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Valorising Ikseon-dong’s Hanok residence as a heritage place

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Frontiers of Architectural Research 2023年第5期12卷 947-965页

作者： Young-Jae Kim Ah-ra-Mi Yun Department of Heritage Conservation and Restoration Korea National University of Cultural HeritageBuyeo 33115Republic of Korea

This study aims to create a basis for sustainable conservation by identifying the heritage value of 166 *** on old land registers and cadastral maps of the 1920s and 1930s,it interpreted the construction procedure,social background,and urban architectural characteristics of the road and plot subdivision of the modern Hanok ***-dong Hanok produced four types of ground plans based on the grid-street *** study argues that these innovative experiments have already been attempted through Bak Young-hyo’s proposals in his Geonbaekseo and the architectural activities of Jeong Segwon,and that the idea of applying various housing types,layouts,and grid-street system planning was embodied through the development of the Hanok complex in ***,this attempt greatly influenced the design of other Hanok complexes built in colonial Gyeongseong after 1936,taking the Ikseon-dong Hanok as a role *** radiation of new perspectives will be a groundwork for the future sustainable conservation of heritage places.

关键词： ModernHanok residence Plot subdivision Ikseon-dong Construction background Heritage interpretation Sustainable conservation

Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesica A López-Mora Valeria García-Zárate Ana Varela-Constantino Sergio U Villegas-De Leon Xitlaly J González-Leal raúl del Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R Colunga-Pedraza Olga G Cantú-Rodríguez César H Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López david Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and Cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

温经活络方治疗胶原诱导性关节炎小鼠模型实验研究

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中国中西医结合杂志 2024年第6期44卷 717-724页

作者：卢璐许小芬崔晓慧胡长锋张纪达浙江中医药大学附属第三医院中药药剂科杭州310013 浙江中医药大学基础医学院杭州310053

目的基于肿瘤坏死因子α(TNF-α)/核因子-κB(NF-κB)及辅助性T细胞17(Th17)细胞分化探讨温经活络方治疗胶原诱导性关节炎(CIA)小鼠作用机制。方法 40只6周雄性DBA/1小鼠采用随机数字表法分为正常对照组、模型组、甲氨蝶呤组和温经活... 详细信息

目的基于肿瘤坏死因子α(TNF-α)/核因子-κB(NF-κB)及辅助性T细胞17(Th17)细胞分化探讨温经活络方治疗胶原诱导性关节炎(CIA)小鼠作用机制。方法 40只6周雄性DBA/1小鼠采用随机数字表法分为正常对照组、模型组、甲氨蝶呤组和温经活络方组,共4组,每组10只。以胶原注射的方式构建胶原诱导性关节炎模型,在初次免疫后21天起分别以双蒸水、甲氨蝶呤、温经活络方干预35天,期间每周评价各组小鼠的体重,从初次免疫后第24天起每周评价各组足肿胀度、关节炎症评分。HE染色检测足趾及踝关节病理改变情况;酶联免疫吸附(ELISA)法检测小鼠血清中抗环瓜氨酸肽抗体(CCP-Ab)、小鼠白细胞介素-6(IL-6)和TNF-α水平;实时定量聚合酶链式反应(RT-qPCR)检测足关节NF-κB、骨保护素(OPG)和破骨细胞分化因子(raNKL)mRNA表达水平;免疫蛋白质印迹(Western Blot)检测小鼠脾脏及足关节NF-κB、p-NF-κB表达情况;流式细胞术检测小鼠脾脏中Th17细胞表达情况。结果与正常组比较,模型组小鼠毛发枯槁,进食量减少,体重明显降低(PraNKL mRNA表达亦明显升高(PraNKL mRNA表达水平下降(Pra关节炎症、降低关节炎症评分、抑制骨质破坏、改善其病理变化。

关键词：类风湿关节炎温经活络方炎症因子核因子-κB 辅助性T细胞17 中药复方

Distribution and space use of seed-dispersing rodents in central Pyrenees:implications for genetic diversity,conservation and plant recruitment

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Integrative Zoology 2018年第3期13卷 307-318页

