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城市中心区的结核病分子流行病学与传统流行病学

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国际结核病与肺部疾病杂志 2001年第4期 172-179页

作者： J.Solsona J.A.Caylà E.Verdú M.P.Estrada S.Garcia D.RocaDirección de Asistencia Primària (DAP) de Ciutat Vella (Barcelona) reas Básicas de Salud (ABS) 'Raval Nord' 'Raval Sud' 'Casc Antic' 'Gàtic' 'Lluís Sayé' y 'Barceloneta' B.Miquel P.Coll F.March the Cooperative Group for Contact Study of Tuberculosis Patients in Ciutat Vella 张宗德 Centro de Prevención y Control de la Tuberculosis 'Dr Lluís Sayé Servicio de Epidemiologia. Instituto Municipal de la Salud Hospital de San Pau Servei de Microbiologia Dirección de Asistencia Primària (DAP) de Ciutat Vella (Barcelona) reas Básicas de Salud (ABS) 'Raval Nord' 'Raval Sud' 'Casc Antic' 'Gàtic' 'Lluís Sayé' y 'Barceloneta' Departament de Genética i Microbiologia Universidad Autònoma de Barcelona Barcelona Spain

背景:分子流行病学在近期的结核病传播中的重要性得到了加强,但同时也发现了一些与传统流行病学的显著区别。目的:1.在城市中心区的结核病高流行区(163/100000)和有成簇危险的人群中用RFLP法确定成簇病例的百分比。2.比较传统接触者追... 详细信息

背景:分子流行病学在近期的结核病传播中的重要性得到了加强,但同时也发现了一些与传统流行病学的显著区别。目的:1.在城市中心区的结核病高流行区(163/100000)和有成簇危险的人群中用RFLP法确定成簇病例的百分比。2.比较传统接触者追踪法(CCT)与RFLP法的作用。分析:1997-1998年间巴塞罗纳市Ciutat Vella区收集的培养阳性的165例标本,利用IS6110和pTBN12(PGRS)序列进行RFLP分析:对251例公布的病例中的171例(68.1％)进行了接触者追踪调查。通过计算比值比(OR)、使用95％的可信区间(CI)评价它们之间的联系。多变量的分析采用逻辑回归。结果:通过RFLP分析,发现76例(46.0％)的分离株在IS6110和PGRS序列上有成簇现象,通过传统接触者追踪法(CCT),在858名接触者中,发现了30名新病人,57名病人存在关联。就RFLP和CCT调查结果来看,主要危险因素为静脉吸毒(IVDU)。44名独居者病例未包括在传统接触者追踪中,50％的病例用RFLP分析存在成簇。RFLP和CCT法的符合率为8/13(61.5％);5例不符合者为新近的非洲移民。在随后的RFLP分析中15/55例病例发现有流行病学关联。结论:成簇病例的百分率很高。CCT在发现新病例时很有用,但在追踪传播路径时存在缺陷。CCT的覆盖面需要在被忽视的个体及与RFLP结果的符合率方面提高。

关键词：结核(TB) 传统接触追踪(CCT) RFLP 流行病学

Post-Hospital Syndrome and Hyponatremia

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Health 2021年第8期13卷 846-856页

作者： José Bellod-Tonda Julio Blázquez-Encinar María Dolores Jover-Ríos Carmen Seguí-Pérez Juan Méndez-Mora Francisco Caparrós-Hernández Álex Méndez-Jover Marc Seguí-Pérez David Baláž Leticia Espinosa del Barrio Jesús Corbacho-Redondo Carles García-Cervera Juan Manuel Núñez-Cruz Isidro Hernández-Isasi Javier Guzmán-Martínez Angie Gómez-Uranga Pedro Esteve-Atiénzar Jorge Peris-García Veronica Martínez-Sempere Eliana Damonte-White Óscar Hernando Ruiz-Ariza Juan Carlos López-Corbalán Lourdes Lajara-Villar Andrea riaño-Pérez Paloma Chazarra-Pérez María Escamilla-Espínola Maria Luisa Asensio-Tomás Miguel Ángel Auladell-Alemany Laura Serna-Torres Asunción Pérez-Fullana Amparo Gómez-Siurana Sergio Menargues-Irles José Miguel Seguí-Ripoll Internal Medicine Department University Hospital of San Juan Alicante Spain Internal Medicine Department Torrevieja University Hospital Alicante Spain Internal Medicine Department Hospital La Vega Baja of Orihuela Alicante Spain CEU Cardinal Herrera University Veterinary Hospital Valencia Spain Secondary School Marist Brothers High School Alicante Spain Department of Clinical Medicine Miguel Hernández University Elche Spain Primary Care Medicine Benilloba Spain Sub-Delegation of the Government Alicante Spain Chemical Engineering Department University of Alicante Alicante Spain

