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Role of seed size, phenology, oogenesis and host distribution in the specificity and genetic structure of seed weevils (Curculio spp.) in mixed forests

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Integrative Zoology 2018年第3期13卷 267-279页

作者： Harold ARIAS-LEClaIRE raúl BONAL daniel GARCÍA-LÓPEZ Josep Maria ESPELTA CREAF Centre for Ecological Research and Forestry ApplicationsCerdanyola del Vallès08193Spain Exact and Natural Sciences School State Distance University of Costa RicaUNEDMercedes de Montes de OcaSan JoséCosta Rica Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Zoology Department Autonomous University of BarcelonaCerdanyola del VallèsSpain

Synchrony between seed growth and oogenesis is suggested to largely shape trophic breadth of seed-feeding insects and ultimately to contribute to their co-existence by means of resource partitioning or in the time when infestation *** we investigated:(i)the role of seed phenology and sexual maturation of females in the host specificity of seed-feeding weevils(Curculio spp.)predating in hazel and oak mixed forests;and(ii)the consequences that trophic breadth and host distribution have in the genetic structure of the weevil *** analyses were used to establish unequivocally host specificity and to determine the population genetic *** identified 4 species with different specificity,namely Curculio nucum females matured earlier and infested a unique host(hazelnuts,Corylus avellana)while 3 species(Curculio venosus,Curculio glandium and Curculio elephas)predated upon the acorns of the 2 oaks(Quercus ilex and Quercus pubescens).The high specificity of *** coupled with a more discontinuous distribution of hazel trees resulted in a significant genetic structure among *** addition,the presence of an excess of local rare haplotypes indicated that *** populations went through genetic expansion after recent ***,these effects were not observed in the more generalist Curculio glandium predating upon ***,co-existence of weevil species in this multi-host-parasite system is influenced by both resource and time *** what extent the restriction in gene flow among *** populations may have negative consequences for their persistence in a time of increasing disturbances(*** in Mediterranean areas)deserves further research.

关键词： Corylus avellana Curculio spp. genetic structure Quercus spp. trophic breadth

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The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significance

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Animal Diseases 2022年第1期2卷 1-15页

作者： daisy Yan One Hyuk ra Bingfang Yan Sidney Kimmel Medical College Thomas Jefferson University1025 Walnut StPhiladelphiaPA 19107USA Department of Anesthesiology Brigham and Women's Hospital75 Francis StBostonMA 02115USA Division of Pharmaceutical Sciences James L Winkle College of PharmacyUniversity of CincinnatiCincinnatiOH 45229USA

Infectious pandemics result in hundreds and millions of deaths,notable examples of the Spanish Flu,the Black Death and *** current pandemic,caused by SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),is unprecedented even in the historical term of *** unprecedentedness is featured by multiple surges,rapid identification of therapeutic options and accelerated development of ***,originally developed for Ebola viral disease,is the first treatment of COVID-19(Coronavirus disease 2019)approved by the United States Food and Drug *** demonstrated by in vitro and preclinical studies,this therapeutic agent is highly potent with a broad spectrum activity against viruses from as many as seven families even cross ***,randomized controlled trials have failed to confirm the efficacy and *** improves some clinical signs but not critical parameters such as *** antiviral agent is an ester/phosphorylation prodrug and excessive hydrolysis which increases cellular *** is given intravenously,leading to concentration spikes and likely increasing the potential of hydrolysis-based *** review has proposed a conceptual framework for improving its efficacy and minimizing toxicity not only for the COVID-19 pandemic but also for future ones caused by remdesivir-sensitive viruses.

