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Antipsoriatic,anti-inflammatory,and analgesic effects of an extract of red propolis

中国药理学报 1997年第3期18卷 274-276页

作者： Nuris LEDÓN Angel CASACÓ Ricardo gonzÁlez Nelson MERINO addys gonzález Zenaida TOLÓN Department of Pharmacology National Center for Scientific ResearchP O Box6990HavanaCuba

AIM:To study the antipsoriatic,anti-inflammatory,and analgesic effects of ethanolic extract of red *** and RESULTS:This extract induced the formation of granular layer in the mouse tail test used as a model of *** 50 mg·kg^(-1)ig showed anti-inflammatory activity in the cotton-pellet granuloma assay in rats,in croton oil-induced edema in mice at a dose of 25%(2.5μL),and in the peritoneal capillary permeability test in mice at a dose of 10 mg·kg^(-1).The extract(25 mg·kg^(-1)ig)showed analgesic effect in the model of acetic acid-induced writhings,whereas 40 mg·kg^(-1)was effective in the hot plate test in ***-Anti-inflammatory,analgesic,and antipsoriatic properties of Cuban red propolis were evident.

关键词： psoriasis propolis indomethacin keratosis anti-inflammatory agents analgesics

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Polymeric Nanohydrogels of Poly(N-Isopropylacrylamide)Combined with Others Functionalized Monomers:Synthesis and Characterization

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Journal of Biomaterials and Nanobiotechnology 2014年第1期5卷 31-38页

作者： Lissette Aguero Luztono Yuneivy Cepero Donates Luis Guillermo Guerrero Ramirez addys gonzalez Palomo Dionisio Zaldivar Silva Issa Katime Departamento de Quimica Macromolecular Centro de BiomaterialesUniversidad de La HabanaHabanaCuba Grupo de Nuevos Materiales y Espectroscopia Supramolecular Facultad de Ciencias y TecnologiaBilbaoEspana Departamento de Biologia de Sistemas Centro de Inmunologia MolecularHabanaCuba

Nanohydrogels from inverse microemulsion (w/o) polymerization, at 25°C, of N-isopropylacrylamide (NIPA) and functionalized monomers are described. The functionalized monomers were: N-(pyridine-4-ylmethyl) acrylamide (NP4MAM) and tert-butyl 2-acrylamidoethyl carbamate (2AAECM). The polymeric nanohydrogel obtained was characterized by attenuated total reflectance Fourier-transformed infrared spectroscopy (ATR-FTIR) and proton nuclear magnetic resonance spectrometry (1HNMR), while their morphology and particle size was assessed by scanning electron microscopy (SEM) and dynamic light scattering. Their thermal properties were studied by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). As a preliminary measure of biocompatibility, in vitro evaluations of the nanohydrogels were carried out by cellular toxicity (colon carcinoma cells, CT-26) and hemocompatibility tests. These evaluations showed that these nanohydrogels were not toxic in the examined concentration range and exhibited preliminary blood compatibility;therefore they could be used in biomedical applications.

关键词： N-Isopropylacrylamide Nanohydrogels Inverse Microemulsion Polymerization In Vitro Biocompatibility

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