作者： Jon URGOITI Alberto MUÑOZ Josep Maria ESPELTa.ra.l BONAL CREAF Cerdanyola del VallésCataloniaSpain Department of Didactics of Experimental Sciences Faculty of EducationUniversity Complutense of MadridMadridSpain Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Research group of Genetic and Cultural Biodiversity Research centre for Cinegetic Resources(CSIC-UCLM-JCCM)Ciudad RealSpain

The function and conservation of many forest ecosystems depend on the distribution and diversity of the community of rodents that consume and disperse *** habitat preferences and interactions are especially relevant in alpine systems where such granivorous rodents reach the southernmost limit of their distribution and are especially sensitive to global *** analyzed the community of granivorous rodents in the Pyrenees,one of the southernmost mountain ranges of *** species were identified by DNA with particular attention to the Apodemus species,which are prominent seed-dispersing rodents in *** confirmed for the first time the presence of the yellow-necked mouse,Apodemus flavicollis,in central Pyrenees,a typical Eurosiberian species that reaches its southernmost distribution limit in this *** also found the wood mouse,Apodemus sylvaticus,a related species more tolerant to Mediterranean *** rodents were spatially segregated by *** was rare at high altitudes,which might cause the genetic differentiation between populations of the different valleys reported *** also found other seed consumers like dormice,Elyomis quercinus,and voles,Myodes glareolus,with marked habitat *** suggest that population isolation among valleys may increase the genetic diversity of rodents,like *** also highlight the potential threat that global warming may represent for species linked to high-altitude refuges at the southern edge of its distribution,like Apodemus ***,we discuss how this threat may have a dimension in the conservation of alpine forests dispersed by these rodent populations.

关键词： DNA analysis Pyrenees rodents seed dispersal vegetation structure

Phytochemical overview and medicinal importance of Coffea species from the past until now

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1101-1110页

作者： éva Brigitta Patay Tímea Bencsik Nóra Papp Department of Pharmacognosy Faculty of PharmacyUniversity of Pécs

Coffea(coffee) species are grown in almost all countries along the Equator. Many members of the genus have a large production history and an important role both in the global market and researches. Seeds(Coffeae semen) are successfully used in food, cosmetic, and pharmaceutical industries due to its caffeine and high polyphenol content. Nowadays, the three best-known coffee species are Arabic(Coffea arabica L.), Robusta(Coffea robusta L. Linden), and Liberian coffees(Coffea liberica Hier.). Even though, many records are available on coffee in scientific literature, wild coffee species like Bengal coffee(Coffea benghalensis Roxb. Ex Schult.) could offer many new opportunities and challenges for phytochemical and medical studies. In this comprehensive summary, we focused on the ethnomedicinal, phytochemical, and medical significance of coffee species up to the present.

关键词： Phytochemistry Medicinal importance Caffeine Polyphenols

Engineered biomimicry for harvesting solar energy:a bird’s eye view

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International Journal of Smart and Nano Materials 2013年第2期4卷 83-90页

作者： raúl J.Martín-Palma Akhlesh lakhtakia Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA

All three methodologies of engineered biomimicry–bioinspiration,biomimetics,and bioreplication–are represented in current research on harvesting solar *** processes and porous surfaces inspired by plants and certain marine animals,respectively,are being investigated for solar *** dye-sensitized solar cells deploy artificial photosynthesis,bioinspired nanostructuring of materials in solar cells improves *** textured coatings for solar cells have been shown to reduce optical reflectance and increase optical absorptance over a broad spectral *** lenses fabricated by a bioreplication technique offer similar promise for reduced reflectance by increasing the angular field of view.

关键词： bioinspiration biomimetics bioreplication solar cell artificial photosynthesis antireflective coating engineering biomimicry

Microstructure and Tensile Behavior of a Nano-Structured Al-Fe Based Alloy

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Journal of rare Earths 2004年第Z2期22卷 65-68页

作者： Won-Yong Kim Jae-Sung Park Mok-Soon Kim Tae-Yeub ra Advanced Materials R&D Center Korea Institute of Industrial Technology # 472Kajwa-dongSuh-guIncheon 404-254Korea School of Materials Science and EngineeringInha University # 253Yonghyun-dongNam-guIncheon 402-751Korea School of Materials Science and EngineeringInha University # 253Yonghyun-dongNam-guIncheon 402-751Korea Advanced Materials R&D CenterKorea Institute of Industrial Technology # 472Kajwa-dongSuh-guIncheon 404-254Korea

