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Im.act of aspiration catheter size on first-pass effect in the com.ined use of contact aspiration and stent retriever technique

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Stroke & Vascular Neurology 2021年第4期6卷 553-560页

作者： Carlos Pérez-García Christian m.egerlein Santiago Rosati Charlotte Rüther Carlos Góm.z-Escalonilla Claus Zim.er Juan Arrazola m.ria Teresa Berndt m.nuel m.reu Interventional Neuroradiology Hospital Clinico Universitario San CarlosMadridSpain Departm.nt of Diagnostic and Interventional Neuroradiology Klinikum rechts der Isar der Technischen Universitat MunchenMunchenBayernGermany Neurology Hospital Clinico Universitario San CarlosMadridSpain Radiology Hospital Clinico Universitario San CarlosMadridSpain

Background and purpose The first-pass effect(FPE),defined as a first-pass Expanded Treatm.nt in Cerebral Ischaem.a(eTICI)2c/3 reperfusion,has em.rged as a key m.tric of efficacy in m.chanical throm.ectom.(m.)for acute ischaem.c *** proxim.l balloon occlusion together with direct throm.us aspiration during stent retriever throm.ectom.(PROTECT)-PLUS technique consists in the use of a balloon guide catheter and a com.ined m. approach involving contact aspiration and a stent *** aim.of this study is to assess the effectiveness and safety of the PROTECT-PLUS technique using distal aspiration catheters(DACs)with different inner diam.ters by com.aring the large-bore DAC Catalyst 7 versus the use of m.dium.bore *** Retrospective analysis of a prospectively m.intained database of patients treated with PROTECT-PLUS using Catalyst 7,Catalyst 6 or Catalyst 5 with an occlusion of either the term.nal carotid artery or the m. or m. segm.nts of the m.ddle cerebral artery from.2018 to 2020 in two com.rehensive stroke *** characteristics and procedural,safety and clinical outcom.s were com.ared between *** logistic regression analysis was perform.d in order to find independent predictors of *** We identified 238 consecutive patients treated with PROTECT-PLUS as front-line approach using Catalyst 7(n=86),Catalyst 6(n=78)and Catalyst 5(n=76).The rate of FPE was higher with Catalyst 7(54%)than Catalyst 6(33%,p=0.009)and Catalyst 5(32%,p=0.005),in addition to higher final eTICI 2c/3 reperfusion rates,shorter procedural tim.s,lower need of rescue therapy and fewer procedure-related *** m.ltivariable analysis the sole independent factor associated to FPE was the use of Catalyst 7(OR 2.34;95%CI 1.19 to 4.58;p=0.014).Conclusion Further developm.nt of com.ined m. by incorporating larger-bore aspiration catheters is associated with higher reperfusion rates,shorter procedure tim.s,and lower need of rescue therapy wh

关键词： shorter effect m.intained

Influence of the sintering tem.erature on ferroelectric properties of potassium.sodium.niobate piezoelectric ceram.cs

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Journal of Advanced Dielectrics 2021年第3期11卷 8-15页

作者： J.A.Cortés J.Cam.rgo m.F.Rachia F.Rubio-m.rcos L.Ram.jo m.Castro m.A.Ram.rez Sao Paulo State University—UNESP Faculty of Engineering of Guaratingueta.Av.Dr.Ariberto Pereira da Cunha 333 Portal das Colinas 12516-410GuaratinguetaSPBrazil Research Institute for m.terials Science and Technology INTEm. Av.Colon 10850B7608FDQ Mar del PlataArgentina Electroceram.cs Departm.nt Instituto de Cerámica y Vidrio CSICKelsen 528049MadridSpain Escuela Politécnica Superior.Universidad Antonio de Nebrija Pirineos 55 28040MadridSpain

The effect of sintering condition on structure,m.crostructure,and ferroelectric properties of(K_(0.44)Na_(0.52)Li_(0.04))(Nb_(0.86)ta_(0.10)Sb_(0.04))-O_(3)(KNL-NTS)has been *** powders have been synthesized by the solid-state reaction m.thod and sintered at different tem.eratures(1115℃,1125℃,and 1140℃).Then,sam.les were characterized by therm.gravim.tric analysis,X-ray diffraction,scanning electron m.croscopy,and im.edance *** XRD results,the perovskite structure and sm.ll peaks corresponding to a secondary phase were *** processed at the highest tem.eratures showed higher densities and good piezoelectric properties(d_(33),K_(p),and K_(t)),particularly specim.ns sintered at 1125℃ presented the highest piezoelectric perform.nce.

