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Gastric antisecretory and antiulcer activity of bovine hemoglobin

World Journal of Gastroenterology 2013年第21期19卷 3291-3299页

作者： abdulrahman k al asmari Saud al Omani Ibrahim Elfaki Mohammad Tariq Ahmed al Malki Saeed al Asmary Research Center Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia Department of Surgery Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia Department of Gastroenterology Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia Family and Community Medicine Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia

AIM: To investigate gastric antisecretory and gastro- protective activity of bovine hemoglobin (B-Hb) in rats. METHODS: Adult albino-Wistar rats were divided into groups of 6 animals each. B-Hb in doses of 100, 300 and 900 mg/kg body weight was tested for gastric acid secretion and antiulcer activity. Gastric secretions were measured 6 h after pylorus ligation in rats pretreated with B-Hb. The acidity was measured by titrating gastric contents against 0.01 mol/L NaOH to pH 7. Indomethacin ulcers were produced by oral administration of 30 mg/kg bw in the rats pretreated with B-Hb one hour before indomethacin. Six hours after indomethacin stomach removed and ulcer index was recorded. Ethanol ulcer were produced by 1 mL of ethanol in the rats pretreated with B-Hb 30 min before the *** hour after ethanol stomach were cut open to score ulcers. Histological examination and analysis of gastric wall mucus, non-protein sulfhydryl groups (NP-SH), and myeloperoxidase (MPO) were carried in gastric tissue following ethanol administration. RESULTS: In control rats pylorus ligation for 6 h resulted in the accumulation of 8.1 ± 0.61 mL of gastric secretion. The treatment of the rats with 100, 300 and 900 mg/kg of B-Hb produced a significant decrease in the volume of gastric secretion 5.6 ± 0.63, 5.5 ± 0.75 and 4.7 ± 0.58 mL respectively as compared to the control group [analysis of variance (ANOVA) F = 4.77, P kg (24.3 ± 3.29 mm2), 300 mg/kg (16.2 ± 1.45 mm2) and 900 mg/kg (12.6 ± 1.85 mm2) produced a dose dependent decreased the lesion scores (ANOVA F = 4.50, P kg (2.5 ± 0.42), 300 mg/kg (2.1 ± 0.4) and 900 mg/kg (0.7 ± 0.21) significantly inhibited the formation of gas

关键词： Bovine hemoglobin Gastric ulcers Indomethacin Ethanol Ischemic injury Rats

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Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease

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World Journal of Gastroenterology 2015年第3期21卷 897-904页

作者： Ebtissam Saleh al-Meghaiseeb Mulfi Mubarak al-Otaibi abdulrahman al-Robayan Reem al-Amro Ahmd Saad al-Malki Misbahul Arfin abdulrahman k al-asmari Department of Gastroenterology Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia Research Center Prince Sultan Military Medical CityRiyadh 11159Suadi Arabia

AIM:To study the association of apolipoprotein E(APOE) polymorphisms with the susceptibility ofinflammatory bowel disease(IBD) in Saudi ***:APOE genotyping was performed to evaluate the allele and genotype frequencies in 378 Saudi subjects including IBD patients with ulcerative colitis(n = 84) or Crohn's disease(n = 94) and matched controls(n = 200) using polymerase chain reaction and reverse-hybridization ***:The frequencies of the APOE ε2 allele and ε2/ε3 and ε2/ε4 genotypes were significantly higher in IBD patients than in controls(P allele and its heterozygous genotypes may increase the susceptibility to *** the contrary,the frequencies of the ε3 allele and ε3/ε3 genotype were lower in IBD patients as compared to controls,suggesting a protective effect of APOE ε3 for *** prevalence of the ε4 allele was also higher in the patient group compared to controls,suggesting that the ε4 allele may also increase the risk of *** results also indicated that the APOE ε4 allele was associated with an early age of IBD *** effect of gender or type of IBD(familial or sporadic) on the frequency distribution of APOE alleles and genotypes was noticed in this ***:APOE polymorphism is associated with risk of developing IBD and early age of onset in Saudi patients,though further studies with a large-size population are warranted.

关键词： Apolipoprotein E Polymorphism Inflammatory bowel d

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Efficacy and safety of non-vitamin k antagonist oral anticoagulants post-kidney transplantation

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World Journal of Transplantation 2019年第6期9卷 134-144页

作者： Muhammad A Bukhari abdulrahman al-Theaby Mohammed Tawhari ali al-Shaggag Ryan Pyrke Azim Gangji Darin Treleaven Christine Ribic Department of Medicine Taif UniversityTaif 26311Saudi Arabia Department of Transplantation King Abdulaziz Medical CityRiyadh 11159Saudi Arabia Department of Nephrology and Transplantation king Fahad Specialist Hospital Dammam 15215Saudi Arabia Department of Nephrology McMaster UniversityHamiltonON L8N 4A6Canada