Room temperature deformation behavior of A1-8Fe-2Mo-2V-1Zr alloy produced by spray forming and subsequent warm-extrusion at 693 K and/or rolling at 423 K was investigated in terms of tensile test and microstructural *** the specimen processed by spray forming and warm extrusion, the microstructure consisting of equiaxed grains with the average grain size of 500 nm in the matrix phase and uniformly dispersed fine intermetallic A13(Fe, Mo, V, Zr) and A16(Fe, Mo, V, Zr) phases less than 100 nm was characterized. It was revealed that subsequent warm rolling after warm extrusion promotes precipitation of a fine dispersoid from the supersaturated matrix phase. Warm rolling was found to be effective to increase the yield and tensile strength in the high strain rate regime. Elongation of the warm rolled specimen showed highe r value than extruded specimen over the whole strain rate region studied.

关键词： microstructure tensile deformation A1-Fe based alloy spray forming extrusion warm rolling precipitation strain rate sensitivity

Effects on the quality of frozen-thawed alpaca(lama pacos)semen using two different cryoprotectants and extenders

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Asian Journal of Andrology 2005年第3期7卷 303-309,页

作者： AlexeiSantiani WilfredoHuanca RómuloSapana TeodosioHuanca NéstorSepúlveda.ra.lSánchez VeterinaryInstitute for Tropical and Highland Research Faculty of Veterinary MedicineUniversidad Nacional Mayor de San MarcosP.O.Box 03-5034Lima 41Perú OuimsachataExperimental Station National Institute of Agrarian ResearchPunoPerú Reproductive Biotechnology Center Universidad de La FronteraP.O.Box 54-DTemucoChile

Aim： To evaluate two extenders and two cryoprotectant agents （CPA） for alpaca semen cryopreservation. Methods： Semen samples were obtained from four adult alpacas （lama pacos） and frozen using extender Ⅰ （TRIS, citrate, egg yolk and glucose） or extender Ⅱ （skim milk, egg yolk and fructose）, each containing either glycerol （G） or ethylene glycol （EG） as CPA. Consequently, four groups were formed： 1） extender Ⅰ-G; 2） extender Ⅰ-EG; 3） extender Ⅱ-G; and 4） extender Ⅱ-EG. Semen was diluted in a two-step process： for cooling to 5 ℃ （extenders without CPA）, and for freezing （extenders with CPA）. Viability and acrosome integrity were assessed using trypan blue and Giemsa stains. Results： When compared, the motility after thawing was higher （P 〈 0.05） in groups Ⅱ-EG （20.0 %±6.7 %） and Ⅱ-G （15.3 %±4.1%） than that in groups Ⅰ-G （4.0 %±1.1%） and Ⅰ-EG （1.0 %±1.4 %）. Viable spermatozoa with intact acrosomes in groups Ⅱ-EG （18.7 %±2.9 %） and Ⅱ-G （12.7 %±5.9 %） were higher than that in groups Ⅰ-G （5.7 %±1.5 %） and Ⅰ-EG （4.0 %±1.0 %）. Conclusion： The skim milk- and egg yolk-based extenders containing ethylene glycol or glycerol to freeze alpaca semen seems to promote the survival of more sperm cells with intact acrosomes than the other extenders. （Asian J Androl 2005 Sep; 7： 303-309）

关键词： cryopreservation glycerol ethylene glycol extenders alpaca spermatozoa

Aquaporins:Their role in cholestatic liver disease

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World Journal of Gastroenterology 2008年第46期14卷 7059-7067页

作者： Guillermo L Lehmann Maria C larocca Leandro R Soria.ra.l A Marinelli Instituto de Fisiología Experimental Consejo Nacional de Investigaciones Científicas y TécnicasFacultad de Ciencias Bioquímicas y FarmacéuticasUniversidad Nacional de Rosario2000 RosarioSanta FeArgentina

This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and *** bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of *** question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of *** in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein *** combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water *** cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability.

关键词： Aquaporin Cholestasis Estrogen Hepatocyte Obstructive cholestasis, Sepsis Water transport