach to diagnosis and management

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2007年

作者： adolfo M. Bronstein Thomas Lempert.

来源：畅想之星图书光盘版（南... 评论

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云计算带给电信运营商的五大益处

软件和集成电路 2022年第6期 10-11页

作者： adolfo Hernandez 亚马逊云科技战略和业务发展部

和其他运营商相比,电信运营商向5G的过渡要更具挑战性。而通过拥抱云技术,电信运营商能够更好地克服5G技术带来的挑战,包括解决复杂的网络编排,整合新技术、应用和运营模式,开发运行新网络技能组合等。电信运营商正面临着多重挑战:一方... 详细信息

和其他运营商相比,电信运营商向5G的过渡要更具挑战性。而通过拥抱云技术,电信运营商能够更好地克服5G技术带来的挑战,包括解决复杂的网络编排,整合新技术、应用和运营模式,开发运行新网络技能组合等。电信运营商正面临着多重挑战:一方面,他们必须开发更多的智能网络(包括边缘计算功能)以应对物联网(IoT)设备数量的快速增长,并研究如何确保5G的投资回报;另一方面,他们还需要应对新冠肺炎疫情造成的财务影响。

关键词：财务影响电信运营商运营模式智能网络设备数量云计算投资回报开发运行

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Anesthetic Management during Cesarean Section in English Bulldogs

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Journal of Life Sciences 2014年第1期8卷 58-64页

作者： Cecilia Vullo Marina Meligrana adolfo Maria Tambella Fabrizio Dini Angela Palumbo Piccionello Giuseppe Catone School of Veterinary Medical Sciences University of CamerinoVia Circonvallazione 93-95 62024 Matelica (MC) Italy

The authors describe their experience with the management of the perioperative period, general anesthesia and the postoperative period in English bulldogs undergoing elective cesarean section and its effect on the neonates. The anesthetist for animals undergoing cesarean operation must be aware of any special needs, not only of the patient undergoing surgery, but also of the neonates. Anesthetic drugs administered to the pregnant patient will readily cross the placenta and affect them, with the exception of local anesthetics. Pregnant female patients are at increased anesthetic risk due to pregnancy-associated physiological alterations, such as altered pulmonary function. The anesthetist is often called to perform anesthesia on brachycephalic dogs for an elective cesarean section. Due to their conformation, these animals may have one or more anatomical abnormalities of the upper airways, which compromise the ability to ventilate adequately. The induction and recovery phases of anesthesia can be extremely dangerous in these patients, but the maintenance phase is generally fairly straightforward because the airways are controlled during maintenance In addition, vagal tone is frequently high and this can contribute towards significant bradycardia and further airway narrowing. All these reasons make general anesthesia in brachycepbalic dogs undergoing cesarean section rather complicated.

关键词： Anesthesia cesarean section English bulldog brachycephalic syndrome.

Graphene electronic fibres with touch-sensing and lightemitting functionalities for smart textiles

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npj Flexible Electronics 2018年第1期2卷 231-236页

作者： Elias Torres Alonso Daniela P.Rodrigues Mukond Khetani Dong-Wook Shin adolfo De Sanctis Hugo Joulie Isabel de Schrijver Anna Baldycheva Helena Alves Ana I.S.Neves Saverio Russo Monica F.Craciun Centre for Graphene Science College of EngineeringMathematics and Physical SciencesUniversity of ExeterEX44QL ExeterUnited Kingdom Department of Physics and CICECO University of Aveiro3819-130 AveiroPortugal Centexbel Technologiepark-Zwijnaarde 79052 GhentBelgium Department of Physics Instituto Superior TécnicoUniversity of LisbonAv.Rovisco Pais 11040-001 LisbonPortugal

The true integration of electronics into textiles requires the fabrication of devices directly on the fibre itself using high-performance materials that allow seamless incorporation into *** electronics and opto-electronics,attained by intertwined fibres with complementary functions are the emerging and most ambitious technological and scientific *** we demonstrate graphene-enabled functional devices directly fabricated on textile fibres and attained by weaving graphene electronic fibres in a *** touch-sensors and light-emitting devices were produced using a roll-to-roll-compatible patterning technique,opening new avenues for woven textile ***,the demonstration of fabric-enabled pixels for displays and position sensitive functions is a gateway for novel electronic skin,wearable electronic and smart textile applications.