关键词： Animal model Carboxylesterases COVID-19 Coronavirus Drug-drug interactions interspecies difference Pandemic Remdesivir SARS-CoV-2

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Dose-dependent effect of histamine on antibody generation in vivo

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 112-116页

作者： Tripathi T Shahid M Khan HM Khan ra Siddiqui MU DePartment of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Microbiology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University

Objective:To delineate immunomodulatory role of histamine on antibody generation pr of ile in rabbit in the present dose-dependent histamine ***:The cohort comprised of three groups(Ⅲ,ⅣandⅤ),containing six rabbits each,and received subcutaneous histamine 50μg/kg×bis in die(b.i.d.),100μg/kg×*** 200μg/kg X b.i.d.,respectively for 10 days (starting from the 1st day).They were subsequently immunized on the 3rd day with intravenous injection of sheep blood cell(SRBC)(1×10 cells/mL).GroupⅡ(positive control)(n=6) received vehicle(sterile distilled water) and immunized at day 3 similarly while groupⅠ(negative control) (n=6) remained non-immunized and received only *** experimentations were performed in *** samples were collected on pre-immunization(pre-I)(day 0),as well as on days 7-,14-,21-,28- and 58- post-immunization(post-I).Immunological parameters[total immunoglobulins(Igs),IgM and IgG]were analyzed by enzyme linked immunosorbent assay (ELISA) ***:Histamine could influence a detectable antibody response to SRBC as early as day 7-post-I,which lasted until day 58- *** results were found statistically significant(Pration(until its presence in the body),and the antibody generation titer in vivo were affected by the concentration of histamine.

关键词： Histamine Immumomodulation T-cell dependent antibody response Humoral immune response SRBC

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正负脉冲电压驱动的电磁螺纹插装阀动态特性分析

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液压与气动 2024年第3期48卷 82-90页

作者：刘增光李林飞岳大灵左秀坤刘超兰州理工大学能源与动力工程学院甘肃兰州730050

提出了一种基于PWM技术的正负脉冲电压控制策略,用于提高锥阀式电磁螺纹插装阀启闭动态响应速度,使其满足数字液压技术的要求。在分析电磁螺纹插装阀结构和工作原理基础上,建立了电磁螺纹插装阀的数学模型,并在AMESim软件中搭建电磁螺... 详细信息

提出了一种基于PWM技术的正负脉冲电压控制策略,用于提高锥阀式电磁螺纹插装阀启闭动态响应速度,使其满足数字液压技术的要求。在分析电磁螺纹插装阀结构和工作原理基础上,建立了电磁螺纹插装阀的数学模型,并在AMESim软件中搭建电磁螺纹插装阀及其测试系统的多物理场耦合建模,研究不同正负脉冲电压持续时间条件下电磁螺纹插装阀线圈电流、阀芯位移、电磁力的变化规律,确定了电磁螺纹插装阀响应速度最快时正负脉冲电压控制策略的最优控制参数。利用半实物仿真系统搭建SCV硬件在环测试实验台,对所提正负脉冲控制策略进行验证。实验表明,与常规电压控制策略相比,当正负脉冲电压控制策略中正负脉冲电压持续时间都为10 ms时,电磁螺纹插装阀的开启时间由30 ms缩短到13.5 ms,其关闭时间由139 ms缩短到14 ms。研究结果为电磁螺纹插装阀的高响应化和数字液压技术的发展提供参考。

关键词：数字液压正负脉冲电压控制电磁螺纹插装阀高速开关阀硬件在环

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Paracremonium moubasheri,a new species from an alkaline sediment of lake Ha.ra.in Wadi-El-Natron,Egypt with a key to the accepted species

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Studies in Fungi 2019年第1期4卷 216-222页

作者： Al-Bedak OA Ismail MA Mohamed ra Assiut University Mycological Centre(AUMC) Assiut UniversityAssiutEgypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiutEgypt

During surveys of extremophilic fungi in hypersaline,alkaline lakes of Wadi-El-Natron,Egypt,an interesting fungus was recovered from a mud sample collected from lake Ha.ra.in Wadi-El-Natron,*** likelihood analysis of Internal Transcribed Spacer(ITS)gene along with morphological comparisons of related taxa revealed a novel taxon,Paracremonium moubasheri which is described and illustrated in the current *** moubasheri can be distinguished from the known species of the genus by its large conidia,in addition to the presence of chlamydospores.