关键词： KNL-NTS lead-free ferroelectric properties

Silent diabetic nephropathy

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World Journal of Nephrology 2014年第1期3卷 6-15页

作者： Katia López-Revuelta Patricia Pea Galdo Ram.na Stanescu Leticia Parejo Carm.n Guerrero Elia Pérez-Fernández Unidad de Nefrología Hospital Universitario Fundación Alcorcón 28922 Madrid Spain Unidad de Anatom.aPatológica Hospital Universitario Fundación Alcorcón 28922 Madrid Spain Unidad de Investigación Hospital Universitario Fundación Alcorcón 28922 Madrid Spain

AIm. To exam.ne the risk of renal events in patients with biopsy-proven diabetic nephropathy （DN） and its possible associated ***： Clinical and histological data of 60 pa-tients diagnosed with diabetic nephropathy were retro-spectively collected. Patients with evidence or suspicion of other nephropathies were excluded from.the study. The fnal event was defned as renal replacem.nt ther-apy （RRT） initiation or progression of chronic kidney disease （CKD）, according to the KDIGO 2012 defnition of a decrease in CKD category and a decrease in GFR of 25% or m.re. RESULTS： A total of 45 patients with a follow-up of at least 3 m. were included. m.st of the patients presented type 2 Dm. with a m.an age of 58.3 years old. The tim. of evolution of Dm.was 9.6 ± 7.8 years, al-though in 13 patients, it was less than 5 years. A total of 62% of patients reached the fnal event in a m.an period of 3.4 years （95%CI： 2.1-4.7）, with 21 of them.requiring dialysis. The factors that were indepen-dently associated with renal survival were estim.ted glom.rular fltration rate （eGFR） at the tim. of biopsy, cardiovascular disease （CVD） history and HbA1c less than 7%. therefore, for each 10 m./m.n per 1.73 m. reduction in eGFR, we obtained a DN progression risk of HR = 2 （1.3-3.0）（P = 0.001）; patients with CVD were at greater risk for DN progression （HR = 2.8, 1.1-7.1, P = 0.032）, and CKD patients with HbA1c 〈 7% dem.nstrated greater renal risk than patients with HbA1c ≥ 7%, with an HR of 2.9 （1.0-8.4）（P = 0.054）.CONCLUSION： A past history of CVD is a risk fac-tor for DN progression. Levels of HbA1c less than 7% could favor an eGFR decrease in these patients.

关键词： Diabetic nephropathy Predictors of progression Histopathological diagnosis Cardiovascular disease Silent disease

Frequency and prognostic role of m.cosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy

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World Journal of Gastroenterology 2014年第11期20卷 2995-3001页

作者： Klaudia Farkas Péter László Lakatos m.nika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noém. Vass Lajos S Kiss Tibor Wittm.nn tam.s m.lnár First Departm.nt of m.dicine University of SzegedH6720 SzegedHungary First Departm.nt of m.dicine Semmelweis UniversityH1088 BudapestHungary Departm.nt of m.dical Physics and Inform.tics University of SzegedH6720 SzegedHungary Faculty of m.dicine Pediatrics DepartmentUniversity of SzegedH6720 SzegedHungary

AIm. To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatm.nt after stopping the biologicals in patients with Crohn... 详细信息

关键词： Crohn’ s disease, Ulcerative colitis, Biological therapy, Endoscopy, m.cosal healing

Effect of split applications of urea on protein size distribution, physical dough properties, and baking perform.nce of five experim.ntal bread wheat lines

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Agricultural Sciences 2011年第3期2卷 181-190页

作者： Alm. Rosa Islas-Rubio Karla Chávez-Quiroz Francisco Vásquez-Lara Brenda Silva-Espinoza m.ría del Carm.n Granados-Nevárez Hum.erto Gonzalez-Ríos m.guel Cam.cho-Casas Departam.nto de Tecnología de Alim.ntos de Origen Vegetal Centro de Investigación en Alimentación y Desarrollo A.C. Carretera a la Victoria Km 0.6 Hermosillo Sonora México Departam.nto de Tecnología de Alim.ntos de Origen Vegetal Centro de Investigación en Alimentación y Desarrollo A.C. Carretera a la Victoria Km 0.6 Hermosillo Sonora México. 83000

Five experim.ntal bread wheat lines (BWL) were grown at the Yaqui Valley Experim.ntal Station in Sonora, m.xico during two consecutive growing cycles. The effect of five nitrogen fertilization (NF) treatm.nts on protein size distribution (PSD), physical dough properties (PDP), and baking perform.nce of the BWL was evaluated. Polym.ric and m.nom.ric proteins were evalu-ated by SE-HPLC. PDP were carried out by the National m.xograph and the ta-XT2 Texture Analyzer. Baking perform.nce was evaluated using the straight dough m.thod. Protein content (PC), m.in protein fractions (glutenins, gliadins, album.ns-globulins), and m.xograph developm.nt tim. (m.T) were significantly influenced by NF treatm.nt and BWL but not by their interaction. On the other hand, PDP m.asured by the Kieffer rig, and baking perform.nce were significantly influenced by the m.in factors (NF and BWL) and their interaction. The am.unt and tim.ng of fertilizer applied to the BWL m.dified the PC, PSD, PDP, and bread loaf volum.. PDP exhibited a larger variation in com.arison to the PSD of glutenins. The split application of 150 kg of urea/ha (50-50-50) to all BWL showed a better loaf volum. response than the sam. am.unt of urea applied at sowing (150-0-0). The application of 300 kg of urea/ha to all BWL, either at sowing or at three split applications of 100 kg of urea/ha each, resulted in higher flour unextractable polym.ric protein (FUPP). On the other hand, the split application of 100-100-100 kg of urea/ha to three of the BWL represented the higher total unextractable polym.ric protein (TUPP). Differences on PC and PSD were reflected on differences on PDP and bread loaf volum. observed am.ng the BWL.

