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Subclinical Hypothyroidism, Its Manifestations and Management a Case Report

Open Journal of Internal Medicine 2023年第3期13卷 173-180页

作者： Pablo Sisiruca Gustavo adolfo Socorro Calderas Saint James School of Medicine Arnos Vale Saint Vincent and the Grenadines Jose Maria Vargas Medical School Faculty of Medicine Universidad Central de Venezuela Caracas Venezuela

Introduction: Thyroid states can be associated with psychiatric manifestations, be it hypothyroid, hyperthyroid or even euthyroid. The effect of depression is significant in subclinical hypothyroidism. Sometimes, its signs and symptoms are indistinguishable from Major Depressive Disorder. Our immunological system and early embryologic origins also play a role in the coexistence of other comorbidities like Pernicious Anemia. Case: A 35-year-old Hispanic female presented with significant low mood, somnolence, weight gain, increased hunger, cold intolerance and epigastric pain. It is important to note the variety of clinical manifestations of our hypothyroidism patient to understand its associations and help us with a better approach to treatment. Discussion: Standard approaches to treatment of Subclinical Hypothyroidism will depend mostly on laboratory findings such as TSH levels and free T4. Individualized therapy chosen for our patient was based on his mood symptoms, laboratory findings and coexistence of Pernicious Anemia. The use of daily 0.025 mg of levothyroxine, 10 mg of escitalopram oxalate and weekly injections of cyanocobalamin were treatments of choice. Conclusion: During follow up of our patient, we can conclude that Levothyroxine and Escitalopram Oxalate were able to improve hypothyroidism symptoms, reduce thyroglobulin and peroxidase antibodies and improve mood symptoms including cognitive functions. In addition to this, weekly cyanocobalamin injections were integrated into the management. As parietal cell antibodies decreased, gastrointestinal symptoms also disappeared. By addressing the concerns of our patient, we improved quality of care, and this is reflected in the patient’s wellbeing in physical and psychological.

关键词： Cyanocobalamin Escitalopram Oxalate Hashimoto’s Thyroiditis Levothyroxine Pernicious Anemia Polyglandular Syndrome

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Fuzzy Logic Implementation of Vulnerability Assessment in a Coastal Aquifer of northern Sicily

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Journal of Geoscience and Environment Protection 2021年第8期9卷 177-188页

作者： Antonio Cimino adolfo Cimino Antonino Oieni Department of Physics University of Palermo Italy Consultant Geologist Sicilian Geologist Association Cammarata Italy Consultant Geologist Sicilian Geologist Association Tusa Italy

Aquifers can be defined as complex ecological systems. Their description is closely influenced by geometrical and geological parameters, which portray the hydrogeological behaviour of underground systems. This paper reports a contribution to assessn>ing groundwater contamination risk in a particular Sicily sector, where deterministic approaches have methodically assessed and mapped vulnerability and quality of groundwater. In detail, in the coastal area of Acquedolci (Northern Sicily), already intensely surveyed in the frame of interdisciplinary projects on geological risk, implementing models and systems have been experimented, also considering fuzzy logic. Cartography issues are here presented and compared, with particular regard to the effect of stochastic hydrogeological elements (i.e. “depth to water”), locally characterized by variability for simultaneous climate, overdraft, irrigation and sea encroachment. n>The n>authors show how fuzzy logic, applied to vulnerability settings, contributes to a better comprehension of the passive scenery offered by aquifers inn style="font-family:""> Acquedolci Sicily area.

关键词： Fuzzy Logic Groundwater Vulnerability Acquedolci Plain SInTACS Method Pearson Correlation Coefficient

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Methotrexate induced sprue-like syndrome

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World Journal of Gastroenterology 2008年第45期14卷 7009-7011页

作者： Marta Maia Boscá Ramon Aón Rosana Villagrasa nelly Balza Cirilo Amorós adolfo Benages Empar Mayordomo Juan Ramon Corts Gastroenterology Department Hospital Clínic Universitari of València Department of Anathomo-Pathology Hospital Clínic Universitari of València Rheumatology Department Hospital Clínic Universitari of València

A 52 year-old male patient diagnosed of ankylosing spon-dylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate. He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed. The histological study of the duodenal biopsies showed villus atrophy. After removing the methotrexate, administrating intra-muscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved.

关键词： Methotrexate Villous atrophy Iron deficiency anemia Paucisymptomatic Absence of celiac antibodies

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Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

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neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo adolfo López-Ornelas Alejandro Rodríguez-Oviedo neptali Gutiérrez de la Cruz Marco Antonio Vargas-Hernández Adriana Jiménez Laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of *** brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or ***'s disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several ***,its impairment has barely been considered as a potential therapeutic *** we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ***,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport

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Synchronization of Robot Manipulators Actuated By Induction Motors with Velocity Estimator

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Computer Modeling in Engineering & Sciences 2019年第11期121卷 609-630页