关键词： Acremonium-like Hypersaline Hypocreales new taxon Phylogeny

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Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

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Chinese Journal of Integrative Medicine 2022年第9期28卷 802-808页

作者： Bo-ra Jeon Muhammad Irfan Seung Eun Lee Jeong Hoon Lee Man Hee Rhee laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal Science(NIHHS)Eumseong27709Republic of Korea

Objective:To examine the antiplatelet and antithrombotic activity of Rumex acetosella ***:Standard light aggregometry was used for platelet aggregation,intracellular calcium mobilization assessed using Fura-2/AM,granule secretion(ATP release)by luminometer,and fibrinogen binding to integrin α_(Ⅱb)β_(3) detected using flow *** blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase(MAPK)and phosphoinositide 3-kinase(PI3K)/Akt ***:Rumex acetosella displayed the ability to inhibit platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin α_(Ⅱb)β_(3).Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation(all Pla extract exhibits antiplatelet activity via modulating GPVI signaling,and it may protect against the development of platelet-related cardiovascular diseases.

关键词： antiplatelet ethnomedicine integrinα_(Ⅱb)β_(3) mitogen-activated protein kinase Rumex acetosella L.

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Extrahepatic hepcidin production:The intriguing outcomes of recent years

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World Journal of Clinical Cases 2019年第15期7卷 1926-1936页

作者： raêd daher Thibaud Lefebvre HervéPuy Zoubida Karim UniversitéParis Diderot Bichat siteParis 75018France Inflammation Research Center(CRI) INSERM U1149/ERL CNRS 8252Paris 75018France laboratory of Excellence GR-ExParis 75018France

Hepcidin is the hyposideremic hormone regulating iron *** is a defensin-like disulfide-bonded peptide with antimicrobial *** main site of hepcidin production is the liver where its synthesis is modulated by iron,inflammation and erythropoietic ***,hepcidin locally produced in several peripheral organs seems to be an important actor for the maintenance of iron homeostasis in these *** review highlights the presence of peripheral hepcidin and its potential *** the role of extrahepatic hepcidin could be of great physiological and therapeutic importance for several specific pathologies.

关键词： Hepcidin Extrahepatic hepcidin Iron metabolism Bacterial infection Inflammation

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Soil organic carbon stocks and belowground biomass in patches in heterogeneous grassland

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Grassland Research 2023年第4期2卷 279-288页

作者： Martin Komainda Eliana Mohn Klára Kajzrová Kilian Obermeyer Jan Titěra Vilém Pavlů Johannes Isselstein Department of Crop Sciences Grassland ScienceGeorg-August-UniversityGöttingenGermany Faculty of Science Humanities and EducationTechnical University of LiberecLiberecCzechia Department of Agroecology and Crop Production Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life SciencesPrahaCzechia University of Vechta VechtaGermany Grassland Research Station Liberec Department of Weeds and Vegetation of AgroecosystemsCrop Research InstitutePrahaCzechia Centre of Biodiversity and Sustainable land Use GöttingenGermany

Background:Selective grazing creates stable patches of contrasting sward height,thereby providing different growth conditions for the grass sward above and below ground and potentially affecting soil organic carbon(SOC)*** hypothesized that the presence of patches leads to greater spatial variability in belowground biomass(BGB)and SOC stocks than occurs between pastures managed under different stocking ***:A long-term grazing experiment consisting of three stocking intensities was used for this *** studied BGB,SOC,and soil total nitrogen(Ntot)stocks in the 0-15 cm soil *** diversity of plant species,soil bulk density,soil phosphorus,potassium,and magnesium contents were ***:There were no significant effects of patch or stocking intensity on BGB,SOC,and Ntot *** patches had a greater Shannon diversity than tall patches(plant-available nutrients in soil correlated positively with sward height(plant species diversity with lower soil nutrient contents in short-patch areas and higher nutrient contents together with light competition in tall-patch areas might balance each other out with respect to BGB and SOC stocks.