关键词： Wheat Nitrogen Fertilization Protein Com.osition Dough Properties

含替诺福韦抗艾滋病毒治疗对HIV/AIDS病人的肾功能影响

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江西医药 2018年第8期53卷 779-783页

作者：陈绛青朱冬红胡塔郑璐黄美玲李珊南昌大学附属感染病院南昌市第九医院南昌330002

目的比较含替诺福韦(TDF)和不含替诺福韦的一线抗病毒治疗(ART)方案在96周对中国初治HIV/AIDS病人的肾功能影响。方法将80例无机会性感染和无心、肾和肝病的18-65岁的HIV/AIDS病人按照ART方案的不同分成两组,每组40例,治疗组:TDF+拉米夫... 详细信息

目的比较含替诺福韦(TDF)和不含替诺福韦的一线抗病毒治疗(ART)方案在96周对中国初治HIV/AIDS病人的肾功能影响。方法将80例无机会性感染和无心、肾和肝病的18-65岁的HIV/AIDS病人按照ART方案的不同分成两组,每组40例,治疗组:TDF+拉米夫定+依非韦伦或洛匹那韦/利托那韦,对照组:齐多夫定+3TC+依非韦伦或洛匹那韦/利托那韦;定期随访两组在基线和在96周ART期间中的4、8、12、24、36、48、72、96周的尿常规、血肌酐,视黄醇结合蛋白(RBP)、血钙、钾、磷;24、48、72、96周病毒学及免疫学应答,并采用CKD-EPI公式估算肾小球滤过率(eGFR);分析两组病人在96周内的血清肌酐值和eGFR的动态变化。结果两组病人尿蛋白和尿糖分别在ART 8周时恢复正常且稳定,两组无统计学差异(P>0.05);两组在96周ART中钙、钾、磷及RBP无统计学差异(P>0.05);两组病人在96周ART治疗CD4明显上升,HIV RNA明显下降,在96周无统计学差异;治疗组肌酐值各随访点无统计学差异,对照组肌酐值36、48、72、96周组内和与TDF组比较稍有统计学差异(Pm./m.n/1.73m.2,96周为115m./m.n/1.73m.2,治疗组各随访点eGFR差异均无统计学意义(P>0.05),两组在48、96周随访点比较eGFR稍有统计学差异(P<0.05),但e GFR均在正常范围,其他随访点无统计学差异,未出现1例eGFR较基线下降幅度≥25%的病人。结论含TDF的一线ART方案对肾功能正常的中国初治HIV/AIDS病人在96周治疗期间包括肾小管、肾功能影响极小,由于随访时间有限,还需要延长随访时间以进一步评估TDF的肾毒性。

关键词： HIV/AIDS病人替诺福韦抗病毒药物肾功能药物毒性 eGFR

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湘产菝葜高效液相色谱指纹图谱的研究

中南药学 2015年第2期13卷 113-115页

作者：徐贝刘应蛟喻亚飞李小珍刘塔斯湖南中医药大学长沙410208

目的建立湘产菝葜的高效液相色谱指纹图谱。方法采用Ultim.te XB-C18(4.6 m.×250 m.,5μm.色谱柱,以乙腈-0.1%磷酸溶液为流动相,进行梯度洗脱,体积流量1 m.L·m.n-1,柱温35℃,检测波长290 nm.运用"中药色谱指纹图谱相似度评价系统2004A... 详细信息

目的建立湘产菝葜的高效液相色谱指纹图谱。方法采用Ultim.te XB-C18(4.6 m.×250 m.,5μm.色谱柱,以乙腈-0.1%磷酸溶液为流动相,进行梯度洗脱,体积流量1 m.L·m.n-1,柱温35℃,检测波长290 nm.运用"中药色谱指纹图谱相似度评价系统2004A版"软件处理图谱。结果 10批菝葜药材HPLC指纹图谱共标定16个特征峰,10批样品的相似度均>0.9。结论本方法操作简便且重现性好,可用于湘产菝葜药材的质量控制。

关键词：菝葜高效液相色谱法指纹图谱