作者： Felipe J.Torres Gerardo V.Guerrero Carlos D.García Ricardo Zavala-Yoe Mario A.García adolfo R.López University of Guanajuato Division of Engineering Campus Irapuato-SalamancaCarretera Salamanca-Valle de Santiago km 3.5+1.8GuanajuatoSalamanca36885México national Technological of Mexico/national Center of Research and Technological Development Av.Palmira S/N colonia PalmiraMorelosCuernavaca62490México School of Engineering and Sciences Monterrey TechnologicalPuente 222 Ejidos de HuipulcoCiudad de México14380México Superior Technological Institute of Irapuato Carretera Irapuato-Silao km 12.5GuanajuatoIrapuato36821México

A complete modeling(including the actuator dynamics)of a robot manipulator that uses three-phase induction motors is presented in this paper.A control scheme is designed to synchronize robot manipulators actuated by induction motors under a masterslave scheme in the case where the joint velocity of the slave robots is *** of the research on the synchronization of robot manipulators assumes the use of ideal actuators to drive the joints;for that reason,in this work,a three-phase induction motor is considered to be a direct-drive actuator for each *** entire model of the mated system is obtained by a combination of the dynamics of the induction motor and robot ***,the synchronization control algorithm for a master-slave scheme in both the joint space and workspace of robot manipulators driven by induction motors is *** observer based on the entire model is proposed to estimate the joint velocity of the slave robot *** the Lyapunov criterion,a stability analysis of the synchronization control with a velocity estimator is *** analytical results show the synchronization and estimation errors are globally,uniformly,and ultimately *** with multiple robots demonstrate the performance of the proposed control algorithm.

关键词： Synchronization robot manipulator induction motor Lyapunov stability observer based on the model

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Recalcitrant cubital tunnel syndrome

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Plastic and Aesthetic Research 2015年第1期2卷 176-182页

作者： adolfo Vigasio Ignazio Marcoccio Eleonora Morandini Hand Surgery and Orthopaedic Microsurgery Unit Istituto Clinico Cittàdi Brescia-Gruppo San Donato25123 BresciaItaly

Ulnar nerve neuropathy at the elbow represents the second most frequent compression neuropathy of the upper *** the five different anatomical areas responsible for ulnar nerve compression at the elbow region,the epitrochlear-olecranon channel and Osborne’s arcade are the most *** additional cause of nerve damage is a dynamic process in which the ulnar nerve dislocates anteriorly at the epitrochlear-olecranon level during elbow flexion,partially or completely,causing nerve friction and constriction leading to chronic neuropathic *** after primary surgery is generally secondary to procedural errors or technical omissions,frequently represented by incomplete nerve decompression,failure to recognize nerve instability after nerve decompression,loosening of the nerve anchor after superficial nerve transposition with consequent spontaneous nerve relocation in the epitrochlear-olecranon channel,perineural fibrosis and neurodesis,which creates new nerve *** association with the clinical evaluation,electromyography studies,magnetic resonance imaging and ultrasound are useful tools that may aid in the decision-making process when considering revision *** anterior transposition is the most commonly employed technique but also has a high failure rate,as opposed to anterior deep transposition that is the method of choice for many surgeons despite being more technically *** results of revision surgery following recalcitrant ulnar nerve compression at the elbow are inferior to those obtained after primary ***,the clinical advantages remain relevant provided that the revision surgery is performed by an expert *** avoid misinterpretation,the patient is completely informed of the quality of results.

关键词： Cubital tunnel syndrome failed nerve decompression nerve transposition recalcitrant nerve compression ulnar nerve

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Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer

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World Journal of Gastroenterology 2009年第19期15卷 2345-2350页

作者： Martha Estela Salcido-neyoy adolfo Sierra-Santoyo Olga Beltrán-Ramírez José Roberto Macías-Pérez Saúl Villa-Trevio Department of Cell Biology Center of Research and Advanced Studies of the National Politechnic InstituteMexicoDFCP 07360México External Section of Toxicology Center of Research and Advanced Studies of the National Politechnic InstituteMexicoDFCP 07360México

AIM： To study the effect of celecoxib （CXB） on diethylnitrosamine activation through the regulation of cytochrome P450 in a hepatocarcinogenesis ***： Six-week-old male Sprague-Dawley rats were randomly divided into five groups, a non-treated group （nT）, a diethylnitrosamine-treated group （DEn）, a DEn＋CXB-treated group （DEn＋CXB）,and CXB 8 d-treated and CXB 32 d-treated groups. The effects of celecoxib on the enzymatic activities of CYP1A1, 2A, 2B1/2, and 2E1 were assessed in hepatic microsomes 24 h after DEn *** in CYPIA1 and CYP2B1/2 protein expression were also evaluated. The rate of DEn metabolism was measured by the production of the deethylation metabolite acetaldehyde, and the denitrosation metabolite ***： DEn＋CXB administration produced a significant increase in the enzymatic activities ofCYP2B1/2 and 1A1, whereas it did not change the activities of CYP2A and 2E1, compared to that of the DEn group. CXB treatment for eight days did not produce a significant effect on enzymatic activity when compared to the nT group; however, when it was administered for prolonged times （CXB 32 d group）,the enzymatic activities were increased in a similar pattern to those in the DEn＋CXB group. The observed increase in the enzymatic activities in the DEn＋CXB group was accompanied by an increase in the CYP2B1/2 protein levels; no changes were observed in the levels of CYPIA1. In vitro, CXB increased the denitrosation of DEn, a pathway of metabolic detoxification. The addition of SKF-525A, a preferential inhibitor of CYP2B, abrogated the denitrosation of ***： These results suggest that the mechanism of action of CXB involves enhancement of the detoxification of DEn by an increasing denitrosation via CYP2B1/2.