关键词： grazing land roots seminatural grassland soil organic matter stocking rate

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Pisco grape pomace:Iron/copper speciation and antioxidant properties,towards their comprehensive utilization

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Food Bioscience 2022年第3期47卷 1213-1221页

作者： Fátima Rodríguez-ramos raúl Cañas-Sarazúa Vilbett Briones-labarca Departamento de Ingeniería en Alimentos Universidad de La SerenaAv.Raúl Bitrán Nachary 1305Box 5991720010La SerenaChile

The pisco and wine industry produces hundreds of tons of grape pomace each year in Chile,generating environmental problems,and demanding urgent strategies for its *** aim of this work was to study the pisco grape pomace based on a physicochemical characterization,an iron/copper speciation analysis,and the optimization for polyphenols recovery,establishing the polyphenolic profile,antioxidant properties,and the Fe^(2+)/Cu^(2+) chelating activity,to promote their revalorization as an ingredient with potential application in the food *** chemical characterization showed mainly high values for crude protein(15.36%dw)and potassium(9240.66 mg/kg).The Fe/Cu speciation depicted that iron and copper soluble forms in pisco pomace flour represented 70.57%and 52.18%,respectively,regarding total *** optimized extract showed mainly pyrogallol,catechin and epicatechin,with concentrations of 1078.43±60.14μg/g,883.20±7.57μg/g and,751.76±23.04μg/g,respectively,with a relevant antioxidant capacity by Oxygen radical Absorbance Capacity(OraC)of 1402.15μmol TE/g dw GPE and,a better chelating ability to complex Fe^(2+) than Cu^(2+).The pisco pomace was for the first time chemically characterize,showing it as a potential source of minerals and antioxidant biocompounds,making it a good candidate for nutritional applications,as a rich source of organic matter or even could be potentially utilized to produce value-added commodities,toward a circular economy.

关键词： Pisco grape pomace Polyphenols Chemical speciation analysis Antioxidant capacity Metal chelating ability

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干旱强度影响祁连山西段不同海拔青海云杉的生长恢复

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植物生态学报 2024年第8期48卷 977-987页

作者：张鹏焦亮薛儒鸿魏梦圆杜达石吴璇王旭鸽李倩西北师范大学地理与环境科学学院甘肃省绿洲资源环境与可持续发展重点实验室兰州730070

随着全球气候变化,干旱的频率和强度不断增加,导致森林退化和树木生长速率下降甚至死亡。了解干旱对树木径向生长的影响机制,量化干旱强度对树木径向生长的影响至关重要。该研究利用相关性分析确定祁连山西段3个海拔青海云杉(Picea cras... 详细信息

随着全球气候变化,干旱的频率和强度不断增加,导致森林退化和树木生长速率下降甚至死亡。了解干旱对树木径向生长的影响机制,量化干旱强度对树木径向生长的影响至关重要。该研究利用相关性分析确定祁连山西段3个海拔青海云杉(Picea crassifolia)径向生长的主要气候限制因子,并基于抵抗力、恢复力、弹性和生长偏离程度比较树木径向生长对不同强度干旱事件的响应差异。结果显示:1)3个海拔树木径向生长均对6月平均气温、降水量和标准化降水蒸散发指数响应最强,尤对后者更为显著,说明干旱胁迫强烈限制树木径向生长。2)3个海拔树木径向生长随干湿变化而显著变化;随着干旱强度增强,树木应对干旱事件的抵抗力下降,恢复力上升。3)在中等和极端干旱事件后,3个海拔树木均表现出补偿性生长,但这种补偿性生长是短暂的,在第二年就基本回到干旱前的生长状态;3个海拔树木在严重干旱事件后第一年没有表现出补偿性生长。因此,严重干旱事件后第一年的生长动态是预测青海云杉生长恢复的关键。

关键词：树木年轮气候变化干旱事件补偿性生长径向生长青海云杉

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