BACkGROUND Novel oral anticoagulants(NOACs)were developed as alternatives to vitamin k antagonists,primarily warfarin,as they do not require routine monitoring and have limited drug-drug and drug-food ***,the efficacy and safety of these agents in kidney transplantation are not well *** To assess the profile and safety of NOACs for patients who had kidney transplantation,and to provide recommendations and guidelines on therapeutic strategies in these *** This was a retrospective study carried out among adult patients who were actively on the following NOACs(apixaban,rivaroxaban or dabigatran)in our renal transplantation program from December 2015 to December *** patients were identified primarily through electronic medical record system(patient data linkage).Data on the clinical and laboratory profile of the patients were retrieved and analyzed with SPSS *** Complete data on 42 renal transplant patients were retrieved:59.5%males,90.5%were whites and 66.7%were older than 60 years *** mean duration since renal transplantation of the patients was 8.8±7.4 *** most common risk factors for the development of end-stage renal disease in the subjects were hypertension(19.0%),polycystic kidney disease(19.0%),followed by diabetic nephropathy(16.7%)and chronic glomerulonephritis(16.7%).The main indications for NOACs use in the cohort were atrial fibrillation in 25 patients(59.5%)and venous thromboembolism in 10 patients(23.8%).Overall,29 patients(69%)were treated with apixaban,10 patients(23.8%)with rivaroxaban and 3 patients(7.14%)with ***(0%)thromboembolic events were observed during the one-year period,but 3(7.1%)bleeding events occurred in the cohort consisting of 1 patient treated with rivaroxaban 15 mg daily and 2 patients who received apixaban 2.5 mg twice *** were no significant changes in serum tacrolimus level three days after the initiation of NOACs among patients treated with tacrolimus(

关键词： Novel oral anticoagulants Adult patients kidney transplantation Renal outcomes Efficacy

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Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

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Design of Machine Learning Based Smart Irrigation System for Precision Agriculture

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Computers, Materials & Continua 2022年第7期72卷 109-124页

作者： khalil Ibrahim Mohammad Abuzanouneh Fahd N.al-Wesabi Amani abdulrahman albraikan Mesfer al Duhayyim M.al-Shabi Anwer Mustafa Hilal Manar Ahmed Hamza Abu Sarwar Zamani k.Muthulakshmi Department of Information Technology College of ComputerQassim UniversityAl-Bukairiyah52571Saudi Arabia Department of Computer Science King Khalid UniversityMuhayel Aseer62529Saudi Arabia&Faculty of Computer and ITSana’a UniversitySana’a61101Yemen Department of Computer Science College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11564Saudi Arabia Department of Natural and Applied Sciences College of Community-AflajPrince Sattam bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Department of Management Information System College of Business and AdministrativeTaibah UniversityMedina42353Saudi Arabia Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Department of Electronics and Communication Engineering Dr.N.G.P Institute of TechnologyCoimbatore641048India

Agriculture 4.0,as the future of farming technology,comprises numerous key enabling technologies towards sustainable *** use of state-of-the-art technologies,such as the Internet of Things,transform traditional cultivation practices,like irrigation,to modern solutions of precision *** achieve effectivewater resource usage and automated irrigation in precision agriculture,recent technologies like machine learning(ML)can be *** this motivation,this paper design an IoT andML enabled smart irrigation system(IoTML-SIS)for precision *** proposed IoTML-SIS technique allows to sense the parameters of the farmland and make appropriate decisions for *** proposed IoTML-SIS model involves different IoT based sensors for soil moisture,humidity,temperature sensor,and ***,the sensed data are transmitted to the cloud server for processing and decision ***,artificial algae algorithm(AAA)with least squares-support vector machine(LS-SVM)model is employed for the classification process to determine the need for ***,the AAA is applied to optimally tune the parameters involved in the LS-SVM model,and thereby the classification efficiency is significantly *** performance validation of the proposed IoTML-SIS technique ensured better performance over the compared methods with the maximum accuracy of 0.975.

关键词： Automatic irrigation precision agriculture smart farming machine learning cloud computing decision making internet of things

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Intelligent Deep Convolutional Neural Network Based Object DetectionModel for Visually Challenged People

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Computer Systems Science & Engineering 2023年第9期46卷 3191-3207页

作者： S.kiruthika Devi Amani abdulrahman albraikan Fahd N.al-Wesabi Mohamed k.Nour Ahmed Ashour Anwer Mustafa Hilal Department of Computing Technology SRM Institute of Science and TechnologyIndia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science College of Science&Art at MahayilKing Khalid UniversitySaudi Arabia Department of Computer Science College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of Engineering Mathematics and Physics Faculty of Engineering and TechnologyFuture University in EgyptNew Cairo11845Egypt Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia

Artificial Intelligence(AI)and Computer Vision(CV)advancements have led to many useful methodologies in recent years,particularly to help visually-challenged *** detection includes a variety of challenges,for example,handlingmultiple class images,images that get augmented when captured by a camera and so *** test images include all these variants as *** detection models alert them about their surroundings when they want to walk *** study compares four CNN-based pre-trainedmodels:ResidualNetwork(ResNet-50),Inception v3,DenseConvolutional Network(DenseNet-121),and SqueezeNet,predominantly used in image recognition *** on the analysis performed on these test images,the study infers that Inception V3 outperformed other pre-trained models in terms of accuracy and *** further improve the performance of the Inception v3 model,the thermal exchange optimization(TEO)algorithm is applied to tune the hyperparameters(number of epochs,batch size,and learning rate)showing the novelty of the *** accuracy was achieved owing to the inclusion of an auxiliary classifier as a regularizer,hyperparameter optimizer,and factorization ***,Inception V3 can handle images of different *** makes Inception V3 the optimum model for assisting visually challenged people in real-world communication when integrated with Internet of Things(IoT)-based devices.

关键词： Pre-trained models object detection visually challenged people deep learning Inception V3 DenseNet-121

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词： convective boundary condition Darcy-Forchheimer medium hybrid nanofluid Joule heating magnetohydrodynamic (MHD) numerical solution squeezing flow regression analysis O361 O175.2

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