关键词： Hepatocarcinogenesis Chemoprevention Diebhylnitrosamine Denitrosation Celecoxib CytochromesP450

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Rectal perforation from endometriosis in pregnancy:Case report and literature review

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World Journal of Gastroenterology 2010年第5期16卷 648-651页

作者： adolfo Pisanu Daniela Deplano Stefano Angioni Rossano Ambu Alessandro Uccheddu Department of Surgery Clinica ChirurgicaUniversity of CagliariOspedale San Giovanni di DioVia Ospedale 4609124CagliariItaly Department of Obstetrics and Gynecology University of CagliariOspedale San Giovanni di DioVia Ospedale 4609124CagliariItaly Department of Pathology University ofCagliariOspedale San Giovanni di DioVia Ospedale 4609124CagliariItaly

This case report describes a woman with spontaneous rectal perforation from decidualized endometriosis in pregnancy.A 37-year-old woman was admitted to our hospital at 30 wk of pregnancy with symptoms suggestive of pyelonephritis,which persisted until 33 wk of gestation when delivery of a premature male baby was performed through a cesarean section. On postoperative day 2,an abdominal computed tomography showed free air in the peritoneal cavity and a pelvic *** celiotomy revealed a diffuse severe fecaloid peritonitis that originated from a 3-cm wide rectal perforation.A Hartmann operation was then *** findings wereconsistent with decidualization of the rectal *** 20 cases of intestinal perforation due to endometriosis have been reported in the *** report is believed to be the first case of spontaneous rectal perforation from endometriosis in pregnancy,and it shows the potential occurrence of serious and unexpected complications of the disease.

关键词： Endometriosis Colonic perforation Acute abdomen Peritonitis Pregnancy

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Recent advances in bird sperm morphometric analysis and its role in male gamete characterization and reproduction technologies

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Asian Journal of Andrology 2016年第6期18卷 882-888页

作者： Julian Santiago-Moreno Milagros Cristina Esteso Silvia Villaverde-Morcillo adolfo Toledano-Diaz Cristina Castafio Rosario Velazquez Antonio Lopez-Sebastian Agustin Lopez Goya Javier Gimeno Martinez Department of Animal Reproduction INIA 28040 Madrid Spain Veterinary Clinical and Research Services Fieb Foundation 28760 Tres Cantos Madrid Spain FAUnIA 28032 Madrid Spain

Postcopulatory sexual selection through sperm competition may be an important evolutionary force affecting many reproductive traits, including sperm morphometrics. Environmental factors such as pollutants, pesticides, and climate change may affect different sperm traits, and thus reproduction, in sensitive bird species. Many sperm-handling processes used in assisted reproductive techniques may also affect the size of sperm cells. The accurately measured dimensions of sperm cell structures （especially the head） can thus be used as indicators of environmental influences, in improving our understanding of reproductive and evolutionary strategies, and for optimizing assisted reproductive techniques （e.g., sperm cryopreservation） for use with birds. Computer-assisted sperm morphometry analysis （CASA-Morph） provides an accurate and reliable method for assessing sperm morphometry, reducing the problem of subjectivity associated with human visual assessment. Computerized systems have been standardized for use with semen from different mammalian species. Avian spermatozoa, however, are filiform, limiting their analysis with such systems, which were developed to examine the approximately spherical heads of mammalian sperm cells. To help overcome this, the standardization of staining techniques to be used in compute^-assessed light microscopical methods is a priority. The present review discusses these points and describes the sperm morphometric characteristics of several wild and domestic bird species.

关键词： avian computer-assisted assay morphometry spermatozoa

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汇率波动同美国分部门进口贸易流量之间关系研究

汇率波动同美国分部门进口贸易流量之间关系研究

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作者： GARCIA CORTES adolfo 复旦大学

学位级别：硕士

本文研究汇率水平及汇率波动对美国分部门进口贸易流量的影响。本文选取2002年1月至2012年12月之间美国同加拿大、中国、德国、日本及墨西哥等国的相关数据来进行上述研究。本文主要采用协整方法及误差纠正模型来研究美国分部门进口贸... 详细信息

本文研究汇率水平及汇率波动对美国分部门进口贸易流量的影响。本文选取2002年1月至2012年12月之间美国同加拿大、中国、德国、日本及墨西哥等国的相关数据来进行上述研究。本文主要采用协整方法及误差纠正模型来研究美国分部门进口贸易流量与其影响因素之间的关系。在研究过程中所使用的汇率波动为动态标准偏差,且实证过程中所用汇率为实际汇率。本文研究结果表明,汇率波动仅对美国对中国的分部门进口贸易流量产生显著正向影响。

关键词：汇率波动美国协整方法

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