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Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer

World Journal of Gastroenterology 2011年第16期17卷 2109-2112页

作者： Ozgur kemik a.u s.rba. kemik Aziz sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz sevim Purisa Erol Kisli sefa Tuzun Cetin Kotan Department of General surgery Yuzuncu Y1l University Medical Faculty Department of Biochemistry Cerrahpasa Medical Faculty University of Istanbul Department of Gastroenterology Medical FacultyUniversity of Yüzüncü Y1l Department of Endocrinology Okmeydani Education and Research Hospital Department of Internal Medicine Medical FacultyUniversity of Yüzüncü Y1l Department of Biostatistics Istanbul Medical FacultyUniversity of Istanbul II.General surgery Haseki Education and Research Hospital

AIM:To eva.uate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric ***:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this *** serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent ***:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological *** were not significantly associated with age,gender,tumor location,or histological ***:Increased MMP-1 and TIMP-1 were associated with gastric *** these markers are not good markers for diagnosis,these markers show in advanced gastric cancer.

关键词： Gastric cancer Matrix metalloproteinase-1 Tissue matrix metalloproteinase-1

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Outcome of surgical treatment of intestinal perforation in typhoid fever

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World Journal of Gastroenterology 2010年第33期16卷 4164-4168页

作者： Aziz sümer zgür kemik Ahmet Cumhur Dülger Aydemir Olmez Ismail Hasirci Erol Kisli Vedat Bayrak Gulay Bulut etin Kotan Department of General surgery Medical FacultyUniversity of YüzüncüY1l Department of Gastroenterology Medical FacultyUniversity of YüzüncüY1l Department of Pathology Medical FacultyUniversity of YüzüncüY1l

AIM:To represent our clinical experience in the treatment of intestinal perforation arising from typhoid ***:The records of 22 surgically-treated patients with typhoid intestinal perforation were eva.uated ***:There were 18 males and 4 females,mean age 37 years(range,8-64 years).Presenting symptoms were fever,abdominal pain,diarrhea or *** cases were subjected to segmental resection and end-to-end anastomosis,while 3 cases received 2-layered primary repair following debridement,one case with multiple perforations received 2-layered primary repair and end ileostomy,one case received segmental resection and end-to-end anastomosis followed by an end ileostomy,and one case received segmental resection and end ileostomy with mucous fistula *** morbidity was seen in 5 cases and mortality was found in one ***:Intestinal perforation resulting from salmonella typhi is an important health problem in Eastern and southeastern *** management of this illness,early and appropriate surgical intervention is vital.

关键词： Intestinal perforation Typhoid fever Treat- ment

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