Introduction: Post-hospital syndrome (PHS) is defined as a period of vulnerability during the first 30 days after a patient is discharged from hospital, in which multiple factors come into play. Hyponatremia is the most frequent hydroelectrolytic disorder in hospitalized patients and may be related to the appearance of PHS. Objective: The objective is to estimate the prevalence of PHS that is assessed as the rate of readmissions in the first 30 days after discharge, in patients with hyponatremia. Material and Methods: It is a descriptive observational study of patients with hyponatremia who were discharged from 1 September 2010 to 2 February 2020 at the Internal Medicine Service of the Hospital University of San Juan (Alicante, Spain). Results: Of the 25 included patients, 5 (20%) were readmitted within a month of discharge, after a mean of 11.4 days (standard deviation [SD] 5.1). The overall mortality of the study was 20% (n = 5), with one case of death in the first 30 days post-hospitalization (4%). In 12 patients (48%) the origin of the hyponatremia was undetermined. The most frequently recorded etiology for the condition was pharmacological (n = 7, 28%), and there was pronounced variability in its clinical and laboratory study. The most widely used corrective measure was drug withdrawal, in 16 patients (64%). Water intake restriction was the most common treatment after discharge (5 patients, 20%), followed by urea (2 patients, 8%), while tolvaptan was not used. Conclusion: Hyponatremia may be the cause of PHS, which could increase the rate of early readmission. Hyponatremia is an underdiagnosed and undertreated entity, so it is necessary to apply an appropriate system to optimize its management and, in future studies, to assess its impact on PHS.

关键词： Hospitalization Hyponatremia Patient Readmission Inappropriate ADH Syndrome

本底个值质控图在放免仪长期稳定性监控中的应用

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同位素 2004年第2期17卷 122-124页

作者：孙建文张勤王叙馥王国明左书耀李雨升青岛大学医学院附属医院核医学科山东青岛266003 青岛大学医学院附属医院放免中心山东青岛266003

在放免仪短期稳定性评价的基础上制作了本底个值质控图并应用于长期稳定性的监控。结果表明,该方法可作为放免仪长期稳定性考核、量化的一个手段。

关键词：本底放免仪质控图

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静脉曲张性溃疡患者的社会人口学和临床研究

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 55-55页

作者： Fernandes Abbade L.P.Department of Dermatology Clinical Hospital of the Medical School of Botucatu Unesp Botucatu-SP 18618-000 Brazil Dr Lastó ria S. de Almeida Rollo H. Stolf H.O. 党倩丽

Background: Venous ulcer is the most serious consequence of chronic venous insufficiency and is responsible for almost 70% of chronic leg ulcers. The main purpose of this research was to describe social, demographic and clinical characteristics of patients with venous ulcers and to identify some professional repercussions of this pathology. Subjects and methods: We evaluated patients with a clinical picture compatible with venous ulcer. The sociodemographic characteristics of the patients, and the clinical characteristics and professional repercussions of the pathology were studied. We used the ankle- brachial index to identify associated arterial disease. The body mass index (BMI) was used for the classification of the nutritional condition of the patients. Results: A total of 120 patients were included in the study (90 females and 30 males; 80.8% White; 44.2% > 60 years old). Ninety-one per cent of the patients had been in educatin for less than 4 years, and 89.7% were on the poverty line. Thirty-five per cent were retired, 2.5% were receiving government help due to disease and 4.2% were unemployed. About 16% of patients were out of work due to the disease, and 49.2% presented some degree of disability in terms of work tasks. The ulcer area was less than 30 cm2 in 69.1% of patients. The first ulcer episode occurred in 13.4 years on average, and 64.2% of patients had recurrent episodes. Females presented on average 5.65 pregnancies, and 75.4% of patients were overweight. Conclusion: Venous ulcer occurred mainly in the low-income population, who presented with little formal education. Generally, the ulcers were present for a long time and were recurrent, with repercussions for the capabilities of patients to work.

关键词：静脉曲张性溃疡社会人口学患者临床研究慢性静脉功能不全慢性下肢溃疡临床特征职业影响体重指数动脉疾病