关键词： textiles smart functional

Damage control orthopaedics: State of the art

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World Journal of Orthopedics 2019年第1期10卷 1-13页

作者： Enrique Guerado Maria Luisa Bertrand Juan Ramon Cano Ana María Cerván adolfo Galán Department of Orthopaedic Surgery and Traumatology Hospital Costa del Sol University of Malaga

Damage control orthopaedics(DCO) originally consisted of the provisional immobilisation of long bone-mainly femur-fractures in order to achieve the advantages of early treatment and to minimise the risk of complications, such as major pain, fat embolism, clotting, pathological inflammatory response, severe haemorrhage triggering the lethal triad, and the traumatic effects of major surgery on a patient who is already traumatised(the "second hit" effect). In recent years, new locations have been added to the DCO concept, such as injuries to the pelvis, spine and upper limbs. Nonetheless, this concept has not yet been validated in well-designed prospective studies, and much controversy ***, some researchers believe the indiscriminate application of DCO might be harmful and produce substantial and unnecessary expense. In this respect, too,normalised parameters associated with the acid-base system have been proposed,under a concept termed early appropriate care, in the view that this would enable patients to receive major surgical procedures in an approach offering the advantages of early total care together with the apparent safety of DCO. This paper discusses the diagnosis and treatment of severely traumatised patients managed in accordance with DCO and highlights the possible drawbacks of this treatment principle.

关键词： Damage control orthopaedics Early total care Early appropriate care Polytrauma Resuscitation External fixation Packing Embolisation Compartment syndrome

ITPK1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.

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Molecular Plant 2021年第11期14卷 1864-1880页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider adolfo Saiardi Dorothea Fiedler Henning J.Jessen Gabriel Schaaf Ricardo F.H.Giehl Department of Plant Nutrition Institute of Crop Science and Resource ConservationRheinische Friedrich-Wilhelms-Universitat Bonn53115 BonnGermany Department of Chemistry and Pharmacy and CIBSS-Centre for Integrative Biological Signalling Studies Albert-Ludwigs University Freiburg79104 FreiburgGermany Medical Research Council Laboratory for Molecular Cell Biology(MRC-LMCB) University College LondonLondon WC1E 6BTUK Department of Biochemistry Indian Institute of ScienceBengaluruKarnataka 560012India Leibniz-Forschungsinstitut fur Molekulare Pharmakologie 13125 BerlinGermany Department of Chemistry Humboldt Universitat zu Berlin12489 BerlinGermany Institute of Agronomy and Crop Physiology Justus-Liebig University Giessen35392 GiessenGermany Department of Physiology&Cell Biology Leibniz-lnstitute of Plant Genetics and Crop Plant Research06466 GaterslebenGermany

In plants, phosphate (Pi) homeostasis is regulated by the interaction of PHR transcription factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates. Here, we combined different methods to obtain a comprehensive picture of how inositol (pyro)phosphate metabolism is regulated by Pi and dependent on the inositol phosphate kinase ITPK1. We found that inositol pyrophosphates are more responsive to Pi than lower inositol phosphates, a response conserved across kingdoms. With CE-ESI-MS we could separate different InsP7 isomers in Arabidopsis and rice, and identify 4/6-InsP7 and a PP-InsP4 isomer hitherto not reported in plants. We found that the inositol pyrophosphates 1/3-InsP7, 5-InsP7 and InsP8 increase severalfold in shoots after Pi resupply and that tissue-specific accumulation of inositol pyrophosphates relies on ITPK1 activities and MRP5-dependent InsP6 compartmentalization. Notably, ITPK1 is critical for Pi-dependent 5-InsP7 and InsP8 synthesis in planta and its activity regulates Pi starvation responses in a PHR-dependent manner. Furthermore, we demonstrate that ITPK1-mediated conversion of InsP6 to 5-InsP7 requires high ATP concentrations and that Arabidopsis ITPK1 has an ADP phosphotransferase activity to dephosphorylate specifically 5-InsP7 under low ATP. Collectively, our study provides deeper insights into Pi-dependent changes in nutritional and energetic states with the synthesis of regulatory inositol pyrophosphates.

关键词： diphosphoinositol pentakisphosphate kinase inositol 1,3,4-trisphosphate 5/6-kinase 1 inositol phosphates inositol pyrophosphates phosphate homeostasis phosphate signaling

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马略卡王国文献馆

世界建筑导报 2021年第3期36卷 60-61页

作者：无 adolfo Gosálvez(摄影) HAND建筑师事务所不详

在西班牙帕尔马(Palma de Mallorca)的历史中心进行建造意味着需要寻找与这座城市独特性格相契合的方式。这里的街道被完整地保留,展示出一种均质和永恒的特性。交替开合的空间使街道在私人与公共领域之间变换。大大小小的庭院为市民提... 详细信息

在西班牙帕尔马(Palma de Mallorca)的历史中心进行建造意味着需要寻找与这座城市独特性格相契合的方式。这里的街道被完整地保留,展示出一种均质和永恒的特性。交替开合的空间使街道在私人与公共领域之间变换。大大小小的庭院为市民提供了悠闲生活节奏,同时形成了通透的街道景观。

关键词：文献馆街道景观公共领域生活节奏西班牙

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